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Author Ingrid Libman

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The Effect of Ethnicity in the Rate of Beta Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis.

Mustafa Tosur, Mario A Cleves, Jay M Sosenko, Ingrid Libman, David A Baidal, Ashok Balasubramanyam, Maria J Redondo, ,

OBJECTIVE:We set forth to compare ethnicities for metabolic and immunological characteristics at the clinical diagnosis of type 1 diabetes (T1D), and assess the effect of ethnicity on beta cell functional loss within three years after clinical diagnosis. RESEARCH METHODS AND DESIGN:We studied participants in TrialNet New Onset Intervention Trials (n=624, ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, :]

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Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance.

Maria J Redondo, Jay Sosenko, Ingrid Libman, Jennifer J F McVean, Mustafa Tosur, Mark A Atkinson, Dorothy Becker, Susan Geyer,

CONTEXT:Multiple islet autoantibody positivity usually precedes clinical (stage 3) type 1 diabetes (T1D). OBJECTIVE:To test the hypothesis that individuals who develop stage 3 T1D with only a single autoantibody have unique metabolic differences. DESIGN:Cross-sectional analysis of participants in the T1D TrialNet study. SETTING:Autoantibody-positive relatives of individuals with stage 3 T1D. ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(5):]

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Risk Factors for Cardiovascular Disease (CVD) in Adults with Type 1 Diabetes: Findings from Prospective Real-life T1D Exchange Registry.

Viral N Shah, Ryan Bailey, Mengdi Wu, Nicole C Foster, Rodica Pop-Busui, Michelle Katz, Jill Crandall, Fida Bacha, Kristen Nadeau, Ingrid Libman, Paul Hiers, Kara Mizokami-Stout, Linda A DiMeglio, Jennifer Sherr, Richard Pratley, Shivani Agarwal, Janet Snell-Bergeon, Eda Cengiz, Sarit Polsky, Sanjeev N Mehta,

CONTEXT:Cardiovascular disease (CVD) is a major cause of mortality in adults with type 1 diabetes. OBJECTIVE:We prospectively evaluated CVD risk factors in a large, contemporary cohort of adults with type 1 diabetes living in the United States. DESIGN:Observational study of CVD and CVD risk factors over a median of 5.3 ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(5):]

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Modern diabetes devices in the school setting: Perspectives from school nurses.

Christine A March, Michelle Nanni, Traci M Kazmerski, Linda M Siminerio, Elizabeth Miller, Ingrid M Libman,

OBJECTIVE:To explore the experiences, practices, and attitudes of school nurses related to modern diabetes devices (insulin pumps, continuous glucose monitors, and hybrid-closed loop systems). RESEARCH DESIGN AND METHODS:Semistructured interviews were conducted with 40 public school nurses caring for children in elementary and middle schools. Developed with stakeholder input, the interview ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, 21(5):832-840]

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Erratum. Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention. Diabetes Care 2019;42:2228-2236.

Emily K Sims, Susan Geyer, Suzanne Bennett Johnson, Ingrid Libman, Laura M Jacobsen, David Boulware, Lisa E Rafkin, Della Matheson, Mark A Atkinson, Henry Rodriguez, Maria Spall, Helena Elding Larsson, Diane K Wherrett, Carla J Greenbaum, Jeffrey Krischer, Linda A DiMeglio, ,

Diabetes Care (Diabetes care)
[2020, 43(4):934]

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The Contemporary Prevalence of Diabetic Neuropathy in Type 1 Diabetes: Findings From the T1D Exchange.

Kara R Mizokami-Stout, Zoey Li, Nicole C Foster, Viral Shah, Grazia Aleppo, Janet B McGill, Richard Pratley, Elena Toschi, Lynn Ang, Rodica Pop-Busui, , ,

OBJECTIVE:To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes in the T1D Exchange Clinic Registry throughout the U.S. RESEARCH DESIGN AND METHODS:DPN was assessed with the Michigan Neuropathy Screening Instrument Questionnaire (MNSIQ) in adults with ≥5 years of type 1 diabetes duration. A ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(4):806-812]

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Early and late C-peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody-positive individuals.

