Full Text Journal Articles by
Author J Lynn Rutkowski

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Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro.

Aziz Gauhar, Cyril V Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J Kungl, Frank S Walsh, J Lynn Rutkowski, Pawel Stocki,

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the severe acute respiratory syndrome coronavirus 2 spike ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21970]

Cited: 0 times

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Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1.

Pawel Stocki, Jaroslaw Szary, Charlotte L M Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S Walsh, J Lynn Rutkowski,

Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. A ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21172]

Cited: 6 times

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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Dag Sehlin, Pawel Stocki, Tobias Gustavsson, Greta Hultqvist, Frank S Walsh, J Lynn Rutkowski, Stina Syvänen,

Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and human TfR1 was used to shuttle protein cargo into the brain. TXB2 was ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(10):13272-13283]

Cited: 4 times

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Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation.

Xinkang Wang, Xiaorong Liu, Yutian Zhan, Edward R Lavallie, Liz Diblasio-Smith, Lisa Collins-Racie, William M Mounts, J Lynn Rutkowski, Xin Xu, Ilia Goltsman, Zaid Abassi, Joseph Winaver, Giora Z Feuerstein,

Peroxisome proliferator-activated receptor (PPAR)-gamma modulators, a class of antidiabetic drugs, have been associated with cardiovascular risks in type 2 diabetes in humans. The objective of this study was to explore possible cardiovascular risk biomarkers associated with PPAR-gamma in rodents that could provide an alert for risk to humans. Normal, myocardial ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2010, 334(3):820-829]

Cited: 11 times

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Translational medicine--a paradigm shift in modern drug discovery and development: the role of biomarkers.

Mark Day, J Lynn Rutkowski, Giora Z Feuerstein,

The success rate of novel medical entities that are submitted for registration by the regulatory agencies and followed successful marketing has been stagnating for the past decade. Failure in efficacy and safety continue to be the prime hurdles and causes of failure. Translational medicine is a new function within the ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2009, 655:1-12]

Cited: 11 times

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Correlation between 2- and 3-dimensional assessment of tumor volume and vascular density by ultrasonography in a transgenic mouse model of mammary carcinoma.

Lei Zhao, Yutian Zhan, J Lynn Rutkowski, Giora Z Feuerstein, Xinkang Wang,

<h4>Objective</h4>Visualization and quantification of angiogenesis are instrumental in development of antiangiogenic therapy. Although both 2-dimensional (2D) and 3-dimensional (3D) ultrasonography have been used to monitor tumor growth and vasculature development, the correlation between them has not been sufficiently investigated. We hereby investigated the 2D and 3D sonographic correlation for tumor ... Read more >>

J Ultrasound Med (Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine)
[2010, 29(4):587-595]

Cited: 3 times

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Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: Implication for future drug discovery and development for AD.

Hong I Wan, J Steve Jacobsen, J Lynn Rutkowski, Giora Z Feuerstein,

Clin Transl Sci (Clinical and translational science)
[2009, 2(3):242-247]

Cited: 16 times

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Cognitive endpoints as disease biomarkers: optimizing the congruency of preclinical models to the clinic.

Mark Day, Fuat Balci, Hong I Wan, Gerard B Fox, J Lynn Rutkowski, Giora Feuerstein,

Cognition is a complex set of processes, including attention, learning and memory, that refers to the capacity to encode, consolidate, store and retrieve recent and remotely stored fact (semantic) and experience-based (episodic) memory. The development of cognitive enhancers is of particular importance to society and the pharmaceutical industry, as cognitive ... Read more >>

Curr Opin Investig Drugs (Current opinion in investigational drugs (London, England : 2000))
[2008, 9(7):696-706]

Cited: 13 times

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