Full Text Journal Articles by
Author Irma Koivula

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Support among healthcare workers for the new mandatory seasonal influenza vaccination policy and its effects on vaccination coverage.

Aleksi Hämäläinen, Riitta-Liisa Patovirta, Ella Mauranen, Sari Hämäläinen, Irma Koivula,

<h4>Introduction</h4>Finland was the first European country to introduce a nation-wide mandatory seasonal influenza vaccination policy for healthcare workers (HCWs) by mandating that administrators of health care institutions only employ vaccinated HCWs. In this study, we examine the effects of the new policy and the view of HCWs on the new ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):384-390]

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Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements.

Juha Rannikko, Ville Holmberg, Matti Karppelin, Pertti Arvola, Reetta Huttunen, Eero Mattila, Niina Kerttula, Teija Puhto, Ülle Tamm, Irma Koivula, Risto Vuento, Jaana Syrjänen, Ulla Hohenthal,

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):]

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Febrile neutropenia in patients with acute myeloid leukemia: Outcome in relation to qSOFA score, C-reactive protein, and blood culture findings.

Marika Lappalainen, Sari Hämäläinen, Tuomo Romppanen, Kari Pulkki, Marja Pyörälä, Irma Koivula, Esa Jantunen, Auni Juutilainen,

<h4>Objectives</h4>To evaluate quick Sequential Organ Failure Assessment (qSOFA) score during febrile neutropenia (FN) in adult patients receiving intensive chemotherapy for acute myeloid leukemia (AML).<h4>Methods</h4>qSOFA score, as well as the association of qSOFA score with ICU admission, infectious mortality, blood culture findings, and C-reactive protein (CRP) measurements during FN were assessed ... Read more >>

Eur J Haematol (European journal of haematology)
[2020, 105(6):731-740]

Cited: 1 time

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Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy.

Sini Korpelainen, Sari Hämäläinen, Matti Vänskä, Irma Koivula, Kari Pulkki, Esa Jantunen, Auni Juutilainen, Anna-Kaisa Purhonen,

In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed ... Read more >>

Cytokine (Cytokine)
[2020, 129:155021]

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Interleukin-1 receptor antagonist as a biomarker of sepsis in neutropenic haematological patients.

Carina Intke, Sini Korpelainen, Sari Hämäläinen, Matti Vänskä, Irma Koivula, Esa Jantunen, Kari Pulkki, Auni Juutilainen,

<h4>Objective</h4>The study aim was to compare the performance of interleukin-1 receptor antagonist (IL-1Ra) to C-reactive protein (CRP) and procalcitonin (PCT) in early prediction of the clinical course of febrile neutropenia.<h4>Methods</h4>The study population consisted of 86 consecutive patients with febrile neutropenia who received intensive chemotherapy for haematological malignancy between November 2009 ... Read more >>

Eur J Haematol (European journal of haematology)
[2018, :]

Cited: 1 time

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Changes in the microbiological epidemiology of febrile neutropenia in autologous stem cell transplant recipients.

Rosa Rönkkö, Auni Juutilainen, Irma Koivula, Matti Vänskä, Tapio Nousiainen, Esa Jantunen, Sari Hämäläinen,

<label>BACKGROUND</label>The aim of the study was to explore the incidence, microbiological etiology and outcome of febrile neutropenia among adult hematological patients following autologous stem cell transplantation (ASCT).<label>METHODS</label>The study population consisted of patients who received ASCT between 1 December 2006 and 30 November 2012. The epidemiology was compared to a retrospective ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2018, 50(6):436-442]

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Asymmetric dimethylarginine in the assessment of febrile neutropenia in hematological patients.

