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Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch-Schonlein Purpura: a meta-analysis.

Bowen Li, Qian Ren, Jizu Ling, Zhongbin Tao, Xuemei Yang, Yuning Li,

The association of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with the severe gastrointestinal (GI) involvement in pediatric Henoch-Schonlein Purpura (HSP) has been reported in many studies. However, the conclusions from the previous studies were controversial. Therefore, for the first time, we performed a meta-analysis to systematically evaluate the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):286-295]

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The applicability of the Global Lung Initiative equations and other regional equations on a sample of healthy Middle Eastern adolescents.

Walid Al-Qerem, Ameen Alassi, Anan S Jarab, Jonathan Ling,

<h4>Background</h4>The Global Lung Initiative 2012 (GLI-2012) spirometry equations are multi-ethnic equations that cover all ages between 3-95. However, there is a need to evaluate the suitability of these equations to a sample of Middle Eastern adolescents prior to being applied in clinical practice. The aim of this study is to ... Read more >>

Clin Respir J (The clinical respiratory journal)
[2021, :]

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Kv4.3 channel dysfunction contributes to trigeminal neuropathic pain manifested with orofacial cold hypersensitivity in rats.

Hirosato Kanda, Jennifer Ling, Ya-Ting Chang, Ferhat Erol, Viacheslav Viatchenko-Karpinski, Akihiro Yamada, Koichi Noguchi, Jianguo G Gu,

Trigeminal neuropathic pain is the most debilitating pain disorder but current treatments including opiates are not effective. A common symptom of trigeminal neuropathic pain is cold allyodynia/hyperalgesia or cold hypersensitivity in orofacial area, a region where exposure to cooling temperatures are inevitable in daily life. Mechanisms underlying trigeminal neuropathic pain ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2021, :]

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The complete mitochondria genome of Aldrichina grahami (Diptera: Calliphoridae)

Zhengyu Zhu, Huidan Liao, Jiang Ling, Yadong Guo, Jifeng Cai, Yanjun Ding,

Abstract Aldrichina grahami is a significant medical and forensic insect belonging to the family calliphoridae. In this study, we present the complete mitochondrial genome of A. grahami for the first time. The mitogenome was 14 903 bp in length, consisting of 22 transfer RNA genes, 2 ribosomal RNA genes and 13 protein-encoding ... Read more >>

Mitochondrial DNA B Resour (Mitochondrial DNA. Part B, Resources)
[0, 1(1):107-109]

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Single-cell analysis reveals the intra-tumor heterogeneity and identifies MLXIPL as a biomarker in the cellular trajectory of hepatocellular carcinoma.

Xiao Dong, Fan Wang, Chuan Liu, Jing Ling, Xuebing Jia, Feifei Shen, Ning Yang, Sibo Zhu, Lin Zhong, Qi Li,

Hepatocellular carcinoma (HCC) is a globally prevailing cancer with a low 5-year survival rate. Little is known about its intricate gene expression profile. Single-cell RNA sequencing is an indispensable tool to explore the genetic characteristics of HCC at a more detailed level. In this study, we profiled the gene expression ... Read more >>

Cell Death Discov (Cell death discovery)
[2021, 7(1):14]

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Frequency of depressive symptoms in Syrian refugees and Turkish maintenance hemodialysis patients during COVID-19 pandemic.

Mustafa Sevinc, Nuri Baris Hasbal, Tamer Sakaci, Taner Basturk, Elbis Ahbap, Mustafa Ortaboz, Emrah Erkan Mazi, Efruz Pirdogan, Jonathan Ling, Abdulkadir Unsal,

<h4>Introduction</h4>Pneumonia of unknown cause was detected on 30 December 2019 in China. It was categorized as an outbreak and named as COVID-19 by the World Health Organization. The pandemic affects all people, but patient groups such as hemodialysis (HD) patients have been particularly affected. We do not know if refugees ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0244347]

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Erratum: Shah, M.I., et al. Properties of Electrospun Nanofibers of Multi-Block Copolymers of [Poly-ε-Caprolactone-b-Poly(tetrahydrofuran-co-ε-caprolactone)]m Synthesized by Janus Polymerization. Polymers 2017, 9, 559.

Muhammad Ijaz Shah, Zhening Yang, Yao Li, Liming Jiang, Jun Ling,

The authors wish to make the following changes to the published paper as listed below [...]. ... Read more >>

Polymers (Basel) (Polymers)
[2020, 13(1):]

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Rhizosphere microbiome dynamics in tropical seagrass under short-term inorganic nitrogen fertilization.

Weiguo Zhou, Junde Dong, Dewen Ding, Lijuan Long, Anning Suo, Xiancheng Lin, Qingsong Yang, Liyun Lin, Yanying Zhang, Juan Ling,

Rhizosphere microbes are crucial to seagrass meadows because they promote plant growth and heath. However, information concerning the response of rhizosphere microorganisms in seagrass sediment in the presence of different nitrogen sources is lacking. Here, by means of high-throughput sequencing, we investigated how addition of inorganic nitrogen affects the rhizosphere ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Establishment of an iPSC line (CSUXHi003-A) from a patient with Waardenburg syndrome type Ⅱ caused by a MITF mutation.

