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Author Irene Litvan

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

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Medication Management Performance in Parkinson's Disease: Examination of Process Errors.

Catherine A Sumida, Francesca V Lopez, Emily J Van Etten, Nicole Whiteley, Raeanne C Moore, Irene Litvan, Stephanie Lessig, Paul E Gilbert, Maureen Schmitter-Edgecombe, J Vincent Filoteo, Dawn M Schiehser,

<h4>Objective</h4>Individuals with Parkinson's disease (PD) are at risk for increased medication mismanagement, which can lead to worse clinical outcomes. However, the nature of the errors (i.e., undertaking or overtaking medications) contributing to mismanagement and their relationship to cognition in PD is unknown. Therefore, this study sought to examine errors committed ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2021, :]

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The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy.

Kevin F Bieniek, Nigel J Cairns, John F Crary, Dennis W Dickson, Rebecca D Folkerth, C Dirk Keene, Irene Litvan, Daniel P Perl, Thor D Stein, Jean-Paul Vonsattel, William Stewart, Kristen Dams-O'Connor, Wayne A Gordon, Yorghos Tripodis, Victor E Alvarez, Jesse Mez, Michael L Alosco, Ann C McKee, ,

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder associated with exposure to head trauma. In 2015, a panel of neuropathologists funded by the NINDS/NIBIB defined preliminary consensus neuropathological criteria for CTE, including the pathognomonic lesion of CTE as "an accumulation of abnormal hyperphosphorylated tau (p-tau) in neurons and astroglia distributed ... Read more >>

J Neuropathol Exp Neurol (Journal of neuropathology and experimental neurology)
[2021, :]

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Sex differences for phenotype in pathologically defined dementia with Lewy bodies.

Ece Bayram, David G Coughlin, Sarah J Banks, Irene Litvan,

<h4>Introduction</h4>Sex differences in dementia with Lewy bodies (DLB) have been reported in clinically defined cohorts; however, clinical diagnostic accuracy in DLB is suboptimal and phenotypic differences have not been assessed in pathologically confirmed participants.<h4>Methods</h4>Core DLB features were compared across 55 women and 156 men with pathologically defined DLB in the ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2021, :]

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Progressive Supranuclear Palsy and Corticobasal Degeneration.

David G Coughlin, Dennis W Dickson, Keith A Josephs, Irene Litvan,

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative tauopathies with neuronal and glial lesions composed of tau that is composed predominantly of isomers with four repeats in the microtubule-binding domain (4R tau). The brain regions vulnerable to pathology in PSP and CBD overlap, but there are differences, particularly ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1281:151-176]

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Delineation of Apathy Subgroups in Parkinson's Disease: Differences in Clinical Presentation, Functional Ability, Health-related Quality of Life, and Caregiver Burden.

Graham M L Eglit, Francesca Lopez, Dawn M Schiehser, Eva Pirogovsky-Turk, Irene Litvan, Stephanie Lessig, J Vincent Filoteo,

<h4>Background</h4>Apathy is a prevalent, multidimensional neuropsychiatric condition in Parkinson's disease (PD). Several authors have proposed apathy subtypes in PD, but no study has examined the classification of PD patients into distinct apathy subtypes, nor has any study examined the clinical utility of doing so.<h4>Objectives</h4>The current study used a data-driven approach ... Read more >>

Mov Disord Clin Pract (Movement disorders clinical practice)
[2021, 8(1):92-99]

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Informant-Reported Cognitive Decline is Associated with Objective Cognitive Performance in Parkinson's Disease.

Marina Z Nakhla, Kelsey A Holiday, J Vincent Filoteo, Zvinka Z Zlatar, Vanessa L Malcarne, Stephanie Lessig, Irene Litvan, Dawn M Schiehser,

<h4>Objective</h4>The utility of informant-based measures of cognitive decline to accurately describe objective cognitive performance in Parkinson's disease (PD) without dementia is uncertain. Due to the clinical relevance of this information, the purpose of this study was to examine the relationship between informant-based reports of patient cognitive decline via the Informant ... Read more >>

J Int Neuropsychol Soc (Journal of the International Neuropsychological Society : JINS)
[2020, :1-11]

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Patterns and predictors of referrals to allied health services for individuals with Parkinson's disease: A Parkinson's foundation (PF) QII study.

