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Prevalence and Immunophenotypic Characteristics of Monoclonal B-Cell Lymphocytosis in Healthy Korean Individuals With Lymphocytosis.

In Young Yoo, Sung Hoan Bang, Dae Jin Lim, Seok Jin Kim, Kyunga Kim, Hee Jin Kim, Sun-Hee Kim, Duck Cho,

Epidemiological studies of monoclonal B-cell lymphocytosis (MBL) have been conducted in limited geographical regions. Little is known about the prevalence of MBL in Asia. We investigated the prevalence and immunophenotypic characteristics of MBL in Koreans who had idiopathic lymphocytosis (lymphocyte count >4.0×109/L) and were ≥40 years of age. A total ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(5):409-413]

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First Case of Bacteremia Caused by Coprobacillus catenaformis.

Won Young Heo, Jong Kwon Lee, Yoo Na Chung, In Young Yoo, On-Kyun Kang, Duk Hyun Sung, Sun Young Cho, Hee Jae Huh, Nam Yong Lee,

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(5):421-423]

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Comparison Between the SFTS-QS Kit and the PowerChek SFTSV Real-time PCR Kit for the Detection of Severe Fever With Thrombocytopenia Syndrome Virus.

In Young Yoo, Ji Youn Kim, Young Kyung Yoon, Hee Jae Huh, Nam Yong Lee,

The recent increase in severe fever with thrombocytopenia syndrome (SFTS) cases has led to the development of the SFTS-QS kit (MiCoBioMed, Seongnam, Korea) for detecting the SFTS virus (SFTSV, now renamed Huaiyangshan banyangvirus). SFTS-QS is a qualitative real-time reverse transcription PCR assay based on lab-on-a-chip technology. We evaluated the performance ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(4):317-320]

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A comprehensive analysis of adult patients with secondary hemophagocytic lymphohistiocytosis: a prospective cohort study.

Sang Eun Yoon, Yeonghee Eun, Kyungmin Huh, Chi Ryang Chung, In Young Yoo, Junhun Cho, Duck Cho, Young Hyeh Ko, Silvia Park, Won Seog Kim, Seok Jin Kim,

Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal condition with various underlying disorders in adult patients and is diagnosed based on the HLH-2004 criteria, which were established based on experience in pediatric patients. However, few studies have prospectively evaluated the treatment outcomes and diagnostic performance of HLH criteria in ... Read more >>

Ann. Hematol. (Annals of hematology)
[2020, :]

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The effectiveness of a career efficacy enhancement program for KOREAN nursing students: A quasi-experimental study.

Young-Mi Jung, In-Young Yoo,

BACKGROUND:Nursing students tend not to consider their career paths during their college years but if they enter nursing without having established a career identity during college, they will have low job satisfaction and high turnover intentions. OBJECTIVES:This study aimed to evaluate the effects of a career efficacy enhancement program on ... Read more >>

Nurse Educ Today (Nurse education today)
[2020, 89:104423]

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Diagnostic Performance of the GENEDIA MTB/NTM Detection Kit for Detecting Mycobacterium tuberculosis and Nontuberculous Mycobacteria With Sputum Specimens.

Sunghwan Shin, In Young Yoo, Hyang Jin Shim, On Kyun Kang, Byung Woo Jhun, Won Jung Koh, Hee Jae Huh, Nam Yong Lee,

The GENEDIA MTB/NTM Detection Kit (GENEDIA MTB/NTM; Green Cross Medical Science Corp., Chungbuk, Korea) is a multiplex real-time PCR assay used for differential identification of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacteria (NTM). While the importance of differential identification of MTB/NTM is recognized, there is limited data on the performance ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(2):169-173]

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Evaluation of the BioFire FilmArray Pneumonia Panel for rapid detection of respiratory bacterial pathogens and antibiotic resistance genes in sputum and endotracheal aspirate specimens.