Marika Lappalainen, Sari Hämäläinen, Auni Juutilainen, Irma Koivula, Kari Pulkki, Esa Jantunen,

Asymmetric dimethylarginine (ADMA) has been recognized as an independent prognostic factor for sepsis mortality in intensive care units. No data are available on kinetics or prognostic value of ADMA in hematological patients. We evaluated the ability of ADMA to act as a predictor for complicated course of febrile neutropenia, defined ... Read more >>

Scand J Clin Lab Invest (Scandinavian journal of clinical and laboratory investigation)
[2017, 77(2):130-134]

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Old enemies in new disguises: emergence of Enterococcus faecium as a significant clinical problem at an adult haematology ward.

Sari Hämäläinen, Jaana Pentikäinen, Jori Reijula, Ella Mauranen, Irma Koivula, Laura Lindholm, Auni Juutilainen, Tapio Nousiainen, Marja Pyörälä, Jaana Vuopio, Esa Jantunen,

Infect Dis (Lond) (Infectious diseases (London, England))
[2017, 49(8):628-631]

Cited: 2 times

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[Herpes zoster in the pharynx].

Sini Sipari, Irma Koivula, Heikki Löppönen,

A 74-year-old woman was suspected of having a peritonsillar abscess. She had a light-coloured coating on the pharynx and the larynx, bordering to the left of the median line, as well as laryngeal edema on the side of the lesion. On the basis of precisely unilateral findings we arrived at ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2016, 132(8):735-739]

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Biomarkers of neutropenic sepsis.

Esa Jantunen, Auni Juutilainen, Sari Hämäläinen, Irma Koivula, Matti Vänskä, Anna-Kaisa Purhonen, Kari Pulkki,

Neutropenic sepsis is a common clinical problem in hematological patients receiving intensive chemotherapy. Complications will develop in a minority of these patients. Biomarkers can be used for the recognition of infection as well as to estimate its severity and risk of complications and also to assess treatment response. Experience gained ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2016, 132(21):1946-1951]

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Human plasma cell-free DNA as a predictor of infectious complications of neutropenic fever in hematological patients.

Anna-Kaisa Purhonen, Auni Juutilainen, Matti Vänskä, Maija Lehtikangas, Päivi Lakkisto, Sari Hämäläinen, Irma Koivula, Esa Jantunen, Kari Pulkki,

Neutropenic fever is common in patients receiving intensive chemotherapy for hematological malignancies. The clinical course may be aggravated by infectious complications like severe sepsis, septic shock or even death. We prospectively studied 100 patients with neutropenic fever and evaluated human plasma cell-free DNA (cfDNA) during the first 3 days after ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2015, 47(4):255-259]

Cited: 4 times

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Soluble form of urokinase-type plasminogen activator receptor as a diagnostic and prognostic marker in hematological patients with neutropenic fever.

Matti Vänskä, Anna-Kaisa Purhonen, Irma Koivula, Esa Jantunen, Sari Hämäläinen, Kari Pulkki, Auni Juutilainen,

Leuk Lymphoma (Leukemia & lymphoma)
[2014, 55(3):718-721]

Cited: 3 times

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Transmission of Streptococcus equi subspecies zooepidemicus infection from horses to humans.

Sinikka Pelkonen, Susanne B Lindahl, Päivi Suomala, Jari Karhukorpi, Sakari Vuorinen, Irma Koivula, Tia Väisänen, Jaana Pentikäinen, Tiina Autio, Tamara Tuuminen,

Streptococcus equi subspecies zooepidemicus (S. zooepidemicus) is a zoonotic pathogen for persons in contact with horses. In horses, S. zooepidemicus is an opportunistic pathogen, but human infections associated with S. zooepidemicus are often severe. Within 6 months in 2011, 3 unrelated cases of severe, disseminated S. zooepidemicus infection occurred in ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2013, 19(7):1041-1048]

Cited: 34 times

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IL-10 combined with procalcitonin improves early prediction of complications of febrile neutropenia in hematological patients.

