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Expression Atlas update: from tissues to single cells.

Irene Papatheodorou, Pablo Moreno, Jonathan Manning, Alfonso Muñoz-Pomer Fuentes, Nancy George, Silvie Fexova, Nuno A Fonseca, Anja Füllgrabe, Matthew Green, Ni Huang, Laura Huerta, Haider Iqbal, Monica Jianu, Suhaib Mohammed, Lingyun Zhao, Andrew F Jarnuczak, Simon Jupp, John Marioni, Kerstin Meyer, Robert Petryszak, Cesar Augusto Prada Medina, Carlos Talavera-López, Sarah Teichmann, Juan Antonio Vizcaino, Alvis Brazma,

Expression Atlas is EMBL-EBI's resource for gene and protein expression. It sources and compiles data on the abundance and localisation of RNA and proteins in various biological systems and contexts and provides open access to this data for the research community. With the increased availability of single cell RNA-Seq datasets ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2020, 48(D1):D77-D83]

Cited: 3 times

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ArrayExpress update - from bulk to single-cell expression data.

Awais Athar, Anja Füllgrabe, Nancy George, Haider Iqbal, Laura Huerta, Ahmed Ali, Catherine Snow, Nuno A Fonseca, Robert Petryszak, Irene Papatheodorou, Ugis Sarkans, Alvis Brazma,

ArrayExpress (https://www.ebi.ac.uk/arrayexpress) is an archive of functional genomics data from a variety of technologies assaying functional modalities of a genome, such as gene expression or promoter occupancy. The number of experiments based on sequencing technologies, in particular RNA-seq experiments, has been increasing over the last few years and submissions of ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2019, 47(D1):D711-D715]

Cited: 21 times

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Management Of Diabetes In Ramadan.

Aliena Badshah, Iqbal Haider, Mohammad Humayun,

Ramadan, the ninth month of Islamic calendar brings alongwith it a sense of responsibility to fast among the Muslim adult population. Though patients with chronic illnesses like Diabetes mellitus are exempted from fasting during the month if their health does not allow, they still wish to fast. This creates a ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2018, 30(4):596-602]

Cited: 0 times

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Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?

Sidra Noor, Mohammad Ismail, Iqbal Haider, Faiza Khadim,

INTRODUCTION AND AIM:Hepatitis patients usually present with comorbidities and polypharmacy which increases risk of potential drug-drug interactions (pDDIs). We explored frequency, levels, predictors, and clinical relevance of pDDIs in hospitalized hepatitis patients. MATERIAL AND METHODS:Retrospective cohort study was used. Clinical profiles of 413 hepatitis patients were reviewed for pDDIs using ... Read more >>

Ann Hepatol (Annals of hepatology)
[2018, 17(6):1001-1011]

Cited: 1 time

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High prevalence of the risk factors for QT interval prolongation and associated drug-drug interactions in coronary care units.

Qasim Khan, Mohammad Ismail, Iqbal Haider,

OBJECTIVES:Patients admitted in coronary care units are susceptible to QT interval prolongation due to numerous risk factors. The purpose of this study was to identify the prevalence of risk factors for QT interval prolongation; QT prolonging medications; drug-drug interactions; their predictors; and torsades de pointes risks of drugs. METHODS:After obtaining ... Read more >>

Postgrad Med (Postgraduate medicine)
[2018, 130(8):660-665]

Cited: 0 times

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Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study.

Mohammad Ismail, Sidra Noor, Umme Harram, Inamul Haq, Iqbal Haider, Faiza Khadim, Qasim Khan, Zahid Ali, Tahir Muhammad, Muhammad Asif,

BACKGROUND:Potential drug-drug interactions (pDDIs) are one of the preventable drug related problems having the risk of serious adverse events or therapeutic failure. In developing countries like Pakistan, this issue remains poorly addressed. The objective of this study was to explore prevalence of pDDIs in the Outpatient Department (OPD) of a ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):762]

Cited: 1 time

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Prevalence of the risk factors for QT prolongation and associated drug-drug interactions in a cohort of medical inpatients.

Qasim Khan, Mohammad Ismail, Iqbal Haider, Zahid Ali,

BACKGROUND/PURPOSE:Medical inpatients are at increased risk of QT interval prolongation due to multiple risk actors and QT prolonging drugs. This study aimed to identify the prevalence of risk factors for QT prolongation; QT prolonging medications; associated drug-drug interactions (QT-DDIs); their predictors; and TdP (torsades de pointes) risks of drugs. METHODS:This ... Read more >>

J. Formos. Med. Assoc. (Journal of the Formosan Medical Association)
[2019, 118(1 Pt 1):109-115]

Cited: 0 times

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Gramene 2018: unifying comparative genomics and pathway resources for plant research.

