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Author Irene Busciglio

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Editorial: understanding IBS pathophysiology through "converging channels" of research-authors' reply.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1215-1216]

Cited: 0 times

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Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan Grover, Antonio Berumen, Stephanie Peters, Ting Wei, Margaret Breen-Lyles, William S Harmsen, Irene Busciglio, Duane Burton, Maria Vazquez Roque, Kenneth R DeVault, Michael Camilleri, Michael Wallace, Surendra Dasari, Helmut Neumann, Lesley A Houghton,

<h4>Background</h4>Irritable bowel syndrome (IBS) patients often experience meal-associated symptoms. However, the underlying mechanisms are unclear.<h4>Aim</h4>To determine small intestinal mechanisms of lipid-induced symptoms and rectal hypersensitivity in IBS METHODS: We recruited 26 IBS patients (12 IBS-C, 14 IBS-D) and 15 healthy volunteers (HV). In vivo permeability was assessed using saccharide excretion ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1179-1192]

Cited: 0 times

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Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults.

Katayoun Khoshbin, Lehar Khanna, Daniel Maselli, Jessica Atieh, Margaret Breen-Lyles, Kayla Arndt, Deborah Rhoten, Roy B Dyer, Ravinder J Singh, Sunita Nayar, Sandra Bjerkness, William S Harmsen, Irene Busciglio, Michael Camilleri,

<h4>Background</h4>Oral monosaccharides and disaccharides are used to measure in vivo human gut permeability through urinary excretion.<h4>Aims</h4>The aims were as follows: (1) to obtain normative data on small intestinal and colonic permeability; (2) to assess variance on standard 16 g fiber diet performed twice; (3) to determine whether dietary fiber influences gut ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 161(2):463-475.e13]

Cited: 1 time

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Combined Fasting Serum C4 and Primary Bile Acids From a Single Stool Sample to Diagnose Bile Acid Diarrhea.

Priya Vijayvargiya, Michael Camilleri, Ann Taylor, Irene Busciglio, Edward V Loftus, Leslie J Donato,

Gastroenterology (Gastroenterology)
[2020, 159(5):1952-1954.e2]

Cited: 2 times

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Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients With Bile Acid Diarrhea in a Randomized Trial.

Priya Vijayvargiya, Michael Camilleri, Paula Carlson, Asha Nair, Sara Linker Nord, Michael Ryks, Deborah Rhoten, Duane Burton, Irene Busciglio, Alan Lueke, W Scott Harmsen, Leslie J Donato,

<h4>Background & aims</h4>Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of colesevelam on bowel functions, consistent with luminal BA sequestration by colesevelam. We compared the effects of colesevelam vs placebo on symptoms and gene expression patterns in the ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(13):2962-2970.e6]

Cited: 2 times

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Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial.

Justin Brandler, Laurence J Miller, Xiao Jing Wang, Duane Burton, Irene Busciglio, Kayla Arndt, William S Harmsen, Michael Camilleri,

Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD). Secretin is a key regulator of GA in animal studies. Our aim was to study the effects of secretin on gastric motility, satiation, postprandial symptoms, and key hormones. We performed two double-blind, randomized, saline-controlled crossover trials ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2020, 318(4):G635-G645]

Cited: 2 times

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Correction: Activated T-Follicular Helper 2 Cells Are Associated With Disease Activity in IgG4-Related Sclerosing Cholangitis and Pancreatitis.

Michael Camilleri, Paula Carlson, Victor Chedid, Priya Vijayvargiya, Duane Burton, Irene Busciglio,

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2019, 10(5):1]

Cited: 0 times

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Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea.

Michael Camilleri, Paula Carlson, Victor Chedid, Priya Vijayvargiya, Duane Burton, Irene Busciglio,

<h4>Introduction</h4>Aquaporin (AQP) channels are involved in regulating fluid homeostasis in the colon. Several AQP channels were detected in human colon epithelial cells. In a previous study, rats fed 1% (wt/wt) sodium cholate had increased AQP3, 7, and 8 levels, suggesting AQP involvement in bile acid diarrhea (BAD). Our aim was ... Read more >>

Clin Transl Gastroenterol (Clinical and translational gastroenterology)
[2019, 10(4):e00019]

Cited: 4 times

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Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome.

Priya Vijayvargiya, Michael Camilleri, Duane Burton, Irene Busciglio, Alan Lueke, Leslie J Donato,

BACKGROUND:Biomarkers in irritable bowel syndrome (IBS) may guide targeted therapy in this multifactorial disease. It has been suggested that 75% accuracy and cost <$500 categorise biomarkers as cost-effective. AIM:To identify differences in faecal bile acids, faecal fat and fasting serum C4 (7a-hydroxy-4-cholesten-3-one) and fibroblast growth factor 19 (FGF19) among patients ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 49(6):744-758]

Cited: 7 times

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Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea.

