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Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement.

Ludger Klimek, Marek Jutel, Cezmi Akdis, Jean Bousquet, Mübeccel Akdis, Claus Bachert, Ioana Agache, Ignacio Ansotegui, Anna Bedbrook, Sinthia Bosnic-Anticevich, Giorgio W Canonica, Tomas Chivato, Alvaro A Cruz, Wiencyslawa Czarlewski, Stefano Del Giacco, Hui Du, Joao A Fonseca, Yadong Gao, Tari Haahtela, Karin Hoffmann-Sommergruber, Juan-Carlos Ivancevich, Nikolai Khaltaev, Edward F Knol, Piotr Kuna, Desiree Larenas-Linnemann, Erik Melen, Joaquim Mullol, Robert Naclerio, Ken Ohta, Yoshitaka Okamoto, Liam O'Mahony, Gabrielle L Onorato, Nikos G Papadopoulos, Ruby Pawankar, Oliver Pfaar, Boleslaw Samolinski, Jurgen Schwarze, Sanna Toppila-Salmi, Mohamed H Shamji, Maria Teresa Ventura, Arunas Valiulis, Arzu Yorgancioglu, Paolo Matricardi, Torsten Zuberbier, ,

The current COVID-19 pandemic influences many areas of social life, medical treatments and the way allergy is performed. Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. ... Read more >>

Allergy (Allergy)
[2020, :]

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EAACI Research and Outreach Committee: Improving standards and facilitating global collaboration through a Research Excellence Network.

Mohamed H Shamji, Cezmi A Akdis, Domingo Barber, Walter Canonica, Tomás Chivato, Stefano Del Giacco, Karin Hoffman-Sommergruber, Marek Jutel, Edward Knol, Markus Ollert, Liam O'Mahony, Oscar Palomares, Joaquin Sastre, Jürgen Schwarze, Sylwia Smolinska, Stephan Vieths, Ioana Agache,

Allergy (Allergy)
[2020, :]

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Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement.

Jean Bousquet, Cezmi Akdis, Marek Jutel, Claus Bachert, Ludger Klimek, Ioana Agache, Ignacio J Ansotegui, Anna Bedbrook, Sinthia Bosnic-Anticevich, Giorgio W Canonica, Tomas Chivato, Alvaro A Cruz, Wienia Czarlewski, Stefano Del Giacco, Hui Du, Joao A Fonseca, Yadong Gao, Tari Haahtela, Karin Hoffmann-Sommergruber, Juan C Ivancevich, Nikolai Khaltaev, Edward F Knol, Piotr Kuna, Desiree Larenas-Linnemann, Joaquim Mullol, Robert Naclerio, Ken Ohta, Y Okamoto, Liam O'Mahony, Gabrielle L Onorato, Nikos G Papadopoulos, Oliver Pfaar, Boleslaw Samolinski, Jürgen Schwarze, Sanna Toppila-Salmi, Maria Teresa Ventura, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, ,

Allergy (Allergy)
[2020, :]

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Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank.

Alexander G Mathioudakis, Adnan Custovic, Antoine Deschildre, Francine M Ducharme, Omer Kalayci, Clare Murray, Antonio Nieto Garcia, Wanda Phipatanakul, David Price, Aziz Sheikh, Ioana Agache, Leonard Bacharier, Matteo Bonini, Jose A Castro-Rodriguez, Giuseppe De Carlo, Timothy Craig, Zuzana Diamant, Wojciech Feleszko, Despo Ierodiakonou, James E Gern, Jonathan Grigg, Gunilla Hedlin, Elham M Hossny, Tuomas Jartti, Alan Kaplan, Robert F Lemanske, Peter Le Souef, Mika J Makela, Paolo M Matricardi, Michael Miligkos, Mário Morais-Almeida, Helena Pite, Paulo M C Pitrez, Petr Pohunek, Graham Roberts, Sylvia Sanchez-Garcia, Ioanna Tsiligianni, Steve Turner, Tonya A Winders, Gary Wong, Paraskevi Xepapadaki, Heather J Zar, Nikolaos G Papadopoulos,

BACKGROUND:Pediatric asthma remains a public health challenge with enormous impact worldwide. OBJECTIVE:The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. METHODS:We first identified unmet needs through an open-question survey administered to international ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

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Biologicals in atopic disease in pregnancy: an EAACI position paper.