Matti Vänskä, Irma Koivula, Esa Jantunen, Sari Hämäläinen, Anna-Kaisa Purhonen, Kari Pulkki, Auni Juutilainen,

Early diagnosis of complicated course in febrile neutropenia is cumbersome due to the non-specificity of clinical and laboratory signs of severe infection. This prospective study included 100 adult hematological patients with febrile neutropenia after intensive chemotherapy at the onset of fever (d0) and for 3 days (d1-d3) thereafter. The study ... Read more >>

Cytokine (Cytokine)
[2012, 60(3):787-792]

Cited: 11 times

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Plasma copeptin in the assessment of febrile neutropenia.

Anna-Kaisa Purhonen, Matti Vänskä, Sari Hämäläinen, Kari Pulkki, Maija Lehtikangas, Taru Kuittinen, Tapio Nousiainen, Irma Koivula, Esa Jantunen, Auni Juutilainen,

Copeptin, the surrogate marker of arginine vasopressin (AVP), has been suggested to be a useful biomarker in monitoring sepsis reflecting hemodynamic imbalance and stress state. This prospective study conducted at a hematology ward in a Finnish University Hospital aimed to investigate whether plasma copeptin predicts the development of complicated course ... Read more >>

Peptides (Peptides)
[2012, 36(1):129-132]

Cited: 5 times

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[Mycoplasma pneumoniae and Stevens-Johnson syndrome].

Tia Väisänen, Sari Hämäläinen, Irma Koivula, Heikki Koskela,

Mycoplasma pneumoniae causes up to 10-40 % of community-acquired pneumonias. The incidence of M. pneumoniae pneumonia is greatest among children and young adults. The symptoms of M. pneumoniae upper and lower respiratory infections are usually mild and often self-limited. The most frequent extrapulmonary complications present in CNS, heart and skin. ... Read more >>

Duodecim (Duodecim; laaketieteellinen aikakauskirja)
[2012, 128(21):2272-2276]

Cited: 0 times

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High pentraxin 3 level predicts septic shock and bacteremia at the onset of febrile neutropenia after intensive chemotherapy of hematologic patients.

Matti Vänskä, Irma Koivula, Sari Hämäläinen, Kari Pulkki, Tapio Nousiainen, Esa Jantunen, Auni Juutilainen,

We evaluated pentraxin 3 as a marker for complications of neutropenic fever in 100 hematologic patients receiving intensive chemotherapy. Pentraxin 3 and C-reactive protein were measured at fever onset and then daily to day 3. Bacteremia was observed in 19 patients and septic shock in 5 patients (three deaths). In ... Read more >>

Haematologica (Haematologica)
[2011, 96(9):1385-1389]

Cited: 22 times

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Biomarkers for bacteremia and severe sepsis in hematological patients with neutropenic fever: multivariate logistic regression analysis and factor analysis.

Auni Juutilainen, Sari Hämäläinen, Kari Pulkki, Taru Kuittinen, Tapio Nousiainen, Esa Jantunen, Irma Koivula,

We compared biomarkers and their changes as predictors for bacteremia and severe sepsis during neutropenic fever after intensive chemotherapy in hematological patients. Serum C-reactive protein (CRP), semi-quantative procalcitonin, aminoterminal pro-brain natriuretic peptide (NT-proBNP), cortisol, lactate, plasma antithrombin and fibrinogen were measured daily from day 0 to day 3/day 4 in ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2011, 52(12):2349-2355]

Cited: 14 times

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Procalcitonin is a useful marker of infection in neutropenia.

Irma Koivula, Auni Juutilainen,

Leuk Res (Leukemia research)
[2011, 35(10):1288-1289]

Cited: 6 times

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Pentraxin 3 predicts complicated course of febrile neutropenia in haematological patients, but the decision level depends on the underlying malignancy.