Angela C Roberts, Miriam R Rafferty, Samuel S Wu, Guanhuong Miao, Fernando Cubillos, Tanya Simuni, , ,

<h4>Introduction</h4>Rehabilitation therapies are critical for optimizing quality-of-life and daily functions for individuals living with Parkinson's disease (PD). Thus, understanding the patterns of and under what conditions physicians make rehabilitation referrals is important for optimizing care.<h4>Method</h4>We analyzed data from 5020 participants (4 countries) collected from 1/3/2016 to 4/20/2018 as part of ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, :]

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Brain volumetric deficits in MAPT mutation carriers: a multisite study.

Stephanie A Chu, Taru M Flagan, Adam M Staffaroni, Lize C Jiskoot, Jersey Deng, Salvatore Spina, Liwen Zhang, Virginia E Sturm, Jennifer S Yokoyama, William W Seeley, Janne M Papma, Dan H Geschwind, Howard J Rosen, Bradley F Boeve, Adam L Boxer, Hilary W Heuer, Leah K Forsberg, Danielle E Brushaber, Murray Grossman, Giovanni Coppola, Bradford C Dickerson, Yvette M Bordelon, Kelley Faber, Howard H Feldman, Julie A Fields, Jamie C Fong, Tatiana Foroud, Ralitza H Gavrilova, Nupur Ghoshal, Neill R Graff-Radford, Ging-Yuek Robin Hsiung, Edward D Huey, David J Irwin, Kejal Kantarci, Daniel I Kaufer, Anna M Karydas, David S Knopman, John Kornak, Joel H Kramer, Walter A Kukull, Maria I Lapid, Irene Litvan, Ian R A Mackenzie, Mario F Mendez, Bruce L Miller, Chiadi U Onyike, Alexander Y Pantelyat, Rosa Rademakers, Eliana Marisa Ramos, Erik D Roberson, Maria Carmela Tartaglia, Nadine A Tatton, Arthur W Toga, Ashley Vetor, Sandra Weintraub, Bonnie Wong, Zbigniew K Wszolek, , John C Van Swieten, Suzee E Lee,

<h4>Objective</h4>MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation carriers have frontotemporal atrophy, yet studies have shown mixed results as to whether presymptomatic carriers have low gray matter volumes. To elucidate whether presymptomatic carriers have lower structural brain volumes ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(1):95-110]

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Changes in Self- and Informant-Reported Frontal Behaviors in Parkinson's Disease: A Longitudinal Study.

Celina F Pluim, Marina Z Nakhla, Molly Split, J Vincent Filoteo, Irene Litvan, Raeanne C Moore, Stephanie Lessig, Dawn M Schiehser,

<h4>Objective</h4>Frontal behaviors (i.e., executive dysfunction, disinhibition, apathy) are common in Parkinson's disease (PD). However, it is unclear if patient and informant reports of patient frontal behaviors are in agreement over time.<h4>Method</h4>Sixty-two PD patients without dementia and their informants (87% spouses/partners) completed the self- and informant-versions of the Frontal Systems Behavior ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2020, :891988720964257]

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Lowering the risk of Parkinson's disease with GLP-1 agonists and DPP4 inhibitors in type 2 diabetes.

Ece Bayram, Irene Litvan,

Brain (Brain : a journal of neurology)
[2020, 143(10):2868-2871]

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Two Patients with Niemann Pick Disease Type C Diagnosed in the Seventh Decade of Life.

Melanie Wu, Rita Ceponiene, Ece Bayram, Irene Litvan,

<h4>Background</h4>Niemann-Pick disease type C (NPC) is a rare, autosomal recessive lysosomal lipid storage disorder. It may present with cerebellar ataxia, vertical supranuclear gaze palsy, and cognitive impairment, and the age of symptom onset in adult-onset NPC is usually earlier than the fourth decade.<h4>Cases</h4>We present 2 patients with adult-onset NPC diagnosed ... Read more >>

Mov Disord Clin Pract (Movement disorders clinical practice)
[2020, 7(8):961-964]

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Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease.

Ece Bayram, Irene Litvan, Brenton A Wright, Cailey Grembowski, Qian Shen, Deborah L Harrington,

Visuospatial working memory (WM) impairments in Parkinson's disease (PD) are more prominent and evolve earlier than verbal WM deficits, suggesting some differences in underlying pathology. WM is regulated by dopaminergic neurotransmission in the prefrontal cortex, but the effect of dopamine on specific processes supporting visuospatial WM are not well understood. ... Read more >>

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn (Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition)
[2020, :1-17]

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Cognitive impairment in Parkinson's disease: Associations between subjective and objective cognitive decline in a large longitudinal study.

