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Author Isabelle Aimone Gastin

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The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study.

Abderrahim Oussalah, Stanislas Gleye, Isabelle Clerc Urmes, Elodie Laugel, Françoise Barbé, Sophie Orlowski, Catherine Malaplate, Isabelle Aimone-Gastin, Beatrice Maatem Caillierez, Marc Merten, Elise Jeannesson, Raphaël Kormann, Jean-Luc Olivier, Rosa-Maria Rodriguez-Guéant, Farès Namour, Sybille Bevilacqua, Nathalie Thilly, Marie-Reine Losser, Antoine Kimmoun, Luc Frimat, Bruno Levy, Sébastien Gibot, Evelyne Schvoerer, Jean-Louis Guéant,

Background:In patients with severe COVID-19, no data are available on the longitudinal evolution of biochemical abnormalities and their ability to predict disease outcomes. Methods:Using a retrospective, longitudinal cohort study design on consecutive patients with severe COVID-19, we used an extensive biochemical dataset of serial data and time-series design to estimate ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 27:100554]

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Setting up a Virtual Calprotectin Clinic in Inflammatory Bowel Diseases: Literature Review and Nancy Experience.

Ferdinando D'Amico, Patrick Netter, Cedric Baumann, Muriel Veltin, Camille Zallot, Isabelle Aimone-Gastin, Silvio Danese, Laurent Peyrin-Biroulet,

Technological progress, including virtual clinics, web or smartphone-based applications, and assessment of fecal calprotectin (FC) at home has favored the implementation of treat to target strategies for patients with inflammatory bowel diseases (IBD). Although these innovations are promising and have been associated with a significant reduction in health costs, their ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(9):]

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Long-Term ACE Inhibitor/ARB Use Is Associated with Severe Renal Dysfunction and Acute Kidney Injury in Patients with severe COVID-19: Results from a Referral Center Cohort in the North East of France.

Abderrahim Oussalah, Stanislas Gleye, Isabelle Clerc Urmes, Elodie Laugel, Jonas Callet, Françoise Barbé, Sophie Orlowski, Catherine Malaplate, Isabelle Aimone-Gastin, Beatrice Maatem Caillierez, Marc Merten, Elise Jeannesson, Raphaël Kormann, Jean-Luc Olivier, Rosa-Maria Rodriguez-Guéant, Farès Namour, Sybille Bevilacqua, Marie-Reine Losser, Bruno Levy, Antoine Kimmoun, Sébastien Gibot, Nathalie Thilly, Luc Frimat, Evelyne Schvoerer, Jean-Louis Guéant,

BACKGROUND:In patients with severe COVID-19, data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences disease outcomes. In patients with severe COVID-19, we assessed the association between chronic ACEI/ARB use and the occurrence of kidney, lung, heart, and liver dysfunctions ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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SFBC working group "Biochemical markers of COVID-19".

Marie-Christine Beauvieux, Annie M Bérard, Isabelle Aimone-Gastin, Françoise Barbé, Yann Barguil, Delphine Collin-Chavagnac, Hervé Delacour, Céline Delevallée, Valérie Nivet-Antoine, Katell Peoc'h, Carole Poupon, François Schmitt, Laurence Piéroni, Vincent Sapin, , , , , , , , , , ,

The SARS-CoV-2 virus is responsible for an epidemic disease called COVID-19, which was initially evidenced in Wuhan, China, and spread very rapidly in China and around the world. In France, the first isolated case seems now to be reported in December 2019, stage 3 of the COVID-19 epidemic was triggered ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2020, 78(3):269-277]

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Compliance with the faecal calprotectin test in patients with inflammatory bowel disease.

Chloé Maréchal, Isabelle Aimone-Gastin, Cédric Baumann, Bastien Dirrenberger, Jean-Louis Guéant, Laurent Peyrin-Biroulet,

We investigated, for the first time, levels of compliance with faecal calprotectin test in inflammatory bowel disease patients.All consecutive adult inflammatory bowel disease patients having been prescribed an faecal calprotectin test between December 2014-July 2015 were included. At their next visit to the hospital, patients had to return a stool ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2017, 5(5):702-707]

Cited: 3 times

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Diagnostic Accuracy of Procalcitonin for Predicting Blood Culture Results in Patients With Suspected Bloodstream Infection: An Observational Study of 35,343 Consecutive Patients (A STROBE-Compliant Article).

