Full Text Journal Articles by
Author J Havlik

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New Broth Macrodilution Volatilization Method for Antibacterial Susceptibility Testing of Volatile Agents and Evaluation of Their Toxicity Using Modified MTT Assay In Vitro.

Marketa Houdkova, Aishwarya Chaure, Ivo Doskocil, Jaroslav Havlik, Ladislav Kokoska,

In this study, a new broth macrodilution volatilization method for the simple and rapid determination of the antibacterial effect of volatile agents simultaneously in the liquid and vapor phase was designed with the aim to assess their therapeutic potential for the development of new inhalation preparations. The antibacterial activity of ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(14):]

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Impact of Frailty on Morbidity and Mortality in Adult Patients Presenting with an Acute Traumatic Cervical Spinal Cord Injury.

Aladine A Elsamadicy, Mani Ratnesh S Sandhu, Isaac G Freedman, Benjamin C Reeves, Andrew B Koo, Astrid Hengartner, John Havlik, Josiah Sherman, Richard Maduka, Isaac K Agboola, Dirk C Johnson, Luis Kolb, Maxwell Laurans,

<h4>Objective</h4>The aim of this study was to determine if baseline frailty was an independent predictor of adverse events (AEs) and in-hospital mortality in patients being treated for acute cervical spinal cord injury (SCI).<h4>Methods</h4>A retrospective cohort study was performed using the National Trauma Database (NTDB) from 2017. Adult patients (>18 years ... Read more >>

World Neurosurg (World neurosurgery)
[2021, :]

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Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies

Tatjana Ruskovska, Irena Budić-Leto, Karla Fabiola Corral-Jara, Vladimir Ajdžanović, Anna Arola-Arnal, Francisca Isabel Bravo, Georgia-Eirini Deligiannidou, Jaroslav Havlik, Milkica Janeva, Elena Kistanova, Christos Kontogiorgis, Irena Krga, Marika Massaro, Marko Miler, Verica Milosevic, Christine Morand, Egeria Scoditti, Manuel Suárez, David Vauzour, Dragan Milenkovic,

Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, ... Read more >>

Nutrients (Nutrients)
[2021, 13(7):]

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Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.

Laurent-Emmanuel Monfoulet, Tatjana Ruskovska, Vladimir Ajdžanović, Jaroslav Havlik, David Vauzour, Banu Bayram, Irena Krga, Karla-Fabiola Corral-Jara, Elena Kistanova, Desislava Abadjieva, Marika Massaro, Egeria Scoditti, Eirini Deligiannidou, Christos Kontogiorgis, Anna Arola-Arnal, Evert M van Schothorst, Christine Morand, Dragan Milenkovic,

<h4>Scope</h4>Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation.<h4>Methods and results</h4>To further ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2021, :e2100227]

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Modified-frailty index does not independently predict complications, hospital length of stay or 30-day readmission rates following posterior lumbar decompression and fusion for spondylolisthesis.

Aladine A Elsamadicy, Isaac G Freedman, Andrew B Koo, Wyatt B David, Benjamin C Reeves, John Havlik, Zach Pennington, Luis Kolb, John H Shin, Daniel M Sciubba,

<h4>Background context</h4>Frailty has been associated with inferior surgical outcomes in various fields of spinal surgery. With increasing healthcare costs, hospital length of stay (LOS) and unplanned readmissions have emerged as clinical proxies reflecting overall value of care. However, there is a paucity of data assessing the impact that baseline frailty ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2021, :]

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Detection of bovine milk adulteration in caprine milk with N-acetyl carbohydrate biomarkers by using 1H nuclear magnetic resonance spectroscopy.

L Rysova, V Legarova, Z Pacakova, O Hanus, I Nemeckova, M Klimesova, J Havlik,

In a return to tradition, the popularity of caprine milk is on the rise. However, particularly in countries with developed dairy industries based on bovine milk, there is the risk of adulteration with bovine milk, which is a cheaper alternative. Thus, a rapid, robust, and simple method for the detection ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

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Stool metabolome-microbiota evaluation among children and adolescents with obesity, overweight, and normal-weight using 1H NMR and 16S rRNA gene profiling.