Auni Juutilainen, Matti Vänskä, Kari Pulkki, Sari Hämäläinen, Tapio Nousiainen, Esa Jantunen, Irma Koivula,

<h4>Objectives</h4>This study aimed at assessing the cut-off levels for pentraxin 3 (PTX3) in predicting complications of neutropenic fever (bacteraemia, septic shock) in haematological patients.<h4>Methods</h4>A prospective study during 2006-2009 was performed at haematology ward in Kuopio University Hospital. A patient was eligible for the study if having neutropenic fever after intensive ... Read more >>

Eur J Haematol (European journal of haematology)
[2011, 87(5):441-447]

Cited: 8 times

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Serum cortisol and inflammatory response in neutropenic fever.

Auni Juutilainen, Sari Hämäläinen, Juuso Niemenpää, Taru Kuittinen, Kari Pulkki, Irma Koivula, Leo Niskanen, Esa Jantunen,

There are no data on serum cortisol of hematological patients at the onset of neutropenic fever and its possible association with the severity of infection. The purpose of this study was to evaluate the association of serum cortisol with the level of C-reactive protein (CRP) and procalcitonin (PCT), widely used ... Read more >>

Ann Hematol (Annals of hematology)
[2011, 90(12):1467-1475]

Cited: 2 times

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Elevated procalcitonin predicts Gram-negative sepsis in haematological patients with febrile neutropenia.

Irma Koivula, Sari Hämäläinen, Esa Jantunen, Kari Pulkki, Taru Kuittinen, Tapio Nousiainen, Auni Juutilainen,

<h4>Objective</h4>To compare semi-quantitative procalcitonin with C-reactive protein in predicting bacteraemia in haematological patients with neutropenic fever.<h4>Methods</h4>A total of 77 patients treated with intensive chemotherapy for haematological malignancy at Kuopio University Hospital were candidates for study entry. Eleven of these patients did not fulfil the criteria for neutropenic fever, and 66 ... Read more >>

Scand J Infect Dis (Scandinavian journal of infectious diseases)
[2011, 43(6-7):471-478]

Cited: 28 times

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Secular trend in candidemia and the use of fluconazole in Finland, 2004-2007.

Eira Poikonen, Outi Lyytikäinen, Veli-Jukka Anttila, Irma Koivula, Jukka Lumio, Pirkko Kotilainen, Hannu Syrjälä, Petri Ruutu,

<h4>Background</h4>In a previous study we observed an increasing trend in candidemia in Finland in the 1990s. Our aim was now to investigate further population-based secular trends, as well as outcome, and evaluate the association of fluconazole consumption and prophylaxis policy with the observed findings.<h4>Methods</h4>We analyzed laboratory-based surveillance data on candidemia ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2010, 10:312]

Cited: 59 times

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Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein.

Sari Hämäläinen, Auni Juutilainen, Taru Kuittinen, Tapio Nousiainen, Irma Matinlauri, Kari Pulkki, Irma Koivula, Esa Jantunen,

Serum amino-terminal pro-brain natriuretic peptide (NT-proBNP) is considered as a prognostic marker in patients with severe sepsis or septic shock, but no data are available on NT-proBNP kinetics in hematological patients with neutropenic fever. Altogether 70 hematological patients with neutropenic fever were included in this prospective study. NT-proBNP and C-reactive ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2010, 51(6):1040-1046]

Cited: 7 times

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Serial plasma lactate measurements in haematological patients with neutropenic fever.

Auni Juutilainen, Sari Hämäläinen, Irma Matinlauri, Taru Kuittinen, Tapio Nousiainen, Kari Pulkki, Irma Koivula, Esa Jantunen,

Elevated plasma lactate and impaired lactate clearance have been associated with poor outcome in patients with severe sepsis. No data are available on the kinetics or prognostic value of plasma lactate in haematological patients with neutropenic fever. A total of 70 haematological patients with 94 episodes of neutropenic fever were ... Read more >>

Scand J Infect Dis (Scandinavian journal of infectious diseases)
[2010, 42(2):102-108]

Cited: 5 times

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