Abderrahim Oussalah, Janina Ferrand, Pierre Filhine-Tresarrieu, Nejla Aissa, Isabelle Aimone-Gastin, Fares Namour, Matthieu Garcia, Alain Lozniewski, Jean-Louis Guéant,

Previous studies have suggested that procalcitonin is a reliable marker for predicting bacteremia. However, these studies have had relatively small sample sizes or focused on a single clinical entity. The primary endpoint of this study was to investigate the diagnostic accuracy of procalcitonin for predicting or excluding clinically relevant pathogen ... Read more >>

(Medicine)
[2015, 94(44):e1774]

Cited: 14 times

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[Survey of professional practices within the framework of the Continuous professional development: an experience led on a national scale on the theme of macroenzymes].

Anthony Leon, Isabelle Aimone-Gastin,

The recent HPST law (reform of the hospital and relative to the patients, to the health and to the territories) states that the formation of the healthcare professionals is now "independent" and "compulsory". This law introduces the term of "Continuous professional development". The "Continuous professional development" groups together the former ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2014, 72(5):582-592]

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[Vitamin B9].

Jean-Claude Guilland, Isabelle Aimone-Gastin,

Vitamin B9 is represented by the group of folate, whose structure is derived from folic acid. The biologically active form is reduced tetrahydrofolates, serving as an essential cofactor in methylation reactions, including the vitamin B12-dependent formation of methionine from homocysteine, and as a carrier of one-carbon units involved in the ... Read more >>

Rev Prat (La Revue du praticien)
[2013, 63(8):1079, 1081-4]

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[Vitamin B12 (cobalamin)].

Jean-Claude Guilland, Isabelle Aimone-Gastin,

The term "vitamin B12" refers to four cobalamins (Cbl), including methyl-Cbl and adenosyl-Cbl, the two enzyme co-factors of methionine synthase and methylmalonyl-CoA mutase, respectively. Vitamin B12 deficiency produces clinical disorders that include mainly megaloblastic anaemia, peripheral and central neurological manifestations. The clinical significance of low blood B12 concentrations in the ... Read more >>

Rev Prat (La Revue du praticien)
[2013, 63(8):1085-7, 1089-90]

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An unusual interference in CK MB assay caused by a macro enzyme creatine phosphokinase (CK) type 2 in HIV-infected patients.

Anthony Léon, Françoise Barbé, Christian Rabaud, Isabelle Aimone-Gastin,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2013, 51(2):e27-9]

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[Reducing the risk of anaphylaxis during anaesthesia. Short text. Société française d'anesthésie et réanimation. Société française d'allergologie].

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Ann Fr Anesth Reanim (Annales francaises d'anesthesie et de reanimation)
[2011, 30(3):212-222]

Cited: 5 times

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[How do we optimally evaluate iron stores in dialyzed patients treated with erythropoiesis stimulating agent?].

Michèle Kessler, Sylvain Salignac, Isabelle Aimone-Gastin,

The treatment of renal anaemia with erythropoiesis stimulating agent is often associated with a functional iron deficiency characterized by normal or elevated iron stores but insufficient iron delivered for erythropoiesis. Biological markers of iron status depend on the compartment where it is located: stored, circulating or available for erythropoiesis. Ferritin ... Read more >>

Nephrol. Ther. (Nephrologie & therapeutique)
[2006, 2 Suppl 4:S261-5]

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[Biochemical markers of iron status].

Isabelle Aimone-Gastin,

Traditionally, the standard biochemical markers of iron status are serum iron, transferrin, transferrin saturation, ferritin and, more recently, soluble transferrin receptor. Diagnosis of iron deficiency is usually associated with a low serum ferritin concentration. The diagnosis can be difficult in diseases in which there is an acute-phase response, because ferritin ... Read more >>

Nephrol. Ther. (Nephrologie & therapeutique)
[2006, 2 Suppl 5:S321-6]

Cited: 1 time

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