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Development of an Enhanced-Throughput Radial Cell Migration Device.

C Ryan Oliver, Andrew C Little, Trisha M Westerhof, Pragathi Pathanjeli, Joel A Yates, Sofia D Merajver,

It is often desirable to evaluate the ability of cells to move in an unrestricted manner in multiple directions without chemical gradients. By combining the standard radial migration assay with injection-molded gaskets and a rigid fixture, we have developed a highly reliable and sensitive method for observing and measuring radial ... Read more >>

SLAS Technol (SLAS technology)
[2020, :2472630320971217]

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Young women's autonomy and information needs in the schools-based HPV vaccination programme: a qualitative study.

Harriet Fisher, Karen Evans, Jo Ferrie, Julie Yates, Marion Roderick, Suzanne Audrey,

BACKGROUND:Until 2019, the English schools-based human papillomavirus (HPV) vaccination programme was offered to young women (but not young men) aged 12 to 13 years to reduce HPV-related morbidity and mortality. The aim of this study is to explore the extent to which young women were able to exercise autonomy within the ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):1680]

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Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes

Alexander Yermanos, Andreas Agrafiotis, Josephine Yates, Chrysa Papadopoulou, Damiano Robbiani, Florian Bieberich, Rodrigo Vazquez-Lombardi, Daniel Neumeuer, Annette Oxenius, Sai Reddy,

Abstract High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously obtain information on adaptive immune receptor repertoires (VDJ repertoires) and transcriptomes. An integrated quantification of immune repertoire parameters such as germline gene usage, clonal expansion, somatic hypermutation ... Read more >>

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Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesis

Melis Arslanhan, Navin Rauniyar, John Yates, Elif Firat-Karalar,

Abstract Aurora kinase A (AURKA) is a conserved kinase that plays crucial roles in numerous cellular processes. Although AURKA overexpression is frequent in human cancers, its pleiotropic functions and complex spatiotemporal regulation have presented challenges in its therapeutic targeting. An essential step to overcome these challenges is the identification of ... Read more >>

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Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation.

Yuanhui Ma, Daniel B McClatchy, Salvador Martínez-Bartolomé, Casimir Bamberger, John R Yates,

Accumulation of aggregated amyloid beta (Aβ) in the brain is believed to impair multiple cellular pathways and play a central role in Alzheimer's disease pathology. However, how this process is regulated remains unclear. In theory, measuring protein synthesis is the most direct way to evaluate a cell's response to stimuli, ... Read more >>

J Proteome Res (Journal of proteome research)
[2020, :]

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Co-production of an educational package for the universal human papillomavirus (HPV) vaccination programme tailored for schools with low uptake: a participatory study protocol.

Harriet Fisher, Suzanne Audrey, Tracey Chantler, Adam Finn, Louise Letley, Sandra Mounier-Jack, Clare Thomas, Julie Yates, Matthew Hickman,

AIM:To co-produce with young people an educational package about the human papillomavirus (HPV) vaccine that is tailored to increase vaccine uptake in schools and populations with lower uptake. INTRODUCTION:Persistent infection with HPV can result in cancers affecting men and especially women. From September 2019, the English-schools-based HPV vaccination programme was ... Read more >>

BMJ Open (BMJ open)
[2020, 10(11):e039029]

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Young women’s autonomy and information needs in the schools-based HPV vaccination programme: A qualitative study

Harriet Fisher, Karen Evans, Jo Ferrie, Julie Yates, Marion Roderick, Suzanne Audrey,

Abstract Background Until 2019, the English schools-based human papillomavirus (HPV) vaccination programme was offered to young women (but not young men) aged 12 to 13 years to reduce HPV-related morbidity and mortality. The aim of this study is to explore the extent to which young women were able to exercise ... Read more >>

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Traveller exposures to animals: a GeoSentinel analysis.

