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Author Isabel Vilaseca

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Letter from the Editorial Board of the Acta Otorrinolaringológica Española.

Isabel Vilaseca, Fernando López,

Acta Otorrinolaringol Esp (Acta otorrinolaringologica espanola)
[2021, :]

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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

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Timing of elective tracheotomy and duration of mechanical ventilation amongst patients admitted to intensive care with severe COVID-19: a multicentre prospective cohort study

Albert Prats-Uribe, Marc Tobed, José Miguel Villacampa, Adriana Agüero, Clara García-Bastida, José Ignacio Tato, Laura Rodrigáñez, Victoria Duque Holguera, Estefanía Hernández-García, Daniel Poletti, Gabriela Simonetti, Vanessa Villarraga, Carla Meler-Claramonte, Álvaro Sánchez Barrueco, Carlos Chiesa-Estomba, Maria Casasayas, Pablo Parente-Arias, Pedro Castro, Daniel Prieto-Alhambra, Isabel Vilaseca, Francesc Xavier Avilés-Jurado, ,

<h4>Background</h4> The COVID-19 pandemic has strained intensive care unit (ICU) resources. Tracheotomy is the most frequent surgery performed on ICU patients and can affect the duration of ICU care. We studied the association between when tracheotomy occurs and weaning from mechanical ventilation, mortality, and intraoperative and postoperative complications. <h4>Methods</h4> Multicentre ... Read more >>

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Timing, Complications, and Safety of Tracheotomy in Critically Ill Patients With COVID-19.

Francesc Xavier Avilés-Jurado, Daniel Prieto-Alhambra, Nesly González-Sánchez, José de Ossó, Claudio Arancibia, María Jesús Rojas-Lechuga, Laura Ruiz-Sevilla, Joan Remacha, Irene Sánchez, Eduardo Lehrer-Coriat, Mauricio López-Chacón, Cristóbal Langdon, Josep María Guilemany, Francisco Larrosa, Isam Alobid, Manuel Bernal-Sprekelsen, Pedro Castro, Isabel Vilaseca,

<h4>Importance</h4>The current coronavirus disease 2019 (COVID-19) pandemic has led to unprecedented needs for invasive ventilation, with 10% to 15% of intubated patients subsequently requiring tracheotomy.<h4>Objective</h4>To assess the complications, safety, and timing of tracheotomy performed for critically ill patients with COVID-19.<h4>Design, setting, and participants</h4>This prospective cohort study assessed consecutive patients admitted ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2020, :]

Cited: 2 times

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Stridor during sleep: description of 81 consecutive cases diagnosed in a tertiary sleep disorders center.

Cristiana Silva, Alex Iranzo, Gerard Maya, Mónica Serradell, Amaia Muñoz-Lopetegi, Paula Marrero-González, Carles Gaig, Joan Santamaría, Isabel Vilaseca,

<h4>Objective</h4>To describe the characteristics of stridor during sleep (SDS) in a series of adults identified by video-polysomnography (V-PSG).<h4>Methods</h4>Retrospective clinical, V-PSG, laryngoscopic and therapeutic data of patients diagnosed with SDS in a tertiary referral sleep disorders center between 1997 and 2017.<h4>Results</h4>Eighty-one patients were identified (56.8% males, age 61.8 ± 11.2 years). ... Read more >>

Sleep (Sleep)
[2020, :]

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Significance of hyposmia in isolated REM sleep behavior disorder.

Alex Iranzo, Paula Marrero-González, Mónica Serradell, Carles Gaig, Joan Santamaria, Isabel Vilaseca,

<h4>Objective</h4>To determine if hyposmia in isolated REM sleep behavior disorder (IRBD) predicts short-term conversion to any α-synucleinopathy and declines with time.<h4>Methods</h4>Olfaction was tested using the University of Pennsylvania Smell Identification Test (UPSIT-40) in 140 consecutive patients with polysomnography-confirmed IRBD and in 77 matched controls. Patients were followed-up during 5.6 ± 3.9 (range ... Read more >>

J Neurol (Journal of neurology)
[2021, 268(3):963-966]

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Alpha-synuclein seeds in olfactory mucosa of patients with isolated rapid-eye-movement sleep behaviour disorder

Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sánchez-Gómez, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Högl, Werner Poewe, Gianluigi Zanusso, ,

<h4>ABSTRACT</h4> Isolated REM sleep behaviour disorder is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological alpha-synuclein in peripheral tissues of isolated REM sleep behaviour disorder patients may identify those progressing to Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal ... Read more >>

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Prodromal Parkinson disease in patients with idiopathic hyposmia.

