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Author Ioannis Mintziras

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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.

Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater,

<h4>Background</h4>Familial pancreatic carcinoma (FPC) is a rare hereditary tumor syndrome with a heterogeneous clinical phenotype. The study of FPC also contributes to a better understanding of the more common sporadic pancreatic ductal adenocarcinoma (PDAC). We report on the past 20 years' experience of the German National Case Collection for Familial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Gastric enterochromaffin-like cell changes in multiple endocrine neoplasia type 1.

Jerena Manoharan, Martin Anlauf, Max B Albers, Ulrike W Denzer, Ioannis Mintziras, Sabine Wächter, Pietro Di Fazio, Carmen Bollmann, Detlef K Bartsch,

<h4>Background</h4>Gastric enterochromaffin-like cell (ECL) tumours can occur in patients with multiple endocrine neoplasia type 1 (MEN1), especially in those affected by Zollinger Ellison syndrome (ZES). Since the prevalence of ECL lesions is not well defined yet, the present study evaluated the presence and extent of ECL lesions in MEN1 patients ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, :]

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Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death.

Sami Matrood, Nicola de Prisco, Thaddeus Wissniowski, Dominik Wiese, Samir Jabari, Heidi Griesmann, Michael Wanzel, Thorsten Stiewe, Daniel Neureiter, Eckhard Klieser, Ioannis Mintziras, Malte Buchholz, Detlef K Bartsch, Vincenzo Gennarino, Pietro Di Fazio,

Introduction Autophagic cell death in cancer cells can be mediated by inhibition of deacetylases. Although extensive studies have focused on the autophagic process in cancer, little is known about the role of autophagy in degrading cytosolic and nuclear components of pancreatic neuroendocrine neoplastic (pNEN) cells leading to cell death, thus ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2020, :]

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Preoperative Bacterobilia Is an Independent Risk Factor of SSIs after Partial PD.

Ioannis Mintziras, Elisabeth Maurer, Veit Kanngiesser, Michael Lohoff, Detlef K Bartsch,

<h4>Introduction</h4>The impact of bacterobilia on postoperative surgical and infectious complications after partial pancreaticoduodenectomy (PD) is still a matter of debate.<h4>Methods</h4>All patients undergoing PD with and without a preoperative biliary drainage (PBD) with complete information regarding microbial bile colonization were included. Logistic regression was applied to assess the influence of bacterobilia ... Read more >>

Dig Surg (Digestive surgery)
[2020, 37(5):428-435]

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C-reactive protein and drain amylase accurately predict clinically relevant pancreatic fistula after partial pancreaticoduodenectomy.

Ioannis Mintziras, Elisabeth Maurer, Veit Kanngiesser, Detlef Klaus Bartsch,

BACKROUND:C-reactive protein (CRP) and procalcitonin (PCT) have shown to be reliable predictors of inflammatory complications and anastomotic leak after colorectal surgery. Their predictive value after partial pancreaticoduodenectomy (PD) remains unclear. MATERIALS AND METHODS:All consecutive pancreaticoduodenectomies (2009-2018) at our hospital were included. Drain amylase was evaluated on postoperative day (POD) 1, ... Read more >>

Int J Surg (International journal of surgery (London, England))
[2020, 76:53-58]

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Single gland excision for MEN1-associated primary hyperparathyroidism.

Jerena Manoharan, Max B Albers, Carmen Bollmann, Elisabeth Maurer, Ioannis Mintziras, Sabine Wächter, Detlef K Bartsch,

IMPORTANCE:Guidelines advocate subtotal parathyroidectomy (SPTX) or total parathyroidectomy with autotransplantation (TPTX) with bilateral cervical thymectomy for primary hyperparathyroidism (pHPT) associated with multiple endocrine neoplasia type 1 (MEN1). However, both procedures are associated with a significant risk of permanent hypoparathyroidism. OBJECTIVE:The aim of the current study was to compare long-term results ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2020, 92(1):63-70]

Cited: 2 times

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Progress report: familial pancreatic cancer.