Birgit Pfaller, Juan José Yepes-Nuñez, Ioana Agache, Cezmi A Akdis, Mohammad Alsalamah, Sevim Bavbek, Apostolos Bossios, Onur Boyman, Adam Chaker, Susan Chan, Alexia Chatzipetrou, George du Toit, Marek Jutel, Paula Kauppi, Antonios Kolios, Carmen Li, Andrea Matucci, Alanna Marson, Sarah Bendien, Oscar Palomares, Barbara Rogala, Zsolt Szepfalusi, Eva Untersmayr, Alessandra Vultaggio, Thomas Eiwegger,

Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information ... Read more >>

Allergy (Allergy)
[2020, :]

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EAACI position paper on diet diversity in pregnancy, infancy and childhood: Novel concepts and implications for studies in allergy and asthma.

Carina Venter, Matthew Greenhawt, Rosan W Meyer, Carlo Agostoni, Imke Reese, George du Toit, Mary Feeney, Kate Maslin, Bright I Nwaru, Caroline Roduit, Eva Untersmayr, Berber Vlieg-Boerstra, Isabella Pali-Schöll, Graham C Roberts, Peter Smith, Cezmi A Akdis, Ioana Agache, Miriam Ben-Adallah, Stephan Bischoff, Remo Frei, Holger Garn, Kate Grimshaw, Karin Hoffmann-Sommergruber, Nonhlanhla Lunjani, Antonella Muraro, Lars K Poulsen, Harald Renz, Milena Sokolowska, Catherine Stanton, Liam O'Mahony,

To fully understand the role of diet diversity on allergy outcomes and to set standards for conducting research in this field, the European Academy of Allergy and Clinical Immunology Task Force on Diet and Immunomodulation has systematically explored the association between diet diversity and allergy outcomes. In addition, a detailed ... Read more >>

Allergy (Allergy)
[2020, 75(3):497-523]

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Genetics and epigenetics of allergy.

Ioana Agache, Catalina Cojanu, Alexandru Laculiceanu, Liliana Rogozea,

PURPOSE OF REVIEW:Allergic diseases are prototypic examples for gene × environment-wide interactions. This review considers the current evidence for genetic and epigenetic mechanisms in allergic diseases and highlights barriers and facilitators for the implementation of these novel tools both for research and clinical practice. RECENT FINDINGS:The value of whole-genome sequencing studies and ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(3):223-232]

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Efficacy and safety of treatment with dupilumab for severe asthma: A systematic review of the EAACI guidelines-Recommendations on the use of biologicals in severe asthma.

Ioana Agache, Yang Song, Claudio Rocha, Jessica Beltran, Margarita Posso, Corinna Steiner, Pablo Alonso-Coello, Cezmi Akdis, Mubeccel Akdis, Giorgio Walter Canonica, Thomas Casale, Tomas Chivato, Jonathan Corren, Stefano Del Giacco, Thomas Eiwegger, Davide Firinu, James E Gern, Eckard Hamelmann, Nicola Hanania, Mika Mäkelä, Irene Hernández Martín, Parameswaran Nair, Liam O'Mahony, Nikolaos G Papadopoulos, Alberto Papi, Hae-Sim Park, Luis Pérez de Llano, Santiago Quirce, Joaquin Sastre, Mohamed Shamji, Jurgen Schwarze, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel,

Dupilumab, a fully human monoclonal antibody against interleukin-4 receptor α, is approved as add-on maintenance treatment for inadequately controlled type 2 severe asthma. This systematic review evaluated the efficacy, safety and economic impact of dupilumab compared to standard of care for uncontrolled severe asthma. PubMed, EMBASE and Cochrane Library were ... Read more >>

Allergy (Allergy)
[2020, 75(5):1058-1068]

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Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma.