Priya Vijayvargiya, Michael Camilleri, Victor Chedid, Paula Carlson, Irene Busciglio, Duane Burton, Leslie J Donato,

BACKGROUND & AIMS:Patients with bile acid diarrhea (BAD) are identified based on increased levels of BAs in fecal samples collected over a 48-hr period while on a 100-gram fat diet (48-hr BA), retention of 75Se-labeled homocholic acid taurine, or serum levels of C4 or FGF19. BAD increases fecal weight and ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, 17(5):922-929.e2]

Cited: 12 times

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Effects of NGM282, an FGF19 variant, on colonic transit and bowel function in functional constipation: a randomized phase 2 trial.

Ibironke Oduyebo, Michael Camilleri, Alfred D Nelson, Disha Khemani, Sara Linker Nord, Irene Busciglio, Duane Burton, Deborah Rhoten, Michael Ryks, Paula Carlson, Leslie Donato, Alan Lueke, Kathline Kim, Stephen J Rossi, Alan R Zinsmeister,

OBJECTIVE:NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials in type 2 diabetes and primary biliary cholangitis, NGM282 was associated with dose-related abdominal cramping and diarrhea. We aimed to examine effects of NGM282 ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2018, 113(5):725-734]

Cited: 9 times

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Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant.

Deepti Jacob, Irene Busciglio, Duane Burton, Houssam Halawi, Ibironke Oduyebo, Deborah Rhoten, Michael Ryks, W Scott Harmsen, Michael Camilleri,

Aprepitant, an NK1 receptor antagonist, is approved for the treatment of chemotherapy-induced or postoperative emesis by blocking NK1 receptors in the brain stem vomiting center. The effects of NK1 receptors on gastric functions and postprandial symptoms in humans are unclear; a single, crossover study did not show a significant effect ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2017, 313(5):G505-G510]

Cited: 12 times

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Performance characteristics of serum C4 and FGF19 measurements to exclude the diagnosis of bile acid diarrhoea in IBS-diarrhoea and functional diarrhoea.

P Vijayvargiya, M Camilleri, P Carlson, A Lueke, J O'Neill, D Burton, I Busciglio, L Donato,

<h4>Background</h4>The serum biomarkers, elevated 7αC4 (C4) and decreased FGF19, have been proposed as screening tests for bile acid diarrhoea.<h4>Aim</h4>To analyse prevalence, specificity and reproducibility of fasting C4 and FGF19 in identifying bile acid diarrhoea in patients with irritable bowel syndrome with predominant diarrhoea or functional diarrhoea (summarised as IBS-D).<h4>Methods</h4>We prospectively ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2017, 46(6):581-588]

Cited: 17 times

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Relationship of gastric emptying or accommodation with satiation, satiety, and postprandial symptoms in health.

Houssam Halawi, Michael Camilleri, Andres Acosta, Maria Vazquez-Roque, Ibironke Oduyebo, Duane Burton, Irene Busciglio, Alan R Zinsmeister,

The contributions of gastric emptying (GE) and gastric accommodation (GA) to satiation, satiety, and postprandial symptoms remain unclear. We aimed to evaluate the relationships between GA or GE with satiation, satiety, and postprandial symptoms in healthy overweight or obese volunteers (total <i>n</i> = 285, 73% women, mean BMI 33.5 kg/m<sup>2</sup>): ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2017, 313(5):G442-G447]

Cited: 14 times

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Bile Acid Deficiency in a Subgroup of Patients With Irritable Bowel Syndrome With Constipation Based on Biomarkers in Serum and Fecal Samples.

Priya Vijayvargiya, Irene Busciglio, Duane Burton, Leslie Donato, Alan Lueke, Michael Camilleri,

<h4>Background & aims</h4>Short-term administration of delayed-release chenodeoxycholic acid to patients with irritable bowel syndrome with constipation (IBS-C) accelerates colonic transit and reduces symptoms. A preliminary study has shown that patients with IBS-C have reduced levels of bile acids (BAs) in feces and reduced synthesis of BA. We compared the levels ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2018, 16(4):522-527]

Cited: 17 times

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Colonic Transit and Bile Acid Synthesis or Excretion in Patients With Irritable Bowel Syndrome-Diarrhea Without Bile Acid Malabsorption.

Cédric Peleman, Michael Camilleri, Irene Busciglio, Duane Burton, Leslie Donato, Alan R Zinsmeister,

<h4>Background and aims</h4>Bile acids (BAs) are passively absorbed to a different extent along the mammalian colon, so that levels are lower in the feces than in proximal colon. Our aim was to explore associations among total, primary, and secretory BA in stool and colonic transit in patients with irritable bowel ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2017, 15(5):720-727.e1]

Cited: 16 times

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Regional Colonic Transit Pattern Does Not Conclusively Identify Evacuation Disorders in Constipated Patients with Delayed Colonic Transit.

Seon-Young Park, Duane Burton, Irene Busciglio, Deborah Eckert, Michael Camilleri,

<h4>Background/aims</h4>After exclusion of structural diseases, chronic constipation may be associated with normal or slow transit or rectal evacuation disorders. We evaluated: (1) clinical features and anorectal function, (2) difference of regional colonic transit according to the presence or absence of evacuation disorders, and (3) association of colonic transit with gender ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2017, 23(1):92-100]

Cited: 2 times

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Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers.