Paula Marrero-González, Alex Iranzo, David Bedoya, Mònica Serradell, Aida Niñerola-Baizán, Andrés Perissinotti, Carles Gaig, Isabel Vilaseca, Isam Alobid, Joan Santamaría, Joaquim Mullol,

<h4>Background</h4>Idiopathic hyposmia (IH) is a prodromal marker of Parkinson disease (PD). However, IH is common in the general population and only a minority will develop PD. Identification of individuals with IH at prodromal stage of PD would serve to select them to implement neuroprotective agents, when available.<h4>Objective</h4>To identify prodromal PD ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(12):3673-3682]

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Alpha-Synuclein Pathology in the Submandibular Gland of LRRK2 p.G2019S Mutation Carriers.

Dolores Vilas, Eduardo Tolosa, Iban Aldecoa, Joan Berenguer, Isabel Vilaseca, Alex Iranzo, Maria Marti, Carles Martí, Francisco Lomeña, Llucia Alós, Ellen Gelpi,

<h4>Background: </h4> The presence of intraneuronal aggregates of phosphorylated alpha-synuclein (pAS), the histological hallmark of Parkinson disease (PD), has been already demonstrated to be present in the autonomic nerve fibres that innervate the submandibular gland in approximately 75% of living PD patients. The presence of pAS in the peripheral autonomic ... Read more >>

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Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC.

Francesc Xavier Avilés-Jurado, Carmen Muñoz, Carla Meler, Joan Carles Flores, Josep Gumà, Ester Benaiges, Josefina Mora, Mercedes Camacho, Xavier León, Isabel Vilaseca, Ximena Terra,

<h4>Background</h4>The identification of prognostic non-invasive biomarkers is a priority for cancer patients' care. Circulating microRNA (miRNAs) have been described in numerous human malignancies as diagnostic, prognostic, and therapeutic cancer biomarkers. The aim of our study was to analyze the expression profile of a set of miRNAs, involved in the modulation ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2020, :]

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Juvenile recurrent respiratory papillomatosis treated with combined erlotinib and celecoxib: Initial report.

María Jesús Rojas-Lechuga, Joan Remacha, Nesly González-Sánchez, Juan José Grau, Paola Castillo, Oliver Haag, Isabel Vilaseca,

Recurrent respiratory papillomatosis (RRP) is a chronic disease caused by human papillomavirus (HPV). RRP is a clinical challenge because of the high recurrence rate, poor surgery response, extension to tracheobronchial tree and because of the risk of malignancy in some cases. There is no consensus on which adjuvant therapy is ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2020, 137:110194]

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The impact of diabetes in head and neck cancer.

Isabel Vilaseca, Gemma Fuster, Francesc-Xavier Avilés-Jurado,

<h4>Purpose of review</h4>A strong association between diabetes mellitus and carcinogenesis has been reported in different organs. The purpose of this review is to summarize the new evidences in relation to diabetes mellitus and its association with the development, prognosis, and therapeutic strategies of head and neck squamous cell carcinomas (HNSCC).<h4>Recent ... Read more >>

Curr Opin Otolaryngol Head Neck Surg (Current opinion in otolaryngology & head and neck surgery)
[2020, 28(2):107-111]

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Transoral reconstruction of oropharyngeal tumors. The Hospital Clínic algorithm.

Francesc Xavier Avilés-Jurado, Isabel Vilaseca,

Transoral approaches to the oropharynx have evolved rapidly in the past years. The development of technical instruments such as specific oropharyngeal retractors, 2D and 3D endoscopic systems, robotic platforms, and a combination of energies, has facilitated transoral resection and bleeding control. This new scenario has raised the need for new ... Read more >>

JPRAS Open (JPRAS open)
[2020, 24:25-31]

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Characterization of the sleep disorder of anti-IgLON5 disease.