Ioana Agache, Jessica Beltran, Cezmi Akdis, Mubeccel Akdis, Carlos Canelo-Aybar, Giorgio Walter Canonica, Thomas Casale, Tomas Chivato, Jonathan Corren, Stefano Del Giacco, Thomas Eiwegger, Davide Firinu, James E Gern, Eckard Hamelmann, Nicola Hanania, Mika Mäkelä, Irene Hernández-Martín, Parameswaran Nair, Liam O'Mahony, Nikolaos G Papadopoulos, Alberto Papi, Hae-Sim Park, Luis Pérez de Llano, Margarita Posso, Claudio Rocha, Santiago Quirce, Joaquin Sastre, Mohamed Shamji, Yang Song, Corinna Steiner, Jurgen Schwarze, Pablo Alonso-Coello, Oscar Palomares, Marek Jutel,

Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searched to identify RCTs and health ... Read more >>

Allergy (Allergy)
[2020, 75(5):1023-1042]

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Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma.

Ioana Agache, Claudio Rocha, Jessica Beltran, Yang Song, Margarita Posso, Ivan Solà, Pablo Alonso-Coello, Cezmi Akdis, Mubeccel Akdis, Giorgio W Canonica, Thomas Casale, Tomas Chivato, Jonathan Corren, Stefano Del Giacco, Thomas Eiwegger, Davide Firinu, James E Gern, Eckard Hamelmann, Nicola Hanania, Mika Mäkelä, Irene Hernández Martín, Parameswaran Nair, Liam O'Mahony, Nikolaos G Papadopoulos, Alberto Papi, Hae-Sim Park, Luis Pérez de Llano, Santiago Quirce, Joaquin Sastre, Mohamed Shamji, Jurgen Schwarze, Carlos Canelo-Aybar, Oscar Palomares, Marek Jutel,

Allergic asthma is a frequent asthma phenotype. Both IgE and type 2 cytokines are increased, with some degree of overlap with other phenotypes. Systematic reviews assessed the efficacy and safety of benralizumab, dupilumab and omalizumab (alphabetical order) vs standard of care for patients with uncontrolled severe allergic asthma. PubMed, Embase ... Read more >>

Allergy (Allergy)
[2020, 75(5):1043-1057]

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Serious Asthma Outcomes and Asthma Exacerbations with Maintenance on Inhaled Corticosteroid (Mometasone Furoate)/Long-Acting Beta Agonist (Formoterol) Combination Compared to Step Down to Mometasone Monotherapy.

Cindy L J Weinstein, Nicholas Ryan, Xiaoli Zhang, Tulin Shekar, Davis Gates, Stephen J Lane, Ioana Agache, Robert A Nathan, ,

BACKGROUND:Because of historical safety concerns with the use of long-acting β-agonists (LABA) in asthma, step-down from inhaled corticosteroid (ICS)/LABA combination therapy to ICS monotherapy is recommended once asthma control is achieved. OBJECTIVE:To evaluate the benefit/risk question about whether patients with asthma who achieve disease control on fixed-dose ICS/LABA combination therapy, ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, 8(5):1634-1644.e1]

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Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper.

Valerie Hox, Evelijn Lourijsen, Arnout Jordens, Kristian Aasbjerg, Ioana Agache, Isam Alobid, Claus Bachert, Koen Boussery, Paloma Campo, Wytske Fokkens, Peter Hellings, Claire Hopkins, Ludger Klimek, Mika Mäkelä, Ralph Mösges, Joaquim Mullol, Laura Pujols, Carmen Rondon, Michael Rudenko, Sanna Toppila-Salmi, Glenis Scadding, Sophie Scheire, Peter-Valentin Tomazic, Thibaut Van Zele, Martin Wagemann, Job F M van Boven, Philippe Gevaert,

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that-potentially severe-side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus ... Read more >>

Clin Transl Allergy (Clinical and Translational Allergy)
[2020, 10:1]

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Perspectives in allergen immunotherapy: 2019 and beyond.