Michael P Muehlenbein, Kristina M Angelo, Patricia Schlagenhauf, Lin Chen, Martin P Grobusch, Philippe Gautret, Alexandre Duvignaud, François Chappuis, Kevin C Kain, Emmanuel Bottieau, Loïc Epelboin, Marc Shaw, Noreen Hynes, Davidson H Hamer, ,

BACKGROUND:Human coexistence with other animals can result in both intentional and unintentional contact with a variety of mammalian and non-mammalian species. International travellers are at risk for such encounters; travellers risk injury, infection and possibly death from domestic and wild animal bites, scratches, licks and other exposures. The aim of ... Read more >>

J Travel Med (Journal of travel medicine)
[2020, 27(7):]

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Tumor microenvironment and Oral Squamous Cell Carcinoma: A crosstalk between the inflammatory state and tumor cell migration.

Alessandro Alves, Leonardo Diel, Grasieli Ramos, Antônio Pinto, Lisiane Bernardi, John Yates, Marcelo Lamers,

OBJECTIVES:To analyze the inflammatory millieu in oral squamous cell carcinoma (OSCC) tumors and the influence of macrophages related-cytokines on the tumor cell migration. MATERIALS AND METHODS:Inflammatory protein profile and macrophage population (M2/M1 ratio) of human OSCC fragments were analyzed by proteomic analysis and flow cytometry assay respectively. To evaluate the ... Read more >>

Oral Oncol (Oral oncology)
[2020, 112:105038]

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PASS-DIA: A Data-Independent Acquisition Approach for Discovery Studies.

Dong-Gi Mun, Santosh Renuse, Mayank Saraswat, Anil Madugundu, Savita Udainiya, Hokeun Kim, Sung-Kyu Robin Park, Hui Zhao, Raja Sekhar Nirujogi, Chan Hyun Na, Nagarajan Kannan, John R Yates, Sang-Won Lee, Akhilesh Pandey,

A data-independent acquisition (DIA) approach is being increasingly adopted as a promising strategy for identification and quantitation of proteomes. As most DIA data sets are acquired with wide isolation windows, highly complex MS/MS spectra are generated, which negatively impacts obtaining peptide information through classical protein database searches. Therefore, the analysis ... Read more >>

Anal Chem (Analytical chemistry)
[2020, 92(21):14466-14475]

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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate.

Sandhya Bangaru, Gabriel Ozorowski, Hannah L Turner, Aleksandar Antanasijevic, Deli Huang, Xiaoning Wang, Jonathan L Torres, Jolene K Diedrich, Jing-Hui Tian, Alyse D Portnoff, Nita Patel, Michael J Massare, John R Yates, David Nemazee, James C Paulson, Greg Glenn, Gale Smith, Andrew B Ward,

Vaccine efforts against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the current COVID-19 pandemic are focused on SARS-CoV-2 spike glycoprotein, the primary target for neutralizing antibodies. We performed cryo-EM and site-specific glycan analysis of one of the leading subunit vaccine candidates from Novavax based on a full-length ... Read more >>

Science (Science (New York, N.Y.))
[2020, :]

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Developing a model of best practice for teams managing crisis in people with dementia: a consensus approach.

Jennifer Yates, Miriam Stanyon, David Challis, Donna Maria Coleston-Shields, Tom Dening, Juanita Hoe, Kaanthan Jawahar, Brynmor Lloyd-Evans, Esme Moniz-Cook, Fiona Poland, Amy Streater, Emma Trigg, Martin Orrell,

BACKGROUND:Teams delivering crisis resolution services for people with dementia and their carers provide short-term interventions to prevent admission to acute care settings. There is great variation in these services across the UK. This article reports on a consensus process undertaken to devise a Best Practice Model and evaluation Tool for ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):505]

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Developing a model of best practice for teams managing crisis in people with dementia: A consensus approach

Jen Yates, Miriam Stanyon, David Challis, Donna Maria Coleston-Shields, Tom Dening, Juanita Hoe, Kaanthan Jawahar, Brynmor Lloyd-Evans, Esme Moniz-Cook, Fiona Poland, Amy Streater, Emma Trigg, Martin Orrell,

Abstract Background: Teams delivering crisis resolution services for people with dementia and their carers provide short-term interventions to prevent admission to acute care settings. There is great variation in these services across the UK. This article reports on a consensus process undertaken to devise a Best Practice Model and evaluation ... Read more >>

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Cytologically targeted next-generation sequencing: a synergy for diagnosing urothelial carcinoma.

