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Author J McDonnell

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Reviving lost binding sites: Exploring calcium binding-site transitions between human and murine CD23.

Veronica F Ilkow, Anna M Davies, Balvinder Dhaliwal, Andrew J Beavil, Brian J Sutton, James M McDonnell,

Immunoglobulin E (IgE) is a central regulatory and triggering molecule of allergic immune responses.IgE's interaction with CD23 modulates both IgE production and functional activities.CD23 is a non-canonical immunoglobulin receptor, unrelated to receptors of other antibody isotypes. Human CD23 is a calcium-dependent (C-type) lectin-like domain that has apparently lost its carbohydrate ... Read more >>

FEBS Open Bio (FEBS open bio)
[2021, :]

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Monitoring Gait Complexity as an Indicator for Running-Related Injury Risk in Collegiate Cross-Country Runners: A Proof-of-Concept Study.

Allison H Gruber, James McDonnell, John J Davis, Jacob E Vollmar, Jaroslaw Harezlak, Max R Paquette,

Dynamical systems theory suggests that studying the complexity of biological signals could lead to a single gait metric that reliably predicts risk of running-related injury (RRI). The purposes of this pilot study were to examine center of mass (COM) acceleration complexity at baseline, prior to RRI, and the change between ... Read more >>

Front Sports Act Living (Frontiers in sports and active living)
[2021, 3:630975]

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Development and external validation of a breast cancer absolute risk prediction model in Chinese population.

Yuting Han, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Yizhen Hu, Ling Yang, Yiping Chen, Huaidong Du, Fangyuan Zhao, Wanqing Wen, Xiao-Ou Shu, Yongbing Xiang, Yu-Tang Gao, Wei Zheng, Hong Guo, Peng Liang, Junshi Chen, Zhengming Chen, Dezheng Huo, Liming Li, ,

<h4>Backgrounds</h4>In contrast to developed countries, breast cancer in China is characterized by a rapidly escalating incidence rate in the past two decades, lower survival rate, and vast geographic variation. However, there is no validated risk prediction model in China to aid early detection yet.<h4>Methods</h4>A large nationwide prospective cohort, China Kadoorie ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2021, 23(1):62]

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Causes of hospitalisation among a cohort of people with HIV from a London centre followed from 2011 to 2018.

Sophia M Rein, Fiona C Lampe, Clinton Chaloner, Adam Stafford, Alison J Rodger, Margaret A Johnson, Jeffrey McDonnell, Fiona Burns, Sara Madge, Alec Miners, Lorraine Sherr, Simon Collins, Andrew Speakman, Andrew N Phillips, Colette J Smith,

<h4>Background</h4>We describe the spectrum of ICD-10 classified causes for hospitalisations occurring between 2011 and 2018 in a cohort of people living with HIV (PLHIV).<h4>Methods</h4>This sub-study includes 798 PLHIV participating in the Antiretroviral, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study who were recruited from a large London centre. A medical ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):395]

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Organic contamination detection for isotopic analysis of water by laser spectroscopy.

Cody Millar, Kim Janzen, Magali F Nehemy, Geoff Koehler, Pedro Hervé-Fernández, Jeffrey J McDonnell,

<h4>Rationale</h4>Hydrogen and oxygen stable isotope ratios (δ<sup>2</sup> H, δ<sup>17</sup> O, and δ<sup>18</sup> O values) are commonly used tracers of water. These ratios can be measured by isotope ratio infrared spectroscopy (IRIS). However, IRIS approaches are prone to errors induced by organic compounds present in plant, soil, and natural water samples. ... Read more >>

Rapid Commun Mass Spectrom (Rapid communications in mass spectrometry : RCM)
[2021, :e9118]

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Methods to Mitigate Industry Influence in Industry Sponsored Research.

Jake M McDonnell, David M Dalton, Daniel P Ahern, Adanna Welch-Phillips, Joseph S Butler,

Medical and surgical research has always had a long-standing relationship with industry-based funding from sources, such as drug and device companies. Concerns exist surrounding the association between funding sources, outcome from studies and publication bias. Studies demonstrating increased odds ratios associated with positive results in industry sponsored studies across medicine ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, 34(4):143-145]

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Children's understanding of epilepsy: A qualitative study.