A D Nelson, M Camilleri, A Acosta, I Busciglio, S Linker Nord, A Boldingh, D Rhoten, M Ryks, D Burton,

<h4>Background</h4>Synthetic human ghrelin accelerates gastric emptying, reduces gastric accommodation, and results in numerical increases in postprandial symptom scores. The ghrelin receptor agonist, relamorelin, accelerates gastric emptying in patients with diabetic gastroparesis.<h4>Aim</h4>To measure pharmacological effects of relamorelin on gastric accommodation, distal antral motility, and satiation in healthy volunteers.<h4>Methods</h4>In a placebo-controlled, double-blind, ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2016, 28(11):1705-1713]

Cited: 18 times

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A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome.

Andres Acosta, Michael Camilleri, Sara Linker-Nord, Irene Busciglio, Johanna Iturrino, Lawrence A Szarka, Alan R Zinsmeister,

BACKGROUND/AIMS:Daikenchuto (TU 100), a botanical agent that modulates gastrointestinal nerves, is used in the treatment of motility and functional disorders. Our aim was to study the effects of TU-100 on rectal compliance and sensation in patients with irritable bowel syndrome (IBS). METHODS:In 20 patients per treatment arm, we conducted a ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2016, 22(1):69-77]

Cited: 3 times

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Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial.

Andres Acosta, Michael Camilleri, Irene Busciglio, Amy Boldingh, Alfred D Nelson, Duane Burton,

<h4>Background</h4>The pentapeptide ghrelin agonist, relamorelin, accelerates colonic transit in patients with chronic constipation (CC). In a murine model, relamorelin decreased excitability of colonic circular smooth muscle cells and colonic intraluminal pressure.<h4>Aim</h4>To determine short-term effects of relamorelin on colonic motility measured by barostat and multilumen manometry in CC.<h4>Methods</h4>In a placebo-controlled, single-dose, ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2016, 61(3):852-860]

Cited: 16 times

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Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea.

Banny S Wong, Michael Camilleri, Paula Carlson, Sanna McKinzie, Irene Busciglio, Olga Bondar, Roy B Dyer, Jesse Lamsam, Alan R Zinsmeister,

<h4>Background & aims</h4>Variations in genes that regulate bile acid (BA) synthesis are associated with colonic transit in patients with irritable bowel syndrome (IBS). We investigated features of BA synthesis and excretion and genetic features of patients with different types of IBS.<h4>Methods</h4>In 26 healthy volunteers, 26 patients with IBS and constipation ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2012, 10(9):1009-15.e3]

Cited: 97 times

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Clinical Features and Colonic Motor Disturbances in Chronic Megacolon in Adults.

Ralph Hurley O'Dwyer, Andrés Acosta, Michael Camilleri, Duane Burton, Irene Busciglio, Adil E Bharucha,

<h4>Background</h4>Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter.<h4>Methods</h4>We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility features, including colonic compliance and ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2015, 60(8):2398-2407]

Cited: 14 times

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Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome.

M Camilleri, A Acosta, I Busciglio, A Boldingh, R B Dyer, A R Zinsmeister, A Lueke, A Gray, L J Donato,

<h4>Background</h4>About one-third of patients with IBS-diarrhoea (irritable bowel syndrome-D) have evidence of increased bile acid synthesis or excretion.<h4>Aims</h4>To assess effects of the bile acid sequestrant, colesevelam, on faecal excretion of BAs, hepatic BA synthesis and diarrhoea in IBS-D; to appraise whether individual or random stool samples accurately reflect 48-h total ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2015, 41(5):438-448]

Cited: 42 times

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Validating biomarkers of treatable mechanisms in irritable bowel syndrome.

M Camilleri, A Shin, I Busciglio, P Carlson, A Acosta, A E Bharucha, D Burton, J Lamsam, A Lueke, L J Donato, A R Zinsmeister,

<h4>Background</h4>A valid biomarker is 'an indicator of normal biologic or pathogenic processes, or pharmacological responses to a therapeutic intervention'. There is no validated biomarker for irritable bowel syndrome (IBS). The aim of the study was to assess ability of three quantitative traits to identify treatable processes to discriminate between IBS-diarrhea ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2014, 26(12):1677-1685]

Cited: 28 times

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RNA sequencing shows transcriptomic changes in rectosigmoid mucosa in patients with irritable bowel syndrome-diarrhea: a pilot case-control study.

Michael Camilleri, Paula Carlson, Andres Acosta, Irene Busciglio, Asha A Nair, Simon J Gibbons, Gianrico Farrugia, Eric W Klee,

Our aim was to conduct a pilot case-control study of RNA expression profile using RNA sequencing of rectosigmoid mucosa of nine females with -diarrhea-predominant irritable bowel syndrome (IBS-D) with accelerated colonic transit and nine female healthy controls. Mucosal total RNA was isolated and purified, and next-generation pair-end sequencing was performed ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2014, 306(12):G1089-98]

Cited: 35 times

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