Taylor Harris, Ankur Sheel, Yang Zong, Lloyd M Hutchinson, Kristine M Cornejo, Lukas Bubendorf, Jennifer Yates, Andrew H Fischer,

INTRODUCTION:Cytology and cystoscopy are used to detect urothelial carcinoma (UC), but together they still fail to detect some UC cases and are not suitable for screening asymptomatic individuals. Mutations are present in more than 98% of UC, mutations have therapeutic significance, and they can be detected by next generation sequencing ... Read more >>

J Am Soc Cytopathol (Journal of the American Society of Cytopathology)
[2020, :]

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Cortical synaptic diversity naturally arises with heterogeneous neural populations

Jacob Yates, Benjamin Scholl,

Abstract Synaptic inputs onto single cortical neurons in vivo exhibit substantial functional diversity with respect to sensory-driven activity. However, it is unclear what this diversity reflects, appearing counter-productive in generating tuned responses to specific stimuli. We propose that functional diversity naturally arises if neurons extract information encoded from noisy input ... Read more >>

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Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death.

Ling Huang, Daniel B McClatchy, Pamela Maher, Zhibin Liang, Jolene K Diedrich, David Soriano-Castell, Joshua Goldberg, Maxim Shokhirev, John R Yates, David Schubert, Antonio Currais,

Amyloid beta (Aβ) accumulates within neurons in the brains of early stage Alzheimer's disease (AD) patients. However, the mechanism underlying its toxicity remains unclear. Here, a triple omics approach was used to integrate transcriptomic, proteomic, and metabolomic data collected from a nerve cell model of the toxic intracellular aggregation of ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(10):828]

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Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.

Nicola Colclough, Kan Chen, Peter Johnström, Nicole Strittmatter, Yumei Yan, Gail L Wrigley, Magnus Schou, Richard Goodwin, Katarina Varnäs, Sally J Adua, Minghui Zhao, Don X Nguyen, Gareth Maglennon, Peter Barton, James Atkinson, Lin Zhang, Annika Janefeldt, Joanne Wilson, Aaron Smith, Akihiro Takano, Ryosuke Arakawa, Mikhail Kondrashov, Jonas Malmquist, Evgeny Revunov, Ana Vazquez-Romero, Mohammad Mahdi Moein, Albert D Windhorst, Natasha A Karp, M Raymond V Finlay, Richard A Ward, James W T Yates, Paul D Smith, Lars Farde, Zack Cheng, Darren A E Cross,

PURPOSE:Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood-brain barrier (BBB) permeability is considered desirable for increasing clinical efficacy. EXPERIMENTAL DESIGN:We examined the level of brain penetration for 16 irreversible and reversible EGFR-TKIs using multiple ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

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Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol.

Laboni Hoque, Ryan Dewolf, David Meyers, Daniel K White, Kathleen M Mazor, Mihaela Stefan, Sybil Crawford, Karim Alavi, Jennifer Yates, Mark Maxfield, Feiran Lou, Karl Uy, Matthias Walz, Alok Kapoor,

BACKGROUND:Frail older surgical patients face more than a two-fold increase in postoperative complications, including myocardial infarction, deep vein thrombosis, pulmonary embolism, pneumonia, ileus, and others. Many of these complications occur because of postoperative loss of stamina and poor mobility. Preoperative exercise may better prepare these vulnerable patients for surgery. We ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):394]

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Clone Wars: Quantitatively Understanding Cancer Drug Resistance.

