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Advances in sustainable approaches utilizing orange peel waste to produce highly value-added bioproducts.

Ali Mohsin, Muhammad Hammad Hussain, Waqas Qamar Zaman, Muhammad Zubair Mohsin, Junhong Zhang, Zebo Liu, Xiwei Tian, Salim-Ur-Rehman, Imran Mehmood Khan, Sobia Niazi, Yingping Zhuang, Meijin Guo,

Orange peel waste (OPW), a discarded part of orange fruit, is a rich source of essential constituents that can be transformed into highly value-added bioproducts. OPW is being generated in million tonnes globally and returns to the environment without complete benefit. Thus, a high volume of annually produced OPW in ... Read more >>

Crit Rev Biotechnol (Critical reviews in biotechnology)
[2021, :1-20]

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Design, synthesis, in vitro antiproliferative evaluation and GSK-3β kinase inhibition of a new series of pyrimidin-4-one based amide conjugates.

Imran Khan, Mushtaq A Tantray, Hinna Hamid, Mohammad Sarwar Alam, Kalicharan Sharma, Prashant Kesharwani,

A new series of novel amide conjugates of pyrimidin-4-one and aromatic/heteroaromatic /secondary cyclic amines has been synthesized and their in vitro antiproliferative activities against a panel of 60 human cancer cell lines of nine different cancer types were tested at NCI. Among the synthesized compounds, compound (4i) showed significant anti-proliferative ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 119:105512]

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Research Progress in the Interconversion, Turnover and Degradation of Chlorophyll.

Xueyun Hu, Tongyu Gu, Imran Khan, Ahmad Zada, Ting Jia,

Chlorophylls (Chls, Chl <i>a</i> and Chl <i>b</i>) are tetrapyrrole molecules essential for photosynthetic light harvesting and energy transduction in plants. Once formed, Chls are noncovalently bound to photosynthetic proteins on the thylakoid membrane. In contrast, they are dismantled from photosystems in response to environmental changes or developmental processes; thus, they ... Read more >>

Cells (Cells)
[2021, 10(11):]

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Production and purification of an active CRM197 in Pichia pastoris and its immunological characterization using a Vi-typhoid antigen vaccine.

Rochelle Aw, Muktadir R Ashik, Ariful A Z M Islam, Imran Khan, Mohammad Mainuddin, Md Ashraful Islam, Mohammad M Ahasan, Karen M Polizzi,

CRM197 is a commonly used glycoconjugate carrier that improves the immunogenicity of vaccines, particularly in infants. Despite the advantages of this diphtheria toxoid mutant, low yields, production in inclusion bodies, and the requirement for specific growth conditions have limited the breadth of successful recombinant protein expression platforms available for its ... Read more >>

Vaccine (Vaccine)
[2021, :]

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Death Be Not Proud: A Commentary on Muslim Acceptance of Death in the Intensive Care Unit.

Imran Khan, Ahmed Saad,

Technologies used in medicine have meant that treatments can keep people biologically alive but often fail to provide meaningful recovery and quality of life. Many of those from the Islamic faith have relied on these technologies for recovery on religious grounds, even when it may be against clinical advice. This ... Read more >>

J Relig Health (Journal of religion and health)
[2021, :]

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Novel clinical biomarkers in blood and pleural effusion for diagnosing patients with tuberculosis distinguishing from malignant tumor

Jian Wang, Zhe-Xiang Feng, Tao Ren, Wei-Yu Meng, Imran Khan, Xing-Xing Fan, Hu-Dan Pan, Liang Liu, Yi-Jun Tang, Xiao-Jun Yao, Run-Ze Li, Mei-Fang Wang, Elaine Lai-Han Leung,

<h4>Background: </h4> Pleural effusion (PE) is a common manifestation of tuberculosis and malignant tumors, but it is difficult to distinguish tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE), especially by non-invasive detection indicators. We aimed to find effective detection indexes in blood and PE for differentiating patients with tuberculosis ... Read more >>

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Enhanced serodiagnostic potential of a fusion molecule consisting of Rv1793, Rv2628 and a truncated Rv2608 of Mycobacterium tuberculosis.

Sadaf Sulman, Saher Shahid, Aasia Khaliq, Atiqa Ambreen, Imran H Khan, Andrea M Cooper, Muhammad Waheed Akhtar,

Serodiagnosis of tuberculosis (TB) can be rapid, reliable and cost-effective if the issue of variable antibody responses of TB patients against different Mycobacterium tuberculosis (Mtb) antigens can be overcome by developing fusion proteins containing epitopes from multiple antigens of Mtb. In this study, Mtb antigens Rv1793, Rv2628, Rv2608 and a ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0258389]

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Development of Cd (II) Ion Probe Based on Novel Polyaniline-Multiwalled Carbon Nanotube-3-aminopropyltriethoxylsilane Composite.