Oliver Pfaar, Ioana Agache, Frédéric de Blay, Sergio Bonini, Adam M Chaker, Stephen R Durham, Radoslaw Gawlik, Peter W Hellings, Marek Jutel, Jörg Kleine-Tebbe, Ludger Klimek, Matthias V Kopp, Andreas Nandy, Ronald L Rabin, Ronald van Ree, Harald Renz, Graham Roberts, Anne-Marie Salapatek, Carsten B Schmidt-Weber, Mohamed H Shamji, Gunter J Sturm, J Christian Virchow, Ulrich Wahn, Christoph Willers, Petra Zieglmayer, Cezmi A Akdis,

The seventh "Future of the Allergists and Specific Immunotherapy (FASIT)" workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following: (a) Biomarkers for ... Read more >>

Allergy (Allergy)
[2019, 74 Suppl 108:3-25]

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Highlights and recent developments in airway diseases in EAACI journals (2018).

Jean Bousquet, Cezmi A Akdis, Clive Grattan, Philippe A Eigenmann, Karin Hoffmann-Sommergruber, Ioana Agache, Marek Jutel,

The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to ... Read more >>

Allergy (Allergy)
[2019, 74(12):2329-2341]

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Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence.

Jean Bousquet, Holger J Schünemann, Akdis Togias, Claus Bachert, Martina Erhola, Peter W Hellings, Ludger Klimek, Oliver Pfaar, Dana Wallace, Ignacio Ansotegui, Ioana Agache, Anna Bedbrook, Karl-Christian Bergmann, Mike Bewick, Philippe Bonniaud, Sinthia Bosnic-Anticevich, Isabelle Bossé, Jacques Bouchard, Louis-Philippe Boulet, Jan Brozek, Guy Brusselle, Moises A Calderon, Walter G Canonica, Luis Caraballo, Vicky Cardona, Thomas Casale, Lorenzo Cecchi, Derek K Chu, Elisio M Costa, Alvaro A Cruz, Wienczyslawa Czarlewski, Gennaro D'Amato, Philippe Devillier, Mark Dykewicz, Motohiro Ebisawa, Jean-Louis Fauquert, Wytske J Fokkens, Joao A Fonseca, Jean-François Fontaine, Bilun Gemicioglu, Roy Gerth van Wijk, Tari Haahtela, Susanne Halken, Despo Ierodiakonou, Tomohisa Iinuma, Juan-Carlos Ivancevich, Marek Jutel, Igor Kaidashev, Musa Khaitov, Omer Kalayci, Jorg Kleine Tebbe, Marek L Kowalski, Piotr Kuna, Violeta Kvedariene, Stefania La Grutta, Désirée Larenas-Linnemann, Susanne Lau, Daniel Laune, Lan Le, Philipp Lieberman, Karin C Lodrup Carlsen, Olga Lourenço, Gert Marien, Pedro Carreiro-Martins, Erik Melén, Enrica Menditto, Hugo Neffen, Gregoire Mercier, Ralph Mosgues, Joaquim Mullol, Antonella Muraro, Leyla Namazova, Ettore Novellino, Robyn O'Hehir, Yoshitaka Okamoto, Ken Ohta, Hae Sim Park, Petr Panzner, Giovanni Passalacqua, Nhan Pham-Thi, David Price, Graham Roberts, Nicolas Roche, Christine Rolland, Nelson Rosario, Dermot Ryan, Boleslaw Samolinski, Mario Sanchez-Borges, Glenis K Scadding, Mohamed H Shamji, Aziz Sheikh, Ana-Maria Todo Bom, Sanna Toppila-Salmi, Ioana Tsiligianni, Marylin Valentin-Rostan, Arunas Valiulis, Erkka Valovirta, Maria-Teresa Ventura, Samantha Walker, Susan Waserman, Arzu Yorgancioglu, Torsten Zuberbier, ,

The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical ... Read more >>

J. Allergy Clin. Immunol. (The Journal of Allergy and Clinical Immunology)
[2020, 145(1):70-80.e3]

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Toward clinically applicable biomarkers for asthma: An EAACI position paper.