Jie Wen, Jian Song, Chufeng He, Jie Ling, Yalan Liu, Hongsheng Chen, Wei Gong, Lingyun Mei, Yong Feng,

Waardenburg syndrome (WS) is a genetic disorder characterized by sensorineural deafness. It has a variable presentation of pigmentation defects. Here, we generated an induced pluripotent stem cell (iPSC) line using episomal plasmid vectors from the fibroblasts of a 4-year-old boy affected with WS type II, caused by a novel mutation ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 51:102157]

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Updates in the Management of Corneal Ectasia.

David A Ramirez, Yong Kam, Caroline W Wilson, Jennifer J Ling,

Int Ophthalmol Clin (International ophthalmology clinics)
[2021, 61(1):29-43]

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USP14 negatively regulates RIG-I-mediated IL-6 and TNF-α production by inhibiting NF-κB activation.

Hongrui Li, Jiazheng Quan, Xibao Zhao, Jing Ling, Weilin Chen,

Ubiquitin specific protease 14 (USP14) is a regulator of protein deubiquitination and proteasome activation, and has been implicated in negative regulation of type I IFN signaling pathway. However, the effect of USP14 on RNA virus-related inflammatory response has not been studied. Retinoic acid-inducible gene I (RIG-I) is the important pattern ... Read more >>

Mol Immunol (Molecular immunology)
[2021, 130:69-76]

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Atypia of undetermined significance/follicular lesions of undetermined significance: What radiologists need to know.

Johnny Ling, Wencheng Li, Neeraj Lalwani,

Atypia of undetermined significance/follicular lesions of undetermined significance (AUS/FLUS) refers to an intermediate histologic category of thyroid nodules in The Bethesda System for Reporting Thyroid Cytopathology. Although the risk of malignancy in this category was originally cited as 5-15%, recent literature has suggested higher rates of related malignancy ranging from ... Read more >>

Neuroradiol J (The neuroradiology journal)
[2020, :1971400920983566]

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Shifts in abundance and network complexity of coral bacteria in response to elevated ammonium stress.

Yanying Zhang, Qingsong Yang, Ying Zhang, Manzoor Ahmad, Juan Ling, Xiaoyu Tang, Junde Dong,

Coral bacteria are highly dynamic and acutely affected by host health and environmental conditions. However, there is limited knowledge of how the dynamics of coral-associated bacterial communities and interactions among bacterial members change in response to dissolved inorganic nutrient stressors. Here, we used high-throughput sequencing of the 16S rRNA gene ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 768:144631]

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Enhanced alteration of poly(vinyl chloride) microplastics by hydrated electrons derived from indole-3-acetic acid assisted by a common cationic surfactant.

Sijia Liang, Shuxia Xu, Chao Wang, Jingyi Ling, Zeyu Xian, Hao Wu, Haoting Tian, Shaoda Zhou, Cheng Gu,

In this study, a new photo-irradiated reductive dechlorination pathway and the underlying transformation mechanism are described for poly(vinyl chloride) microplastics (PVC-MPs). PVC-MPs underwent photo-reductive dechlorination process with the release of chloride ions. This reaction could be facilitated in the presence of indole-3-acetic acid (IAA) and hexadecyltrimethylammonium bromide (CTAB) under neutral ... Read more >>

Water Res (Water research)
[2020, 191:116797]

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Impact of Scleral Contact Lens Use on the Rate of Corneal Transplantation for Keratoconus.

Jennifer J Ling, Shahzad I Mian, Joshua D Stein, Moshiur Rahman, Joel Poliskey, Maria A Woodward,

<h4>Purpose</h4>To evaluate the association of scleral contact lens (SCL) use on the risk for keratoplasty for people with keratoconus.<h4>Methods</h4>The electronic health records of patients receiving eye care at the University of Michigan Kellogg Eye Center between August 1, 2012, and December 31, 2018, were reviewed. Patients with a diagnostic code ... Read more >>

Cornea (Cornea)
[2021, 40(1):39-42]

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RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.

Jun Ling, Haijian Cai, Muya Lin, Shunli Qi, Jian Du, Lijian Chen,

It has been widely accepted that autophagic cell death exacerbates the progression of cerebral ischemia/reperfusion (I/R). Our previous study revealed that overexpression of reticulon protein 1-C (RTN1-C) is involved in cerebral I/R injury. However, the underlying mechanisms have not been studied intensively. This study was designed to evaluate the effect ... Read more >>

Acta Biochim Biophys Sin (Shanghai) (Acta biochimica et biophysica Sinica)
[2020, :]

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Application of high-flow nasal cannula in hypoxemic patients with COVID-19: a retrospective cohort study.