Raja S Alruwais, Waheed A Adeosun, Amjad E Alsafrani, Hadi M Marwani, Abdullah M Asiri, Imran Khan, Mohammad Jawaid, Anish Khan,

Cadmium belongs to the group of potentially toxic metals that have high health and environmental significance. Due to its adverse effects on the environment, this study develops an effective electrochemical sensor for detecting a polyaniline-multiwalled carbon nanotube-3-aminopropyltriethoxysilane (PANI-MWCNT-APTES) substrate cast on the GCE. The as-prepared PANI-MWCNT-APTES was prepared by a ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(11):]

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Kinetically modelled approach of xanthan production using different carbon sources: A study on molecular weight and rheological properties of xanthan.

Ali Mohsin, Kanagat Akbota Akyliyaevna, Waqas Qamar Zaman, Muhammad Hammad Hussain, Muhammad Zubair Mohsin, Sarah Al-Rashed, Xin Tan, Xiwei Tian, Kistaubayeva Aida, Muhammad Tariq, Muhammad Salman Haider, Imran Mahmood Khan, Sobia Niazi, Yingping Zhuang, Meijin Guo,

The present study emphasizes improving the overall yield, productivity and quality of xanthan by Xanthomonas campestris using different carbon sources via optimizing the fermentation media and kinetic modelling work. After optimization, six carbon sources and one nitrogen source were selected for xanthan production in 5 L bioreactor. Kinetic modelling was applied ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, :]

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Recent advancements in solid-liquid triboelectric nanogenerators for energy harvesting and self-powered applications.

Subhodeep Chatterjee, Snigdha Roy Burman, Imran Khan, Subhajit Saha, Dukhyun Choi, Sangmin Lee, Zong-Hong Lin,

The abundance of water on earth provides a large window to utilize the mechanical energy within river currents and ocean waves. In this regard, hydropower harvesting through solid-liquid contact electrification has received considerable interest in the recent past. Despite advancements in nanotechnology, liquid energy harvesting devices, especially solid-liquid triboelectric nanogenerators ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(34):17663-17697]

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The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor.

Marie-Lise Lacombe, Frederic Lamarche, Olivier De Wever, Teresita Padilla-Benavides, Alyssa Carlson, Imran Khan, Anda Huna, Sophie Vacher, Claire Calmel, Céline Desbourdes, Cécile Cottet-Rousselle, Isabelle Hininger-Favier, Stéphane Attia, Béatrice Nawrocki-Raby, Joël Raingeaud, Christelle Machon, Jérôme Guitton, Morgane Le Gall, Guilhem Clary, Cedric Broussard, Philippe Chafey, Patrice Thérond, David Bernard, Eric Fontaine, Malgorzata Tokarska-Schlattner, Patricia Steeg, Ivan Bièche, Uwe Schlattner, Mathieu Boissan,

<h4>Background</h4>Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane.<h4>Results</h4>We constructed loss-of-function mutants of NDPK-D, lacking either NDP kinase activity or membrane interaction and expressed mutants or wild-type protein in cancer cells. In a complementary approach, we performed ... Read more >>

BMC Biol (BMC biology)
[2021, 19(1):228]

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Cellular antioxidant potential and inhibition of foodborne pathogens by a sesquiterpene ilimaquinone in cold storaged ground chicken and under temperature-abuse condition.

Vivek K Bajpai, Ashutosh Bahuguna, Vishal Kumar, Imran Khan, Salman H Alrokayan, Haseeb A Khan, Jesus Simal-Gandara, Jianbo Xiao, MinKyun Na, Sonam Sonwal, Hoomin Lee, Myunghee Kim, Yun Suk Huh, Young-Kyu Han, Shruti Shukla,

A sesquiterpene quinone, ilimaquinone, was accessed for its cellular antioxidant efficacy and possible antimicrobial mechanism of action against foodborne pathogens (Staphylococcus aureus and Escherichia coli) in vitro and in vivo. Ilimaquinone was found to be protective against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress as validated by the reduction in the ROS levels, including ... Read more >>

Food Chem (Food chemistry)
[2021, 373(Pt A):131392]

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Environmental quality and the asymmetrical nonlinear consequences of energy consumption, trade openness and economic development: prospects for environmental management and carbon neutrality.

