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Author Incilay Lay

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Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method.

Neslihan Aksu, Afshin Samadi, Ahmet Yalçınkaya, Tuğçe Çetin, Burcu Eser, İncilay Lay, Türkan Nadir Öziş, Yeşim Öztaş, Suna Sabuncuoğlu,

Silicosis is one of the prolonged and irreversible occupational diseases. Crystalline silica dust, which has been linked with silicosis, occurs in different industrial areas such as constructions, ceramic, quarry, and pottery. There are significant numbers of newly diagnosed cases every year in Turkey. Patients with silicosis suffer from inflammatory respiratory ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, 467(1-2):117-125]

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Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot Study.

Emine Merve Savaş, Seda Hanife Oğuz, Afshin Samadi, Selen Yılmaz Işıkhan, Uğur Ünlütürk, İncilay Lay, Alper Gürlek,

Background: Apoptosis inhibitor of macrophage (AIM) and monocyte chemotactic protein-1 (MCP-1) are molecules that cause migration of M1 macrophages to visceral adipocytes, which is the first step in development of metabolic syndrome. The aim of this study is to evaluate the status of AIM and MCP-1 in metabolic syndrome and ... Read more >>

Metab Syndr Relat Disord (Metabolic syndrome and related disorders)
[2020, 18(4):197-205]

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A Comprehensive Review on Oxysterols and Related Diseases.

Afshin Samadi, Suna Sabuncuoglu, Mahshid Samadi, Selen Yilmaz Isikhan, Salvatore Chirumbolo, Massimiliano Peana, Incilay Lay, Ahmet Yalcinkaya, Ahmet Yalcinkaya, Geir Bjørklund,

The present review aims at providing a complete and comprehensive summary of current literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the formation of a large number of oxidation products, generally known as oxysterols. They are intermediates in the biosynthesis of bile acids, steroid hormones, and ... Read more >>

Curr. Med. Chem. (Current medicinal chemistry)
[2020, :]

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Plasma Ceramides and Sphingomyelins of Pediatric Patients Increase in Primary Ciliary Dyskinesia but Decrease in Cystic Fibrosis.

Dilara Bal Topçu, Gokcen Tugcu, Filiz Ozcan, Mutay Aslan, Ahmet Yalcinkaya, Sanem Eryilmaz Polat, Mina Hizal, Ebru Elmas Yalcin, Deniz Dogru Ersoz, Ugur Ozcelik, Nural Kiper, Incilay Lay, Yesim Oztas,

We investigated plasma sphingomyelin (CerPCho) and ceramide (Cer) levels in pediatric patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). Plasma samples were obtained from CF (n = 19) and PCD (n = 7) patients at exacerbation, discharge, and stable periods. Healthy children (n = 17) of similar age served as control. ... Read more >>

Lipids (Lipids)
[2020, 55(3):213-223]

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Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience.

Canan Unal, Hatice Asuman Ozkara, Atakan Tanacan, Erdem Fadiloglu, Incilay Lay, Meral Topçu, Ayse Nur Cakar, Mehmet Sinan Beksac,

Prenat. Diagn. (Prenatal diagnosis)
[2019, 39(12):1080-1085]

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Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus.

Afshin Samadi, Selen Yilmaz Isikhan, Alexey A Tinkov, Incilay Lay, Monica Daniela Doşa, Anatoly V Skalny, Margarita G Skalnaya, Salvatore Chirumbolo, Geir Bjørklund,

BACKGROUND:The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2020, 39(6):1849-1856]

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Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea.

Özden Savaş, Ahmet Emre Süslü, Incilay Lay, Serdar Özer,

PURPOSE:The relationship of plasma malondialdehyde (MDA) with major parameters of PSG was investigated to find out if there was a correlation between these variables. METHODS:Polysomnograms were done on a total of 37 adults who do not have a history of any systemic illness, smoking, and supplement use. Plasma MDA measurements ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2019, 276(12):3533-3538]

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Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study.

Yıldız Hayran, Incilay Lay, Mehmet Cem Mocan, Tuba Bozduman, Sibel Ersoy-Evans,

BACKGROUND:Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea. OBJECTIVE:This study aimed to determine the association between VEGF gene polymorphisms ... Read more >>

J. Am. Acad. Dermatol. (Journal of the American Academy of Dermatology)
[2019, 81(2):348-354]

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Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease.

