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Tris(2-chloroethyl) Phosphate (TCEP) Elicits Hepatotoxicity by Activating Human Cancer Pathway Genes in HepG2 Cells.

Abdullah M Al-Salem, Quaiser Saquib, Maqsood A Siddiqui, Javed Ahmad, Abdulaziz A Al-Khedhairy,

Tris(2-chloroethyl) phosphate (TCEP) is one of the organophosphorus flame retardants (OPFRs) used in consumer commodities and have been detected in human body fluids. Research on TCEP-induced transcriptomic alterations and toxicological consequences in liver cells is still lacking. Herein, human hepatocellular (HepG2) cells were treated with 100, 200, and 400 μM ... Read more >>

Toxics (Toxics)
[2020, 8(4):]

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Effect of Nardostachys jatamansi DC. on Apoptosis, Inflammation and Oxidative Stress Induced by Doxorubicin in Wistar Rats.

Mhaveer Singh, Mohammad Ahmed Khan, Kamal Y T, Javed Ahmad, Usama A Fahmy, Sabna Kotta, Nabil A Alhakamy, Sayeed Ahmad,

The study aimed to investigate the protective action of jatamansi (Nardostachys jatamansi DC.) against doxorubicin cardiotoxicity. Methanolic extract of jatamansi (MEJ) was prepared and standardized using HPTLC fingerprinting, GC-MS chemoprofiling, total phenolic content, and antioxidant activity in vitro. Further in vivo activity was evaluated using rodent model. Animals were divided ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(11):]

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Synergistic bactericidal effects of pairs of photosensitizer molecules activated by ultraviolet A light against bacteria in plasma.

Qinati Feyissa, Fei Xu, Zina Ibrahim, Ying Li, Kevin L Xu, Zihan Guo, Justen Ahmad, Jaroslav G Vostal,

BACKGROUND:The current approach to reducing bacterial contamination in blood transfusion products is through detection or pathogen reduction methods, some of which utilize ultraviolet (UV) light photosensitizers. A small number of photosensitizers are being used as single agents in combination with UV light, but their efficacy can be limited against some ... Read more >>

Transfusion (Transfusion)
[2020, :]

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Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease.

Md Sahab Uddin, Sharifa Hasana, Jamil Ahmad, Md Farhad Hossain, Md Mosiqur Rahman, Tapan Behl, Abdur Rauf, Ausaf Ahmad, Abdul Hafeez, Asma Perveen, Ghulam Md Ashraf,

Alzheimer's disease (AD) is an irrevocable chronic brain disorder featured by neuronal loss, microglial accumulation, and progressive cognitive impairment. The proper pathophysiology of this life-threatening disorder is not completely understood and no exact remedies are found yet. Over the last few decades, research on AD has mainly highlighted in pathomechanisms ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2020, :]

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Formulation design and evaluation of aceclofenac nanogel for topical application.

Md Shoaib Alam, Mohammed S Algahtani, Javed Ahmad, Kanchan Kohli, Sheikh Shafiq-Un-Nabi, Musarrat Husain Warsi, Mohammad Zaki Ahmad,

Aim: The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials & methods: Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressure homogenization technique. Carbopol 940 was added as a gelling agent. Results & conclusion: ... Read more >>

Ther Deliv (Therapeutic delivery)
[2020, :]

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Commentary on: Transitioning From Conventional Textured to Nanotextured Breast Implants: Our Early Experience and Modifications for Optimal Breast Augmentation Outcomes.

Ryan E Austin, Jamil Ahmad, Frank Lista,

Aesthet Surg J (Aesthetic surgery journal)
[2020, :]

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Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme.

Md Habban Akhter, Md Rizwanullah, Javed Ahmad, Saima Amin, Mohammad Zaki Ahmad, Md Akram Minhaj, Md Ali Mujtaba, Javed Ali,

Glioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). ... Read more >>

Drug Res (Stuttg) (Drug research)
[2020, :]

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Pakistani Student Nurses' perceptions of their hospital's health professionals' attitudes and suggested ways to improve patient care - An untainted view.

Sachal Aqeel Safdar, Humaira Zafar, Jawwad Ahmad, Rashid Qayyum, Sajid Naseem, Chaudhry Aqeel Safdar,

Background & Objectives:Feedback brings a fresh perspective and improvement in any organization. Health professionals (HPs) lose insight of the gaps in medical care. The views of student nurses can help improve systems. The objective of this study was to assess the views of our student nurses and how they perceive ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2020, 36(7):1671-1677]

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Hot Topics in Breast Surgery.

Ryan E Austin, Frank Lista, Jamil Ahmad,

Since the first implant-based breast surgeries were performed nearly 70 years ago, breast augmentation it has changed drastically. As understanding of breast augmentation has advanced, so too have the technologies and techniques used to improve results and minimize the risk of complications in breast implant surgery. This article reviews some of ... Read more >>

Clin Plast Surg (Clinics in plastic surgery)
[2021, 48(1):131-139]

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Evidence-Based Performance Measures for Rhinoplasty: A Multi-Disciplinary Performance Measure Set.

