Full Text Journal Articles by
Author Isabelle Lascombe


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Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure.

Céline Elie-Caille, Isabelle Lascombe, Adeline Péchery, Hugues Bittard, Sylvie Fauconnet,

N-cadherin is a transmembrane glycoprotein expressed by mesenchymal origin cells and is located at the adherens junctions. It regulates also cell motility and contributes to cell signaling. In previous studies, we identified that its anomalous expression in bladder carcinoma was a tumor progression marker. A pharmacological approach to inhibit N-cadherin expression ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, 471(1-2):113-127]

Cited: 0 times

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Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up.

Christel Mathis, Isabelle Lascombe, Franck Monnien, Hugues Bittard, François Kleinclauss, Isabelle Bedgedjian, Sylvie Fauconnet, Séverine Valmary-Degano,

BACKGROUND:Non-muscle invasive bladder cancers (NMIBC: pTa, pT1) are characterised by a high risk of recurrence and/or progression. Identification of prognostic markers is needed to improve both diagnosis and management of the disease. The aim of this study was to analyse the expression of A-FABP (adipocyte-fatty acid binding protein) and to ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):1239]

Cited: 1 time

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Cell death and restoration of TRAIL-sensitivity by ciglitazone in resistant cervical cancer cells.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe,

Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(64):107744-107762]

Cited: 0 times

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Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells.

Adeline Péchery, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

GW501516 is a selective and high-affinity synthetic agonist of peroxisome proliferator-activated receptor β/δ (PPARβ/δ). This molecule promoted the inhibition of proliferation and apoptosis in few cancer cell lines, but its anticancer action has never been investigated in bladder tumor cells. Thus, this study was undertaken to determine whether GW501516 had ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2016, 37(11):14789-14802]

Cited: 5 times

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The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism.

Emmanuelle Roche, Isabelle Lascombe, Hugues Bittard, Christiane Mougin, Sylvie Fauconnet,

Peroxisome Proliferator-Activated Receptor-β (PPARβ) is a ligand-inducible transcription factor activated by both natural (fatty acids and derivatives) and high affinity synthetic agonists. It is thought to play a role in angiogenesis development and Vascular Endothelial Growth Factor (VEGF) regulation but its contribution remains unclear. Until now, the PPARβ agonism effect ... Read more >>

Cell. Signal. (Cellular signalling)
[2014, 26(2):433-443]

Cited: 5 times

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The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Ciglitazone belongs to the thiazolidinediones class of antidiabetic drug family and is a high-affinity ligand for the Peroxisome Proliferator-Activated Receptor γ (PPARγ). Apart from its antidiabetic activity, this molecule shows antineoplastic effectiveness in numerous cancer cell lines.Using RT4 (derived from a well differentiated grade I papillary tumor) and T24 (derived ... Read more >>

PLoS ONE (PloS one)
[2011, 6(12):e28354]

Cited: 16 times

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Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells.

Marie Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Thiazolidinediones, including rosiglitazone and troglitazone, are insulin-sensitizing drugs and high-affinity ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma). Apart from their antidiabetic activity, these molecules possess antitumor properties. We investigated their potential apoptotic effects on RT4 (derived from a well-differentiated Grade I papillary tumor) and T24 (derived from an undifferentiated ... Read more >>

Int. J. Cancer (International journal of cancer)
[2010, 127(8):1769-1784]

Cited: 12 times

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A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells.

Guillaume Boiteux, Isabelle Lascombe, Emmanuelle Roche, Marie-Laure Plissonnier, Anne Clairotte, Hugues Bittard, Sylvie Fauconnet,

Superficial pT1 bladder tumors are characterized by a high risk of recurrence and progression in grade and stage. Few studies provided evidence that loss of adipocyte-fatty acid binding protein (A-FABP) expression was associated with bladder cancer progression. A-FABP is a lipid binding protein playing a role in intracellular lipid transport ... Read more >>

Int. J. Cancer (International journal of cancer)
[2009, 124(8):1820-1828]

Cited: 36 times

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Expression analysis of VEGF-A and VEGF-B: relationship with clinicopathological parameters in bladder cancer.

