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Author Israel Hodish

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Challenges in Insulin Therapy for Type 2 Diabetes : Regarding the Article "Expert Opinion: A Call for Basal Insulin Titration in Patients with Type 2 Diabetes in Daily Practice: Southeast European Perspective" by Nicolae Hancu et al.

Israel Hodish,

Diabetes Ther (Diabetes therapy : research, treatment and education of diabetes and related disorders)
[2021, :]

Cited: 0 times

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Insulin requirements are eternally dynamic.

Israel Hodish,

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2021, 23(10):2409-2410]

Cited: 0 times

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For debate; pharmacological priorities in advanced type 2 diabetes.

Israel Hodish,

A multitude of therapeutic agents have been available to treat patients with Type 2 diabetes. Unfortunately, many patients with advanced Type 2 diabetes continue to suffer from complications and premature death. To date, all available guidelines emphasize a variety of therapeutic aspects, goals, and pharmacological combinations, without directing the clinician ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2020, 34(5):107510]

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Insulin dosing guidance to optimise type 2 diabetes management - Authors' reply.

Richard M Bergenstal, Mary L Johnson, Eran Bashan, Israel Hodish,

Lancet (Lancet (London, England))
[2019, 394(10206):1321]

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Automated insulin dosing guidance to optimise insulin management in patients with type 2 diabetes: a multicentre, randomised controlled trial.

Richard M Bergenstal, Mary Johnson, Rebecca Passi, Anuj Bhargava, Natalie Young, Davida F Kruger, Eran Bashan, Stanley G Bisgaier, Deanna J Marriott Isaman, Israel Hodish,

<h4>Background</h4>Insulin therapy is most effective if dosage titrations are done regularly and frequently, which is seldom practical for most clinicians, resulting in an insulin titration gap. The d-Nav Insulin Guidance System (Hygieia, Livonia, MI, USA) is a handheld device that is used to measure glucose, determine glucose patterns, and automatically ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10176):1138-1148]

Cited: 7 times

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Temporary Reductions in Insulin Requirements Are Associated with Hypoglycemia in Type 2 Diabetes.

Roy Harper, Eran Bashan, Stanley G Bisgaier, Mark Willis, Deanna J M Isaman, Israel Hodish,

Background: In patients with type 2 diabetes, insulin therapy necessitates regular and frequent dosage titration to overcome variations in insulin requirements. The goal of this study was to evaluate changes in insulin requirements, using data from a technology-based insulin-titration service. Methods: To keep glycemia stable, the service adjusts and records ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2018, 20(12):817-824]

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THE EFFICACY AND SAFETY OF CO-ADMINISTRATION OF SITAGLIPTIN WITH METFORMIN IN PATIENTS WITH TYPE 2 DIABETES AT HOSPITAL DISCHARGE.

Roma Y Gianchandani, Francisco J Pasquel, Daniel J Rubin, Kathleen M Dungan, Priyathama Vellanki, Heqiong Wang, Isabel Anzola, Patricia Gomez, Israel Hodish, Sangeeta Lathkar-Pradhan, Jennifer Iyengar, Guillermo E Umpierrez,

<h4>Objective</h4>Few randomized controlled trials have focused on the optimal management of patients with type 2 diabetes (T2D) during the transition from the inpatient to outpatient setting. This multicenter open-label study explored a discharge strategy based on admission hemoglobin A1c (HbA1c) to guide therapy in general medicine and surgery patients with ... Read more >>

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2018, 24(6):556-564]

Cited: 2 times

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Insulin therapy, weight gain and prognosis.

Israel Hodish,

Insulin therapy is mainly used by people with type 2 diabetes who have failed other therapies and have become insulin-deficient. This group represents about a quarter of all people with type 2 diabetes. Almost all those with type 2 diabetes who start insulin therapy or intensify it gain weight, which ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2018, 20(9):2085-2092]

Cited: 7 times

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Type 2 diabetes specialty clinic model for the accountable care organization era.

Heather Klingeman, Martha Funnell, Amolak Jhand, Sangeeta Lathkar-Pradhan, Israel Hodish,

<h4>Aims</h4>A third of the patients with Type 2 diabetes have an advance disease that requires complex pharmacotherapies and advanced expertise, dependent on multiple clinical interactions. Unfortunately, limited providers availability enables only sporadic interactions. Additionally, the expanding Accountable Care Organization (ACO) concept enhances providers' compensation when clinical performance is improving while ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2017, 31(10):1521-1526]

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Efficacy of sitagliptin for the hospital management of general medicine and surgery patients with type 2 diabetes (Sita-Hospital): a multicentre, prospective, open-label, non-inferiority randomised trial.

Francisco J Pasquel, Roma Gianchandani, Daniel J Rubin, Kathleen M Dungan, Isabel Anzola, Patricia C Gomez, Limin Peng, Israel Hodish, Tim Bodnar, David Wesorick, Vijay Balakrishnan, Kwame Osei, Guillermo E Umpierrez,

<h4>Background</h4>The role of incretin-based drugs in the treatment of patients with type 2 diabetes admitted to hospital has not been extensively assessed. In this study, we compared the safety and efficacy of a dipeptidyl peptidase-4 inhibitor (sitagliptin) plus basal insulin with a basal-bolus insulin regimen for the management of patients ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2017, 5(2):125-133]

Cited: 48 times

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Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor.