In Young Yoo, Kyungmin Huh, Hyang Jin Shim, Sun Ae Yun, Yoo Na Chung, On Kyun Kang, Hee Jae Huh, Nam Yong Lee,

OBJECTIVES:The performance of the investigational-use-only version of the BioFire FilmArray Pneumonia Panel (FA-Pneumo), a high-order nested multiplex PCR, was evaluated for the detection of typical respiratory bacterial pathogens and antibiotic resistance genes in sputa and endotracheal aspirate (ETA) specimens. METHODS:Thirty-one sputa and 69 ETA specimens were analyzed. The diagnostic performance ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 95:326-331]

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Comparison of 16S Ribosomal RNA Targeted Sequencing and Culture for Bacterial Identification in Normally Sterile Body Fluid Samples: Report of a 10-Year Clinical Laboratory Review.

In Young Yoo, On Kyun Kang, Myoung Keun Lee, Yae Jean Kim, Sun Young Cho, Kyungmin Huh, Cheol In Kang, Doo Ryeon Chung, Kyong Ran Peck, Hee Jae Huh, Nam Yong Lee,

As 16S ribosomal RNA (rRNA)-targeted sequencing can detect DNA from non-viable bacteria, it can be used to identify pathogens from clinical samples even in patients pretreated with antibiotics. We compared the results of 16S rRNA-targeted sequencing and culture for identifying bacterial species in normally sterile body fluid (NSBF): cerebrospinal, pericardial, ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(1):63-67]

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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System.

In Young Yoo, On Kyun Kang, Hyang Jin Shim, Hee Jae Huh, Nam Yong Lee,

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK 2 system (bioMérieux, Marcy-l'Étoile, France). Twenty-seven MRSA isolates from 14 patients exhibiting linezolid MICs ≥8 μg/mL were examined by broth ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(1):57-62]

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Intermittent Treatment with Azithromycin and Ethambutol for Noncavitary Mycobacterium avium Complex Pulmonary Disease.

Seong Mi Moon, In Young Yoo, Hee Jae Huh, Nam Yong Lee, Byung Woo Jhun,

We evaluated the efficacy of intermittent azithromycin and ethambutol therapy for noncavitary Mycobacterium avium complex pulmonary disease (MAC-PD). Twenty-nine (76%) of 38 patients achieved sputum culture conversion after 12 months of treatment, and sputum smear positivity was an independent factor for failure to achieve culture conversion (adjusted odds ratio, 26.7; 95% ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 64(1):]

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First Isolation of Mycobacterium virginiense From a Human Pulmonary Specimen.

Jaewan Jung, In Young Yoo, Byung Woo Jhun, Won Jung Koh, Nam Yong Lee, Hee Jae Huh,

Ann Lab Med (Annals of laboratory medicine)
[2019, 39(6):596-598]

Cited: 1 time

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Flow Cytometric Analysis of T Cells in Hemophagocytic Lymphohistiocytosis.

Min Seung Park, In Young Yoo, Hee Jin Kim, Sun Hee Kim, Seok Jin Kim, Duck Cho,

BACKGROUND:T cell immunophenotypes in patients with hemophagocytic lymphohistiocytosis (HLH) have been described. Downregulation of CD5 or CD7 on T cells has been reported in patients with Epstein-Barr virus (EBV)-positive HLH. As the utility of T cell immunophenotypes as an adjunctive diagnostic or a prognostic marker for HLH has not been ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2019, 39(5):430-437]

Cited: 1 time

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GenoType NTM-DR Performance Evaluation for Identification of Mycobacterium avium Complex and Mycobacterium abscessus and Determination of Clarithromycin and Amikacin Resistance.

Hee Jae Huh, Su-Young Kim, Hyang Jin Shim, Dae Hun Kim, In Young Yoo, On-Kyun Kang, Chang-Seok Ki, So Youn Shin, Byung Woo Jhun, Sung Jae Shin, Charles L Daley, Won-Jung Koh, Nam Yong Lee,

We evaluated the GenoType NTM-DR (NTM-DR) line probe assay for identifying Mycobacterium avium complex (MAC) species and Mycobacterium abscessus subspecies and for determining clarithromycin and amikacin resistance. Thirty-eight reference strains and 145 clinical isolates (58 MAC and 87 M. abscessus isolates), including 54 clarithromycin- and/or amikacin-resistant strains, were involved. The ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2019, 57(8):]

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Evaluation of Stability of Thiopurine Metabolites Using a Validated LC-MS/MS Method.