Marcela K Tello-Ruiz, Sushma Naithani, Joshua C Stein, Parul Gupta, Michael Campbell, Andrew Olson, Sharon Wei, Justin Preece, Matthew J Geniza, Yinping Jiao, Young Koung Lee, Bo Wang, Joseph Mulvaney, Kapeel Chougule, Justin Elser, Noor Al-Bader, Sunita Kumari, James Thomason, Vivek Kumar, Daniel M Bolser, Guy Naamati, Electra Tapanari, Nuno Fonseca, Laura Huerta, Haider Iqbal, Maria Keays, Alfonso Munoz-Pomer Fuentes, Amy Tang, Antonio Fabregat, Peter D'Eustachio, Joel Weiser, Lincoln D Stein, Robert Petryszak, Irene Papatheodorou, Paul J Kersey, Patti Lockhart, Crispin Taylor, Pankaj Jaiswal, Doreen Ware,

Gramene (http://www.gramene.org) is a knowledgebase for comparative functional analysis in major crops and model plant species. The current release, #54, includes over 1.7 million genes from 44 reference genomes, most of which were organized into 62,367 gene families through orthologous and paralogous gene classification, whole-genome alignments, and synteny. Additional gene ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2018, 46(D1):D1181-D1189]

Cited: 29 times

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Vanishing White Matter (VWM) Disease Presenting As Neuro-Ovarian Failure.

Abidullah Khan, Mohammad Humayun, Maimoona Ayub, Iqbal Haider, Fahad Ajmal, Syed Saad Shah,

A 19-year girl was admitted with a one-month history of worsening spastic paraparesis, cerbellar ataxia, visual decline and worsening headaches on a background of walking difficulty, progressive quadriparesis and migraine since the age of 10 years. She had no sensory loss, and cranial nerves examination was notable for optic atrophy ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2017, 27(3):S41-S42]

Cited: 0 times

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Prevalence of QT interval prolonging drug-drug interactions (QT-DDIs) in psychiatry wards of tertiary care hospitals in Pakistan: a multicenter cross-sectional study.

Qasim Khan, Mohammad Ismail, Iqbal Haider, Fahadullah Khan,

Background QT prolongation and associated arrhythmias, torsades de pointes (TdP), are considerable negative outcomes of many antipsychotic and antidepressant agents frequently used by psychiatric patients. Objective To identify the prevalence, levels, and predictors of QT prolonging drug-drug interactions (QT-DDIs), and AZCERT (Arizona Center for Education and Research on Therapeutics) classification ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2017, 39(6):1256-1264]

Cited: 2 times

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QT interval prolongation in hospitalized patients on cardiology wards: a prospective observational study.

Qasim Khan, Mohammad Ismail, Iqbal Haider, Inam Ul Haq, Sidra Noor,

Prolonged QT interval may lead to a lethal form of arrhythmia, torsades de pointes (TdP), which is associated with cardiovascular mortality. Therefore, we aimed to identify prevalence of QT interval prolongation, compare clinical characteristics of patients with normal and prolonged QT interval, and identify predictors of QT interval prolongation.A prospective ... Read more >>

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2017, 73(11):1511-1518]

Cited: 3 times

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Psoriatic Arthritis Is an Indicator of Significant Renal Damage in Patients with Psoriasis: An Observational and Epidemiological Study.

Abidullah Khan, Iqbal Haider, Maimoona Ayub, Mohammad Humayun,

Background. Psoriasis affects joints in around 30% of the patients. Recent studies have demonstrated an increased risk of essential hypertension, ischemic heart disease, and stroke in psoriatic patients. However, the prevalence of renal disease in patients with psoriasis has not been evaluated properly. Objectives. Objectives were to evaluate renal functions ... Read more >>

Int J Inflam (International journal of inflammation)
[2017, 2017:5217687]

Cited: 1 time

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Classic Raymond Syndrome.

Majid Khan, Sadaf Naveed, Iqbal Haider, Mohammad Humayun, Abidullah Khan,

Classic Raymond syndrome presents with abducens nerve palsy on the ipsilateral side with contralateral hemiparesis and facial nerve paralysis. A 60-year gentleman presented with deviation of left angle of mouth and right sided weakness. Examination showed that he had left sided abducens nerve palsy, with contralateral central facial paralysis and ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2017, 27(3):185-186]

Cited: 0 times

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Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus.

Abidullah Khan, Iqbal Haider, Maimoona Ayub, Salman Khan,

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. ... Read more >>

F1000Res (F1000Research)
[2017, 6:126]

Cited: 2 times

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Potential drug-drug interactions in pediatric patients admitted to intensive care unit of Khyber Teaching Hospital, Peshawar, Pakistan: A cross-sectional study.