José Diógenes Jaimes, Andrea Slavíčková, Jakub Hurych, Ondřej Cinek, Ben Nichols, Lucie Vodolánová, Karel Černý, Jaroslav Havlík,

Characterization of metabolites and microbiota composition from human stool provides powerful insight into the molecular phenotypic difference between subjects with normal weight and those with overweight/obesity. The aim of this study was to identify potential metabolic and bacterial signatures from stool that distinguish the overweight/obesity state in children/adolescents. Using 1H ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0247378]

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Winter honeybee (Apis mellifera) populations show greater potential to induce immune responses than summer populations after immune stimuli.

Silvie Dostálková, Pavel Dobeš, Martin Kunc, Jana Hurychová, Mária Škrabišová, Marek Petřivalský, Dalibor Titěra, Jaroslav Havlík, Pavel Hyršl, Jiří Danihlík,

In the temperate climates of central Europe and North America, two distinct honeybee (<i>Apis mellifera</i>) populations are found in colonies: short-living summer bees emerge in spring and survive until summer, whereas long-living winter bees emerge in late August and overwinter. Besides the difference in their life spans, each of these ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2021, 224(Pt 3):]

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The Effects of Pulmonary Risk Factors on Hospital Resource Use After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Correction.

Aladine A Elsamadicy, Isaac G Freedman, Andrew B Koo, Wyatt B David, John Havlik, Adam J Kundishora, Daniel M Sciubba, Kristopher T Kahle, Michael DiLuna,

<h4>Objective</h4>The aim of this study was to determine the impact of preoperative pulmonary risk factors (PRFS) on surgical outcomes after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS).<h4>Methods</h4>A retrospective cohort study was performed using the American College of Surgeons National Surgical Quality Improvement Program-Pediatric database from 2016 to 2018. ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 149:e737-e747]

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Characteristics of Reported Industry Payments to Neurosurgeons: A 5-Year Open Payments Database Study.

Aladine A Elsamadicy, Isaac G Freedman, Andrew B Koo, Benjamin C Reeves, John Havlik, Wyatt B David, Christopher S Hong, Luis Kolb, Maxwell Laurans, Charles C Matouk, Michael DiLuna,

<h4>Objective</h4>The aim of this study was to characterize the payments made by medical industry to neurosurgeons from 2014 to 2018.<h4>Methods</h4>A retrospective study was performed from January 1, 2014 to December 31, 2018 of the Open Payments Database. Collected data included the total number of industry payments, the aggregate value of industry ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 145:e90-e99]

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Impact of Preoperative Anemia on Outcomes After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.

Aladine A Elsamadicy, Isaac G Freedman, Andrew B Koo, Wyatt B David, John Havlik, Adam J Kundishora, Christopher S Hong, Daniel M Sciubba, Kristopher T Kahle, Michael DiLuna,

<h4>Objective</h4>The aim of this study was to investigate the relationship of preoperative anemia and outcomes after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS).<h4>Methods</h4>A retrospective cohort study was performed using the American College of Surgeons National Surgical Quality Improvement Program-Pediatric database from 2016 to 2018. All pediatric patients (age ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 146:e214-e224]

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1H NMR chemometric models for classification of Czech wine type and variety.

Anna Mascellani, Gokce Hoca, Marek Babisz, Pavel Krska, Pavel Kloucek, Jaroslav Havlik,

A set of 917 wines of Czech origin were analysed using nuclear magnetic resonance spectroscopy (NMR) with the aim of building and evaluating multivariate statistical models and machine learning methods for the classification of 6 types based on colour and residual sugar content, 13 wine grape varieties and 4 locations ... Read more >>

Food Chem (Food chemistry)
[2021, 339:127852]

Cited: 2 times

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The bystander effect in rats.