Imran Khan, Hongdou Lei, Ashfaq Ahmad Shah, Inayat Khan, Khan Baz, Mansoor Ahmad Koondhar, Aseem Abu Hatab,

Economic expansion gives rise to modern and energy-efficient technologies and, thus, contributes to a decline in energy usage. Developing countries, including Pakistan, require tremendous efforts to sustain economic growth. However, to attain economic growth, these countries have to cope with greenhouse gas (GHG) emissions and other environmental problems. This research ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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"Looks Can be Deceptive" - Radicular Cyst Mimicking a Developmental Origin Cyst.

Imran Khan, Mohammad Irfan Ansari, Shahnaz Mansoori, Mohd Saalim,

<h4>Abstract</h4>Cysts of the jaws are not rare, among them the radicular cyst being the most common. It is an inflammatory type of odontogenic cyst forming as a consequence of a long-standing sequel of pulpal necrosis. In contrast to its usual location of occurrence (ie, the maxilla), herewith we report a ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2021, 32(7):e616-e618]

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A non-inferiority trial comparing two recombinant vaccines (Hepa-B vs. Engerix-B) for hepatitis B among adults in Dhaka, Bangladesh.

Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Imam Tauheed, Tasnuva Ahmed, Faisal Ahmmed, Faez Ahmed, Mahbubul Karim, Mohammad Mainul Ahasan, Masudur Rahman Mia, Mir Mohammad Ibna Masud, Abdul Wahab Khan, Muhammad Masum Billah, Zebun Nahar, Imran Khan, Md Rahad Hossain, A Z M Ariful Islam, Alex S Panday, Md Muktadir Rahman Ashik, Firdausi Qadri,

Worldwide Hepatitis B is known as one of the imperative causes of mortality and morbidity as well as occupational health hazard among health workers. Bangladesh is intermediate endemic country for Hepatitis B infection for which the government has introduced hepatitis B vaccination into the Expanded Programme on Immunization (EPI) nationwide ... Read more >>

Vaccine (Vaccine)
[2021, 39(43):6385-6390]

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Efficient Synthesis and Characterization of [email protected] Metal-Organic Frameworks Nanocomposite and Its Application for Zn(II) Ion Sensing.

Amjad E Alsafrani, Waheed A Adeosun, Hadi M Marwani, Imran Khan, Mohammad Jawaid, Abdullah M Asiri, Anish Khan,

A new class of conductive metal-organic framework (MOF), polyaniline- aluminum succinate ([email protected]) nanocomposite was prepared by oxidative polymerization of aniline monomer using potassium persulfate as an oxidant. Several analytical techniques such as FTIR, FE-SEM, EDX, XRD, XPS and TGA-DTA were utilized to characterize the obtained MOFs nanocomposite. DC electrical conductivity ... Read more >>

Polymers (Basel) (Polymers)
[2021, 13(19):]

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Partners in crime: The Lewis Y antigen and fucosyltransferase IV in Helicobacter pylori-induced gastric cancer.

Faisal Aziz, Imran Khan, Shruti Shukla, Debasish Kumar Dey, Qiu Yan, Abhijit Chakraborty, Hisae Yoshitomi, Seung-Kyu Hwang, Sonam Sonwal, Hoomin Lee, Yuvaraj Haldorai, Jianbo Xiao, Yun Suk Huh, Vivek K Bajpai, Young-Kyu Han,

Helicobacter pylori (H. pylori) is a major causative agent of chronic gastritis, gastric ulcer and gastric carcinoma. H. pylori cytotoxin associated antigen A (CagA) plays a crucial role in the development of gastric cancer. Gastric cancer is associated with glycosylation alterations in glycoproteins and glycolipids on the cell surface. H. ... Read more >>

Pharmacol Ther (Pharmacology & therapeutics)
[2021, :107994]

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Neuroprotective effect of sumatriptan in pentylenetetrazole-induced seizure is mediated through N-methyl-D-aspartate/nitric oxide and cAMP response element-binding protein signaling pathway.

Faiza Mumtaz, Asma Rashki, Muhammad Imran Khan, Amir Shadboorestan, Alireza Abdollahi, Mahmoud Ghazi-Khansari, Ghallab Alotaibi, Ahmad Reza Dehpour,

Seizure occurs as a result of uncontrolled electrical disturbances within the brain. Various biomolecules such as N-methyl-D-aspartate (NMDA), nitric oxide (NO), and cAMP response element-binding protein (CREB) have been implicated in the pathophysiology of seizure. Sumatriptan is a specific 5-Hydroxytryptamine 1B/1D receptor agonist and has neuroprotective effects in various neuropsychiatric ... Read more >>

Fundam Clin Pharmacol (Fundamental & clinical pharmacology)
[2021, :]

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Jasminum sambac: A Potential Candidate for Drug Development to Cure Cardiovascular Ailments.