Ioannis Mintziras, Detlef K Bartsch,

A hereditary predisposition to pancreatic ductal adenocarcinoma (PDAC) is reported in approximately 5% of patients. Familial pancreatic cancer (FPC) accounts for the vast majority of hereditary PDAC cases. FPC defines families with two or more affected first-degree relatives with PDAC that do not fulfil the criteria of any other inherited ... Read more >>

Fam Cancer (Familial cancer)
[2019, 18(3):359-362]

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Palliative surgical bypass is superior to palliative endoscopic stenting in patients with malignant gastric outlet obstruction: systematic review and meta-analysis.

Ioannis Mintziras, Michael Miligkos, Sabine Wächter, Jerena Manoharan, Detlef Klaus Bartsch,

<h4>Background</h4>Gastrojejunostomy (GJ) and self-expanding metal stents (SEMS) are the two most common palliative treatment options for patients with malignant gastric outlet obstruction (GOO). Randomised trials and retrospective studies have shown discrepant results, so that there is still a controversy regarding the optimal treatment of GOO.<h4>Methods</h4>Medline, Web of Science and Cochrane ... Read more >>

Surg Endosc (Surgical endoscopy)
[2019, 33(10):3153-3164]

Cited: 2 times

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Indications for resection and perioperative outcomes of surgery for pancreatic neuroendocrine neoplasms in Germany: an analysis of the prospective DGAV StuDoQ|Pancreas registry.

Ioannis Mintziras, Tobias Keck, Jens Werner, Stefan Fichtner-Feigl, Uwe Wittel, Norbert Senninger, Thorsten Vowinkel, Jörg Köninger, Matthias Anthuber, Bernd Geißler, Detlef Klaus Bartsch, ,

<h4>Purpose</h4>Pancreatic neuroendocrine neoplasms (pNENs) are rare, and their surgical management is complex. This study evaluated the current practice of pNEN surgery across Germany, including its adherence with guidelines and its perioperative outcomes.<h4>Methods</h4>Patients who underwent surgery for pNENs (April 2013-June 2017) were retrieved from the prospective StuDoQ|Pancreas registry of the German ... Read more >>

Surg Today (Surgery today)
[2019, 49(12):1013-1021]

Cited: 1 time

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Incidental findings in pancreas screening programs for high-risk individuals: Results from three European expert centers.

Isaura S Ibrahim, Catharina Brückner, Alfredo Carrato, Julie Earl, Akin Inderson, Wouter H de Vos Tot Nederveen Cappel, Ioannis Mintziras, Elvira Matthäi, Jens Figiel, Martin Wasser, Hans Moreau, Bert Bonsing, Emily P Slater, Detlef K Bartsch, Hans Fa Vasen,

<h4>Background</h4>Widespread abdominal imaging has led to a substantial increase in the detection of incidentalomas. Currently, an increasing number of centers offer surveillance of the pancreas to individuals at high risk (IARs) of pancreatic ductal adenocarcinoma (PDAC).<h4>Objective</h4>The aims of this study were to evaluate the frequency and type of incidental findings ... Read more >>

United European Gastroenterol J (United European gastroenterology journal)
[2019, 7(5):682-688]

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Reply letter to: "Response to: Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: Systematic review and meta-analysis".

Ioannis Mintziras, Michael Miligkos, Sabine Wächter, Jerena Manoharan, Elisabeth Maurer, Detlef Klaus Bartsch,

Int J Surg (International journal of surgery (London, England))
[2019, 66:101-102]

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Implementation of Current ENETS Guidelines for Surgery of Small (≤2 cm) Pancreatic Neuroendocrine Neoplasms in the German Surgical Community: An Analysis of the Prospective DGAV StuDoQ|Pancreas Registry.

Ioannis Mintziras, Tobias Keck, Jens Werner, Stefan Fichtner-Feigl, Uwe Wittel, Norbert Senninger, Thorsten Vowinkel, Jörg Köninger, Matthias Anthuber, Bernd Geißler, Detlef Klaus Bartsch, ,

<h4>Background</h4>ENETS guidelines recommend parenchyma-sparing procedures without formal lymphadenectomy, ideally with a minimally invasive laparoscopic approach for sporadic small pNENs (≤2 cm). Non-functioning (NF) small pNENs can also be observed. The aim of the study was to evaluate how these recommendations are implemented in the German surgical community.<h4>Methods</h4>Data from the prospective StuDoQ|Pancreas ... Read more >>

World J Surg (World journal of surgery)
[2019, 43(1):175-182]

Cited: 3 times

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Sarcopenia and sarcopenic obesity are significantly associated with poorer overall survival in patients with pancreatic cancer: Systematic review and meta-analysis.