Sylvie Fauconnet, Stephane Bernardini, Isabelle Lascombe, Guillaume Boiteux, Anne Clairotte, Franck Monnien, Eric Chabannes, Hugues Bittard,

The present investigation was conducted first to determine whether correlation exists between VEGF-A and -B mRNA levels and clinicopathological parameters and to assess their prognostic value in bladder cancer, then to clarify the expression level and biological significance of VEGF-A isoforms. Total RNA was isolated from 37 specimens of bladder ... Read more >>

Oncol. Rep. (Oncology reports)
[2009, 21(6):1495-1504]

Cited: 18 times

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Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.

Hervé Wallerand, Ying Cai, Zev A Wainberg, Isla Garraway, Isabelle Lascombe, Gaëlle Nicolle, Jean-Paul Thiery, Hugues Bittard, François Radvanyi, Robert R Reiter,

OBJECTIVES: A particular interest in epithelial-mesenchymal transition (EMT), which takes place during embryonic development, provided potential mechanisms involved in the progression of many epithelial tumors, including bladder cancer (BC). The phospho-Akt signaling pathway is supposed to be involved in invasion and progression of human tumors, including BC. Moreover, it has ... Read more >>

Urol. Oncol. (Urologic oncology)
[2010, 28(2):180-188]

Cited: 25 times

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The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism.

Nicolas Clere, Laurent Bermont, Sylvie Fauconnet, Isabelle Lascombe, Maëlle Saunier, Lucie Vettoretti, Marie-Laure Plissonnier, Christiane Mougin,

Altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix. Infection by high-risk human papillomavirus and persistent expression of viral oncogene ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2007, 313(15):3239-3250]

Cited: 17 times

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N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors.

Isabelle Lascombe, Anne Clairotte, Sylvie Fauconnet, Stéphane Bernardini, Hervé Wallerand, Bernadette Kantelip, Hugues Bittard,

PURPOSE: Loss of intercellular adhesion and increased cell motility promote tumor cell invasion and spreading. In bladder cancer, loss or reduced E-cadherin expression has been associated with poor survival, and aberrant expression of N-cadherin has been associated with the invasive phenotype of bladder carcinoma cells. The purpose of this study ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2006, 12(9):2780-2787]

Cited: 54 times

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Expression of E-cadherin and alpha-, beta-, gamma-catenins in patients with bladder cancer: identification of gamma-catenin as a new prognostic marker of neoplastic progression in T1 superficial urothelial tumors.

Anne Clairotte, Isabelle Lascombe, Sylvie Fauconnet, Frédéric Mauny, Sophie Félix, Marie-Paule Algros, Hugues Bittard, Bernadette Kantelip,

Loss of intercellular adhesion facilitates tumor invasion. To clarify the relation between altered expression of cell adhesion molecules and progression of T1 superficial bladder tumors, 101 cases (71 T1 tumors, 30 T2/T3 tumors) were examined immunohistochemically for E-cadherin and alpha-, beta-, and gamma-catenins. A highly significant correlation was observed between ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2006, 125(1):119-126]

Cited: 29 times

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Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells.

Sylvie Fauconnet, Isabelle Lascombe, Eric Chabannes, Gérard-Louis Adessi, Béatrice Desvergne, Walter Wahli, Hugues Bittard,

The growth of any solid tumor depends on angiogenesis. Vascular endothelial growth factor (VEGF) plays a prominent role in vesical tumor angiogenesis regulation. Previous studies have shown that the peroxisome proliferator-activated receptor gamma (PPARgamma) was involved in the angiogenesis process. Here, we report for the first time that in two ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2002, 277(26):23534-23543]

Cited: 67 times

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