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Causes of Hospitalisation Over 2011-2018 Among a Cohort of People With HIV From a London Centre

Sophia Rein, Fiona Lampe, Clinton Chaloner, Adam Stafford, Alison Rodger, Margaret Johnson, Jeffrey McDonnell, Fiona Burns, Sara Madge, Alec Miners, Lorraine Sherr, Simon Collins, Andrew Speakman, Andrew Phillips, Colette Smith,

Abstract Objective: To describe the spectrum of ICD-10 classified causes for hospitalisations occurring between 2011/2012 and 2018 in a cohort of PLHIV. Methods: This sub-study includes 798 HIV-positive individuals participating in the Antiretroviral, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study who were recruited from a large London centre. A ... Read more >>

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Methods to Mitigate Industry Influence in Industry Sponsored Research.

Jake M McDonnell, David M Dalton, Daniel P Ahern, Adanna Welch-Phillips, Joseph S Butler,

Medical and surgical research has always had a long-standing relationship with industry-based funding from sources, such as drug and device companies. Concerns exist surrounding the association between funding sources, outcome from studies and publication bias. Studies demonstrating increased odds ratios associated with positive results in industry sponsored studies across medicine ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Effects of corrective strabismus surgery on social anxiety and self-consciousness in adults.

Kimberly J Estes, Rebecca K Parrish, James Sinacore, Patricia B Mumby, James F McDonnell,

PURPOSE:To report the results of a questionnaire-based interventional study to evaluate the effects of strabismus surgery on private self-consciousness, public self-consciousness, and social anxiety using a validated self-consciousness survey instrument. METHODS:Patients who underwent strabismus surgery completed a demographics and a self-consciousness scale form both pre- and postoperatively. The total and ... Read more >>

J AAPOS (Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus)
[2020, :]

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Two-stage anterior and posterior fusion versus one-stage posterior fusion in patients with Scheuermann's kyphosis.

Jake M McDonnell, Daniel P Ahern, Darren F Lui, Haiming Yu, Jan Lehovsky, Hilali Noordeen, Sean Molloy, Joseph S Butler, Alexander Gibson,

AIMS:Whether a combined anteroposterior fusion or a posterior-only fusion is more effective in the management of patients with Scheuermann's kyphosis remains controversial. The aim of this study was to compare the radiological and clinical outcomes of these surgical approaches, and to evaluate the postoperative complications with the hypothesis that proximal ... Read more >>

Bone Joint J (The bone & joint journal)
[2020, 102-B(10):1368-1374]

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Safety of Intranasal Steroids: an Updated Perspective.

John McDonnell, Katherine Weller, Lily C Pien,

PURPOSE OF REVIEW:Intranasal corticosteroid sprays have been available as over-the-counter (OTC) medications since 2013. As such, clinicians need to be up-to-date with the risks and the safety of INS, as patients may have concerns and detailed questions. The following is a review of the recent medical literature regarding the safety ... Read more >>

Curr Allergy Asthma Rep (Current allergy and asthma reports)
[2020, 20(11):69]

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Auto-Decompression - Preserved Neurological Function in Bilateral Cervical Facet Dislocations.

T Ó Doinn, A J Hughes, D P Ahern, J McDonnell, E Kavanagh, S Morris, J S Butler,

Introduction Bilateral cervical facet dislocation (BCFD) is an uncommon injury with a high incidence of severe neurological impairment. We describe 4 cases of BCFD with preserved neurological function. Case 1: A 78-year-old female who suffered two ground level falls (GLFs). Pre-operative American Spinal Injury Association (ASIA) Score was C5D. Imaging ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):131]

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Does Conjugation With Structural Carriers Augment the Fusion Properties of Demineralized Bone Matrix?

Jake M McDonnell, Katharina N Rodrigues, Daniel P Ahern, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Discography or SPECT/CT: What is the Best Diagnostic Tool for the Surgical Assessment of Degenerative Disk Disease?

Tayler D Ross, Shane Evans, Daniel P Ahern, Jake McDonnell, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD.

Klaus F Rabe, Fernando J Martinez, Gary T Ferguson, Chen Wang, Dave Singh, Jadwiga A Wedzicha, Roopa Trivedi, Earl St Rose, Shaila Ballal, Julie McLaren, Patrick Darken, Magnus Aurivillius, Colin Reisner, Paul Dorinsky, ,

BACKGROUND:Triple fixed-dose regimens of an inhaled glucocorticoid, a long-acting muscarinic antagonist (LAMA), and a long-acting β2-agonist (LABA) for chronic obstructive pulmonary disease (COPD) have been studied at single dose levels of inhaled glucocorticoid, but studies at two dose levels are lacking. METHODS:In a 52-week, phase 3, randomized trial to evaluate ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(1):35-48]

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Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs).