Kelly A Mills, Ruth B Schneider, Marie Saint-Hilaire, G Webster Ross, Robert A Hauser, Anthony E Lang, Matthew J Halverson, David Oakes, Shirley Eberly, Irene Litvan, Karen Blindauer, Camila Aquino, Tanya Simuni, Connie Marras,

<h4>Background</h4>Cognitive decline creates substantial morbidity and cost in Parkinson's disease (PD) and clinicians have limited tools for counseling patients on prognosis. We aimed to use data from a randomized, controlled trial of isradipine in Parkinson's disease (STEADY-PD III) to determine which objective cognitive domain deficits drive patient complaints of cognitive ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 80:127-132]

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Orthostatic hypotension preceding dementia with Lewy bodies by over 15 years: a clinicopathologic case report.

Katherine Longardner, Dennis W Dickson, Irene Litvan,

Clin Auton Res (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2020, 30(6):575-577]

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Orthostatic Hypotension Is Associated With Cognitive Decline in Parkinson Disease.

Katherine Longardner, Ece Bayram, Irene Litvan,

<b>Introduction:</b> Cognitive impairment and orthostatic hypotension (OH) are common, disabling Parkinson disease (PD) symptoms that are strongly correlated. Whether the relationship is causative or associative remains unknown. OH may occur without classic orthostatic symptoms of cerebral hypoperfusion (i.e., lightheadedness or dizziness). Whether longitudinal differences in cognition occur between symptomatic and ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:897]

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Can Autonomic Testing and Imaging Contribute to the Early Diagnosis of Multiple System Atrophy? A Systematic Review and Recommendations by the Movement Disorder Society Multiple System Atrophy Study Group.

Maria Teresa Pellecchia, Iva Stankovic, Alessandra Fanciulli, Florian Krismer, Wassilios G Meissner, Jose-Alberto Palma, Jalesh N Panicker, Klaus Seppi, Gregor K Wenning, ,

<h4>Background</h4>In the current consensus diagnostic criteria, the diagnosis of probable multiple system atrophy (MSA) is based solely on clinical findings, whereas neuroimaging findings are listed as aid for the diagnosis of possible MSA. There are overlapping phenotypes between MSA-parkinsonian type and Parkinson's disease, progressive supranuclear palsy, and dementia with Lewy ... Read more >>

Mov Disord Clin Pract (Movement disorders clinical practice)
[2020, 7(7):750-762]

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Parkinson disease with mild cognitive impairment: Domain-specific cognitive complaints predict dementia.

Carmen Gasca-Salas, Sarah Duff-Canning, Melissa J Armstrong, Paul J Eslinger, Ruth B Schneider, Nancy Kennedy, Kelvin L Chou, Carol Persad, Irene Litvan, Sandra Weintraub, Connie Marras,

<h4>Background</h4>The presence of subjective cognitive complaints (SCC) as a predictor of cognitive impairment in Parkinson´s disease (PD) has shown conflicting results. Most previous studies only assessed complaints in the memory domain. We investigate the association of SCCs across cognitive domains with development of mild cognitive impairment (PD-MCI) and dementia (PDD) ... Read more >>

Acta Neurol Scand (Acta neurologica Scandinavica)
[2020, 142(6):585-596]

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Understanding the relationship between freezing of gait and other progressive supranuclear palsy features.

Saba Rezvanian, Irene Litvan, David Standaert, Joseph Jankovic, Stephen G Reich, Deborah Hall, David R Shprecher, Yvette Bordelon, Richard Dubinsky, Benzi Kluger,

<h4>Introduction</h4>Freezing of gait (FoG) leads to falls and reduces quality of life, but little is known about FoG in progressive supranuclear palsy (PSP). This study aim was to identify the clinical parameters associated with FoG in PSP patients.<h4>Methods</h4>349 patients meeting the National Institute for Neurological Disorders and Society for PSP ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 78:56-60]

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Clinical and pathologic features of cognitive-predominant corticobasal degeneration.