Jeni Harden, Rebecca Black, Martyn Pickersgill, Jay Shetty, Ailsa McLellan, Celia Brand, Michelle Small, Jane McDonnell, Lorna Clarke, Richard F Chin,

<h4>Purpose</h4>To use a qualitative research approach to determine children's understandings of epilepsy and their epilepsy treatment.<h4>Methods</h4>Children aged 7-16 years with physician-confirmed active epilepsy (i.e., having had an epileptic seizure in the past year and or currently taking antiepileptic drugs (AEDs), and not known to have an intellectual disability, were invited to ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2021, 120:107994]

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Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses.

Wenxiu Wang, Jingjia Wang, Jun Lv, Canqing Yu, Chunli Shao, Yida Tang, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Liang Chang, Lei Fan, Junshi Chen, Zhengming Chen, Tao Huang, Liming Li, , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background and aims</h4>Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of such associations in Chinese adults.<h4>Methods and results</h4>The China Kadoorie Biobank enrolled 512,891 adults in ... Read more >>

Nutr Metab Cardiovasc Dis (Nutrition, metabolism, and cardiovascular diseases : NMCD)
[2021, :]

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Educational disparities in ischaemic heart disease among 0.5 million Chinese adults: a cohort study.

Lu Chen, Yunlong Tan, Canqing Yu, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Xiaohuan Wang, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li, ,

<h4>Background</h4>The relationship between educational attainment and ischaemic heart disease (IHD) is limited in evidence in middle-income countries like China. Exploring lifestyle-related mediators, which might be not universal between socioeconomic status and health outcomes in diverse regions, can contribute to interventions targeted at the Chinese to narrow the educational gap in ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2021, :]

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The efficacy of remote virtual care in comparison to traditional clinical visits for elective orthopaedic patients: A meta-analysis of prospective randomised controlled trials.

J M McDonnell, D P Ahern, T D Ross, D Gibbons, K A Synnott, J S Butler,

<h4>Introduction</h4>The Orthopaedic Trauma Association has recommended limitation of in-person encounters to absolute necessity. One method of ensuring standard patient care within these guidelines is through the implementation of telemedicine.<h4>Aims</h4>To evaluate the efficacy of telemedicine for elective orthopaedic patients in the recovery and/or rehabilitation period.<h4>Methods</h4>A systematic review and meta-analysis of articles ... Read more >>

Surgeon (The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland)
[2021, :]

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A meta-analysis of the diagnostic accuracy of hounsfield units on computed topography relative to dual-energy X-ray absorptiometry for the diagnosis of osteoporosis in the spine surgery population.

Daniel P Ahern, Jake M McDonnell, Mathieu Riffault, Shane Evans, Scott C Wagner, Alexander R Vaccaro, David A Hoey, Joseph S Butler,

<h4>Background</h4>The preoperative identification of osteoporosis in the spine surgery population is of crucial importance. Limitations associated with dual-energy x-ray absorptiometry, such as access and reliability, have prompted the search for alternative methods to diagnose osteoporosis. The Hounsfield Unit(HU), a readily available measure on computed tomography, has garnered considerable attention in ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2021, :]

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'Tracking Together'-Simultaneous Use of Human and Dog Activity Trackers: Protocol for a Factorial, Randomized Controlled Pilot Trial.

Wasantha Jayawardene, Lesa Huber, Jimmy McDonnell, Laurel Curran, Sarah Larson, Stephanie Dickinson, Xiwei Chen, Erika Pena, Aletha Carson, Jeanne Johnston,

Dog-walkers are more likely to achieve moderate-intensity physical activity. Linking the use of activity trackers with dog-walking may be beneficial both in terms of improving the targeted behavior and increasing the likelihood of sustained use. This manuscript aims to describe the protocol of a pilot study which intends to examine ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(4):]

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Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial.