James W T Yates, Hitesh Mistry,

A key aim of early clinical development for new cancer treatments is to detect the potential for efficacy early and to identify a safe therapeutic dose to take forward to phase II. Because of this need, researchers have sought to build mathematical models linking initial radiologic tumor response, often assessed ... Read more >>

JCO Clin Cancer Inform (JCO clinical cancer informatics)
[2020, 4:938-946]

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Quantitative analysis of global protein stability rates in tissues.

Daniel B McClatchy, Salvador Martínez-Bartolomé, Yu Gao, Mathieu Lavallée-Adam, John R Yates,

Protein degradation is an essential mechanism for maintaining proteostasis in response to internal and external perturbations. Disruption of this process is implicated in many human diseases. We present a new technique, QUAD (Quantification of Azidohomoalanine Degradation), to analyze the global degradation rates in tissues using a non-canonical amino acid and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15983]

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Impact of new consent procedures on uptake of the schools-based human papillomavirus (HPV) vaccination programme.

Harriet Fisher, Matthew Hickman, Joanne Ferrie, Karen Evans, Michael Bell, Julie Yates, Marion Roderick, Rosy Reynolds, John MacLeod, Suzanne Audrey,

BACKGROUND:Local policy change initiating new consent procedures was introduced during 2017-2018 for the human papillomavirus (HPV) vaccination programme year in two local authorities in the south-west of England. This study aims to assess impact on uptake and inequalities. METHODS:Publicly available aggregate and individual-level routine data were retrieved for the programme ... Read more >>

J Public Health (Oxf) (Journal of public health (Oxford, England))
[2020, :]

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Pharmacotherapy and Lung Function Decline in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review.

Bartolome R Celli, Julie A Anderson, Nicholas J Cowans, Courtney Crim, Benjamin F Hartley, Fernando J Martinez, Andrea N Morris, Holly Quasny, Julie Yates, Jørgen Vestbo, Peter M A Calverley,

BACKGROUND:Whether pharmacological therapy alters decline in forced expiratory volume in 1 second (FEV1) in chronic obstructive pulmonary disease (COPD) remains controversial. Because pharmacotherapy improves health status, exacerbation rate and symptoms, it is unethical to complete placebo-controlled long-term studies aimed at modifying FEV1 decline. OBJECTIVE:We conducted a systematic review of placebo-controlled ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, :]

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Evaluation of Quality of Life in Adult Individuals With Cleft Lip and/or Palate.

Marwan Aljohani, Julian Yates, Martin Ashley, Lucy O'Malley,

OBJECTIVES:The purpose of the present study was to systematically review literature relating to the quality of life (QoL) in adult individuals with cleft lip and/or palate (CLP) and identify which aspect of QoL adults with CLP find to be the most problematic, in comparison to a general non-cleft population. DESIGN:Different ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, :]

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Differential effects of glutamate N-methyl-D-aspartate receptor antagonists on risky choice as assessed in the risky decision task.

Justin R Yates, Matthew J Horchar, Alexis L Ellis, Joy L Kappesser, Prodiges Mbambu, Tanner G Sutphin, Destiny S Dehner, Hephzibah O Igwe, Makayla R Wright,

RATIONALE:Risky choice can be measured using the risky decision task (RDT). In the RDT, animals choose between a large, risky option that is paired with probabilistic foot shock and a small, safe option that is never paired with shock. To date, studies examining the neurochemical basis of decision-making in the ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2020, :]

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Effect of Cleansers on the Colour Stability of Zirconia Impregnated PMMA Bio-Nanocomposite.

Saleh Zidan, Nikolaos Silikas, Julfikar Haider, Julian Yates,

Exposure of denture base acrylic resins to the oral environment and storage media for extended periods of time results in colour change due to changes in the properties of the material. The purpose of this in vitro study was to assess the colour stability of high-impact heat-polymerized denture base acrylic ... Read more >>

Nanomaterials (Basel) (Nanomaterials (Basel, Switzerland))
[2020, 10(9):]

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