Heba M Ismail, Dorothy J Becker, Ingrid Libman, Kevan C Herold, Maria J Redondo, Mark A Atkinson, Mario A Cleves, Jerry Palmer, Jay Sosenko, ,

We examined whether the timing of the C-peptide response during an oral glucose tolerance test (OGTT) in relatives of patients with type 1 diabetes (T1D) is predictive of disease onset. We examined baseline 2-h OGTTs from 670 relatives participating in the Diabetes Prevention Trial-Type 1 (age: 13.8 ± 9.6 years; body mass index ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2020, 22(6):997-1000]

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Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

Christine Ferrara-Cook, Susan Michelle Geyer, Carmella Evans-Molina, Ingrid M Libman, Dorothy J Becker, Stephen E Gitelman, Maria Jose Redondo, ,

OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive pediatric TrialNet participants (ages 1.6-18.6 years at baseline). Cumulative ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(3):580-587]

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Longitudinal Changes in Continuous Glucose Monitoring Use Among Individuals With Type 1 Diabetes: International Comparison in the German and Austrian DPV and U.S. T1D Exchange Registries.

Kellee M Miller, Julia Hermann, Nicole Foster, Sabine E Hofer, Michael R Rickels, Thomas Danne, Mark A Clements, Eggert Lilienthal, David M Maahs, Reinhard W Holl, , ,

Diabetes Care (Diabetes care)
[2019, :]

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Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention.

Emily K Sims, Susan Geyer, Suzanne Bennett Johnson, Ingrid Libman, Laura M Jacobsen, David Boulware, Lisa E Rafkin, Della Matheson, Mark A Atkinson, Henry Rodriguez, Maria Spall, Helena Elding Larsson, Diane K Wherrett, Carla J Greenbaum, Jeffrey Krischer, Linda A DiMeglio, ,

OBJECTIVE:To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study. RESEARCH DESIGN AND METHODS:We used multivariable logistic regression models to examine continued engagement of eligible participants at two time points: ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(12):2228-2236]

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Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.

Melanie Cree-Green, Bryan C Bergman, Eda Cengiz, Larry A Fox, Tamara S Hannon, Kellee Miller, Brandon Nathan, Laura Pyle, Darcy Kahn, Michael Tansey, Eileen Tichy, Eva Tsalikian, Ingrid Libman, Kristen J Nadeau,

CONTEXT:Type 1 diabetes in adolescence is characterized by insulin deficiency and insulin resistance (IR), both thought to increase cardiovascular disease risk. We previously demonstrated that adolescents with type 1 diabetes have adipose, hepatic, and muscle IR, and that metformin lowers daily insulin dose, suggesting improved IR. However, whether metformin improves ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2019, 104(8):3265-3278]

Cited: 1 time

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Biologic and social factors predict incident kidney disease in type 1 diabetes: Results from the T1D exchange clinic network.

Janet B McGill, Mengdi Wu, Rodica Pop-Busui, Kara Mizokami-Stout, William V Tamborlane, Grazia Aleppo, Rose A Gubitosi-Klug, Michael J Haller, Steven M Willi, Nicole C Foster, Chelsea Zimmerman, Ingrid Libman, Sarit Polsky, Michael R Rickels,

AIMS:Diabetic kidney disease (DKD) is a major complication of type 1 diabetes (T1D). To better understand the development of DKD in modern clinical practice, we evaluated risk factors in participants from the T1D Exchange Registry who completed 5-years of longitudinal follow-up. METHODS:Participants had T1D duration ≥ 1 year, age ≥ 10 years, eGFR ≥ 60 ml/min and no albuminuria ... Read more >>

J. Diabetes Complicat. (Journal of Diabetes and Its Complications)
[2019, 33(10):107400]

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Liraglutide in Children and Adolescents with Type 2 Diabetes.

