Full Text Journal Articles by
Author Ines Chaar

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Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Marwa Weslati, Rahma Boughriba, Abdelmajid B Hmida, Saadia Bouraoui,

Recent studies suggest that SDF-1 and CXCR4 are expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in colorectal cancer (CRC) tissue has not been fully elucidated.The purpose of this study was to assess ... Read more >>

Cancer Biomark (Cancer biomarkers : section A of Disease markers)
[2015, 15(6):869-879]

Cited: 12 times

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Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer.

Sameh Amara, Ines Chaar, Meriem Khiari, Donia Ounissi, Abdelmajid B Hmida, Sabeh Regaya Mzabi, Saadia Bouraoui,

The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from ... Read more >>

J Immunoassay Immunochem (Journal of immunoassay & immunochemistry)
[2015, 36(2):182-194]

Cited: 4 times

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Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.

Chaar Ines, Ounissi Donia, Boughriba Rahma, Azza Ben Ammar, Amara Sameh, Taher Khalfallah, Ben Hmida Abdelmajid, Mzabi Sabeh, Bouraoui Saadia,

According to the multistep route of genetic alterations in the colorectal adenoma-carcinoma sequence, the complex K-ras/p53 mutation is one of the first alterations to occur and represent an important genetic event in colorectal cancer (CRC). An evaluation of the mutation spectra in K-ras and p53 gene was effected in 167 ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(7):7163-7175]

Cited: 5 times

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Biological significance of promoter hypermethylation of p14/ARF gene: relationships to p53 mutational status in Tunisian population with colorectal carcinoma.

Ines Chaar, Sameh Amara, Olfa Elhadj Elamine, Mariem Khiari, Donia Ounissi, Taher Khalfallah, Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui,

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate whether their alterations could be considered as a predictor factor of prognosis ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2014, 35(2):1439-1449]

Cited: 13 times

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Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population.

Ines Chaar, Sameh Amara, Mariem Khiari, Donia Ounissi, Monia Dhraif, Abd E M Ben Hamida, Lassad Gharbi, Sabeh Mzabi, Saadia Bouraoui,

The prevalence of p53 mutations in colorectal cancer could reach 90%. The most important regulator of this protein that was identified originally was the Murine Double Minute2 (MDM2) oncoprotein, by which the levels of p53 were fixed through an autoregulatory feedback loop. In cancer cases, the overexpression of MDM2 deregulates ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2013, 21(3):228-236]

Cited: 2 times

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Evaluation of microsatellite instability, MLH1 expression and hMLH1 promoter hypermethylation in colorectal carcinomas among Tunisians patients.

Lilia Kria Ben Mahmoud, Amira Arfaoui, Mariem Khiari, Ines Chaar, Amine Lounis, Souraya Sammoud, Abdel Majid Ben Hmida, Lasaad Gharbi, Sabeh Regaya Mzabi, Saadia Bouraoui,

About 10% to 15% of sporadic colorectal cancers demonstrate high level of microsatellite instability that is generally associated with aberrant methylation of hMLH1 promoter.To investigate the association between MSI status, hMLH1 protein expression and methylation status of the hMLH1 promoter in a cohort of Tunisian sporadic colorectal cancer.Expression of MLH1 ... Read more >>

Tunis Med (La Tunisie medicale)
[2012, 90(8-9):646-653]

Cited: 2 times

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The prognostic value of the immunohistochemical expression and mutational pattern of the key mediator of Wnt signaling: beta-catenin in Tunisian patients with colorectal carcinoma.

Meriem Khiari, Amira Arfaoui, Lilia Kriaa, Inés Chaar, Sameh Amara, Med Amine Lounis, Souraya Sammoud, Monia Dhraeif, Lassaad Gharbi, Sabeh Mzabi-Regaya, Saadia Bouraoui,

Beta-catenin plays a critical role with E-cadherin in cell-cell adhesion and is also a key molecule of the highly conserved Wnt signaling pathway that regulates cell proliferation and differentiation. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The objective of this study was ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2012, 20(1):62-70]

Cited: 5 times

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Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population.