Carles Gaig, Alex Iranzo, Christian Cajochen, Isabel Vilaseca, Cristina Embid, Josep Dalmau, Francesc Graus, Joan Santamaria,

<h4>Study objective</h4>To characterize the sleep disorder of anti-IgLON5 disease.<h4>Methods</h4>We reviewed 27 video-polysomnographies (V-PSG), 6 multiple sleep latency tests (MSLT), 2 videsomnoscopies with dexmedetomidine, and 10 actigraphies recorded during the disease course of five patients. Due to severe sleep architecture abnormalities, we used a novel modified sleep scoring system combining conventional ... Read more >>

Sleep (Sleep)
[2019, 42(9):]

Cited: 2 times

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Refining the staging in head & neck tumors. Role of nuclear medicine.

Africa Muxí, Sergi Vidal-Sicart, Isabel Vilaseca,

Rev Esp Med Nucl Imagen Mol (Revista espanola de medicina nuclear e imagen molecular)
[2019, 38(3):137-139]

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Clinical Practice Guideline recommendations on examination of the upper airway for adults with suspected obstructive sleep apnoea-hypopnoea syndrome.

Eduard Esteller, Marina Carrasco, Miguel Ángel Díaz-Herrera, Javier Vila, Gabriel Sampol, Joan Juvanteny, Ramon Sieira, Alex Farré, Isabel Vilaseca,

In November 2014 the Spanish Society of Otolaryngology, the Spanish Sleep Society and the Spanish Society of Maxillofacial Surgery proposed and endorsed the development of a Clinical Practice Guideline on the physical examination of the upper airway in patients with obstructive sleep apnoea. The Guideline strictly followed the recommendations of ... Read more >>

Acta Otorrinolaringol Esp (Acta otorrinolaringologica espanola)
[2019, 70(6):364-372]

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Factors of local recurrence and organ preservation with transoral laser microsurgery in laryngeal carcinomas; CHAID decision-tree analysis.

Isabel Vilaseca, Anna Nogués-Sabaté, Francesc Xavier Avilés-Jurado, Joan Berenguer, Juan José Grau, Eugenia Verger, Alfons Nadal, Africa Muxí, Manuel Bernal-Sprekelsen, José Luis Blanch,

<h4>Background</h4>Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.<h4>Objective</h4>To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).<h4>Methods</h4>Local relapse and LC-TLM were evaluated in 1119 patients. Logistic regression and CHAID decision tree analysis were performed.<h4>Results</h4>Local relapse correlated to previous radiotherapy failure (8.45, ... Read more >>

Head Neck (Head & neck)
[2019, 41(3):756-764]

Cited: 3 times

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Alpha-synuclein aggregates in the parotid gland of idiopathic REM sleep behavior disorder.

Ana Fernández-Arcos, Isabel Vilaseca, Iban Aldecoa, Mónica Serradell, Eduard Tolosa, Joan Santamaría, Ellen Gelpi, Alex Iranzo,

<h4>Background</h4>The neuropathological hallmark of Parkinson's disease (PD) is the presence of aggregates of phosphorylated alpha-synuclein (pAS) in the nervous system.<h4>Method</h4>We report a patient with video-polysomnography-confirmed idiopathic REM sleep behavior disorder that underwent parotidectomy because of parotid gland cancer. Immunohistochemistry of the gland tissue revealed abundant pAS deposits. One year after ... Read more >>

Sleep Med (Sleep medicine)
[2018, 52:14-17]

Cited: 1 time

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Intra and interobserver agreement of narrow band imaging for the detection of head and neck tumors.

Anna Nogués-Sabaté, Francesc Xavier Aviles-Jurado, Laura Ruiz-Sevilla, Eduardo Lehrer, Alfonso Santamaría-Gadea, Meritxell Valls-Mateus, Isabel Vilaseca,

<h4>Background</h4>Narrow band imaging (NBI) in combination with white light endoscopy (WLE) has improved the accuracy for the diagnosis and follow-up of head and neck carcinomas by identifying changes in the vascular patterns of the mucosa. However, NBI evaluation is explorer-dependent and may be influenced by the learning curve. The aim ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2018, 275(9):2349-2354]

Cited: 4 times

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α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder.