Ioannis Mintziras, Michael Miligkos, Sabine Wächter, Jerena Manoharan, Elisabeth Maurer, Detlef Klaus Bartsch,

<h4>Backround</h4>The role of sarcopenia and sarcopenic obesity in patients with pancreatic ductal adenocarcinoma(PDAC) remains controversial.<h4>Material and methods</h4>Medline and Web of Science were searched for studies reporting survival in sarcopenic and/or sarcopenic obese patients with pancreatic cancer. Primary outcome was mortality in patients with sarcopenia and/or sarcopenic obesity versus non-sarcopenic and/or ... Read more >>

Int J Surg (International journal of surgery (London, England))
[2018, 59:19-26]

Cited: 17 times

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Chemoprevention with Enalapril and Aspirin in Men1(+/T) Knockout Mouse Model.

Jerena Manoharan, Volker Fendrich, Pietro Di Fazio, Carmen Bollmann, Silvia Roth, Barbara Joos, Ioannis Mintziras, Max B Albers, Annette Ramaswamy, Philippe Bertolino, Chang X Zhang, Emily P Slater, Detlef K Bartsch, Caroline L Lopez-Lopez,

Pancreatic neuroendocrine neoplasias (pNEN) are the most common cause of death in adult patients with multiple endocrine neoplasia type 1 (MEN1). So far, only few chemopreventive strategies (e.g., with somatostatin analogues) have been evaluated for MEN1 associated pNENs. In this experimental study on 75 Men1(+/T) knockout mice, the effect of ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2018, 107(3):257-266]

Cited: 1 time

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Individualised Multimodal Treatment Strategies for Anaplastic and Poorly Differentiated Thyroid Cancer.

Sabine Wächter, Annette Wunderlich, Silvia Roth, Ioannis Mintziras, Elisabeth Maurer, Sebastian Hoffmann, Frederik A Verburg, Sebastian A Fellinger, Katharina Holzer, Detlef K Bartsch, Pietro Di Fazio,

The prognosis of anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) is poor, due to their radioiodine refractoriness (RAI-R), high metastatic potential and current lack of effective treatment strategies. We aimed to examine the efficacy of the tyrosine kinase inhibitors (TKIs) sorafenib and selumetinib and the histone deacetylase inhibitor (HDACI) ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(5):]

Cited: 6 times

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Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.

Ulrich Friedrich Wellner, Hryhoriy Lapshyn, Detlef K Bartsch, Ioannis Mintziras, Ulrich Theodor Hopt, Uwe Wittel, Hans-Jörg Krämling, Hubert Preissinger-Heinzel, Matthias Anthuber, Bernd Geissler, Jörg Köninger, Katharina Feilhauer, Merten Hommann, Luisa Peter, Natascha C Nüssler, Thomas Klier, Ulrich Mansmann, Tobias Keck, ,

<h4>Purpose</h4>The aim of this study was to assess intraoperative, postoperative, and oncologic outcome in patients undergoing laparoscopic distal pancreatectomy (LDP) versus open distal pancreatectomy (ODP) for benign and malignant lesions of the pancreas.<h4>Methods</h4>Data from patients undergoing distal pancreatic resection were extracted from the StuDoQ|Pancreas registry of the German Society for ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2017, 32(2):273-280]

Cited: 10 times

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High risk of fistula formation in vacuum-assisted closure therapy in patients with open abdomen due to secondary peritonitis-a retrospective analysis.

Ioannis Mintziras, Michael Miligkos, Detlef Klaus Bartsch,

<h4>Purpose</h4>The aim of this study was to evaluate the efficacy of vacuum-assisted closure therapy in patients with open abdomen due to secondary peritonitis and to identify possible risk factors of fistula formation.<h4>Methods</h4>The hospital OPS-database (time period 2005-2014) was searched to identify patients treated with an open abdomen due to secondary ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2016, 401(5):619-625]

Cited: 2 times

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