Full Text Journal Articles by
Author Irene Young


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Sub millimetre flexible fibre probe for background and fluorescence free Raman spectroscopy.

Stephanos Yerolatsitis, András Kufcsák, Katjana Ehrlich, Harry A C Wood, Susan Fernandes, Tom Quinn, Vikki Young, Irene Young, Katie Hamilton, Ahsan R Akram, Robert R Thomson, Keith Finlayson, Kevin Dhaliwal, James M Stone,

Using the shifted-excitation Raman difference spectroscopy technique and an optical fibre featuring a negative curvature excitation core and a coaxial ring of high numerical aperture collection cores, we have developed a portable, background and fluorescence free, endoscopic Raman probe. The probe consists of a single fibre with a diameter of ... Read more >>

J Biophotonics (Journal of biophotonics)
[2021, 14(10):e202000488]

Cited: 1 time

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T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer.

Richard A O'Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Guilia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram,

The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME). Cancer associated fibroblasts (CAFs) are the dominant stromal cell in the TME and co-localize with T cells in non-small cell lung cancer. We demonstrate the bidirectional ... Read more >>

Oncoimmunology (Oncoimmunology)
[2021, 10(1):1940675]

Cited: 0 times

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Molecular detection of Gram-positive bacteria in the human lung through an optical fiber-based endoscope.

Bethany Mills, Alicia Megia-Fernandez, Dominic Norberg, Sheelagh Duncan, Adam Marshall, Ahsan R Akram, Thomas Quinn, Irene Young, Annya M Bruce, Emma Scholefield, Gareth O S Williams, Nikola Krstajić, Tushar R Choudhary, Helen E Parker, Michael G Tanner, Kerrianne Harrington, Harry A C Wood, Timothy A Birks, Jonathan C Knight, Christopher Haslett, Kevin Dhaliwal, Mark Bradley, Muhammed Ucuncu, James M Stone,

<h4>Purpose</h4>The relentless rise in antimicrobial resistance is a major societal challenge and requires, as part of its solution, a better understanding of bacterial colonization and infection. To facilitate this, we developed a highly efficient no-wash red optical molecular imaging agent that enables the rapid, selective, and specific visualization of Gram-positive ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(3):800-807]

Cited: 0 times

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Lessons from a pilot for uncontrolled donation after circulatory death in the ED in the UK.

Matthew James Reed, Ian Currie, John Forsythe, Irene Young, John Stirling, Lesley Logan, Gareth R Clegg, Gabriel C Oniscu,

Worldwide there is a shortage of available organs for patients requiring transplants. However, some countries such as France, Italy and Spain have had greater success by allowing donations from patients with unexpected and unrecoverable circulatory arrest who arrive in the ED. Significant advances in the surgical approach to organ recovery ... Read more >>

Emerg Med J (Emergency medicine journal : EMJ)
[2020, 37(3):155-161]

Cited: 0 times

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Testicular Volume Changes in Laparoscopic Staged Fowler-Stephens Orchiopexy: Studying the Impact of Testicular Vessel Division.

Ahmed Abdelhalim, Joshua D Chamberlin, Irene Young, Miriam Fahim, Kai-Wen Chuang, Irene M McAleer, Elias Wehbi, Heidi A Stephany, Antoine E Khoury,

<h4>Objective</h4>To study the effect of testicular vessel division on testicular volume during laparoscopic staged Fowler Stephens orchiopexy (LSFSO).<h4>Methods</h4>Testicular dimensions were prospectively measured intraoperatively at both first (S1) and second stages (S2) of LSFSO, and with scrotal ultrasound 3-12 months postoperatively. Testicular volumes were compared to reference ranges. Volume changes were ... Read more >>

Urology (Urology)
[2019, 127:113-118]

Cited: 1 time

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Safe discharge parameters for patients with isolated antenatal hydronephrosis.

Orchid Djahangirian, Irene Young, Crystal Dorgalli, Ashley Bissaillon, Ngoc-Anh Tran, Arman Walia, Ahmed Abdelhalim, Peter Wang, Blake Selby, John Billimek, Elias Wehbi, Irene McAleer, Antoine Khoury,

INTRODUCTION:Antenatal hydronephrosis is a steady source of urology referrals since the era of routine fetal ultrasonography. Although most resolve, there are no guidelines for follow-up. OBJECTIVE:Our goal is to define safe parameters with which patients can be discharged early and avoid unnecessary follow-up. METHODS:We retrospectively reviewed all patients referred to ... Read more >>

J Pediatr Urol (Journal of pediatric urology)
[2018, 14(4):321.e1-321.e5]

Cited: 0 times

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The use of lumbar epidural/transforaminal steroids for managing spinal disease.

Irene A Young, Garrett S Hyman, Llewellyn N Packia-Raj, Andrew J Cole,

Lumbar epidural steroid injections are used to manage low back and leg pain (ie, sciatica). Utilization of the procedure is increasing, with Medicare spending for lumbar epidural procedures topping $175 million annually. Few prospective randomized controlled trials have clearly demonstrated the efficacy of epidural steroid injections; many have shown conflicting ... Read more >>

J Am Acad Orthop Surg (The Journal of the American Academy of Orthopaedic Surgeons)
[2007, 15(4):228-238]

Cited: 25 times

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The advantages of the ITS2 region of the nuclear rDNA cistron for analysis of phylogenetic relationships of insects: a Drosophila example.

Irene Young, Annette W Coleman,

We examined the utility for phylogenetic reconstruction of the second internal transcribed spacer (ITS2), lying between the nuclear 5.8S gene and the gene for large subunit ribosomal RNA, using sequences of Ceratitis, Bactrocera, Musca, and Drosophila. We aligned and analyzed 13 sequences from GenBank and 11 new sequences from diverse ... Read more >>

Mol Phylogenet Evol (Molecular phylogenetics and evolution)
[2004, 30(1):236-242]

Cited: 44 times

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Paraspinal electromyography that compares concentric with monopolar needles: a blinded study.

Henry C Tong, Irene A Young, John Koch, Andrew J Haig, Karen S J Yamakawa, Agnes Wallbom,

To establish interrater reliability for paraspinal muscle needle electromyography study with both monopolar and concentric needles in symptomatic and asymptomatic persons and to further establish normative data for paraspinal needle study.At a university spine center, participants with and without radiating low back pain were evaluated with the mini-paraspinal mapping paraspinal ... Read more >>

Am J Phys Med Rehabil (American journal of physical medicine & rehabilitation)
[2003, 82(12):917-924]

Cited: 12 times

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Sudden onset of cervical spondylotic myelopathy during sleep: a case report.

Irene A Young, Stephen P Burns, James W Little,

Cervical spondylotic myelopathy is a common cause of compressive spinal cord dysfunction. The typical course involves either a gradual or an episodic increase in symptoms and neurologic deficits, with impairment evolving over a period of months to years. Acute neurologic deterioration in conjunction with cervical spondylosis has been described almost ... Read more >>

Arch Phys Med Rehabil (Archives of physical medicine and rehabilitation)
[2002, 83(3):427-429]

Cited: 6 times

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