Full Text Journal Articles by
Author Imtiaz Mahmood Tahir

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Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review.

Muhammad Jahangeer, Zahed Mahmood, Naveed Munir, Umm-E-Amara Waraich, Imtiaz Mahmood Tahir, Muhammad Akram, Syed Muhammad Ali Shah, Syed Muhammad Ali Shah, Ayesha Zulfqar, Rida Zainab,

Naegleria fowleri, a thermophilic flagellate amoeba known as a "brain-eating" amoeba, is the aetiological agent of a perilous and devastating waterborne disease known as primary amoebic meningoencephalitis (PAM), both in humans as well as in animals. PAM is a rare but fatal disease affecting young adults all around the world, ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, 47(2):199-212]

Cited: 1 time

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Role of medicinal plants in HIV/AIDS therapy.

Umme Laila, Muhammad Akram, Mohammad Ali Shariati, Asif Mehmmod Hashmi, Naheed Akhtar, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Naveed Munir, Muhammad Riaz, Naheed Akhter, Ghazala Shaheen, Qamar Ullah, Rabia Zahid, Saeed Ahmad,

Human immunodeficiency virus (HIV) causes the potentially life-threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2019, 46(12):1063-1073]

Cited: 1 time

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Disposition kinetics, renal clearance and urinary excretion of cefixime in adolescent Pakistani boys - DRUG ANALYSIS REPORT.

Muhammad Waqas Khadam, Muhammad Mudassar Ashraf, Umbreen Naz, Nadeem Irfan Bukhari, Imtiaz Mahmood Tahir, Dawood Asghar,

OBJECTIVE:To investigate the role of environmental variation, genetic differences and age on disposition kinetics, renal clearance and urinary excretion of oral cefixime 400mg in healthy boys. METHODS:The cross-sectional study was conducted at the University of Agriculture, Faisalabad, Pakistan, from August 2014 to July 2015, and comprised healthy boys aged 12-17 ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2019, 69(3):367-372]

Cited: 0 times

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Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review.

Ghazala Shaheen, Muhammad Akram, Farhat Jabeen, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Daniyal, Muhammad Riaz, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Sabira Sultana, Rida Zainab, Muslim Khan,

Urinary tract infection (UTI) is one of the most severe public health problem affecting both sexes but females are more susceptible due to the differences in urogenital and reproductive anatomy, physiology and lifestyle. As in UTI, different parts of the urinary tract are affected and morbidity due to UTI is ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2019, 46(7):613-624]

Cited: 1 time

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Hexose monophosphate shunt, the role of its metabolites and associated disorders: A review.

Muhammad Akram, Syed Muhammad Ali Shah, Naveed Munir, Muhammad Daniyal, Imtiaz Mahmood Tahir, Zahed Mahmood, Muhammad Irshad, Muhammad Akhlaq, Sabira Sultana, Rida Zainab,

The hexose monophosphate (HMP) shunt acts as an essential component of cellular metabolism in maintaining carbon homeostasis. The HMP shunt comprises two phases viz. oxidative and nonoxidative, which provide different intermediates for the synthesis of biomolecules like nucleotides, DNA, RNA, amino acids, and so forth; reducing molecules for anabolism and detoxifying the reactive oxygen species ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, :]

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Correlation of metformin with intravenous iodinated contrast media and precautions.

Muhammad Adeel Shah, Samia Gul Niazi, Imtiaz Mahmood Tahir, Ifra Shahid, Abida Parveen, Sadia Sana, Naheed Akhter, Naila Iftikhar, Saba Ashraf, Zafaar Siddique, Yasmin Mushtaq, Muslim Khan, Muhammad Akram,

To discuss metformin and iv-contrast induced acute renal failure with its reported cases worldwide, associated risk factors and precautions that can be taken to reduce this tragedy & to address this sensitive issue to my technologist family working in clinical situations. As these studies were observational studies and just report ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2 (Supplementary)):859-863]

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Phytochemical analysis and hepatoprotective effect of polyherbal formulation on CCl4 induced hepatotoxicity in mice.

Fahad Said Khan, Muhammad Akram, Nosheen Aslam, Jawad Zaheer, Sodah Bint Mustafa, Shamaila Kausar, Abdul Hamid Khan, Iftikhar Ahmad Khan, Naveed Munir, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Aamir Sharif,

The potent phytotherapeutic modalities against the hepatotoxicity have motivated us to explore numerous plants and polyherbal preparations because conventional drug discovery is more expensive and tedious. So, this study was conducted to evaluate the hepatoprotective potential of a polyherbal formulation (PHF), comprising of Solanum nigrum, Silybum marianum, Atrmesia absinthium, Achillea ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2719-2723]

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Quality of life before and after total knee arthroplasty in clinical settings across Lahore, Pakistan.