William V Tamborlane, Margarita Barrientos-Pérez, Udi Fainberg, Helle Frimer-Larsen, Mona Hafez, Paula M Hale, Muhammad Y Jalaludin, Margarita Kovarenko, Ingrid Libman, Jane L Lynch, Paturi Rao, Naim Shehadeh, Serap Turan, Daniel Weghuber, Timothy Barrett, ,

BACKGROUND:Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in the disease. However, early loss of glycemic control has been observed with metformin monotherapy. Whether liraglutide added to metformin (with or without basal insulin treatment) is safe and effective in youth with type 2 ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(7):637-646]

Cited: 1 time

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Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Heba M Ismail, Carmella Evans-Molina, Linda A DiMeglio, Dorothy J Becker, Ingrid Libman, Emily K Sims, David Boulware, Kevan C Herold, Lisa Rafkin, Jay Skyler, Mario A Cleves, Jerry Palmer, Jay M Sosenko, ,

BACKGROUND:In new onset type 1 diabetes (T1D), overall C-peptide measures such as area under the curve (AUC) C-peptide and peak C-peptide are useful for estimating the extent of β-cell dysfunction, and for assessing responses to intervention therapy. However, measures of the timing of C-peptide responsiveness could have additional value. OBJECTIVES:We ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2019, 20(4):408-413]

Cited: 0 times

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Psychosocial predictors of diabetes risk factors and complications: An 11-year follow-up.

Vicki S Helgeson, Trevor J Orchard, Howard Seltman, Dorothy Becker, Ingrid Libman,

OBJECTIVE:The goal of this study was to use the risk and resistance framework to examine whether a set of psychosocial variables measured at age 12 in youth with Type 1 diabetes would predict the emergence of diabetes risk and complication variables 11 years and 13 years later. METHOD:We interviewed youth ... Read more >>

Health Psychol (Health psychology : official journal of the Division of Health Psychology, American Psychological Association)
[2019, 38(7):567-576]

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Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Michael J Haller, S Alice Long, J Lori Blanchfield, Desmond A Schatz, Jay S Skyler, Jeffrey P Krischer, Brian N Bundy, Susan M Geyer, Megan V Warnock, Jessica L Miller, Mark A Atkinson, Dorothy J Becker, David A Baidal, Linda A DiMeglio, Stephen E Gitelman, Robin Goland, Peter A Gottlieb, Kevan C Herold, Jennifer B Marks, Antoinette Moran, Henry Rodriguez, William E Russell, Darrell M Wilson, Carla J Greenbaum, ,

A three-arm, randomized, double-masked, placebo-controlled phase 2b trial performed by the Type 1 Diabetes TrialNet Study Group previously demonstrated that low-dose anti-thymocyte globulin (ATG) (2.5 mg/kg) preserved β-cell function and reduced HbA1c for 1 year in new-onset type 1 diabetes. Subjects (N = 89) were randomized to 1) ATG and ... Read more >>

Diabetes (Diabetes)
[2019, 68(6):1267-1276]

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Effects of Exercise Modality on Insulin Resistance and Ectopic Fat in Adolescents with Overweight and Obesity: A Randomized Clinical Trial.

SoJung Lee, Ingrid Libman, Kara Hughan, Jennifer L Kuk, Jong H Jeong, Di Zhang, Silva Arslanian,

OBJECTIVE:To examine whether a combined aerobic exercise and resistance exercise is more effective than either aerobic exercise or resistance exercise alone in improving insulin sensitivity and reducing total adiposity and ectopic fat in adolescents. STUDY DESIGN:A total of 118 sedentary adolescents with overweight/obesity (body mass index >85th percentile, 12-17 years) ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2019, 206:91-98.e1]

Cited: 2 times

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Celiac Autoimmunity Is Associated With Lower Blood Pressure and Renal Risk in Type 1 Diabetes.

Katherine V Williams, Christina L Cristaldi, Rachel G Miller, Vincent C Arena, Ingrid Libman, Yihe Huang, Dorothy J Becker, Trevor J Orchard,

Context:Though the long-term consequences of celiac disease (CD) in type 1 diabetes are unclear, CD has been associated with increased prevalence of end-stage renal disease (ESRD) independent of type 1 diabetes. Objective:We evaluated whether celiac autoimmunity is related to the cumulative incidence of microalbuminuria [albumin excretion rate (AER) 20 to ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2018, 103(10):3828-3836]

Cited: 0 times

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A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Maria J Redondo, Susan Geyer, Andrea K Steck, Seth Sharp, John M Wentworth, Michael N Weedon, Peter Antinozzi, Jay Sosenko, Mark Atkinson, Alberto Pugliese, Richard A Oram, ,

OBJECTIVE:We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS:We studied the 1,244 TrialNet Pathway to Prevention study participants (T1D patients' relatives without diabetes and with one or more positive autoantibodies) ... Read more >>

Diabetes Care (Diabetes care)
[2018, 41(9):1887-1894]

Cited: 10 times

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Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.

