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Author J Carthy

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Enteritis and Severe Abdominal Pain as the First Presentation of Covid-19.

A Kecler-Pietrzyk, G Orsi, J Carthy, W C Torreggiani,

Presentation A male patient with no significant past medical history presented to emergency department with progressive in severity abdominal pain, associated with mild nausea and diarrhea. No other significant symptoms were reported. Diagnosis On investigation with CT, duodenojejunitis was diagnosed as the cause of abdominal pain. Lung basal changes were ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):102]

Cited: 0 times

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Arkadia via SNON enables NODAL-SMAD2/3 signaling effectors to transcribe different genes depending on their levels

Jonathon Carthy, Marilia Ioannou, Vasso Episkopou,

Abstract How cells assess levels of signaling and select to transcribe different target genes depending on the levels of activated effectors remains elusive. High NODAL-signalling levels specify anterior/head, lower specify posterior, and complete loss abolishes anterior-posterior patterning in the mammalian embryo. Here we show that cells assess NODAL-activated SMAD2 and ... Read more >>

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TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders.

Jonathon M Carthy,

The myofibroblast is a highly specialized cell type that plays a critical role during normal tissue wound healing, but also contributes pathologically to chronic inflammatory conditions such as fibrosis and cancer. As fibrotic conditions continue to be a major burden to the public health system, novel therapies that target the ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2018, 233(1):98-106]

Cited: 17 times

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A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity.

Maria Birkou, Christos T Chasapis, Konstantinos D Marousis, Ariadni K Loutsidou, Detlef Bentrop, Moreno Lelli, Torsten Herrmann, Jonathon M Carthy, Vasso Episkopou, Georgios A Spyroulias,

Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amplification of transforming growth factor beta (TGF-β) signaling responses by targeting for degradation the negative regulators of the pathway, Smad6 and Smad7, and the nuclear co-repressors Ski and Skil (SnoN). Arkadia's function in vivo depends on ... Read more >>

J Mol Biol (Journal of molecular biology)
[2017, 429(15):2373-2386]

Cited: 2 times

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Inhibition of vascular endothelial growth factor reduces cardiac allograft vasculopathy.

Safia Chatur, Brian W-C Wong, Jon M Carthy, Bruce M McManus,

Cardiac allograft vasculopathy (CAV) is a leading expression of chronic organ rejection at and beyond 1 year post-transplantation. Host bone marrow (BM)-derived cell migration to the allograft has been demonstrated in earlier work. Vascular endothelial growth factor (VEGF) is endogenously overexpressed within allografts. Graft neo-angiogenesis has been proposed as a ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2016, 35(9):1124-1130]

Cited: 3 times

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Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Jon M Carthy, Martin Stöter, Claudia Bellomo, Michael Vanlandewijck, Angelos Heldin, Anita Morén, Dimitris Kardassis, Timothy C Gahman, Andrew K Shiau, Marc Bickle, Marino Zerial, Carl-Henrik Heldin, Aristidis Moustakas,

Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful. Using human keratinocytes and a robotic high-content imaging platform, we screened for chemical compounds that reverse transforming growth factor β (TGF-β)-induced epithelial-mesenchymal ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:29868]

Cited: 5 times

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In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients.

Savvas Petanidis, Efrosini Kioseoglou, Kalliopi Domvri, Paul Zarogoulidis, Jon M Carthy, Doxakis Anestakis, Aristidis Moustakas, Athanasios Salifoglou,

Epithelial to mesenchymal transition (EMT) plays a key role in tumor progression and metastasis as a crucial event for cancer cells to trigger the metastatic niche. Transforming growth factor-β (TGF-β) has been shown to play an important role as an EMT inducer in various stages of carcinogenesis. Previous reports had ... Read more >>

Int J Biochem Cell Biol (The international journal of biochemistry & cell biology)
[2016, 74:121-134]

Cited: 11 times

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Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

Jon M Carthy, Anders Sundqvist, Angelos Heldin, Hans van Dam, Dimitris Kletsas, Carl-Henrik Heldin, Aristidis Moustakas,

Transforming growth factor-β (TGF-β) is a multifunctional cytokine which stimulates the differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound healing, but also accumulate pathologically in a number of chronic inflammatory conditions where they are key contributors to aberrant tissue remodeling and fibrosis, and in cancer stroma. In ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2015, 230(12):3084-3092]

Cited: 29 times

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Versican localizes to the nucleus in proliferating mesenchymal cells.