Zuzana Diamant, Susanne Vijverberg, Kjell Alving, Arzu Bakirtas, Leif Bjermer, Adnan Custovic, Sven-Erik Dahlen, Mina Gaga, Roy Gerth van Wijk, Stefano Del Giacco, Eckard Hamelmann, Liam G Heaney, Enrico Heffler, Ömer Kalayci, Konstantinos Kostikas, Rene Lutter, Anna-Carin Olin, Svetlana Sergejeva, Angela Simpson, Peter J Sterk, Ellen Tufvesson, Ioana Agache, Sven F Seys,

Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their expression varies across the heterogeneous spectrum of asthma. Type 2 inflammatory responses are characterized by increased levels of eosinophils, FeNO, and type 2 cytokines in blood and/or airways. Presently, type ... Read more >>

Allergy (Allergy)
[2019, 74(10):1835-1851]

Cited: 4 times

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The role of mobile health technologies in allergy care: An EAACI position paper.

Paolo Maria Matricardi, Stephanie Dramburg, Alberto Alvarez-Perea, Darío Antolín-Amérigo, Christian Apfelbacher, Marina Atanaskovic-Markovic, Uwe Berger, Michael S Blaiss, Simon Blank, Elisa Boni, Matteo Bonini, Jean Bousquet, Knut Brockow, Jeroen Buters, Victoria Cardona, Jean-Christoph Caubet, Özlem Cavkaytar, Tania Elliott, Ignacio Esteban-Gorgojo, Joao A Fonseca, James Gardner, Philippe Gevaert, Ileana Ghiordanescu, Peter Hellings, Karin Hoffmann-Sommergruber, A Fusun Kalpaklioglu, Farid Marmouz, Ángela Meijide Calderón, Ralph Mösges, Alla Nakonechna, Markus Ollert, José Oteros, Giovanni Pajno, Catalina Panaitescu, Daniel Perez-Formigo, Oliver Pfaar, Constantinos Pitsios, Michael Rudenko, Dermot Ryan, Silvia Sánchez-García, Jennifer Shih, Salvatore Tripodi, Lauri-Ann Van der Poel, Harmieke van Os-Medendorp, Gilda Varricchi, Jörn Wittmann, Margitta Worm, Ioana Agache,

Mobile health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health-related services, data and information flow, patient self-management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task ... Read more >>

Allergy (Allergy)
[2020, 75(2):259-272]

Cited: 1 time

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Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.