Atzaz Moin Ul Din Shah, Farjad Afzal, Muhammad Ans, Sultan Ayaz, Samia Gul Niazi, Muhammad Asim, Imtiaz Mahmood Tahir, Muhammad Akram,

Knee osteoarthritis is a common disabling condition that affects a larger number of populations aged above 40 years and this habitually required knee arthroplasty to reinstate leg function, to improve the pain as well as to improve stability. The main objective of this study was to determine the health-related quality ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2 (Supplementary)):769-772]

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Phytochemical screening and antipyretic effects of hydroalcoholic extracts of selected medicinal plants of Rawalakot, Azad Jammu and Kashmir in albino rats.

Mahvish Ajaz, Muhammad Akram, Hafiz Muhammad Asif, Abid Hussain, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Daniyal, Fahad Said Khan,

Pyrexia occurs due to infection, malignancy and other diseases. Majority of the antipyretic drugs are synthetic in nature which exerts side effects such as gastric ulcer, hepatic necrosis and renal damage. The antipyretic potential of the hydro-alcoholic extracts of Achillea millefolium, Taraxacum officinale, Salix alba and Trigonella foenum were investigated ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2):581-592]

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Prevalence and co-infection of Malaria and Typhoid in the local population of Faisalabad, Pakistan.

Hasan Abdaal Jalani, Syed Muhammad Ali Shah, Fozia Anjum, Samreen Gul Khan, Naheed Akhter, Muslim Khan, Muhammad Akram, Imtiaz Mahmood Tahir, Naveed Munir,

Malaria and typhoid fever are among the major infectious diseases which impose significant health and socioeconomic burden on affected populations. Further, co-infection and resembling symptomatology in both infections, mostly leads to misdiagnosis and mistreatment. So co-infection of malaria and typhoid fever is becoming a major issue in tropical and subtropical ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(1(Supplementary)):323-326]

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Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats.

Imtiaz Mahmood Tahir, Naheed Akhter, Abida Parveen, Huma Mehboob, Sadaf Saleem, Naveed Munir, Syed Muhammad-Ali Shah, Jawad Zaheer, Fahad Said Khan, Sabira Sultana, Muhammad Akram,

In diabetic patients, electrolyte disorders frequently occur with the characteristic changes in minerals like calcium and magnesium etc. Several medicines are used to manage diabetes mellitus but they exert adverse effects. Plants are a valuable alternative to synthetic medicines because they are easily available, economical and have fewer side effects. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(5(Supplementary)):2077-2083]

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The evaluation ofefficacy and safety of Cough (EMA) granules used for upper respiratory disorders.

Muhammad Faizan Khan, Muhammad Akram, Naheed Akhter, Muhammad Mukhtiar, Rabia Zahid, Fahad Said Khan, Muhammad Daniyal, Imtiaz Mahmood Tahir, Khalil Ahmed, Aamir Sharif, Shamaila Kausar, Syed Muhammad Ali Shah, Khan Usmanghani,

Ivy leaf is used for the treatment of respiratory diseases with the intensive mucus formation, respiratory infections, and irritating cough coming from the common cold. Conferring to clinical trials, the efficacy, and tolerability of ivy leaf is good. The main compounds accountable for biological activity are triterpene and saponins. Ivy ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2617-2622]

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Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Diabetes is a condition where the fasting blood glucose level elevated above the normal range (80-120mg/dL). This increase in blood glucose level may be due to the insulin deficiency i.e. insulin dependent diabetes mellitus (IDDM or type I) or due to insulin resistance i.e. non-insulin dependent diabetes mellitus (NIDDM or ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1539-1548]

Cited: 1 time

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Enhanced production of Lovastatin by filamentous fungi through solid state fermentation.

Shagufta Kamal, Naheed Akhter, Samreen Gul Khan, Shumaila Kiran, Tahir Farooq, Muhammad Akram, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Akhlaq, Fahad Said, Jawad Zaheer,

Lovastatin is a natural competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme-A (HMG-CoA) reductase and inhibits specifically rate limiting step in cholesterol biosynthesis. Further, lovastatin in comparison with synthetic drugs has no well-reported side effects. Four pure isolated filamentous fungal strains including Aspergillus niger IBL, Aspergillus terreus FFCBP-1053, Aspergillus flavus PML and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1583-1589]

Cited: 0 times

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Effect of caffeine on anti-clotting activity of warfarin in healthy male albino rabbits.