Israel Hodish, Lindsay Schmidt, Andreas G Moraitis,

Objective. To report the unusual case of an adrenal lymphangioma presenting in a patient with an adrenal cystic lesion and biochemical testing concerning for pheochromocytoma. The pertinent diagnostic and imaging features of adrenal lymphangiomas are reviewed. Methods. We describe a 59-year-old patient who presented with hyperhidrosis and a 2.2 by ... Read more >>

Case Rep Endocrinol (Case reports in endocrinology)
[2015, 2015:380151]

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A novel approach to optimise glycaemic control in insulin users.

Eran Bashan, Roy Harper, Yixi Bi, Israel Hodish,

Insulin therapy has been available for almost a century. However, its success rate is still disappointing where the majority of users sustain harmfully elevated glycated haemoglobin (HbA1c) levels. The key element essential for effective and safe insulin therapy is frequent dosage titration to overcome constant variations in insulin requirements. In ... Read more >>

BMJ Case Rep (BMJ case reports)
[2015, 2015:]

Cited: 1 time

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Insulin therapy for pre-hyperglycemic beta-cell endoplasmic reticulum crowding.

Afaf Absood, Benjamin Gandomani, Anthony Zaki, Vlad Nasta, Andrew Michail, Peter M W Habib, Israel Hodish,

Insulin therapy improves β-cell function in early stages of diabetes by mechanisms that may exceed alleviation of glucotoxicity. In advance type 2 diabetes, hyperglycemia causes β-cell damage and ultimately β-cell loss. At such an advanced stage, therapeutic modalities are often inadequate. Growing evidence indicates that in early stages of type-2 ... Read more >>

PLoS One (PloS one)
[2013, 8(2):e54351]

Cited: 7 times

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Can a tool that automates insulin titration be a key to diabetes management?

Richard M Bergenstal, Eran Bashan, Margaret McShane, Mary Johnson, Israel Hodish,

<h4>Background</h4>Most patients who use insulin do not achieve optimal glycemic control and become susceptible to complications. Numerous clinical trials have shown that frequent insulin dosage titration is imperative to achieve glycemic control. Unfortunately, implementation of such a paradigm is often impractical. We hypothesized that the Diabetes Insulin Guidance System (DIGS™) ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2012, 14(8):675-682]

Cited: 18 times

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Frequent insulin dosage adjustments based on glucose readings alone are sufficient for a safe and effective therapy.

Eran Bashan, Israel Hodish,

<h4>Problem</h4>Frequent dosage adjustments are necessary to achieve effective insulin therapy. However, a controversy surrounds the pertinent clinical parameters required to make effective and safe insulin titrations. We hypothesize that glucose readings are sufficient to adjust insulin dosage provided that it is done on a weekly basis.<h4>Methods</h4>In a prospective pilot study, ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2012, 26(3):230-236]

Cited: 7 times

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In vivo misfolding of proinsulin below the threshold of frank diabetes.

Israel Hodish, Afaf Absood, Leanza Liu, Ming Liu, Leena Haataja, Dennis Larkin, Ahmed Al-Khafaji, Anthony Zaki, Peter Arvan,

<h4>Objective</h4>Endoplasmic reticulum (ER) stress has been described in pancreatic β-cells after onset of diabetes-a situation in which failing β-cells have exhausted available compensatory mechanisms. Herein we have compared two mouse models expressing equally small amounts of transgenic proinsulin in pancreatic β-cells.<h4>Research design and methods</h4>In hProCpepGFP mice, human proinsulin (tagged with ... Read more >>

Diabetes (Diabetes)
[2011, 60(8):2092-2101]

Cited: 27 times

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The effort required to achieve and maintain optimal glycemic control.

Elyse S Rosenthal, Eran Bashan, William H Herman, Israel Hodish,

<h4>Background</h4>Insulin therapy is most effective when dosage is frequently adjusted. We sought to evaluate the effort required to maintain A1C below 7% once attained in older patients with type 2 diabetes.<h4>Methods</h4>A total of 2380 insulin dosage adjustment episodes were analyzed for their intensity and frequency. The data were divided into ... Read more >>

J Diabetes Complications (Journal of diabetes and its complications)
[2011, 25(5):283-288]

Cited: 8 times

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APPARATUS AND METHODS FOR TAKING BLOOD GLUCOSE MEASUREMENTS AND RECOMMENDING INSULIN DOSES

BIELAWA HOLLY, DEMETRIS CARISSA, GOEBEL JAMES, MORTON CAROL TREAT, POMORSKI MICHELLE, PURICELLI THOMAS, RODGERS JIM, BASHAN ERAN, ISRAEL HODISH, HINDINGER JOHN R,

The present disclosure related to an apparatus that may be used for taking blood glucose measurements and providing individualized insulin dose recommendations wherein the apparatus is easy to use and facilitates improved diabetes control in patients. Also disclosed are related methods. ... Read more >>

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Are glucose readings sufficient to adjust insulin dosage?