In Young Yoo, Kyunghoon Lee, Ok Ja Ji, Hye In Woo, Soo Youn Lee,

Measurement of thiopurine metabolites is helpful to monitor adverse effects and assess compliance in patients on thiopurine treatment. The purpose of this study was to develop and validate an analytical method for measurement of thiopurine metabolites, thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine nucleotide (6-MMPN), in RBCs. We developed and validated a ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2018, 38(3):255-260]

Cited: 1 time

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Rapid and label-free identification of individual bacterial pathogens exploiting three-dimensional quantitative phase imaging and deep learning

Geon Kim, Daewoong Ahn, Minhee Kang, YoungJu Jo, Donghun Ryu, Hyeonjung Kim, Jinyeop Song, Jea Sung Ryu, Gunho Choi, Hyun Jung Chung, Kyuseok Kim, Doo Ryeon Chung, In Young Yoo, Hee Jae Huh, Hyunseok Min, Nam Yong Lee, YongKeun Park,

ABSTRACT For appropriate treatments of infectious diseases, rapid identification of the pathogens is crucial. Here, we developed a rapid and label-free method for identifying common bacterial pathogens as individual bacteria by using three-dimensional quantitative phase imaging and deep learning. We achieved 95% accuracy in classifying 19 bacterial species by exploiting ... Read more >>

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Simultaneous Detection of Clostridioides difficile Glutamate Dehydrogenase and Toxin A/B: Comparison of the C. DIFF QUIK CHEK COMPLETE and RIDASCREEN Assays.

In Young Yoo, Dong Joon Song, Hee Jae Huh, Nam Yong Lee,

Various commercial assays have recently been developed for detecting glutamate dehydrogenase (GDH) and/or toxin A/B to diagnose Clostridioides difficile infection (CDI). We compared the performance of two assays for the simultaneous detection of C. difficile GDH and toxin A/B, using 150 stool samples: C. DIFF QUIK CHEK COMPLETE (QCC; TechLab, ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2019, 39(2):214-217]

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Advantages of the AdvanSure MDR-TB GenoBlot assay containing disputed rpoB mutation-specific probes in a routine clinical laboratory setting.

In Young Yoo, Hee Jae Huh, On-Kyun Kang, Byung Woo Jhun, Won-Jung Koh, Nam Yong Lee,

BACKGROUND:The AdvanSure MDR-TB GenoBlot Assay detects isoniazid- and rifampin-resistant tuberculosis using mutation-specific probes, including probes to disputed rpoB mutations. The aim of this study was to evaluate the clinical usefulness of molecular drug susceptibility testing (DST) using the AdvanSure assay with weekly batch testing in routine clinical laboratory settings in ... Read more >>

Respir Med (Respiratory medicine)
[2019, 146:71-75]

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A Case of Cruoricaptor ignavus Isolated From the Blood of a Patient With Ewing Sarcoma.

Jongwon Oh, In Young Yoo, Dong Joon Song, Ji Won Lee, Yae Jean Kim, Chang Seok Ki, Nam Yong Lee, Hee Jae Huh,

Ann Lab Med (Annals of laboratory medicine)
[2018, 38(6):613-615]

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Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates.

Su-Young Kim, Byung Woo Jhun, Seong Mi Moon, Sun Hye Shin, Kyeongman Jeon, O Jung Kwon, In Young Yoo, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L Daley, Gee Young Suh, Won-Jung Koh,

Data on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and the Mycobacterium abscessus complex (MABC) are limited. In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 MAC or MABC clinical isolates, including 72 moxifloxacin-resistant ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2018, 62(9):]

Cited: 1 time

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Performance evaluation of the QMAC-dRAST for staphylococci and enterococci isolated from blood culture: a comparative study of performance with the VITEK-2 system.