Nobutaka Sakae, Octavio A Santos, Otto Pedraza, Irene Litvan, Melissa E Murray, Ranjan Duara, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Keith A Josephs, Dennis W Dickson,

<h4>Objective</h4>To describe clinical and pathologic characteristics of corticobasal degeneration (CBD) with cognitive predominant problems during the disease course.<h4>Methods</h4>In a series of autopsy-confirmed cases of CBD, we identified patients with cognitive rather than motor predominant features (CBD-Cog), including 5 patients thought to have Alzheimer disease (AD) and 10 patients thought to ... Read more >>

Neurology (Neurology)
[2020, 95(1):e35-e45]

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Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease.

Daniel Weintraub, Chelsea Caspell-Garcia, Tanya Simuni, Hyunkeun R Cho, Christopher S Coffey, Dag Aarsland, Roy N Alcalay, Matthew J Barrett, Lana M Chahine, Jamie Eberling, Alberto J Espay, Jamie Hamilton, Keith A Hawkins, James Leverenz, Irene Litvan, Irene Richard, Liana S Rosenthal, Andrew Siderowf, Michele York, ,

OBJECTIVE:To determine the evolution of numerous neuropsychiatric symptoms and cognitive abilities in Parkinson disease from disease onset. METHODS:Prospectively collected, longitudinal (untreated, disease onset to year 5), observational data from Parkinson's Progression Markers Initiative annual visits was used to evaluate prevalence, correlates, and treatment of 10 neuropsychiatric symptoms and cognitive impairment ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(4):449-461]

Cited: 3 times

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Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials.

Gianina Toller, Kamalini Ranasinghe, Yann Cobigo, Adam Staffaroni, Brian Appleby, Danielle Brushaber, Giovanni Coppola, Bradford Dickerson, Kimiko Domoto-Reilly, Julie Fields, Jamie Fong, Leah Forsberg, Nupur Ghoshal, Neill Graff-Radford, Murray Grossman, Hilary Heuer, Gink-Yuek Hsiung, Edward Huey, David Irwin, Kejal Kantarci, Daniel Kaufer, Diana Kerwin, David Knopman, John Kornak, Joel Kramer, Irene Litvan, Ian Mackenzie, Mario Mendez, Bruce Miller, Rosa Rademakers, Eliana Ramos, Katya Rascovsky, Erik Roberson, Jeremy Syrjanen, Carmela Tartaglia, Sandra Weintraub, Brad Boeve, Adam Boxer, Howard Rosen, Katherine Rankin, ,

<h4>Objective</h4>To investigate whether the Revised Self-Monitoring Scale (RSMS), an informant measure of socioemotional sensitivity, is a potential clinical endpoint for treatment trials for patients with behavioral variant frontotemporal dementia (bvFTD).<h4>Methods</h4>We investigated whether RSMS informant ratings reflected disease severity in 475 participants (71 bvFTD mutation+, 154 bvFTD mutation-, 12 behavioral mild ... Read more >>

Neurology (Neurology)
[2020, 94(22):e2384-e2395]

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α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease.

Cecilia S Lindestam Arlehamn, Rekha Dhanwani, John Pham, Rebecca Kuan, April Frazier, Juliana Rezende Dutra, Elizabeth Phillips, Simon Mallal, Mario Roederer, Karen S Marder, Amy W Amara, David G Standaert, Jennifer G Goldman, Irene Litvan, Bjoern Peters, David Sulzer, Alessandro Sette,

A diagnosis of motor Parkinson's disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal relation between α-synuclein (α-syn) T cell reactivity and PD. A longitudinal case study revealed that elevated α-syn-specific T cell responses were detected prior to the diagnosis of ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1875]

Cited: 4 times

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Progressive Supranuclear Palsy and Statin Use.

Ece Bayram, Connie Marras, David G Standaert, Benzi M Kluger, Yvette M Bordelon, David R Shprecher, Irene Litvan, ,

<h4>Introduction</h4>Statins were proposed to be neuroprotective; however, the effects are unknown in progressive supranuclear palsy (PSP), a pure tauopathy.<h4>Methods</h4>Data of 284 PSP cases and 284 age-matched, sex-matched, and race-matched controls were obtained from the environmental and genetic PSP (ENGENE-PSP) study. Cases were evaluated with the PSP Rating Scale, Unified Parkinson's ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(7):1253-1257]

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Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial.

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<h4>Background</h4>Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD).<h4>Objective</h4>To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD.<h4>Design</h4>Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial. (ClinicalTrials.gov: NCT02168842).<h4>Setting</h4>57 Parkinson Study Group sites in North America.<h4>Participants</h4>Patients with early-stage PD ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2020, 172(9):591-598]

Cited: 6 times

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