Mohammad Ismail, Sana Aziz, Sidra Noor, Iqbal Haider, Faryal Shams, Inamul Haq, Faiza Khadim, Qasim Khan, Fahadullah Khan, Muhammad Asif,

To investigate frequencies, levels, clinical relevance and predictors of potential drug-drug interactions (pDDIs) in pediatric intensive care unit (PICU).Case notes of 411 patients were reviewed for pDDIs through Micromedex. Frequencies, levels and clinical relevance of pDDIs were reported. Logistic regression was applied to calculate the odds-ratios for predictors of pDDIs.We ... Read more >>

J Crit Care (Journal of critical care)
[2017, 40:243-250]

Cited: 3 times

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Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

Abidullah Khan, Iqbal Haider, Maimoona Ayub, Salman Khan,

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. ... Read more >>

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Cited: 2 times

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Lujan-Fryns Syndrome (LFS): A Unique Combination of Hypernasality, Marfanoid Body Habitus, and Neuropsychiatric Issues, Presenting as Acute-Onset Dysphagia.

Abidullah Khan, Mohammad Humayun, Iqbal Haider, Maimoona Ayub,

BACKGROUND:Lujan-Fryns syndrome (LFS) is an extremely rare, X-linked disorder, for which the full clinical spectrum is still unknown. Usually, it presents with neuropsychiatric problems such as learning disabilities and behavioral issues in a typical combination with marfanoid features. Often, there is a positive family history for the disorder. However, sporadic ... Read more >>

Clin Med Insights Case Rep (Clinical medicine insights. Case reports)
[2016, 9:115-118]

Cited: 0 times

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Coexisting giant splenic artery and portal vein aneurysms leading to non-cirrhotic portal hypertension: a case report.

Abidullah Khan, Maimoona Ayub, Iqbal Haider, Mohammad Humayun, Zakir Shah, Fahad Ajmal,

Splenic artery aneurysms are the commonest visceral and third most common abdominal artery aneurysms, having a strong association with both pregnancy and multiparity. Here we report possibly the first case of a giant splenic artery aneurysm in association with a smaller portal vein aneurysm, in a woman who had never ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2016, 10(1):270]

Cited: 2 times

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Analytic Study In Patients Presenting To A Tertiary Care Hospital Regarding The Artemether-Lumefantrine Induced Qtc Interval Changes In ECG.

Aliena Badshah, Iqbal Haider, Shams Suleman,

BACKGROUND:Malaria is one of the most common causes of morbidity and mortality in our part of the world. Artemether-Lumefantrine (AL) Combination therapy is widely used for the treatment of malaria both in outpatients and inpatients hospital settings. Some of the previous anti-malarial were associated with prolongation of QTc interval. Similar ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2017, 29(1):33-36]

Cited: 0 times

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Potential drug-drug interactions in medical intensive care unit of a tertiary care hospital in Pakistan.

Mohammad Ismail, Farmanullah Khan, Sidra Noor, Iqbal Haider, Inam-Ul Haq, Zahid Ali, Zahir Shah, Mohsin Hassam,

Background Patients admitted to intensive care unit (ICU) present with severe and life-threatening illnesses. Most of them suffer from various comorbidities. They usually receive complex pharmacotherapy with large number of medicines which increase the risk of drug-drug interactions (DDIs). Objective The present report aimed to investigate prevalence and levels of ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2016, 38(5):1052-1056]

Cited: 6 times

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Primary Sjogren's Syndrome Presenting as Acute Interstitial Pneumonitis/Hamman-Rich Syndrome.

Abidullah Khan, Mohammad Humayun, Iqbal Haider, Maimoona Ayub, Zakir Shah, Fahad Ajmal,

A previously well, 45-year-old Pakistani lady was admitted to the medical unit on-call of Khyber Teaching Hospital (KTH) Peshawar with a 5-day history of fever, productive cough with copious mucoid sputum, dyspnea, and pleuritic chest pain. She also complained of dry eyes, mouth, and vagina. Her chest X-ray showed diffuse ... Read more >>

Case Rep Med (Case reports in medicine)
[2016, 2016:4136765]

Cited: 0 times

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Epithelioid Haemangioendothelioma (EHE) of the Liver.

Abidullah Khan, Mohammad Humayun, Iqbal Haider, Wazir Muhammad Khan, Fahad Ajmal, Maimoona Ayub,

A45-year previously known hypertensive lady presented with 2-year history of upper abdominal pain, heaviness, and weight loss. Her radiological assessment suggested the possibility of hepatoma or liver metastases. Considering her age, overall good health and absence of cirrhosis, a liver biopsy was taken which showed hepatic epithelioidhaemangioendothelioma (HEHE), a rare ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2016, 26(6 Suppl):S28-30]

Cited: 1 time

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Protective Role of G6PD Deficiency in Aluminium Phosphide Poisoning.

Mohammad Humayun, Iqbal Haider, Aliena Badshah, Fazle Subhan,

A 15-year-old boy was referred to the hospital from the periphery with a history of ingestion of 5 wheat pills (aluminium phosphide) 5 days back. He had been given a stomach wash in his village hospital prior to referral. On arrival, he was jaundiced and had developed haematuria too, but ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2015, 25 Suppl 1:S66-8]

Cited: 1 time

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