John L Havlik, Yuri Y Vieira Sugano, Maura Clement Jacobi, Rahul R Kukreja, John H Clement Jacobi, Peggy Mason,

To investigate whether the classic bystander effect is unique to humans, the effect of bystanders on rat helping was studied. In the presence of rats rendered incompetent to help through pharmacological treatment, rats were less likely to help due to a reduction in reinforcement rather than to a lack of ... Read more >>

Sci Adv (Science advances)
[2020, 6(28):eabb4205]

Cited: 4 times

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Dietary Fibres Differentially Impact on the Production of Phenolic Acids from Rutin in an In Vitro Fermentation Model of the Human Gut Microbiota.

Jaroslav Havlik, Vittoria Marinello, Andrew Gardyne, Min Hou, William Mullen, Douglas J Morrison, Thomas Preston, Emilie Combet, Christine A Edwards,

Polyphenols are often ingested alongside dietary fibres. They are both catabolised by, and may influence, the intestinal microbiota; yet, interactions between them and the impact on their resultant microbial products are poorly understood. Dietary fibres (inulin, pectin, psyllium, pyrodextrin, wheat bran, cellulose-three doses) were fermented in vitro with human faeces ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 1 time

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Metabolism of cis- and trans-Resveratrol and Dihydroresveratrol in an Intestinal Epithelial Model.

Veronika Jarosova, Ondrej Vesely, Ivo Doskocil, Katerina Tomisova, Petr Marsik, Jose D Jaimes, Karel Smejkal, Pavel Kloucek, Jaroslav Havlik,

<i>Trans</i>-resveratrol, a well-known plant phenolic compound, has been intensively investigated due to its association with the so-called French paradox. However, despite its high pharmacological potential, <i>trans</i>-resveratrol has shown relatively low bioavailability. <i>Trans</i>-resveratrol is intensively metabolized in the intestine and liver, yielding metabolites that may be responsible for its high bioactivity. ... Read more >>

Nutrients (Nutrients)
[2020, 12(3):]

Cited: 3 times

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Winter honeybee (Apis mellifera) populations show greater potential to induce immune response than summer ones after immune stimuli.

Silvie Dostálková, Pavel Dobeš, Martin Kunc, Jana Hurychová, Mária Škrabišová, Marek Petřivalský, Dalibor Titěra, Jaroslav Havlík, Pavel Hyršl, Jiří Danihlík,

In the temperate climates of middle Europe and North America, two distinct honeybee (Apis mellifera) populations are found in colonies: short-living summer bees emerge in spring and survive until summer, whereas long-living winter bees emerge in late August and overwinter. Besides the difference in their life spans, each of these ... Read more >>

J Exp Biol (The Journal of experimental biology)
[2020, :]

Cited: 0 times

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Noninvasive Assessment of Aortic Pulse Wave Velocity by the Brachial Occlusion-Cuff Technique: Comparative Study.

Vratislav Fabian, Lukas Matera, Kristyna Bayerova, Jan Havlik, Vaclav Kremen, Jan Pudil, Pavol Sajgalik, David Zemanek,

Cardiovascular diseases are one of most frequent cause of morbidity and mortality in the world. There is an emerging need for integrated, non-invasive, and easy-to-use clinical tools to assess accurately cardiovascular system primarily in the preventative medicine. We present a novel design for a non-invasive pulse wave velocity (PWV) assessment ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(16):]

Cited: 1 time

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Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System.

Jakub Treml, Veronika Leláková, Karel Šmejkal, Tereza Paulíčková, Šimon Labuda, Sebastian Granica, Jaroslav Havlík, Dagmar Jankovská, Tereza Padrtová, Jan Hošek,

The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 ... Read more >>

Biomolecules (Biomolecules)
[2019, 9(9):]

Cited: 4 times

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The Year of the Honey Bee (Apis mellifera L.) with Respect to Its Physiology and Immunity: A Search for Biochemical Markers of Longevity.