Ines Chaar, Toumi Amira Arfaoui, El Hadj Olfa El Amine, Lilia Ben Mahmoud, Mariem Khiari, Soraya Sammoud, Amine Lounis, Semeh Amara, Lassad Gharbi, Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui,

MDM2 was originally identified as an oncoprotein that binds to p53 and inhibits p53-mediated transactivation. Scientists have described functional single-nucleotide polymorphisms (SNP) in the MDM2 gene. They showed that the genotype of SNP 309 induces an increase in the level of MDM2 protein, which causes attenuation of the p53 pathway. ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2012, 24(3):320-327]

Cited: 11 times

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Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia.

Souraya Sammoud, Meriem Khiari, Amara Semeh, Lounis Amine, Chaar Ines, Arfaoui Amira, Kriaa Lilia, Khalfallah Taher, Mzabi Sabeh, Bouraoui Saadia,

The K-ras proto-oncogene encodes a protein (p21-ras) belonging to the family of GTP/GDP-binding proteins with GTPase activity. The activation of ras family genes plays an important role in colorectal tumorigenesis. Frequency of K-ras mutations and overexpression of the protein in colorectal cancer (CRC) vary between 14% and 50% and between ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2012, 20(2):146-152]

Cited: 7 times

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Loss of galectin-3 expression in mucinous colorectal carcinomas is associated with 5'CpG island methylation in Tunisian patients.

Lilia Kria Ben Mahmoud, Amira Arfaoui, Mariem Khiari, Ines Chaar, Olfa El Amine, Abdel Majid Ben Hmida, Lasaad Gharbi, Sabeh Regaya Mzabi, Saadia Bouraoui,

The β-galactoside-binding protein galectin-3 (gal-3) has pleitropic biological functions and has been implicated in cell growth, differentiation, adhesion, RNA processing, apoptosis, and malignant transformation. To investigate the pattern of inactivation of the gal-3 gene (LGALS3) in colorectal cancers (CRC), we studied a series of Tunisian patients with CRC to identify ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2011, 19(3):258-265]

Cited: 6 times

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The prognostic value of p73 overexpression in colorectal carcinoma: a clinicopathologic, immunohistochemical, and statistical study of 204 patients.

Amira Arfaoui Toumi, Olfa El Amine El Hadj, Lilia Kriaa Ben Mahmoud, Abd El Majid Ben Hmida, Ines Chaar, Lasaad Gharbi, Sabeh Mzabi, Saadia Bouraoui,

INTRODUCTION:The protein p73 is the first identified homolog of the tumor suppressor gene p53, but its function in tumor development has not been established. Indeed, the results regarding the p73 implication in colorectal cancers is still controversial. AIM:We investigated whether the p73 is implicated in colorectal cancer, whether the p73 ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2010, 18(2):128-136]

Cited: 6 times

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Relationship between p73 polymorphism and the immunohistochemical profile of the full-length (TAp73) and NH2-truncated (ΔNp73) isoforms in Tunisian patients.

Amira Toumi Arfaoui, Lilia Kriaa Ben Mahmoud, Abdelmajid Ben Hmida, Mariem Khiari, Amine Lounis Mohamed, Ines Chaar, Taher Khalfallah, Sabeh Mzabi Regaya, Saadia Bouraoui,

BACKGROUND:We examined the association of one linked GC/AT polymorphism at p73 with the risk of colorectal cancer. AIM:In this study, we investigated whether this polymorphism was related to the risk of colorectal cancer, and whether there were relationships between the polymorphism and loss of heterozygosity, protein expression, or clinicopathologic variables. ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2010, 18(6):546-554]

Cited: 4 times

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[P73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?].

Lilia Kria Ben Mahmoud, Amira Arfaoui Toumi, Ines Chaâr, Ahlem Lahmer, Tahar Khalfallah, Sabeh Regaya Mzabi, Saadia Bouraoui,

BACKGROUND:The p73 gene encodes a nuclear protein that is highy homologous to p53. p73 also shares some common functions with p53 protein indicating that p73 gene is a p53-like tumor suppressor. AIM:In this study, we examined by immunohistochemestry the p73 expression on 120 cases of colorectal carcinomas and evaluated its ... Read more >>

Tunis Med (La Tunisie medicale)
[2009, 87(4):267-272]

Cited: 0 times

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