J Jean Bousquet, Holger J Schünemann, Alkis Togias, Marina Erhola, Peter W Hellings, Torsten Zuberbier, Ioana Agache, Ignacio J Ansotegui, Josep M Anto, Claus Bachert, Sven Becker, Martin Bedolla-Barajas, Michael Bewick, Sinthia Bosnic-Anticevich, Isabelle Bosse, Louis P Boulet, Jean Marc Bourrez, Guy Brusselle, Niels Chavannes, Elisio Costa, Alvaro A Cruz, Wienczyslawa Czarlewski, Wytske J Fokkens, Joao A Fonseca, Mina Gaga, Tari Haahtela, Maddalena Illario, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, L T T Le, Desiree Larenas-Linnemann, Daniel Laune, Olga M Lourenço, Enrica Menditto, Joaquin Mullol, Yashitaka Okamoto, Nikos Papadopoulos, Nhân Pham-Thi, Robert Picard, Hilary Pinnock, Nicolas Roche, Regina E Roller-Wirnsberger, Christine Rolland, Boleslaw Samolinski, Aziz Sheikh, Sanna Toppila-Salmi, Ioanna Tsiligianni, Arunas Valiulis, Erkka Valovirta, Tuula Vasankari, Maria-Teresa Ventura, Samantha Walker, Sian Williams, Cezmi A Akdis, Isabella Annesi-Maesano, Sylvie Arnavielhe, Xavier Basagana, Eric Bateman, Anna Bedbrook, K S Bennoor, Samuel Benveniste, Karl C Bergmann, Slawomir Bialek, Nils Billo, Carsten Bindslev-Jensen, Leif Bjermer, Hubert Blain, Mateo Bonini, Philippe Bonniaud, Jacques Bouchard, Vitalis Briedis, Christofer E Brightling, Jan Brozek, Roland Buhl, Roland Buonaiuto, Giorgo W Canonica, Victoria Cardona, Ana M Carriazo, Warner Carr, Christine Cartier, Thomas Casale, Lorenzo Cecchi, Alfonso M Cepeda Sarabia, Eka Chkhartishvili, Derek K Chu, Cemal Cingi, Elaine Colgan, Jaime Correia de Sousa, Anne Lise Courbis, Adnan Custovic, Biljana Cvetkosvki, Gennaro D'Amato, Jane da Silva, Carina Dantas, Dejand Dokic, Yves Dauvilliers, Antoni Dedeu, Giulia De Feo, Philippe Devillier, Stefania Di Capua, Marc Dykewickz, Ruta Dubakiene, Motohiro Ebisawa, Yaya El-Gamal, Esben Eller, Regina Emuzyte, John Farrell, Antjie Fink-Wagner, Alessandro Fiocchi, Jean F Fontaine, Bilun Gemicioğlu, Peter Schmid-Grendelmeir, Amiran Gamkrelidze, Judith Garcia-Aymerich, Maximiliano Gomez, Sandra González Diaz, Maia Gotua, Nick A Guldemond, Maria-Antonieta Guzmán, Jawad Hajjam, John O'B Hourihane, Marc Humbert, Guido Iaccarino, Despo Ierodiakonou, Maddalena Illario, Juan C Ivancevich, Guy Joos, Ki-Suck Jung, Marek Jutel, Igor Kaidashev, Omer Kalayci, Przemyslaw Kardas, Thomas Keil, Mussa Khaitov, Nikolai Khaltaev, Jorg Kleine-Tebbe, Marek L Kowalski, Vicky Kritikos, Inger Kull, Lisa Leonardini, Philip Lieberman, Brian Lipworth, Karin C Lodrup Carlsen, Claudia C Loureiro, Renaud Louis, Alpana Mair, Gert Marien, Bassam Mahboub, Joao Malva, Patrick Manning, Esteban De Manuel Keenoy, Gailen D Marshall, Mohamed R Masjedi, Jorge F Maspero, Eve Mathieu-Dupas, Poalo M Matricardi, Eric Melén, Elisabete Melo-Gomes, Eli O Meltzer, Enrica Menditto, Jacques Mercier, Neven Miculinic, Florin Mihaltan, Branislava Milenkovic, Giuliana Moda, Maria-Dolores Mogica-Martinez, Yousser Mohammad, Steve Montefort, Ricardo Monti, Mario Morais-Almeida, Ralf Mösges, Lars Münter, Antonella Muraro, Ruth Murray, Robert Naclerio, Luigi Napoli, Leila Namazova-Baranova, Hugo Neffen, Kristoff Nekam, Angelo Neou, Enrico Novellino, Dieudonné Nyembue, Robin O'Hehir, Ken Ohta, Kimi Okubo, Gabrielle Onorato, Solange Ouedraogo, Isabella Pali-Schöll, Susanna Palkonen, Peter Panzner, Hae-Sim Park, Jean-Louis Pépin, Ana-Maria Pereira, Oliver Pfaar, Ema Paulino, Jim Phillips, Robert Picard, Davor Plavec, Ted A Popov, Fabienne Portejoie, David Price, Emmanuel P Prokopakis, Benoit Pugin, Filip Raciborski, Rojin Rajabian-Söderlund, Sietze Reitsma, Xavier Rodo, Antonino Romano, Nelson Rosario, Menahenm Rottem, Dermot Ryan, Johanna Salimäki, Mario M Sanchez-Borges, Juan-Carlos Sisul, Dirceu Solé, David Somekh, Talant Sooronbaev, Milan Sova, Otto Spranger, Cristina Stellato, Rafael Stelmach, Charlotte Suppli Ulrik, Michel Thibaudon, Teresa To, Ana Todo-Bom, Peter V Tomazic, Antonio A Valero, Rudolph Valenta, Marylin Valentin-Rostan, Rianne van der Kleij, Olivier Vandenplas, Giorgio Vezzani, Frédéric Viart, Giovanni Viegi, Dana Wallace, Martin Wagenmann, De Y Wang, Susan Waserman, Magnus Wickman, Dennis M Williams, Gary Wong, Piotr Wroczynski, Panayiotis K Yiallouros, Arzu Yorgancioglu, Osman M Yusuf, Heahter J Zar, Stéphane Zeng, Mario Zernotti, Luo Zhang, Nan S Zhong, Mihaela Zidarn, , ,

Background:In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body:As an example ... Read more >>

Clin Transl Allergy (Clinical and Translational Allergy)
[2019, 9:44]

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Severe asthma phenotypes and endotypes.