Ricarda M Hoffmann, Silvia Mele, Anthony Cheung, Daniel Larcombe-Young, Gintare Bucaite, Eirini Sachouli, Iva Zlatareva, Hassan O J Morad, Rebecca Marlow, James M McDonnell, Mariangela Figini, Katie E Lacy, Andrew J N Tutt, James F Spicer, David E Thurston, Sophia N Karagiannis, Silvia Crescioli,

Antibody-Drug Conjugates (ADCs) developed as a targeted treatment approach to deliver toxins directly to cancer cells are one of the fastest growing classes of oncology therapeutics, with eight ADCs and two immunotoxins approved for clinical use. However, selection of an optimum target and payload combination, to achieve maximal therapeutic efficacy ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8869]

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Publisher Correction: Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Mohd A Karim, Christiana Kartsonaki, Derrick A Bennett, Iona Y Millwood, Michael R Hill, Daniel Avery, Zheng Bian, Huaidong Du, Yu Guo, Yijian Qian, Chan Qu, Iain Turnbull, Dan Schmidt-Valle, Chunmei Wang, Canqing Yu, Jun Lv, Junshi Chen, Robert Clarke, Liming Li, Zhengming Chen, Michael V Holmes, Robin G Walters, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8084]

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Do Equivalence Trials Display Superiority Over the Traditional Comparative Study Methods in Orthopedic Surgery?

Andrew J Hughes, Hugo C Temperley, Daniel P Ahern, Jake McDonnell, Joseph S Butler,

Superiority and equivalence trials are 2 commonly encountered methods of designing randomized controlled trials. Traditionally, the goal of a randomized controlled trial is to show superiority. However, in more recent times, there has been a tendency to show equivalence in clinical randomized trials. These differing conclusions at first glance seem ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(5):201-204]

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Are Carbon-fiber Implants More Efficacious Than Traditional Metallic Implants for Spine Tumor Surgery?

Jake M McDonnell, Katharina Nagassima Rodrigues Dos Reis, Daniel P Ahern, John Mahon, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Timing of surgical fixation in traumatic spinal fractures.

John Mahon, Daniel P Ahern, Shane R Evans, Jake McDonnell, Joseph S Butler,

AIMS:The timing of surgical fixation in spinal fractures is a contentious topic. Existing literature suggests that early stabilization leads to reduced morbidity, improved neurological outcomes, and shorter hospital stay. However, the quality of evidence is low and equivocal with regard to the safety of early fixation in the severely injured ... Read more >>

Bone Joint J (The bone & joint journal)
[2020, 102-B(5):627-631]

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Surgeon proficiency in robot-assisted spine surgery.

Jake Michael McDonnell, Daniel P Ahern, Tiarnan Ó Doinn, Denys Gibbons, Katharina Nagassima Rodrigues, Nick Birch, Joseph S Butler,

Continuous technical improvement in spinal surgical procedures, with the aim of enhancing patient outcomes, can be assisted by the deployment of advanced technologies including navigation, intraoperative CT imaging, and surgical robots. The latest generation of robotic surgical systems allows the simultaneous application of a range of digital features that provide ... Read more >>

Bone Joint J (The bone & joint journal)
[2020, 102-B(5):568-572]

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Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults.

Yiping Chen, Neil Wright, Yu Guo, Iain Turnbull, Christiana Kartsonaki, Ling Yang, Zheng Bian, Pei Pei, Dongxia Pan, Yidan Zhang, Haiqiang Qin, Yilong Wang, Jun Lv, Ming Liu, Zilong Hao, Yongjun Wang, Canqing Yu, Richard Peto, Rory Collins, Liming Li, Robert Clarke, Zhengming Chen, ,

BACKGROUND:Stroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis and treatment, little is known about the short-term and long-term prognosis after a first stroke in low-income and middle-income countries, including China. We aimed to assess the short-term and long-term risk of recurrent stroke and ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2020, 8(4):e580-e590]

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Systemic inflammation is associated with incident stroke and heart disease in East Asians.

Mohd A Karim, Christiana Kartsonaki, Derrick A Bennett, Iona Y Millwood, Michael R Hill, Daniel Avery, Zheng Bian, Huaidong Du, Yu Guo, Yijian Qian, Chan Qu, Iain Turnbull, Dan Schmidt-Valle, Chunmei Wang, Canqing Yu, Jun Lv, Junshi Chen, Robert Clarke, Liming Li, Zhengming Chen, Michael V Holmes, Robin G Walters, ,

Systemic inflammation, reflected by increased plasma concentrations of C-reactive protein (CRP) and fibrinogen, is associated with increased risk of coronary heart disease, but its relevance for stroke types remains unclear. Moreover, evidence is limited in non-European populations. We investigated associations of CRP and fibrinogen with risks of incident major coronary ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5605]

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NMR backbone assignment of the Cε4 domain of immunoglobulin E.