Eran Bashan, William H Herman, Israel Hodish,

<h4>Aims/hypothesis</h4>insulin therapy is effective predominantly when dosage is frequently adjusted. However, a controversy surrounds the pertinent clinical parameters required to make effective and safe frequent dosage adjustments. We hypothesize that glucose readings are sufficient to adjust insulin dosage provided that dosage is adjusted every 1-4 weeks.<h4>Methods</h4>to test the hypothesis, we ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2011, 13(1):85-92]

Cited: 11 times

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Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.

Ming Liu, Israel Hodish, Leena Haataja, Roberto Lara-Lemus, Gautam Rajpal, Jordan Wright, Peter Arvan,

Type 1B diabetes (typically with early onset and without islet autoantibodies) has been described in patients bearing small coding sequence mutations in the INS gene. Not all mutations in the INS gene cause the autosomal dominant Mutant INS-gene Induced Diabetes of Youth (MIDY) syndrome, but most missense mutations affecting proinsulin ... Read more >>

Trends Endocrinol Metab (Trends in endocrinology and metabolism: TEM)
[2010, 21(11):652-659]

Cited: 89 times

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Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.

Israel Hodish, Ming Liu, Gautam Rajpal, Dennis Larkin, Ronald W Holz, Aaron Adams, Leanza Liu, Peter Arvan,

It has previously been shown that misfolded mutant Akita proinsulin in the endoplasmic reticulum engages directly in protein complexes either with nonmutant proinsulin or with "hProCpepGFP" (human proinsulin bearing emerald-GFP within the C-peptide), impairing the trafficking of these "bystander" proinsulin molecules (Liu, M., Hodish, I., Rhodes, C. J., and Arvan, ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(1):685-694]

Cited: 44 times

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Systemic administration of radiation-potentiated anti-angiogenic gene therapy against primary and metastatic cancer based on transcriptionally controlled HSV-TK.

Israel Hodish, Reshef Tal, Aviv Shaish, Nira Varda-Bloom, Shoshana Greenberger, Ariela Rauchwerger, Eyal Breitbart, Livnat Bangio, Dikla Ben-Shushan, Raphael Pfeffer, Bela Feder, Ana Waitsman, Iris Barshack, Iris Goldberg, Shaly Mazaki-Tovi, Michael Peled, Dror Harats,

Transcription-targeted gene delivery directed against angiogenic endothelial cells is a new approach against advanced cancer. Moreover, the herpes simplex virus-thymidine kinase (HSV-TK) gene coupled with low dose radiotherapy is an efficient and externally controlled cytotoxic system. We have previously demonstrated enhanced endothelial-specific cell expression and killing using the modified murine ... Read more >>

Cancer Biol Ther (Cancer biology & therapy)
[2009, 8(5):424-432]

Cited: 8 times

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Location of ectopic adrenocortical hormone-secreting tumors causing Cushing's syndrome in the paranasal sinuses.

Israel Hodish, Thomas J Giordano, Monica N Starkman, David E Schteingart,

<h4>Background</h4>The majority of ectopic adrenocorticotropic hormone (ACTH)-secreting tumors are localized in the chest or abdomen. Occasionally, these tumors are found in the paranasal sinuses.<h4>Methods</h4>We present 2 unusual cases of ectopic ACTH syndrome whose ACTH-secreting tumors were localized in the paranasal sinuses and describe their biochemical and radiological presentation.<h4>Results</h4>The first patient ... Read more >>

Head Neck (Head & neck)
[2009, 31(5):699-706]

Cited: 10 times

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Endothelial-targeted Gene Transfer of Hypoxia-inducible Factor-1α Augments Ischemic Neovascularization Following Systemic Administration.

Reshef Tal, Aviv Shaish, Karen Rofe, Erez Feige, Nira Varda-Bloom, Arnon Afek, Iris Barshack, Livnat Bangio, Israel Hodish, Shoshana Greenberger, Michael Peled, Eyal Breitbart, Dror Harats,

Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of the response to low oxygen levels and has been used for therapeutic angiogenesis. Various routes of administration have been used for delivering genes to the ischemic region including the intramuscular (IM) and intraarterial routes. When compared with these delivery methods, the intravenous ... Read more >>

Mol Ther (Molecular therapy : the journal of the American Society of Gene Therapy)
[2008, 16(12):1927-1936]

Cited: 0 times

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Long-term effects of pegvisomant in patients with acromegaly.

Israel Hodish, Ariel Barkan,

Despite improved surgical and radiotherapy techniques and the development of long-acting somatostatin analogs, some patients with acromegaly cannot attain biochemical remission. As a consequence they continue to endure debilitating symptoms and mortality remains high. Pegvisomant, a recombinant growth-hormone-receptor antagonist, suppresses production of insulin-like growth factor I. Since the introduction of ... Read more >>

Nat Clin Pract Endocrinol Metab (Nature clinical practice. Endocrinology & metabolism)
[2008, 4(6):324-332]

Cited: 19 times

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