Ahmet Yalcinkaya, Afshin Samadi, Incilay Lay, Selma Unal, Suna Sabuncuoglu, Yesim Oztas,

Sickle cell disease (SCD) causes anemia, oxidative stress, chronic inflammation, and lipid abnormalities. Oxysterols are oxidized derivatives of cholesterol and affect cholesterol metabolism and eryptosis. Our aim was to determine whether the plasma concentrations of 7-ketocholesterol (7-KC) and cholestane-3β,5α,6β-triol (C-triol) were associated with hemolysis and lipid profile in patients with ... Read more >>

Scand. J. Clin. Lab. Invest. (Scandinavian journal of clinical and laboratory investigation)
[2019, 79(6):381-387]

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MON-438 A Novel Insight into the Pathophysiology of Acromegalic Cardiomyopathy: Integrating Serum FSTL1 Levels and FSTL1 Polymorphisms with Cardiac MRI Findings.

Suleyman Sendur, Tuncay Hazirolan, Busra Aydin, Incilay Lay, Mehmet Alikasifoglu, Tomris Erbas,

Abstract Despite prolonged survival, the mortality rate of acromegalic patients is still higher. Cardiovascular disorders continue to be the most common cause of death. The exact pathophysiologic mechanisms of acromegalic cardiomyopathy (AC) remain to be established. In this study, we investigated the role of FSTL1 levels and gene ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

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The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β , 5α , 6β -triol and their Role in the Diagnosis of Coronary Artery Disease.

Muhammed Emin Keles, Afshin Samadi, Selen Yilmaz Isikhan, Yusuf Ziya Sener, Ali Sezgin, Emine Keles, Incilay Lay, Uğur Canpolat,

Background:Oxysterols have been shown to play a role in plaque formation while ischemia modified albumin (IMA) is widely accepted as an acute marker for ischemia. The effort test is one of the methods used to identify the presence of coronary artery disease. Thus, there may be a relationship between effort ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):249-255]

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MON-113 Taste Sensitivity is Related to Incretin Response to Oral Glucose Challenge, Dietary Habits and Body Composition: A Novel Link with Energy Metabolism.

Selcuk Dagdelen, Seyma Avci, Taha Solakoglu, Cem Simsek, Busra Firlatan, Incilay Lay, Ugur Unluturk, Aylin Acikgoz, Tomris Erbas,

AbstractIntroduction: The effects of interindividual variability of taste sensitivity on energy metabolism is not yet known. We have studied the effect of taste sensitivities on dietary habits, body composition, and incretin responses to the oral glucose challenge (OGC) in non-obese healthy subjects. Methods: Eighteen, non-smoker healthy subjects (9M/9F, age: 21.6 ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

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The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats.

Ipek Acar, Alper Cetinkaya, Incilay Lay, Esin Ileri-Gurel,

Objectives: The calcium-sensing receptor (CaSR), the major sensor of extracellular Ca2+, is expressed in various tissues, including the gastrointestinal tract. Although the essential ligand of CaSR is calcium, its activity can be regulated by aromatic L-amino acids. The expression of CaSR on enteroendocrine cells suggests that CaSR functions as a ... Read more >>

Nutr Neurosci (Nutritional neuroscience)
[2020, 23(6):481-489]

Cited: 2 times

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Screening for mucopolysaccharidoses in the Turkish population: Analytical and clinical performance of an age-range specific, dye-based, urinary glycosaminoglycan assay.

Khaled El Moustafa, Serap Sivri, Sevilay Karahan, Turgay Coşkun, Filiz Akbıyık, İncilay Lay,

Comprehensive analytical and diagnostic performance of urinary quantitative GAG analysis with dimethylmethylene blue (DMB) and the age-specific reference ranges were determined in Turkish population, which has a high incidence of MPSs. Precision, linearity, recovery and accuracy/trueness, limits, stability, and effect of interferents were tested according to CLSI guideline. Clinical performance ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2017, 464:72-78]

Cited: 1 time

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Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene.

Tuba Bozduman, Sibel Ersoy Evans, Sevilay Karahan, Yildiz Hayran, Filiz Akbiyik, Incilay Lay,

Evidence regarding the vascular endothelial growth factor A (VEGFA) as a potent mediator of angiogenesis and inflammation in psoriasis has revealed variations in this gene as surrogate markers of psoriasis.VEGFA gene polymorphisms (-1540 C/A, -1512 Ins18, -460 T/C, and +405 C/G) in psoriasis susceptibility in Turkish population were investigated.A total ... Read more >>

Ann Dermatol (Annals of dermatology)
[2016, 28(1):30-39]

Cited: 3 times

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