Ming Hu, Qiang Zhou, Ruiqiang Zheng, Xuyan Li, Jianmin Ling, Yumei Chen, Jing Jia, Cuihong Xie,

<h4>Background</h4>It had been shown that High-flow nasal cannula (HFNC) is an effective initial support strategy for patients with acute respiratory failure. However, the efficacy of HFNC for patients with COVID-19 has not been established. This study was performed to assess the efficacy of HFNC for patients with COVID-19 and describe ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):324]

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Duration of FOLFOX Adjuvant Chemotherapy in High-Risk Stage II and Stage III Colon Cancer With Deficient Mismatch Repair.

Huabin Hu, Zehua Wu, Chao Wang, Yan Huang, Jianwei Zhang, Yue Cai, Xiaoyu Xie, Jianxia Li, Cailu Shen, Weiwei Li, Jiayu Ling, Xuehu Xu, Yanhong Deng,

<h4>Background</h4>We evaluated the impact of 3 months of mFOLFOX6 adjuvant chemotherapy or surgery alone in comparison with 6 months of mFOLFOX6 on disease-free survival (DFS) in deficient mismatch repair (dMMR) colon cancer (CC) patients.<h4>Methods</h4>This retrospective study identified a cohort of patients with high-risk stage II and III dMMR CC who ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:579478]

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Development and characterization of soybean protein isolate and fucoidan nanoparticles for curcumin encapsulation.

Lihong Fan, Yuqing Lu, Xiao-Kun Ouyang, Junhong Ling,

Curcumin (Cur) is a natural polyphenol with beneficial biological and pharmacological activities; however, it has limited applications owing to its low solubility and light sensitivity. The protein-polysaccharide complex can effectively embed lipid-soluble drugs to increase their stability and dispensability in aqueous solutions. Soybean protein isolate (Spi) and fucoidan (Fuc) were ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 169:194-205]

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Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway.

Weixu Luo, Yuanshan Han, Pan Meng, Qin Yang, Hongqing Zhao, Jia Ling, Yuhong Wang,

<h4>Background</h4>Breast cancer is one of the most common cancer with high risk in females all over the world. It is usually complicated with depression, which can further accelerate the development and progression of breast tumors. We aim to identify a new drug and identify its functional mechanism in the regulation ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:13003-13014]

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How to measure the effects and potential adverse events of palliative sedation? An integrative review.

Alazne Belar, María Arantzamendi, Sheila Payne, Nancy Preston, Maaike Rijpstra, Jeroen Hasselaar, Lukas Radbruch, Michael Vanderelst, Julie Ling, Carlos Centeno,

<h4>Background</h4>Palliative sedation is the monitored use of medications intended to relieve refractory suffering. The assessment of palliative sedation has been focused on the assess of the level of consciousness but a more comprehensive approach to assessment is needed.<h4>Aim</h4>To understand how the potential effects and possible adverse events of palliative sedation ... Read more >>

Palliat Med (Palliative medicine)
[2020, :269216320974264]

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Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer.

Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P Zhou, Shu-Hai Lin, Jiong Deng,

Cancer cells need to generate large amounts of glutathione (GSH) to buffer oxidative stress during tumor development. A rate-limiting step for GSH biosynthesis is cystine uptake via a cystine/glutamate antiporter Xc-. Xc- is a sodium-independent antiporter passively driven by concentration gradients from extracellular cystine and intracellular glutamate across the cell ... Read more >>

Cancer Res (Cancer research)
[2020, :]

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Students’ ”D”ILEMMA: An Assessment of Knowledge, Attitudes and Practice Toward Vitamin D Among University Students

Negia Mohamed, Walid Al-Qerem, Ezeddin Gassar, Mohammad Hailat, Faiza Elhamdy, Jonathan Ling,

<h4>Background: </h4> The message delivered to the public regarding vitamin D is unclear, and contradictory; particularly regarding sun exposure; previous studies in Jordan have revealed high prevalence of low vitamin D among university students. The aim of this study was to investigate university students’ knowledge, attitudes and practice regarding vitamin ... Read more >>

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Indications for Wear, Visual Outcomes, and Complications of Custom Imprint 3D Scanned Scleral Contact Lens Use.

Joanna I M Silverman, James M Huffman, M Bridget Zimmerman, Jennifer J Ling, Mark A Greiner,

<h4>Purpose</h4>To report indications for wear, visual outcomes, and complications of EyePrintPRO (EPP) scleral contact lens (SCL) use.<h4>Methods</h4>A retrospective review identified all patients fitted with this device between December 2013 and March 2018. Baseline demographics, wear indication, and contact lens history were determined. Habitual-corrected visual acuity was measured at baseline and ... Read more >>

Cornea (Cornea)
[2020, :]

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RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia.

Ji Ling, Maria Sckaff, Manisha Tiwari, Yifang Chen, Jingting Li, Jackson Jones, George L Sen,

Proper epithelial development and homeostasis depends on strict control of oriented cell division. Current evidence shows that this process is regulated by intrinsic polarity factors and external spatial cues. Owing to the lack of an appropriate model system that can recapitulate the architecture of the skin, deregulation of spindle orientation ... Read more >>

J Cell Sci (Journal of cell science)
[2020, 133(23):]

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