Taylor M Triolo, Alexandra Fouts, Laura Pyle, Liping Yu, Peter A Gottlieb, Andrea K Steck, ,

OBJECTIVE:There are variable reports of risk of concordance for progression to islet autoantibodies and type 1 diabetes in identical twins after one twin is diagnosed. We examined development of positive autoantibodies and type 1 diabetes and the effects of genetic factors and common environment on autoantibody positivity in identical twins, ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(2):192-199]

Cited: 4 times

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Response to Comment on Redondo et al. Racial/Ethnic Minority Youth With Recent-Onset Type 1 Diabetes Have Poor Prognostic Factors. Diabetes Care 2018;41:1017-1024.

Maria Jose Redondo, Ingrid Libman, Peiyao Cheng, Craig Kollman, Mustafa Tosur, Robin L Gal, Fida Bacha, Georgeanna J Klingensmith, Mark Clements, ,

Diabetes Care (Diabetes care)
[2018, 41(7):e125-e126]

Cited: 0 times

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Ethnic differences in progression of islet autoimmunity and type 1 diabetes in relatives at risk.

Mustafa Tosur, Susan M Geyer, Henry Rodriguez, Ingrid Libman, David A Baidal, Maria J Redondo, ,

AIMS/HYPOTHESIS:We hypothesised that progression of islet autoimmunity and type 1 diabetes mellitus differs among races/ethnicities in at-risk individuals. METHODS:In this study, we analysed the data from the Type 1 Diabetes TrialNet Pathway to Prevention Study. We studied 4873 non-diabetic, autoantibody-positive relatives of individuals with type 1 diabetes followed prospectively (11% ... Read more >>

Diabetologia (Diabetologia)
[2018, 61(9):2043-2053]

Cited: 2 times

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Adiposity and Asthma in a Nationwide Study of Children and Adults in the United States.

Erick Forno, Yueh-Ying Han, Ingrid M Libman, Radhika H Muzumdar, Juan C Celedón,

RATIONALE:Although obesity has been associated with asthma, body mass index is suboptimal to fully characterize adiposity. OBJECTIVES:We examined the relation between adiposity and asthma in a large sample of the U.S. population, using indices defined by dual-energy X-ray absorptiometry. METHODS:We analyzed data from 8,886 children (aged 8-19 yr) and 12,795 ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2018, 15(3):322-330]

Cited: 6 times

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Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study.

Anna E Long, Isabel V Wilson, Dorothy J Becker, Ingrid M Libman, Vincent C Arena, F Susan Wong, Andrea K Steck, Marian J Rewers, Liping Yu, Peter Achenbach, Rosaura Casas, Johnny Ludvigsson, Alistair J K Williams, Kathleen M Gillespie,

AIMS/HYPOTHESIS:Multiple islet autoimmunity increases risk of diabetes, but not all individuals positive for two or more islet autoantibodies progress to disease within a decade. Major islet autoantibodies recognise insulin (IAA), GAD (GADA), islet antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A). Here we describe the baseline characteristics of a unique cohort ... Read more >>

Diabetologia (Diabetologia)
[2018, 61(6):1484-1490]

Cited: 3 times

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Racial/Ethnic Minority Youth With Recent-Onset Type 1 Diabetes Have Poor Prognostic Factors.

Maria Jose Redondo, Ingrid Libman, Peiyao Cheng, Craig Kollman, Mustafa Tosur, Robin L Gal, Fida Bacha, Georgeanna J Klingensmith, Mark Clements, ,

To compare races/ethnicities for characteristics, at type 1 diabetes diagnosis and during the first 3 years postdiagnosis, known to influence long-term health outcomes.We analyzed 927 Pediatric Diabetes Consortium (PDC) participants <19 years old (631 non-Hispanic white [NHW], 216 Hispanic, and 80 African American [AA]) diagnosed with type 1 diabetes and ... Read more >>

Diabetes Care (Diabetes care)
[2018, 41(5):1017-1024]

Cited: 8 times

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