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Effects of the GluN2B-selective antagonist Ro 63-1908 on acquisition and expression of methamphetamine conditioned place preference in male and female rats.

Justin R Yates, Hunter L Campbell, Lauren L Hawley, Matthew J Horchar, Joy L Kappesser, Makayla R Wright,

<h4>Background</h4>Methamphetamine abuse has increased significantly in recent years. Currently, there are no FDA-approved pharmacotherapies for the treatment of methamphetamine use disorder. The goal of the current study was to determine if the N-methyl-d-aspartate (NMDA) GluN2B-selective antagonist Ro 63-1908 can block the conditioned rewarding effects of methamphetamine as assessed in conditioned ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2021, 225:108785]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

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DeGlyPHER: an ultrasensitive method for analysis of viral spike N-glycoforms

Sabyasachi Baboo, Jolene Diedrich, Salvador Martínez-Bartolomé, Xiaoning Wang, Torben Schiffner, Bettina Groschel, William Schief, James Paulson, John Yates,

Viruses can evade the host immune system by displaying numerous glycans on their surface “spike-proteins” that cover immune epitopes. We have developed an ultrasensitive “single pot” method to assess glycan occupancy and the extent of glycan processing from high-mannose to complex forms at each N-glycosylation site. Though aimed at characterizing ... Read more >>

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Predicting Hospital Outpatient Attendance Using Random Forest Classifiers

Jonathan Holdship, Harpreet Dhanoa, Adrian Hopper, Claire Steves, Mark Butler, Ingrid Wolfe, Katie Tucker, Carolyn Cooper, Jeremy Yates,

Background: Patient non-attendance of outpatient appointments is a major concern for healthcare providers. These non-attendances are detrimental to the patient's health and a major cost to the provider. However, non-targeted interventions may cost more in administrative resources than the missed appointments themselves. <br><br>Methods: In this work, a random ... Read more >>

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A spatially resolved mechanistic growth law for cancer drug development

Adam Nasim, James Yates, Gianne Derks, Carina Dunlop,

Mathematical models used in pre-clinical drug discovery tend to be empirical growth laws. Such models are well suited to fitting the data available, mostly longitudinal studies of tumour volume, however, they typically have little connection with the underlying physiological processes. This lack of a mechanistic underpinning restricts their flexibility and ... Read more >>

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Stereotactic Body Radiotherapy for Palliation of Hematuria Arising From Urothelial Carcinoma of the Kidney in Unfavorable Surgical Candidates.

Jesse Aronowitz, Linda Ding, Jennifer Yates, Yang Zong, Larry Zheng, Zhong Jiang, Jessica Yancey, Kriti Mittal, Thomas J Fitzgerald,

<h4>Introduction</h4>Hematuria can be a distressing and debilitating complication of urothelial carcinoma (UC) of the kidney for patients who are not candidates for surgery or ureteroscopic ablation. We retrospectively assessed the efficacy, tolerability, and safety of stereotactic body radiotherapy (SBRT) for controlling gross hematuria in this patient population.<h4>Materials and methods</h4>Institutional Review ... Read more >>

Am J Clin Oncol (American journal of clinical oncology)
[2021, 44(5):175-180]

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Finding commonalities in rare diseases through the undiagnosed diseases network.

Josephine Yates, Alba Gutiérrez-Sacristán, Vianney Jouhet, Kimberly LeBlanc, Cecilia Esteves, Thomas N DeSain, Nick Benik, Jason Stedman, Nathan Palmer, Guillaume Mellon, Isaac Kohane, Paul Avillach,

<h4>Objective</h4>When studying any specific rare disease, heterogeneity and scarcity of affected individuals has historically hindered investigators from discerning on what to focus to understand and diagnose a disease. New nongenomic methodologies must be developed that identify similarities in seemingly dissimilar conditions.<h4>Materials and methods</h4>This observational study analyzes 1042 patients from the ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2021, :]

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 10 times

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Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles.

Ashraf M Mohieldin, Rajasekharreddy Pala, Richard Beuttler, James J Moresco, John R Yates, Surya M Nauli,

Extracellular vesicles (EVs) are cell-derived membrane vesicles that are released into the extracellular space. EVs encapsulate key proteins and mediate intercellular signalling pathways. Recently, primary cilia have been shown to release EVs under fluid-shear flow, but many proteins encapsulated in these vesicles have never been identified. Primary cilia are ubiquitous ... Read more >>

J Extracell Vesicles (Journal of extracellular vesicles)
[2021, 10(6):e12086]

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A meta-analysis of tumour response and relapse kinetics based on 34,881 patients: A question of cancer type, treatment and line of treatment.

James W T Yates, S Y Amy Cheung,

<h4>Purpose</h4>Cancer disease burden is commonly assessed radiologically in solid tumours in support of response assessment via the RECIST criteria. These longitudinal data are amenable to mathematical modelling and these models characterise the initial tumour size, initial tumour shrinkage in responding patients and rate of regrowth as patient's disease progresses. Knowing ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 150:42-52]

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Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease.