Martin Kunc, Pavel Dobeš, Jana Hurychová, Libor Vojtek, Silvana Beani Poiani, Jiří Danihlík, Jaroslav Havlík, Dalibor Titěra, Pavel Hyršl,

It has been known for many years that in temperate climates the European honey bee, <i>Apis mellifera</i>, exists in the form of two distinct populations within the year, short-living summer bees and long-living winter bees. However, there is only limited knowledge about the basic biochemical markers of winter and summer ... Read more >>

Insects (Insects)
[2019, 10(8):]

Cited: 2 times

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In-hive variation of the gut microbial composition of honey bee larvae and pupae from the same oviposition time.

Zuzana Hroncova, Jiri Killer, Josef Hakl, Dalibor Titera, Jaroslav Havlik,

<h4>Background</h4>Knowledge of microbiota composition, persistence, and transmission as well as the overall function of the bacterial community is important and may be linked to honey bee health. This study aimed to investigate the inter-individual variation in the gut microbiota in honey bee larvae and pupae.<h4>Results</h4>Individual larvae differed in the composition ... Read more >>

BMC Microbiol (BMC microbiology)
[2019, 19(1):110]

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Effects of chlorogenic acid, epicatechin gallate, and quercetin on mucin expression and secretion in the Caco-2/HT29-MTX cell model.

Tereza Volstatova, Alessandra Marchica, Zuzana Hroncova, Rodolfo Bernardi, Ivo Doskocil, Jaroslav Havlik,

Mucins are a family of large glycoproteins that represent the major structural components of the mucus and are encoded by 20 different mucin genes. Mucin expression can be modulated by different stimuli. In this study, we analyzed four mucins (MUC2, MUC3, MUC13, and MUC17) in coculture of Caco-2/HT29-MTX cells to ... Read more >>

Food Sci Nutr (Food science & nutrition)
[2019, 7(2):492-498]

Cited: 1 time

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Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals.

Lukas Balek, Marcela Buchtova, Michaela Kunova Bosakova, Miroslav Varecha, Silvie Foldynova-Trantirkova, Iva Gudernova, Iva Vesela, Jan Havlik, Jitka Neburkova, Stuart Turner, Mateusz Adam Krzyscik, Malgorzata Zakrzewska, Lars Klimaschewski, Peter Claus, Lukas Trantirek, Petr Cigler, Pavel Krejci,

The blocking of specific protein-protein interactions using nanoparticles is an emerging alternative to small molecule-based therapeutic interventions. However, the nanoparticles designed as "artificial proteins" generally require modification of their surface with (bio)organic molecules and/or polymers to ensure their selectivity and specificity of action. Here, we show that nanosized diamond crystals ... Read more >>

Biomaterials (Biomaterials)
[2018, 176:106-121]

Cited: 2 times

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Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential.

Jan Tauchen, Lukas Huml, Ludvik Bortl, Ivo Doskocil, Veronika Jarosova, Petr Marsik, Adela Frankova, Zoyla Mirella Clavo Peralta, Maria-Elena Chuspe Zans, Jaroslav Havlik, Oldrich Lapcik, Ladislav Kokoska,

Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only <i>Dysphania ambrosioides</i> exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells ... Read more >>

Nat Prod Res (Natural product research)
[2019, 33(18):2718-2721]

Cited: 1 time

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Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota

C A Edwards, J Havlik, W Cong, W Mullen, T Preston, D J Morrison, E Combet,

A high‐fibre diet and one rich in fruit and vegetables have long been associated with lower risk of chronic disease. There are several possible mechanisms underpinning these associations, but one likely important factor is the production of bioactive molecules from plant‐based foods by the bacteria in the colon. This links ... Read more >>

(Nutrition bulletin.)
[2017, 42(4):356-360]

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Polyphenols and health: Interactions between fibre, plant polyphenols and the gut microbiota.

C A Edwards, J Havlik, W Cong, W Mullen, T Preston, D J Morrison, E Combet,

A high-fibre diet and one rich in fruit and vegetables have long been associated with lower risk of chronic disease. There are several possible mechanisms underpinning these associations, but one likely important factor is the production of bioactive molecules from plant-based foods by the bacteria in the colon. This links ... Read more >>

Nutr Bull (Nutrition bulletin)
[2017, 42(4):356-360]

Cited: 23 times

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