Michele A Manahan, Fred Fedok, Caryn Davidson, Jamil Ahmad, Minas Constantinides, Richard Davis, Oren Friedman, Robert Gilman, Lisa Ishii, Geoffrey Keyes, Samuel J Lin, Benjamin Marcus, Alan Matarasso, Sam P Most, Faisal Quereshy, Sammy Sinno, Derek Steinbacher, Travis Tollefson, Rod Rohrich,

The American Society of Plastic Surgeons (ASPS), American Academy of Otolaryngology-Heand and Neck Surgery (AAO-HNS), and the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) commissioned the multi-disciplinary Rhinoplasty Performance Measure Development Work Group to identify and draft quality measures for the care of patients undergoing both functional and ... Read more >>

Plast Reconstr Surg (Plastic and reconstructive surgery)
[2020, :]

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Scalp Myiasis in an Ulcerated Abscess in a 7-year Old Child.

Abdullah Khan, Faheemullah Khan, Jawad Ahmad, Hameed Ullah, Wiqar Ahmad,

Null. ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2020, 30(11):1234-1235]

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Evaluation of biochemical defense response to Spodoptera litura infestation in cotton (Gossypium hirsutum L.) genotypes

Arslan Hafeez, Samina Jam Nazeer Ahmad, Jam Nazeer Ahmad, Muhammad Imran Tipu, Tanwir Ahmad Malik,

Abstract Background: The cotton armyworm ( Spodoptera litura) is one of the most devastating pests of many economically important crops including cotton which cause substantial yield losses due to its feeding pattern on leaves and other plant parts. Plants respond to herbivore damage through an array of defense responses to ... Read more >>

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Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group.

Daisy Crawley, Lei Zhang, Emily J H Jones, Jumana Ahmad, Bethany Oakley, Antonia San José Cáceres, Tony Charman, Jan K Buitelaar, Declan G M Murphy, Christopher Chatham, Hanneke den Ouden, Eva Loth, ,

Flexible behavior is critical for everyday decision-making and has been implicated in restricted, repetitive behaviors (RRB) in autism spectrum disorder (ASD). However, how flexible behavior changes developmentally in ASD remains largely unknown. Here, we used a developmental approach and examined flexible behavior on a probabilistic reversal learning task in 572 ... Read more >>

PLoS Biol (PLoS biology)
[2020, 18(10):e3000908]

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The Association of PPE Availability, Training and Practices with COVID-19 Sero-prevalence in Nurses and Paramedics in Tertiary Care Hospitals of Peshawar, Pakistan.

Junaid Ahmad, Saeed Anwar, Abdul Latif, Najib Ul Haq, Muhammad Sharif, Ahmed Ali Nauman,

BACKGROUND:Nurses and paramedics by being the frontline workers of the healthcare profession need to be equipped with the relevant knowledge, skills and protective gears against different forms of infection, including COVID-19. Though the governments and concerned stakeholders have provided P.P.E.s, training and information to protect the healthcare professionals, however until ... Read more >>

Disaster Med Public Health Prep (Disaster medicine and public health preparedness)
[2020, :1-18]

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The Epidemiology of Natural Hazards, Disasters, and Epidemics: A Systematic Worldwide Mortality Analysis of 210 Countries for 15 Years (2001-2015)

Junaid Ahmad, Good Luck, Mokbul Morshed Ahmad, Irfan Rana,

Background: In recent years, the unprecedented death tolls as a result of natural hazards, disasters, and epidemics made everyone interested from the general public to country heads to know about the mortality rates. The coronavirus issue is the most recent example, which is all over the media, and everyone is ... Read more >>

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A race for a better understanding of COVID-19 vaccine non-adopters.

Zhaohui Su, Jun Wen, Jaffar Abbas, Dean McDonnell, Ali Cheshmehzangi, Xiaoshan Li, Junaid Ahmad, Sabina Šegalo, Daniel Maestro, Yuyang Cai,

In this paper, we aim to underscore the need for a more nuanced understanding of vaccine non-adopters. As the availability of vaccines does not translate into their de facto adoption-a phenomenon that may be more pronounced amid "Operation Warp Speed"-it is important for public health professionals to thoroughly understand their ... Read more >>

Brain Behav Immun Health (Brain, behavior, & immunity - health)
[2020, 9:100159]

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Ischemic Stroke Occurs Less Frequently in Patients With COVID-19: A Multicenter Cross-Sectional Study.

Kimon Bekelis, Symeon Missios, Javaad Ahmad, Nicos Labropoulos, Clemens M Schirmer, Daniel R Calnan, Jonathan Skinner, Todd A MacKenzie,

BACKGROUND AND PURPOSE:The impact of coronavirus disease 2019 (COVID-19) on the occurrence of ischemic stroke has been the subject of increased speculation but has not been confirmed in large observational studies. We investigated the association between COVID-19 and stroke. METHODS:We performed a cross-sectional study involving patients discharged from a healthcare ... Read more >>

Stroke (Stroke)
[2020, 51(12):3570-3576]

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Mycobacterium smegmatis Bacteria Expressing Mycobacterium tuberculosis-Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response.