Alex Iranzo, Sergi Borrego, Isabel Vilaseca, Carles Martí, Mónica Serradell, Raquel Sánchez-Valle, Gabor G Kovacs, Francesc Valldeoriola, Carles Gaig, Joan Santamaria, Eduard Tolosa, Ellen Gelpi,

Study Objectives:To assess whether biopsy of the labial minor salivary glands safely detects phosphorylated α-synuclein (pAS) deposits in idiopathic rapid eye movement sleep behavior disorder (IRBD), a condition that precedes the cardinal manifestations of synuclein disorders associated with Lewy-type pathology, namely, Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ... Read more >>

Sleep (Sleep)
[2018, 41(8):]

Cited: 1 time

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Narrow band imaging for head and neck malignancies: Lessons learned from mistakes.

Meritxell Valls-Mateus, Anna Nogués-Sabaté, Jose Luis Blanch, Manuel Bernal-Sprekelsen, Francesc Xavier Avilés-Jurado, Isabel Vilaseca,

BACKGROUND:The accuracy of white light endoscopy in combination with narrow band imaging (WLE + NBI) for diagnosis of squamous cell carcinoma (SCC) does not reach 100%. We evaluated the characteristics of the false-negative and false-positive cases. METHODS:Five hundred thirty lesions of the upper airways were evaluated. The WLE was followed by NBI ... Read more >>

Head Neck (Head & neck)
[2018, 40(6):1164-1173]

Cited: 0 times

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Immunohistochemical Expression of Cortactin and Focal Adhesion Kinase Predicts Recurrence Risk and Laryngeal Cancer Risk Beyond Histologic Grading.

M Ángeles Villaronga, Francisco Hermida-Prado, Rocío Granda-Díaz, Sofía T Menéndez, Saúl Álvarez-Teijeiro, Miquel Quer, Isabel Vilaseca, Eva Allonca, Marta Garzón-Arango, Victoria Sanz-Moreno, Aurora Astudillo, Juan P Rodrigo, Juana M García-Pedrero,

<b>Background:</b> Cortactin (<i>CTTN</i>) and the focal adhesion kinase (<i>FAK</i>) are two major candidate genes to, respectively, drive 11q13- and 8q24-associated aggressive behavior in various cancers. Recent evidence uncovered their clinical relevance in early stages of tumorigenesis as promising biomarkers for cancer risk assessment.<b>Methods:</b> Using a multicenter validation study, CTTN and ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2018, 27(7):805-813]

Cited: 3 times

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Prognostic relevance of insulin resistance on disease-free survival in head and neck squamous cell carcinomas: Preliminary results.

Francesc Xavier Avilés-Jurado, Joan Carles Flores, Josep Gumà, Victoria Ceperuelo-Mallafré, Raquel Casanova-Marqués, David Gómez, Joan Josep Vendrell, Xavier León, Isabel Vilaseca, Ximena Terra,

<h4>Background</h4>The primary purpose of this study was to investigate the significance of pretreatment glycemic parameters in the prognosis of head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>Plasma samples of 71 patients with untreated HNSCC were obtained at the time of diagnosis. The prognostic value of fasting insulin, glucose, glycosylated hemoglobin levels, ... Read more >>

Head Neck (Head & neck)
[2017, 39(12):2501-2511]

Cited: 1 time

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Usefulness of office examination with narrow band imaging for the diagnosis of head and neck squamous cell carcinoma and follow-up of premalignant lesions.

Isabel Vilaseca, Meritxell Valls-Mateus, Anna Nogués, Eduardo Lehrer, Mauricio López-Chacón, Francesc Xavier Avilés-Jurado, José Luis Blanch, Manuel Bernal-Sprekelsen,

<h4>Background</h4>The purpose of this study was to evaluate the value of narrow band imaging (NBI) examination in the office for the diagnosis and follow-up of upper airway premalignant and malignant lesions.<h4>Methods</h4>Four hundred eighty lesions were evaluated with white light endoscopy (WLE) and NBI before a biopsy/excision. Additionally, 151 premalignant lesions ... Read more >>

Head Neck (Head & neck)
[2017, 39(9):1854-1863]

Cited: 5 times

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A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions.

Juan P Rodrigo, M Ángeles Villaronga, Sofía T Menéndez, Francisco Hermida-Prado, Miquel Quer, Isabel Vilaseca, Eva Allonca, Daniel Pedregal Mallo, Aurora Astudillo, Juana M García-Pedrero,

NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer risk marker. ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):11110]

Cited: 7 times

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