Jon M Carthy, Thomas Abraham, Anna J Meredith, Seti Boroomand, Bruce M McManus,

OBJECTIVE:Versican is a versatile and highly interactive chondroitin sulfate proteoglycan that is found in the extracellular matrix (ECM) of many tissues and is a major component of developing and developed lesions in atherosclerotic vascular disease. In this paper, we present data to indicate that versican may have important intracellular functions ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2015, 24(6):368-374]

Cited: 8 times

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Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.

Ulrich Valcourt, Jonathon Carthy, Yukari Okita, Lindsay Alcaraz, Mitsuyasu Kato, Sylvie Thuault, Laurent Bartholin, Aristidis Moustakas,

In recent years, the importance of the cell biological process of epithelial-mesenchymal transition (EMT) has been established via an exponentially growing number of reports. EMT has been documented during embryonic development, tissue fibrosis, and cancer progression in vitro, in animal models in vivo and in human specimens. EMT relates to ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2016, 1344:147-181]

Cited: 10 times

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1,25 Dihydroxyvitamin D3 Inhibits TGFβ1-Mediated Primary Human Cardiac Myofibroblast Activation.

Anna Meredith, Seti Boroomand, Jon Carthy, Zongshu Luo, Bruce McManus,

Epidemiological and interventional studies have suggested a protective role for vitamin D in cardiovascular disease, and basic research has implicated vitamin D as a potential inhibitor of fibrosis in a number of organ systems; yet little is known regarding direct effects of vitamin D on human cardiac cells. Given the ... Read more >>

PLoS One (PloS one)
[2015, 10(6):e0128655]

Cited: 15 times

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Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.

Jon M Carthy, Ulla Engström, Carl-Henrik Heldin, Aristidis Moustakas,

The Wnt ligands are a family of secreted signaling proteins which play key roles in a number of cellular processes under physiological and pathological conditions. Wnts bind to their membrane receptors and initiate a signaling cascade which leads to the nuclear localization and transcriptional activity of β-catenin. The development of ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2016, 117(4):938-945]

Cited: 7 times

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Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts.

Jon M Carthy, Anna J Meredith, Seti Boroomand, Thomas Abraham, Zongshu Luo, Darryl Knight, Bruce M McManus,

Versican, a chondroitin sulphate proteoglycan, is one of the key components of the provisional extracellular matrix expressed after injury. The current study evaluated the hypothesis that a versican-rich matrix alters the phenotype of cultured fibroblasts.The full-length cDNA for the V1 isoform of human versican was cloned and the recombinant proteoglycan ... Read more >>

PLoS One (PloS one)
[2015, 10(7):e0133056]

Cited: 8 times

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Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 years.

J P H Wilding, V Woo, K Rohwedder, J Sugg, S Parikh, ,

Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), has been shown to improve glycaemic control, stabilize insulin dosing and mitigate insulin-associated weight gain over 48 weeks in patients whose type 2 diabetes mellitus (T2DM) was inadequately controlled despite high doses of insulin. Here the efficacy and safety of dapagliflozin therapy ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2014, 16(2):124-136]

Cited: 122 times

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WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication.

Jon M Carthy, Zongshu Luo, Bruce M McManus,

Evidence suggests a role for Wnt signaling in vascular wound repair and remodeling events. Despite this, very little is known about the effect of Wnt ligands on the structure and function of vascular cells. In this study, we treated vascular smooth muscle cells with 250 ng/ml of recombinant Wnt3a for 72 h ... Read more >>

Lab. Invest. (Laboratory investigation; a journal of technical methods and pathology)
[2012, 92(2):246-255]

Cited: 9 times

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Mapping of the Wnt/β-catenin/TCF response elements in the human versican promoter.

Maziar Rahmani, Jon M Carthy, Bruce M McManus,

Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix and is considered to be crucial to several key cellular processes involved in development and disease. There is differential temporal and spatial expression of versican by multiple cell types and in different developmental and pathological ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2012, 836:35-52]

Cited: 9 times

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Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial.

John P H Wilding, Vincent Woo, Norman G Soler, Andrea Pahor, Jennifer Sugg, Katja Rohwedder, Shamik Parikh, ,

BACKGROUND: Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2, may improve glycemic control with a lower dose of insulin and attenuate the associated weight gain in patients with inadequate control despite high doses of insulin. OBJECTIVE: To evaluate the efficacy and safety of adding dapagliflozin therapy in patients whose type ... Read more >>

Ann. Intern. Med. (Annals of internal medicine)
[2012, 156(6):405-415]

Cited: 239 times

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Versican and CD44 in in vitro valvular interstitial cell injury and repair.

