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Author Imelda T Sandoval

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Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay.

Wentao Dai, Imelda T Sandoval, Shengxin Cai, Kaylee A Smith, Richard Glenn C Delacruz, Kevin A Boyd, Jessica J Mills, David A Jones, Robert H Cichewicz,

Phenotype-based screening of a fungal extract library yielded an active sample from a Penicillium sp. isolate that impaired zebrafish motility. Bioassay-guided purification led to the identification of 14 meroterpenoids including six new metabolites, arisugacins L-Q (4, 5, 8, and 12-14), seven known arisugacins (1-3, 6, 7, 9, and 10), and ... Read more >>

J Nat Prod (Journal of natural products)
[2019, 82(9):2627-2637]

Cited: 0 times

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Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas.

Richard Glenn C Delacruz, Imelda T Sandoval, Kyle Chang, Braden N Miller, Laura Reyes-Uribe, Ester Borras, Patrick M Lynch, Melissa W Taggart, Ernest T Hawk, Eduardo Vilar, David A Jones,

Germline mutations in the tumor suppressor Adenomatous Polyposis Coli (APC) define Familial Adenomatous Polyposis (FAP), the genetic predisposition to developing adenomatous polyps. Recent sequencing of FAP adenomas have challenged established dogma that APC mutations alone represent the adenoma mutational landscape because recurrent somatic mutations in non-WNT pathway genes were also ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(39):3939-3951]

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Toxic effects of a methanolic coal dust extract on fish early life stage.

Angélica Guerrero-Castilla, Jesús Olivero-Verbel, Imelda T Sandoval, David A Jones,

Coal dust is a contaminant that impacts the terrestrial and aquatic environment with a complex mixture of chemicals, including PAHs and metals. This study aims to evaluate the toxic effect of a methanolic coal dust extract on a fish early life stage by analyzing phenotypic alterations, transcriptome changes, and mortality ... Read more >>

Chemosphere (Chemosphere)
[2019, 227:100-108]

Cited: 0 times

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A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).

Imelda T Sandoval, Richard Glenn C Delacruz, Braden N Miller, Shauna Hill, Kristofor A Olson, Ana E Gabriel, Kevin Boyd, Christeena Satterfield, Holly Van Remmen, Jared Rutter, David A Jones,

Elucidating signaling pathways that regulate cellular metabolism is essential for a better understanding of normal development and tumorigenesis. Recent studies have shown that mitochondrial pyruvate carrier 1 (MPC1), a crucial player in pyruvate metabolism, is downregulated in colon adenocarcinomas. Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous ... Read more >>

Elife (eLife)
[2017, 6:]

Cited: 7 times

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Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.

Imelda T Sandoval, Elizabeth J Manos, Ryan M Van Wagoner, Richard Glenn C Delacruz, Kornelia Edes, Dennis R Winge, Chris M Ireland, David A Jones,

A major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish ... Read more >>

Chem Biol (Chemistry & biology)
[2013, 20(6):753-763]

Cited: 10 times

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Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay.

Xiaomei Wei, Tim S Bugni, Mary Kay Harper, Imelda T Sandoval, Elizabeth J Manos, Jennifer Swift, Ryan M Van Wagoner, David A Jones, Chris M Ireland,

Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolated from the sponge Xestospongia cf. carbonaria, collected in Palau. Structures were assigned on the basis of extensive 1D and 2D NMR studies as ... Read more >>

Mar Drugs (Marine drugs)
[2010, 8(6):1769-1778]

Cited: 4 times

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A two-step model for colon adenoma initiation and progression caused by APC loss.

Reid A Phelps, Stephanie Chidester, Somaye Dehghanizadeh, Jason Phelps, Imelda T Sandoval, Kunal Rai, Talmage Broadbent, Sharmistha Sarkar, Randall W Burt, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal ... Read more >>

Cell (Cell)
[2009, 137(4):623-634]

Cited: 166 times

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Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.

Lincoln D Nadauld, Stephanie Chidester, Dawne N Shelton, Kunal Rai, Talmage Broadbent, Imelda T Sandoval, Peter W Peterson, Elizabeth J Manos, Chris M Ireland, H Joseph Yost, David A Jones,

Congenital hypertrophy/hyperplasia of the retinal pigmented epithelium is an ocular lesion found in patients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina. Injection of dominant-negative Lef reduced Wnt signaling in the lens but ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2006, 103(36):13409-13414]

Cited: 25 times

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Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development.

Dawne N Shelton, Imelda T Sandoval, Annie Eisinger, Stephanie Chidester, Anokha Ratnayake, Chris M Ireland, David A Jones,

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to underlie the initiation of many colorectal carcinomas. Loss of APC function results in accumulation of beta-catenin and activation of beta-catenin/TCF-dependent transcription. Recent studies have implicated APC in controlling retinoic acid biosynthesis during normal intestinal development through a WNT-independent ... Read more >>

Cancer Res. (Cancer research)
[2006, 66(15):7571-7577]

Cited: 37 times

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Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.

Lincoln D Nadauld, Reid Phelps, Brent C Moore, Annie Eisinger, Imelda T Sandoval, Stephanie Chidester, Peter W Peterson, Elizabeth J Manos, Bradford Sklow, Randall W Burt, David A Jones,

Mutations in the human adenomatous polyposis coli (APC) gene are thought to initiate colorectal tumorigenesis. The tumor suppressor function of APC is attributed primarily to its ability to regulate the WNT pathway by targeting the destruction of beta-catenin. We report here a novel role for APC in regulating degradation of ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(49):37828-37835]

Cited: 31 times

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Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.

Lincoln D Nadauld, Imelda T Sandoval, Stephanie Chidester, H Joseph Yost, David A Jones,

Mutations in the APC (adenomatous polyposis coli) tumor suppressor gene cause uncontrolled proliferation and impaired differentiation of intestinal epithelial cells. Recent studies indicate that human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the expression of human RDHL. These data suggest a model wherein APC controls ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(49):51581-51589]

Cited: 38 times

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The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L.

Cicely Jette, Peter W Peterson, Imelda T Sandoval, Elizabeth J Manos, Eryn Hadley, Chris M Ireland, David A Jones,

Development of normal colon epithelial cells proceeds through a systematic differentiation of cells that emerge from stem cells within the base of colon crypts. Genetic mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon adenoma and carcinoma formation by enhancing colonocyte proliferation and impairing differentiation. We ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(33):34397-34405]

Cited: 33 times

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Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.

Imelda T Sandoval, Rohan A Davis, Tim S Bugni, Gisela P Concepcion, Mary Kay Harper, Chris M Ireland,

Bioassay-guided fractionation of two Philippine sponges of the genus Petrosia has resulted in the isolation of the novel natural product cribrostatin 7 (1) and the known compounds renierone (2) and O-demethylrenierone (3). The structures of these isoquinoline quinones were determined by interpretation of spectroscopic data. Compounds 1, 2 and 3 ... Read more >>

Nat. Prod. Res. (Natural product research)
[2004, 18(1):89-93]

Cited: 3 times

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