Amanda Jane Leach, Edward Kim Mulholland, Mathuram Santosham, Paul John Torzillo, Peter McIntyre, Heidi Smith-Vaughan, Nicole Wilson, Beth Arrowsmith, Jemima Beissbarth, Mark D Chatfield, Victor M Oguoma, Paul Licciardi, Sue Skull, Ross Andrews, Jonathan Carapetis, Joseph McDonnell, Vicki Krause, Peter Stanley Morris,

<h4>Background</h4>Aboriginal children living in remote communities are at high risk of early and persistent otitis media. <i>Streptococcus pneumoniae</i> and non-typeable <i>Haemophilus influenzae</i> (NTHi) are primary pathogens. Vaccines with potential to prevent early OM have not been evaluated in this population. We compared immunogenicity (ELISA and opsonophagocytic activity) of a combination ... Read more >>

Vaccine X (Vaccine: X)
[2021, 7:100086]

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Recreational drug use and use of drugs associated with chemsex among HIV-negative and HIV-positive heterosexual men and women attending sexual health and HIV clinics in England.

Ada R Miltz, Alison J Rodger, Janey Sewell, Richard Gilson, Sris Allan, Christopher Scott, Tariq Sadiq, Paymaneh Farazmand, Jeffrey McDonnell, Andrew Speakman, Lorraine Sherr, Andrew N Phillips, Anne M Johnson, Simon Collins, Fiona C Lampe, ,

<h4>Background</h4>There is little information on the prevalence of recreational drug use among UK heterosexual men and women, in particular on use of drugs associated with 'chemsex' within gay communities. The aim of this study was to examine among HIV-negative and HIV-positive heterosexual men and women in England: (i) the prevalence ... Read more >>

Int J Drug Policy (The International journal on drug policy)
[2021, 91:103101]

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Opposing associations of depression with sexual behaviour: implications for epidemiological investigation among gay, bisexual and other men who have sex with men.

Ada R Miltz, Alison J Rodger, Andrew N Phillips, Janey Sewell, Simon Edwards, Sris Allan, Lorraine Sherr, Anne M Johnson, William J Burman, Fiona C Lampe, ,

<h4>Objective</h4>The aim of this report is to investigate the nature of the relationship between depression and condomless sex (CLS) among gay, bisexual and other men who have sex with men (GBMSM).<h4>Methods</h4>Data are from the Antiretrovirals, Sexual Transmission Risk and Attitude (ASTRA) study of people living with HIV and attending one ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2021, :]

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REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.

David M Weinreich, Sumathi Sivapalasingam, Thomas Norton, Shazia Ali, Haitao Gao, Rafia Bhore, Bret J Musser, Yuhwen Soo, Diana Rofail, Joseph Im, Christina Perry, Cynthia Pan, Romana Hosain, Adnan Mahmood, John D Davis, Kenneth C Turner, Andrea T Hooper, Jennifer D Hamilton, Alina Baum, Christos A Kyratsous, Yunji Kim, Amanda Cook, Wendy Kampman, Anita Kohli, Yessica Sachdeva, Ximena Graber, Bari Kowal, Thomas DiCioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, ,

<h4>Background</h4>Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads.<h4>Methods</h4>In this ongoing, double-blind, phase 1-3 trial involving nonhospitalized patients with Covid-19, we investigated two fully human, neutralizing monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, used in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(3):238-251]

Cited: 104 times

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Promoting advance care planning in African American faith communities: literature review and assessment of church-based programs.

Jenny McDonnell, Ellen Idler,

Advance care planning is under-used among Black Americans, often because of experiences of racism in the health care system, resulting in a lower quality of care at the end of life. African American faith communities are trusted institutions where such sensitive conversations may take place safely. Our search of the ... Read more >>

Palliat Care Soc Pract (Palliative care and social practice)
[2020, 14:2632352420975780]

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What Is the Superior Technique for Long Construct Spinopelvic Fixation in Adult Spinal Deformity Surgery: Iliac Screws or S2-Alar-Iliac Screws.

Adanna Welch-Phillips, Tayler D Ross, Jake M McDonnell, Daniel P Ahern, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Prospective association of social circumstance, socioeconomic, lifestyle and mental health factors with subsequent hospitalisation over 6-7 year follow up in people living with HIV.