Jon M Carthy, Seti Boroomand, Bruce M McManus,

BACKGROUND: Versican is one of the key components of the extracellular matrix (ECM) that is expressed during injury, inflammatory, and repair processes. The current study evaluated the relationship between versican and the membrane receptor CD44 during in vitro valvular interstitial cell (VIC) injury and repair. METHODS: Subconfluent, confluent, and wounded ... Read more >>

Cardiovasc Pathol (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2012, 21(2):74-82]

Cited: 8 times

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Minimally invasive imaging method based on second harmonic generation and multiphoton excitation fluorescence in translational respiratory research.

Thomas Abraham, Samuel Wadsworth, Jon M Carthy, Dmitri V Pechkovsky, Bruce McManus,

For translational respiratory research including in the development of clinical diagnostic tools, a minimally invasive imaging method, which can provide both cellular and extracellular structural details with sufficient specificity, sensitivity and spatial resolution, is particularly useful. Multiphoton microscopy causes excitation of endogenously fluorescent macromolecular systems and induces highly specific second ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2011, 16(1):22-33]

Cited: 10 times

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Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner.

Jon M Carthy, Farshid S Garmaroudi, Zongshu Luo, Bruce M McManus,

Growing evidence suggests the Wnt family of secreted glycoproteins and their associated signaling pathways, linked to development, are recapitulated during wound repair and regeneration events. However, the role of the Wnt pathway in such settings remains unclear. In the current study, we treated mouse fibroblasts with 250 ng/mL of recombinant ... Read more >>

PLoS One (PloS one)
[2011, 6(5):e19809]

Cited: 79 times

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Collagen matrix remodeling in 3-dimensional cellular space resolved using second harmonic generation and multiphoton excitation fluorescence.

Thomas Abraham, Jon Carthy, Bruce McManus,

The structural remodeling of collagen is important in biological processes such as fibrosis, developmental morphogenesis and wound repair. Highly ordered collagen macromolecules produce second harmonic generation signals without the need for any exogenous label. Conversely, the cellular components stained with exogenous labels generate multiphoton excitation fluorescence signals. Both these signals ... Read more >>

J. Struct. Biol. (Journal of structural biology)
[2010, 169(1):36-44]

Cited: 18 times

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Versican: signaling to transcriptional control pathways.

Maziar Rahmani, Brian W Wong, Lisa Ang, Caroline C Cheung, Jon M Carthy, Hubert Walinski, Bruce M McManus,

Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease. Versican participates in cell adhesion, proliferation, migration, and angiogenesis, and hence plays a central role in tissue morphogenesis and maintenance. In ... Read more >>

Can. J. Physiol. Pharmacol. (Canadian journal of physiology and pharmacology)
[2006, 84(1):77-92]

Cited: 59 times

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.

G Scott Ralph, Pippa A Radcliffe, Denise M Day, Janine M Carthy, Marie A Leroux, Debbie C P Lee, Liang-Fong Wong, Lynsey G Bilsland, Linda Greensmith, Susan M Kingsman, Kyriacos A Mitrophanous, Nicholas D Mazarakis, Mimoun Azzouz,

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease resulting in the selective death of motor neurons in the brain and spinal cord. Some familial cases of ALS are caused by dominant mutations in the gene encoding superoxide dismutase (SOD1). The emergence of interfering RNA (RNAi) for specific gene silencing ... Read more >>

Nat. Med. (Nature medicine)
[2005, 11(4):429-433]

Cited: 269 times

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Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells.

Maziar Rahmani, Jason T Read, Jon M Carthy, Paul C McDonald, Brian W Wong, Mitra Esfandiarei, Xiaoning Si, Zongshu Luo, Honglin Luo, Paul S Rennie, Bruce M McManus,

The proteoglycan versican is pro-atherogenic and central to vascular injury and repair events. We identified the signaling pathways and promoter elements involved in regulation of versican expression in vascular smooth muscle cells. Phosphatidylinositol 3-kinase inhibitor, LY294002, significantly decreased versican-luciferase (Luc) promoter activity and endogenous mRNA levels. We further examined the ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2005, 280(13):13019-13028]

Cited: 54 times

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Management: bandwagons roll.

J Carthy,

Nurs Stand (Nursing standard (Royal College of Nursing (Great Britain) : 1987))
[1994, 8(38):48-49]

Cited: 2 times

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