Hee Jae Huh, Dong Joon Song, Hyang Jin Shim, Won Kyung Kwon, Min-Seung Park, Mi Ra Ryu, Eun Hye Cho, Jongwon Oh, In Young Yoo, Nam Yong Lee,

Objectives:To evaluate the performance of a rapid antimicrobial susceptibility testing (AST) platform based on microfluidic chip technology, the QMAC-dRAST, which enables AST from colony isolates or positive blood culture broth (PBCB), and to compare the performance of the QMAC-dRAST for staphylococci and enterococci with that of the VITEK-2 system based ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2018, 73(5):1267-1271]

Cited: 2 times

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Novel 4-bp Intronic Deletion (c.1560+5_1560+8del) [corrected] in LEMD3 in a Korean Patient With Osteopoikilosis.

In Young Yoo, Ju Sun Song, Chang Seok Ki, Jong Won Kim, Hoon Suk Cha, Yong Ki Min,

Osteopoikilosis is an autosomal dominant bone disorder characterized by symmetric multiple osteosclerotic lesions throughout the axial and appendicular skeleton. Pathogenic variants in the LEMD3 have been identified as the cause of osteopoikilosis. LEMD3 encodes an inner nuclear membrane protein that interacts with bone morphogenetic protein (BMP) and transforming growth factor ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2017, 37(6):540-543]

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Performance of an Automated Fluorescence Antinuclear Antibody Image Analyzer.

In Young Yoo, Jong Won Oh, Hoon Suk Cha, Eun Mi Koh, Eun Suk Kang,

The gold standard for antinuclear antibody (ANA) screening is the indirect immunofluorescence (IIF) assay with human epithelial cells (HEp-2). However, a number of substantial disadvantages of manual IIF assays have highlighted the need for the automation and standardization of fluorescent ANA (FANA) testing. We evaluated the performance of EUROPattern Suite ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2017, 37(3):240-247]

Cited: 3 times

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Comparison of BacT/Alert FAN and FAN Plus Bottles with Conventional Medium for Culturing Cerebrospinal Fluid.

In Young Yoo, Sejong Chun, Dong Joon Song, Hee Jae Huh, Nam Yong Lee,

We compared the BacT/Alert system FAN and FAN Plus media to conventional media for culturing cerebrospinal fluid (CSF) with 2,545 samples. FAN/FAN Plus bottles showed better performance for isolating microorganisms in CSF than conventional media (positive rate, 7.2% [182/2,545] versus 3.1% [80/2,545]). The incremental recovery rate of Cryptococcus neoformans from ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2016, 54(11):2837-2840]

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The effects of mobile applications in cardiopulmonary assessment education.

In-Young Yoo, Young-Mi Lee,

Mobile applications can be used as effective simulations for nursing education. However, little is known regarding the effects of mobile application-mediated training on nursing. The aim of this study was to determine the effectiveness of mobile applications by comparing the effectiveness of a high-fidelity human patient simulator to that of ... Read more >>

Nurse Educ Today (Nurse education today)
[2015, 35(2):e19-23]

Cited: 6 times

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Syntheses, structures, and magnetic characterizations of cyanide-bridged Fe(III)Mn(III) chains constructed by mer-Fe(III)tricyanide and Mn(III) Schiff bases: magnetostructural relationship.

In Young Yoo, Dae Won Ryu, Jung Hee Yoon, Ah Ram Sohn, Kwang Soo Lim, Beong Ki Cho, Eui Kwan Koh, Chang Seop Hong,

Five Fe(III)Mn(III) bimetallic compounds [Fe(iqc)(CN)(3)][Mn(5-Xsalen)]·pMeOH·qMeCN·rH(2)O [Hiqc = N-(quinolin-8-yl)isoquinoline-1-carboxamide; salen = N,N'-ethylenebis(salicylideneiminato) dianion; X = H(2), F(3, 3a), Cl(4), Br(5)] were prepared by assembling a newly designed mer-Fe tricyanide (Ph(4)P)[Fe(iqc)(CN)(3)]·0.5H(2)O (1) and the respective Mn Schiff bases Mn(5-Xsalen)(+). Compounds 2-4 show linear chain structures in which trans-positioned cyanides of the Fe ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2012, 41(6):1776-1785]

Cited: 5 times

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