Ioana Agache,

Current management of severe asthma relying either on guidelines (bulk approach) or on disease phenotypes (stratified approach) did not improve the burden of the disease. Several severe phenotypes are described: clinical, functional, morphological, inflammatory, molecular and microbiome-related. However, phenotypes do not necessarily relate to or give insights into the underlying ... Read more >>

Semin. Immunol. (Seminars in immunology)
[2019, 46:101301]

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Next-generation care pathways for allergic rhinitis and asthma multimorbidity: a model for multimorbid non-communicable diseases-Meeting Report (Part 2).

Jean Bousquet, Nhân Pham-Thi, Anna Bedbrook, Ioana Agache, Isabella Annesi-Maesano, Ignacio Ansotegui, Josep M Anto, Claus Bachert, Samuel Benveniste, Mike Bewick, Nils Billo, Sinthia Bosnic-Anticevich, Isabelle Bosse, Guy Brusselle, Moïses A Calderon, G Walter Canonica, Luis Caraballo, Victoria Cardona, Ana Maria Carriazo, Eugene Cash, Lorenzo Cecchi, Derek K Chu, Elaine Colgan, Elisio Costa, Alvaro A Cruz, Wienczyslawa Czarlewski, Stephen Durham, Motohiro Ebisawa, Marina Erhola, Jean-Luc Fauquert, Wytske J Fokkens, Joao A Fonseca, Nick Guldemond, Tomohisa Iinuma, Maddalena Illario, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, Désirée Larenas-Linneman, Daniel Laune, Lan T T Le, Olga Lourenço, Joao O Malva, Gert Marien, Enrica Menditto, Joaquim Mullol, Lars Münter, Yoshitaka Okamoto, Gabrielle L Onorato, Nikos G Papadopoulos, Maritta Perala, Oliver Pfaar, Abigail Phillips, Jim Phillips, Hilary Pinnock, Fabienne Portejoie, Pablo Quinones-Delgado, Christine Rolland, Ulysse Rodts, Boleslaw Samolinski, Mario Sanchez-Borges, Holger J Schünemann, Mohamed Shamji, David Somekh, Alkis Togias, Sanna Toppila-Salmi, Ioanna Tsiligianni, Omar Usmani, Samantha Walker, Dana Wallace, Arunas Valiulis, Rianne Van der Kleij, Maria Teresa Ventura, Sian Williams, Arzu Yorgancioglu, Torsten Zuberbier,

J Thorac Dis (Journal of Thoracic Disease)
[2019, 11(9):4072-4084]

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Biologicals in allergic diseases and asthma: Toward personalized medicine and precision health: Highlights of the 3rd EAACI Master Class on Biologicals, San Lorenzo de El Escorial, Madrid, 2019.

Oscar Palomares, Eva Untersmayr, Jan Gutermuth, Ioana Agache, Sofia Ajeganova, Sevim Bavbek, Susan Chan, Marek Jutel, Santiago Quirce, Peter Schmid-Grendelmeier, Carsten Schmidt-Weber, María José Torres, Thomas Eiwegger,

Allergy (Allergy)
[2020, 75(4):936-940]

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2019 ARIA Care pathways for allergen immunotherapy.