Simran Kaur Arora, Nilofer Naqvi, Anwar Alam, Javeed Ahmad, Basma Saud Alsati, Javaid Ahmad Sheikh, Prabin Kumar, Dipendra Kumar Mitra, Syed Asad Rahman, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham,

Mycobacterium tuberculosis (M. tb), the intracellular pathogen causing tuberculosis, has developed mechanisms that endow infectivity and allow it to modulate host immune response for its survival. Genomic and proteomic analyses of non-pathogenic and pathogenic mycobacteria showed presence of genes and proteins that are specific to M. tb. In silico studies ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:564565]

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Disease Detection in Plum Using Convolutional Neural Network under True Field Conditions.

Jamil Ahmad, Bilal Jan, Haleem Farman, Wakeel Ahmad, Atta Ullah,

The agriculture sector faces crop losses every year due to diseases around the globe, which adversely affect food productivity and quality. Detecting and identifying plant diseases at an early stage is still a challenge for farmers, particularly in developing countries. Widespread use of mobile computing devices and the advancements in ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(19):]

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Seroprevalence and Risk Factors of SARS CoV-2 in Health Care Workers of Tertiary-Care Hospitals in the Province of Khyber Pakhtunkhwa, Pakistan

Mohsina Haq, Asif Rehman, Muhammad Noor, Jawad Ahmed, Junaid Ahmad, Muhammad irfan, Saeed Anwar, Sajjad Ahmad, Said Amin, Fawad Rahim, Najib Ul Haq,

Background: High number of SARS CoV2 infected patients has overburdened healthcare delivery system, particularly in low-income countries. In the recent past many studies from the developed countries have been published on the prevalence of SARS CoV2 antibodies and the risk factors of COVID 19 in healthcare-workers but little is known ... Read more >>

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How do core autism traits and associated symptoms relate to quality of life? Findings from the Longitudinal European Autism Project.

Bethany Fm Oakley, Julian Tillmann, Jumana Ahmad, Daisy Crawley, Antonia San José Cáceres, Rosemary Holt, Tony Charman, Tobias Banaschewski, Jan Buitelaar, Emily Simonoff, Declan Murphy, Eva Loth,

LAY ABSTRACT:Previous studies suggest that some autistic individuals report lower satisfaction, or well-being, with different aspects of everyday life than those without autism. It is unclear whether this might be partly explained by symptoms of anxiety and/or depression, which affect at least 20%-50% of autistic people. In this study, we ... Read more >>

Autism (Autism : the international journal of research and practice)
[2020, :1362361320959959]

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Temporal Profiles of Social Attention Are Different Across Development in Autistic and Neurotypical People.

Teresa Del Bianco, Luke Mason, Tony Charman, Julian Tillman, Eva Loth, Hannah Hayward, Frederick Shic, Jan Buitelaar, Mark H Johnson, Emily J H Jones, ,

BACKGROUND:Sociocommunicative difficulties, including abnormalities in eye contact, are core diagnostic features of autism spectrum disorder (ASD). Many studies have used eye tracking to measure reduced attention to faces in autistic people; however, most of this work has not taken advantage of eye-tracking temporal resolution to examine temporal profiles of attention. ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, :]

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The Prevalence of Incidentally Detected Urolithiasis in Subjects Undergoing Computerized Tomography.

Sajeel Saeed, Ansar Ullah, Jawad Ahmad, Sidra Hamid,

Background and objective Urolithiasis is defined as the presence of calculi in the urinary tract. Multiple studies have shown that urinary tract stones are one of the most common incidental findings in medical imaging. These stones are potentially dangerous and can cause severe impairment to renal function if they remain ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10374]

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Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.

Jawid Nazir Ahmad, Peter Sebo,

Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity of Bordetella pertussis adenylate cyclase toxin manipulates the differentiation of monocytes ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:2181]

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HLA-B*35:01 and Green Tea Induced Liver Injury.

Jay H Hoofnagle, Herbert L Bonkovsky, Elizabeth J Phillips, Yi-Ju Li, Jawad Ahmad, Huiman Barnhart, Francisco Durazo, Robert J Fontana, Jiezhun Gu, Ikhlas Khan, David E Kleiner, Christopher Koh, Don C Rockey, Leonard B Seeff, Jose Serrano, Andrew Stolz, Hans L Tillmann, Raj Vuppalanchi, Victor J Navarro, ,

BACKGROUND:Herbal supplements and particularly multi-ingredient products have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. METHODS:Among 1414 patients enrolled in the U.S. Drug Induced Liver Injury Network who underwent formal causality assessment, 40 ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2020, :]

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