Casimir Bamberger, Sandra Pankow, Salvador Martínez-Bartolomé, Michelle Ma, Jolene Diedrich, Robert A Rissman, John R Yates,

Misfolding and aggregation of amyloid-β peptide and hyperphosphorylated tau are molecular markers of Alzheimer's disease (AD), and although the 3D structures of these aberrantly folded proteins have been visualized in exquisite detail, no method has been able to survey protein folding across the proteome in AD. Here, we present covalent ... Read more >>

J Proteome Res (Journal of proteome research)
[2021, 20(5):2762-2771]

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Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes.

Alexander Yermanos, Andreas Agrafiotis, Raphael Kuhn, Damiano Robbiani, Josephine Yates, Chrysa Papadopoulou, Jiami Han, Ioana Sandu, Cédric Weber, Florian Bieberich, Rodrigo Vazquez-Lombardi, Andreas Dounas, Daniel Neumeier, Annette Oxenius, Sai T Reddy,

High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously obtain information on adaptive immune receptor repertoires (VDJ repertoires) and transcriptomes. An integrated quantification of immune repertoire parameters, such as germline gene usage, clonal expansion, somatic hypermutation and ... Read more >>

NAR Genom Bioinform (NAR genomics and bioinformatics)
[2021, 3(2):lqab023]

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Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy.

Priscilla D Negraes, Cleber A Trujillo, Nam-Kyung Yu, Wei Wu, Hang Yao, Nicholas Liang, Jonathan D Lautz, Ellius Kwok, Daniel McClatchy, Jolene Diedrich, Salvador Martinez de Bartolome, Justin Truong, Ryan Szeto, Timothy Tran, Roberto H Herai, Stephen E P Smith, Gabriel G Haddad, John R Yates, Alysson R Muotri,

Early-onset epileptic encephalopathies are severe disorders often associated with specific genetic mutations. In this context, the CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by early-onset seizures, intellectual delay, and motor dysfunction. Although crucial for proper brain development, the precise targets of CDKL5 and its relation to patients' symptoms ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2021, :]

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Exposure to a sublethal menadione concentration modifies the mycelial secretome and conidial enzyme activities of Metarhizium anisopliae sensu lato and increases its virulence against Rhipicephalus microplus.

Caio Junior Balduino Coutinho-Rodrigues, Rafael Lopes da Rosa, Maria Clemente de Freitas, Jéssica Fiorotti, Markus Berger, Lucélia Santi, Walter Orlando Beys-da-Silva, John R Yates, Vânia Rita Elias Pinheiro Bittencourt,

Menadione (MND) is known to induce oxidative stress in fungal cells. Here, we explore how exposure to this molecule alters conidial enzyme activities, fungal efficacy against Rhipicephalus microplus, and mycelial secretion (secretome) of an isolate of Metarhizium anisopliae sensu lato. First, the fungus was exposed to different MND concentrations in ... Read more >>

Microbiol Res (Microbiological research)
[2021, 248:126753]

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Glycolipid-Containing Nanoparticle Vaccine Engages Invariant NKT Cells to Enhance Humoral Protection against Systemic Bacterial Infection but Abrogates T-Independent Vaccine Responses.

Travis Shute, Eyal Amiel, Noran Alam, Jennifer L Yates, Katya Mohrs, Elizabeth Dudley, Briana Salas, Chloe Mesa, Adriana Serrata, Daniel Angel, Brandy K Vincent, Amanda Weyers, Paula A Lanthier, Emilie Vomhof-Dekrey, Rachel Fromme, Mitchell Laughlin, Olivia Durham, Jianjun Miao, Devon Shipp, Robert J Linhardt, Kelly Nash, Elizabeth A Leadbetter,

CD4<sup>+</sup> T cells enable the critical B cell humoral immune protection afforded by most effective vaccines. We and others have recently identified an alternative source of help for B cells in mice, invariant NK T (iNKT) cells. iNKT cells are innate glycolipid-specific T cells restricted to the nonpolymorphic Ag-presenting molecule ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, 206(8):1806-1816]

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Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer.

Anbarasu Kumaraswamy, Katherine R Welker Leng, Thomas C Westbrook, Joel A Yates, Shuang G Zhao, Christopher P Evans, Felix Y Feng, Todd M Morgan, Joshi J Alumkal,

<h4>Context</h4>In addition to genetic alterations, epigenetic alterations play a crucial role during prostate cancer progression. A better understanding of the epigenetic factors that promote prostate cancer progression may lead to the design of rational therapeutic strategies to target prostate cancer more effectively.<h4>Objective</h4>To systematically review recent literature on the role of ... Read more >>

Eur Urol (European urology)
[2021, :]

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In situ solid-state nanopore fabrication.