Sophia M Rein, Colette J Smith, Clinton Chaloner, Adam Stafford, Alison J Rodger, Margaret A Johnson, Jeffrey McDonnell, Fiona Burns, Sara Madge, Alec Miners, Lorraine Sherr, Simon Collins, Andrew Speakman, Andrew N Phillips, Fiona C Lampe,

<h4>Background</h4>Predictors of hospitalisation in people with HIV (PLHIV) in the contemporary treatment era are not well understood.<h4>Methods</h4>This ASTRA sub-study used clinic data linkage and record review to determine occurrence of hospitalisations among 798 PLHIV from baseline questionnaire (February to December 2011) until 1 June 2018. Associations of baseline social circumstance, ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2021, 31:100665]

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Regenerative Medicine Modalities for the Treatment of Degenerative Disk Disease.

Jake M McDonnell, Daniel P Ahern, Tayler D Ross, Patrick B Morrissey, Scott C Wagner, Alexander R Vaccaro, Joseph S Butler,

Degenerative disk disease is a pathologic state associated with axial skeletal pain, radiculopathy, and myelopathy, and will inevitably increase in prevalence in parallel with an aging population. The objective of regenerative medicine is to convert the inflammatory, catabolic microenvironment of degenerative disease into an anti-inflammatory, anabolic environment. This comprehensive review ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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What Is the Superior Screw Fixation Technique for Posterior Decompression and Fusion in the Management of Cervical Spondylotic Myelopathy: Pedicle Screw or Lateral Mass Screw?

Shane Evans, Katharina Nagassima Rodrigues Dos Reis, Jake M McDonnell, Daniel P Ahern, Denys Gibbons, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Artificial Intelligence and the Future of Spine Surgery: A Practical Supplement to Modern Spine Care?

Katharina Nagassima Rodrigues Dos Reis, Shane Evans, Jake M McDonnell, Daniel P Ahern, Joseph S Butler,

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Causes of Hospitalisation Over 2011-2018 Among a Cohort of People With HIV From a London Centre

Sophia Rein, Fiona Lampe, Clinton Chaloner, Adam Stafford, Alison Rodger, Margaret Johnson, Jeffrey McDonnell, Fiona Burns, Sara Madge, Alec Miners, Lorraine Sherr, Simon Collins, Andrew Speakman, Andrew Phillips, Colette Smith,

<h4>Objective: </h4> To describe the spectrum of ICD-10 classified causes for hospitalisations occurring between 2011/2012 and 2018 in a cohort of PLHIV. <h4>Methods: </h4>: This sub-study includes 798 HIV-positive individuals participating in the Antiretroviral, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study who were recruited from a large London centre. ... Read more >>

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Effects of corrective strabismus surgery on social anxiety and self-consciousness in adults.

Kimberly J Estes, Rebecca K Parrish, James Sinacore, Patricia B Mumby, James F McDonnell,

<h4>Purpose</h4>To report the results of a questionnaire-based interventional study to evaluate the effects of strabismus surgery on private self-consciousness, public self-consciousness, and social anxiety using a validated self-consciousness survey instrument.<h4>Methods</h4>Patients who underwent strabismus surgery completed a demographics and a self-consciousness scale form both pre- and postoperatively. The total and subscale ... Read more >>

J AAPOS (Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus)
[2020, 24(5):280.e1-280.e4]

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Two-stage anterior and posterior fusion versus one-stage posterior fusion in patients with Scheuermann's kyphosis.

Jake M McDonnell, Daniel P Ahern, Darren F Lui, Haiming Yu, Jan Lehovsky, Hilali Noordeen, Sean Molloy, Joseph S Butler, Alexander Gibson,

<h4>Aims</h4>Whether a combined anteroposterior fusion or a posterior-only fusion is more effective in the management of patients with Scheuermann's kyphosis remains controversial. The aim of this study was to compare the radiological and clinical outcomes of these surgical approaches, and to evaluate the postoperative complications with the hypothesis that proximal ... Read more >>

Bone Joint J (The bone & joint journal)
[2020, 102-B(10):1368-1374]

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