Jean Bousquet, Oliver Pfaar, Alkis Togias, Holger J Schünemann, Ignacio Ansotegui, Nikolaos G Papadopoulos, Ioanna Tsiligianni, Ioana Agache, Josep M Anto, Claus Bachert, Anna Bedbrook, Karl-Christian Bergmann, Sinthia Bosnic-Anticevich, Isabelle Bosse, Jan Brozek, Moises A Calderon, Giorgio W Canonica, Luigi Caraballo, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Derek Chu, Elisio Costa, Alvaro A Cruz, Wienczyslawa Czarlewski, Stephen R Durham, George Du Toit, Mark Dykewicz, Motohiro Ebisawa, Jean Luc Fauquert, Montserrat Fernandez-Rivas, Wytske J Fokkens, João Fonseca, Jean-François Fontaine, Roy Gerth van Wijk, Tari Haahtela, Susanne Halken, Peter W Hellings, Despo Ierodiakonou, Tomohisa Iinuma, Juan Carlos Ivancevich, Lars Jacobsen, Marek Jutel, Igor Kaidashev, Musa Khaitov, Omer Kalayci, Jörg Kleine Tebbe, Ludger Klimek, Marek L Kowalski, Piotr Kuna, Violeta Kvedariene, Stefania La Grutta, Désirée Larenas-Linemann, Susanne Lau, Daniel Laune, Lan Le, Karin Lodrup Carlsen, Olga Lourenço, Hans-Jørgen Malling, Gert Marien, Enrica Menditto, Gregoire Mercier, Joaquim Mullol, Antonella Muraro, Robyn O'Hehir, Yoshitaka Okamoto, Giovanni B Pajno, Hae-Sim Park, Petr Panzner, Giovanni Passalacqua, Nhan Pham-Thi, Graham Roberts, Ruby Pawankar, Christine Rolland, Nelson Rosario, Dermot Ryan, Bolesław Samolinski, Mario Sanchez-Borges, Glenis Scadding, Mohamed H Shamji, Aziz Sheikh, Gunter J Sturm, Ana Todo Bom, Sanna Toppila-Salmi, Maryline Valentin-Rostan, Arunas Valiulis, Erkka Valovirta, Maria-Teresa Ventura, Ulrich Wahn, Samantha Walker, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Torsten Zuberbier, ,

Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides ... Read more >>

Allergy (Allergy)
[2019, 74(11):2087-2102]

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Peptide allergen immunotherapy-unraveling new pathways.

Ioana Agache,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(3):658-660]

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Changing the history of anaphylaxis mortality statistics through the World Health Organization's International Classification of Diseases-11.

Luciana Kase Tanno, Robert Chalmers, Ana Luiza Bierrenbach, F Estelle R Simons, Bryan Martin, Nicolas Molinari, Isabella Annesi-Maesano, Margitta Worm, Victoria Cardona, Nikolaos G Papadopoulos, Mario Sanchez-Borges, Lanny J Rosenwasser, Ignacio Ansontegui, Motohiro Ebisawa, Juan Carlos Sisul, Edgardo Jares, Maximiliano Gomez, Ioana Agache, Peter Hellings, Antonella Muraro, Francis Thien, Ruby Pawankar, James L Sublett, Thomas Casale, Pascal Demoly, ,

We review the history of the classification and coding changes for anaphylaxis and provide current and perspective information in the field. In 2012, an analysis of Brazilian data demonstrated undernotification of anaphylaxis-related deaths because of the difficulties of coding using the International Classification of Diseases, 10th Revision. This work triggered ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(3):627-633]

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Severe asthma: Entering an era of new concepts and emerging therapies: Highlights of the 4th international severe asthma forum, Madrid, 2018.

Sven F Seys, Santiago Quirce, Ioana Agache, Cezmi A Akdis, Montserrat Alvaro-Lozano, Dario Antolín-Amérigo, Leif Bjermer, Irina Bobolea, Matteo Bonini, Apostolos Bossios, Paul Brinkman, Andy Bush, Moises Calderon, Walter Canonica, Psacal Chanez, Mariana Couto, Ignacio Davila, Stefano Del Giacco, Victoria Del Pozo, Jonas S Erjefält, Philippe Gevaert, Paul Hagedoorn, Liam G Heaney, Enrico Heffler, Peter W Hellings, Marek Jutel, Omer Kalayci, Marcin Maciej Kurowski, Stelios Loukides, Parameswaran Nair, Oscar Palomares, Eva Polverino, Silvia Sanchez-Garcia, Joaquin Sastre, Jürgen Schwarze, Antonio Spanevello, Charlotte S Ulrik, Omar Usmani, Maarten Van den Berge, Martina Vasakova, Susanne Vijverberg, Zuzana Diamant,

Allergy (Allergy)
[2019, 74(11):2244-2248]

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