Jasper P Fried, Jacob L Swett, Binoy Paulose Nadappuram, Jan A Mol, Joshua B Edel, Aleksandar P Ivanov, James R Yates,

Nanopores in solid-state membranes are promising for a wide range of applications including DNA sequencing, ultra-dilute analyte detection, protein analysis, and polymer data storage. Techniques to fabricate solid-state nanopores have typically been time consuming or lacked the resolution to create pores with diameters down to a few nanometres, as required ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2021, 50(8):4974-4992]

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Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex.

Haissi Cui, Mridu Kapur, Jolene K Diedrich, John R Yates, Susan L Ackerman, Paul Schimmel,

During mRNA translation, tRNAs are charged by aminoacyl-tRNA synthetases and subsequently used by ribosomes. A multi-enzyme aminoacyl-tRNA synthetase complex (MSC) has been proposed to increase protein synthesis efficiency by passing charged tRNAs to ribosomes. An alternative function is that the MSC repurposes specific synthetases that are released from the MSC ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, 49(7):3603-3616]

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Use of intramuscular ketamine by paramedics in the management of severely agitated patients.

Stephen Bernard, Renee Roggenkamp, Ashleigh Delorenzo, Michael Stephenson, Karen Smith, ,

<h4>Objective</h4>Administration of a sedative agent is required for safe transport of prehospital patients with severe agitation to EDs. Ambulance services in Australasia use ketamine, droperidol or midazolam as first line agent but the optimal agent is uncertain. In Victoria, intramuscular (IM) ketamine is used. The present study aimed to examine ... Read more >>

Emerg Med Australas (Emergency medicine Australasia : EMA)
[2021, :]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

Cited: 1 time

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Norstictic acid is a selective allosteric transcriptional regulator

Julie Garlick, Steven Sturlis, Paul Bruno, Joel Yates, Amanda Peiffer, Yejun Liu, Laura Goo, LiWei Bao, Samantha De Salle, Giselle Tamayo-Castillo, Charles Brooks, Sofia Merajver, Anna Mapp,

Inhibitors of transcriptional protein-protein interactions (PPIs) have high value both as tools and for therapeutic applications. The PPI network mediated by the transcriptional coactivator Med25, for example, regulates stress-response and motility pathways and dysregulation of the PPI networks contributes to oncogenesis and metastasis. The canonical transcription factor binding sites within ... Read more >>

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Coupling of spliceosome complexity to intron diversity

Jade Sales-Lee, Daniela Perry, Bradley Bowser, Jolene Diedrich, Beiduo Rao, Irene Beusch, John Yates, Scott Roy, Hiten Madhani,

<h4>SUMMARY</h4> We determined that over 40 spliceosomal proteins are conserved between many fungal species and humans but were lost during the evolution of S. cerevisiae , an intron-poor yeast with unusually rigid splicing signals. We analyzed null mutations in a subset of these factors, most of which had not been ... Read more >>

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Development and Validation of a Cbct-Based Artificial Intelligence System for Accurate Diagnoses of Dental Diseases

Matvey Ezhov, Maxim Gusarev, Maria Golitsyna, Julian Yates, Evgeny Kushnerev, Dania Tamimi, Secil Aksoy, Eugene Shumilov, Alex Sanders, Kaan Orhan,

Cone-beam computed tomography (CBCT) in dental practice is becoming increasingly popular. However, the correct teeth identification, positioning and diagnosis based on CBCT can be tedious and challenging for the untrained eye. This is due to additional training, specific knowledge and time required for analysis and diagnosis. When compared to conventional ... Read more >>

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Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.

Bartolome Celli, Nicholas Locantore, Julie C Yates, Per Bakke, Peter M A Calverley, Courtney Crim, Harvey O Coxson, David A Lomas, William MacNee, Bruce E Miller, Hana Mullerova, Stephen I Rennard, Edwin K Silverman, Emiel Wouters, Ruth Tal-Singer, Alvar Agusti, Jørgen Vestbo, ,

<h4>Rationale</h4>There are no validated measures of disease activity in COPD. Since "active" disease is expected to have worse outcomes (<i>e.g.</i> mortality), we explored potential markers of disease activity in patients enrolled in the ECLIPSE cohort in relation to 8-year all-cause mortality.<h4>Methods</h4>We investigated 1) how changes in relevant clinical variables over ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(3):]

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The Experience of Apathy in Dementia: A Qualitative Study.

Waqaar Baber, Chern Yi Marybeth Chang, Jennifer Yates, Tom Dening,

We aimed to explore and gain an understanding into how people with dementia experience apathy, and consequently suggest effective interventions to help them and their carers. Twelve participants (6 dyads of 6 people with dementia and their family carers) were recruited from "memory cafes" (meeting groups for people with dementia ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(6):]

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