Imran Ahmad Khan, Musaddique Hussain, Shaukat Hussain Munawar, Muhammad Omer Iqbal, Shafia Arshad, Ashira Manzoor, Mazhar Abbas Shah, Khizar Abbas, Waleed Shakeel, Shahzada Khurram Syed,

<i>Jasminum sambac</i> (L.) is a South Asian folkloric medicinal plant that has traditionally been used to treat cardiovascular problems. The current investigation was meticulously organized to explore the pharmacological foundation for the medicinal uses of <i>J. sambac</i> pertaining to cardiovascular ailments and to investigate the core mechanisms. Mechanistic investigation revealed ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(18):]

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Current status of novel pyridine fused derivatives as anticancer agents: An insight into future perspectives and structure activity relationship (SAR).

Ajay Manaithiya, Ozair Alam, Vrinda Sharma, Mohd Javed Naim, Shruti Mittal, Faizul Azam, Asif Husain, Aadil Ahmad Sheikh, Mohd Imran, Imran A Khan,

Cancer is a heterogeneous disease characterized by an abnormal and uncontrolled division of the cells leading to tumors that invade the adjacent normal tissues. After cardiovascular diseases, it is the second most prevalent disease accounting for one in every six deaths worldwide. This alarming rate thus, demands an urgent need ... Read more >>

Curr Top Med Chem (Current topics in medicinal chemistry)
[2021, :]

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Morphological, Biochemical, and Proteomic Studies Revealed Impact of Fe and P Crosstalk on Root Development in Phaseolus vulgaris L.

Madhiya Manzoor, Sajad Majeed Zargar, Parveen Akhter, Uneeb Urwat, Reetika Mahajan, Sajad Ahmad Bhat, Tanveer Ali Dar, Imran Khan,

Mineral stress is one of the major abiotic stresses faced by crop plants. The present study was undertaken to investigate the impact of mineral stress (iron (Fe) and phosphorus (P)) on various morphological and biochemical responses of the shoot and root tissues and root architecture of common bean (Phaseolus vulgaris ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2021, 193(12):3898-3914]

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The Bnapus50K array: a quick and versatile genotyping tool for Brassica napus genomic breeding and research.

Qing Xiao, Huadong Wang, Nuan Song, Zewen Yu, Khan Imran, Weibo Xie, Shuqing Qiu, Fasong Zhou, Jing Wen, Cheng Dai, Chaozhi Ma, Jinxing Tu, Jinxiong Shen, Tingdong Fu, Bin Yi,

Rapeseed is a globally cultivated commercial crop, primarily grown for its oil. High-density single nucleotide polymorphism (SNP) arrays are widely used as a standard genotyping tool for rapeseed research, including for gene mapping, genome-wide association studies, germplasm resource analysis, and cluster analysis. Although considerable rapeseed genome sequencing data have been ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2021, 11(10):]

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Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review.

Alissa Hendricks-Wenger, Lauren Arnold, Jessica Gannon, Alex Simon, Neha Singh, Hannah Sheppard, Margaret A Nagai-Singer, Khan Mohammad Imran, Kiho Lee, Sherrie Clark-Deener, Christopher Byron, Michael R Edwards, Martha M Larson, John H Rossmeisl, Sheryl L Coutermarsh-Ott, Kristin Eden, Nikolaos Dervisis, Shawna Klahn, Joanne Tuohy, Irving C Allen, Eli Vlaisavljevich,

New therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely non-invasive, non-thermal, and non-ionizing tumor ablation method. Histotripsy can produce consistent and rapid ablations, even near critical structures. Additional ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2021, PP:]

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Author Correction: Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.

Imran Khan, Saeed Ur Rahman, Elieza Tang, Karl Engel, Bradford Hall, Ashok B Kulkarni, Praveen R Arany,

Sci Rep (Scientific reports)
[2021, 11(1):17706]

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Preparation, characterization, and antibiofilm activity of cinnamic acid conjugated hydroxypropyl chitosan derivatives.

Lin Yue, Min Wang, Imran Mahmood Khan, Jianguo Xu, Chifang Peng, Zhouping Wang,

In this study, cinnamic acid (CA) conjugated hydroxypropyl chitosan (HPCS) derivatives (HPCS-CA) with different degrees of substitution (DS) were successfully synthesized. The reaction was divided into two steps: the first step was to modify chitosan (CS) to HPCS, and the second step was to graft CA onto HPCS. Structural characterization ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 189:657-667]

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