Shamaila Zafar, Muhammad Mudassar Ashraf, Asghar Ali, Nosheen Aslam, Asma Ashraf, Sara Zafar, Rahat Andleeb, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Daniyal,

Drug-drug interactions are most commonly occurring phenomenon in clinical practice. Many physicians are afraid of being involved in an allegation of malpractices due to the occurrence of any severe interaction. These interactions not only occur between drugs but also between any kind of food, tobacco smoke, caffeine and alcohol etc. ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(2(Suppl.)):611-616]

Cited: 0 times

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Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review.

Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob,

Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2018, 32(5):811-822]

Cited: 9 times

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Mutagenicity, cytotoxic and antioxidant activities of Ricinus communis different parts.

Mazhar Abbas, Abid Ali, Muhammad Arshad, Asia Atta, Zahed Mehmood, Imtiaz Mahmood Tahir, Munawar Iqbal,

Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. communis along with antioxidant and antimicrobial activities. Cytotoxicity was evaluated by hemolytic and brine shrimp assays, whereas Ames ... Read more >>

(Chemistry Central journal)
[2018, 12(1):3]

Cited: 1 time

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Pharmacokinetic behavior of montelukast in indigenous healthy male volunteers.

Amtul Fayyaz, Junaid Ali Khan, Muhammad Mudassar Ashraf, Naheed Akhter, Bilal Aslam, Muhammad Fiaz Khalid, Sidra Altaf, Rana Dawood Naseer, Muhammad Akram, Syed Muhammad Ali Shah, Muhammad Waqas Khadam, Imtiaz Mahmood Tahir,

Aim of present study was to investigate the pharmacokinetic behavior of Montelukast in the healthy male volunteers under indigenous conditions. One tablet of montelukast 10 mg was administered in each subject and blood at different time intervals. Concentration of montelukast in plasma samples was analyzed by high performance liquid chromatography ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(6(Supplementary)):2435-2439]

Cited: 0 times

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Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of Acetaminophen.

Huma Mehboob, Imtiaz Mahmood Tahir, Tahira Iqbal, Sadaf Saleem, Sofia Perveen, Aboubakker Farooqi,

Interindividual variability in polymorphic uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) ascribed to genetic diversity is associated with relative glucuronidation level among individuals. The present research was aimed to study the effect of 2 important single nucleotide polymorphisms (SNPs; rs8330 and rs10929303) of UGT1A1 gene on glucuronidation status of acetaminophen in healthy volunteers ... Read more >>

(Dose-response : a publication of International Hormesis Society)
[2017, 15(3):1559325817723731]

Cited: 0 times

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Therapeutic effect of atorvastatin on kidney functions and urinary excretion of Glimepiride in healthy adult human male subjects.

Tayyaba Sana, Bilal Aslam, Nosheen Aslam, Muhammad Mudassar Ashraf, Asma Ashraf, Tahir Aqeel Malik, Sammia Gul Niazi, Imtiaz Mahmood Tahir, Muhammad RiazurRehman, Hamad Ahmed,

Glimepiride and atorvastatin in combination are commonly employed for treating the hyperglycemia and dyslipidemia, respectively, in patients of type 2 diabetes. The present study was designed to find out the influence of atorvastatin on urinary excretion and renal clearance of Glimepiride in healthy adult male volunteers. In each experimental subject, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(6 Suppl):2321-2326]

Cited: 1 time

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Review-Medicinal plants and management of Diabetes Mellitus: A review.

Sodah Bint Mustafa, Zahid Mehmood, Naheed Akhter, Abida Kauser, Iqbal Hussain, Abid Rashid, Muhammad Akram, Imtiaz Mahmood Tahir, Naveed Munir, Muhammad Riaz, Samia Gul Niazi, Abid Ali, Muhammad Mudassar Ashraf, Umbreen Naz, Hammad Ahmed, S M Ali Shah, Khan Usmanghani,

Diabetes is a metabolic disorder characterized by chronic hyperglycemia and associated with dysfunction and failure of various body organs. Alarming increase in prevalence rate has made this disorder a major health problem globally. The available treatment modalities are not sufficient to combat diabetes and associated complications. A number of medicinal ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(5 Suppl):1885-1891]

Cited: 2 times

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Impact of reactive oxygen species on antioxidant capacity of male reproductive system.

Muhammad Riaz, Zahed Mahmood, Muhammad Shahid, M Usman Qamar Saeed, Imtiaz Mahmood Tahir, Sm Ali Shah, Naveed Munir, Ahmed El-Ghorab,

The present research work was aimed to study the mutual interaction of reactive oxygen species (ROS) and basal cells antioxidant capacity in the male reproductive system and to further establish the association between selected heavy metals and stress markers. Total oxidant status (TOS) and total antioxidant status (TAS) of serum ... Read more >>

Int J Immunopathol Pharmacol (International journal of immunopathology and pharmacology)
[2016, 29(3):421-425]

Cited: 3 times

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