Stefi V Benjamin, Paul I Creeke, Alistair J Henry, James M McDonnell,

Immunoglobulin E (IgE) plays a central role in allergic reactions. IgE is a dynamic molecule that is capable of undergoing large conformational changes. X-ray crystal structures of the Fc region of IgE in complex with various ligands have shown that IgE-Fc can exist in extended and various bent conformations. IgE-Fc ... Read more >>

Biomol NMR Assign (Biomolecular NMR assignments)
[2020, 14(1):151-155]

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Attitudes to disclosure of HIV-serostatus to new sexual partners and sexual behaviours among HIV-diagnosed gay, bisexual and other men who have sex with men in the UK.

Marina Daskalopoulou, Alison J Rodger, Andrew N Phillips, Richard Gilson, Lorraine Sherr, Sonali Wayal, Jane Anderson, Kazeem Aderogba, Jeffrey McDonnell, Edmund Wilkins, Elaney Youssef, Andrew Speakman, William J Burman, Fiona C Lampe,

We assessed attitudes to disclosure to new sexual partners and association with sexual behaviours among HIV-diagnosed gay, bisexual, and other men who have sex with men (GBMSM) in the UK Antiretrovirals, Sexual Transmission Risk and Attitudes (ASTRA) study in 2011-12. Among 1373 GBMSM diagnosed with HIV for ≥3 months and ... Read more >>

AIDS Care (AIDS care)
[2020, 32(10):1323-1332]

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Retraction Note: Global analysis of streamflow response to forest management.

Jaivime Evaristo, Jeffrey J McDonnell,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nature (Nature)
[2020, 578(7794):326]

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Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.

Alkistis N Mitropoulou, Tom Ceska, James T Heads, Andrew J Beavil, Alistair J Henry, James M McDonnell, Brian J Sutton, Anna M Davies,

Immunoglobulin E (IgE) plays a central role in the allergic response, in which cross-linking of allergen by FcεRI-bound IgE triggers mast cell and basophil degranulation and the release of inflammatory mediators. The high-affinity interaction between IgE and FcεRI is a long-standing target for therapeutic intervention in allergic disease. Omalizumab is ... Read more >>

Acta Crystallogr F Struct Biol Commun (Acta crystallographica. Section F, Structural biology communications)
[2020, 76(Pt 3):116-129]

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Habitual snoring, adiposity measures and risk of type 2 diabetes in 0.5 million Chinese adults: a 10-year cohort.

Yuxia Wei, Bang Zheng, Junning Fan, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Yiping Chen, Jianxin Chen, Xunfu Zhong, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li, ,

OBJECTIVES:The present study aimed to examine whether habitual snoring was independently associated with risk of type 2 diabetes among Chinese adults, and to assess the role that adiposity measures play in the snoring-diabetes association, as well as to evaluate the joint influence of snoring and adiposity measures on diabetes. RESEARCH ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Physical activity, sedentary leisure-time and risk of incident type 2 diabetes: a prospective study of 512 000 Chinese adults.

Derrick A Bennett, Huaidong Du, Fiona Bragg, Yu Guo, Neil Wright, Ling Yang, Zheng Bian, Yiping Chen, Canqing Yu, Sisi Wang, Fanwen Meng, Jun Lv, Junshi Chen, Liming Li, Robert Clarke, Zhengming Chen, ,

Objective:Aim to examine the independent and joint associations of physical activity (PA) and sedentary leisure-time (SLT) with risk of diabetes and assess the extent to which these associations were mediated by adiposity. Research design and methods:The prospective China Kadoorie Biobank recruited ~512 000 adults from 10 diverse areas across China. Self-reported ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2019, 7(1):e000835]

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Further experiments comparing direct vapor equilibration and cryogenic vacuum distillation for plant water stable isotope analysis.

Cody Millar, Dyan Pratt, David J Schneider, Geoff Koehler, Jeffrey J McDonnell,

Rapid Commun Mass Spectrom (Rapid communications in mass spectrometry : RCM)
[2019, 33(23):1850-1854]

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Soy intake and breast cancer risk: a prospective study of 300,000 Chinese women and a dose-response meta-analysis.

Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Meng Gao, Huaidong Du, Ling Yang, Yiping Chen, Xi Zhang, Tao Wang, Junshi Chen, Zhengming Chen, Canqing Yu, Dezheng Huo, Liming Li, ,

Epidemiological evidence on the association of soy intake with breast cancer risk is still inconsistent due to different soy intake levels across previous studies and small number of breast cancer cases. We aimed to investigate this issue by analyzing data from the China Kadoorie Biobank (CKB) study and conducting a ... Read more >>

Eur J Epidemiol (European journal of epidemiology)
[2020, 35(6):567-578]

Cited: 2 times

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