Full Text Journal Articles by
Author Ilana Kahn

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Mental Health Disorders and Psychosocial Distress in Pediatric Celiac Disease.

Shayna Coburn, Meredith Rose, Maegan Sady, Margaret Parker, William Suslovic, Vanessa Weisbrod, Benny Kerzner, Randi Streisand, Ilana Kahn,

OBJECTIVES:Celiac disease (CeD) has been associated with increased mental health disorders (MHD) and psychosocial distress in children, which may complicate treatment with the gluten-free diet (GFD). This single-center cross-sectional study examined psychological comorbidities in children with CeD to assess psychological needs in CeD care. METHODS:Participants were 73 parents (95% mothers) ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, 70(5):608-614]

Cited: 0 times

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Psychological Needs and Services in a Pediatric Multidisciplinary Celiac Disease Clinic.

Shayna Coburn, Meredith Rose, Randi Streisand, Maegan Sady, Margaret Parker, William Suslovic, Vanessa Weisbrod, Benny Kerzner, Ilana Kahn,

This study aims to describe the psychological needs in children with celiac disease (CD) and to examine the feasibility of psychological consultation in a multidisciplinary clinic. Participants (N = 69) included children with CD and their parents who completed a pre-clinic mental health survey and a 30-min psychological consultation as part of ... Read more >>

J Clin Psychol Med Settings (Journal of clinical psychology in medical settings)
[2019, :]

Cited: 0 times

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era.

Elizabeth Wells, Yael Hacohen, Amy Waldman, Jan M Tillema, Ariane Soldatos, Beau Ances, Susanne Benseler, Bibi Bielekova, Russel C Dale, Josep Dalmau, William Gaillard, Mark Gorman, Benjamin Greenberg, Ann Hyslop, Carlos A Pardo, Robert C Tasker, E Ann Yeh, Amit Bar-Or, Sean Pittock, Adeline Vanderver, Brenda Banwell, ,

In the original version of this Review published online and in print, the contribution of attendees of the International Neuroimmune Meeting to the content of the Review was not acknowledged. The author list has been corrected in the PDF and HTML versions of this article to acknowledge that the Review ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2018, 14(12):749]

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Bardia Nourbakhsh, Alice Rutatangwa, Michael Waltz, Mary Rensel, Manikum Moodley, Jennifer Graves, Theron Charles Casper, Amy Waldman, Anita Belman, Benjamin Greenberg, Manu Goyal, Yolanda Harris, Ilana Kahn, Timothy Lotze, Soe Mar, Teri Schreiner, Gregory Aaen, Janace Hart, Jayne Ness, Jennifer Rubin, Jan-Mendelt Tillema, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Xiaorong Shao, Lisa Barcellos, Judith James, Emmanuelle Waubant, ,

Objective:While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(10):1222-1228]

Cited: 2 times

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Neuroimmune disorders of the central nervous system in children in the molecular era.

Elizabeth Wells, Yael Hacohen, Amy Waldman, Jan M Tillema, Ariane Soldatos, Beau Ances, Susanne Benseler, Bibi Bielekova, Russel C Dale, Josep Dalmau, William Gaillard, Mark Gorman, Benjamin Greenberg, Ann Hyslop, Carlos A Pardo, Robert C Tasker, E Ann Yeh, Amit Bar-Or, Sean Pittock, Adeline Vanderver, Brenda Banwell, ,

Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2018, 14(7):433-445]

Cited: 5 times

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

Cited: 0 times

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Genetic risk factors for pediatric-onset multiple sclerosis.

Milena A Gianfrancesco, Pernilla Stridh, Xiaorong Shao, Brooke Rhead, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(14):1825-1834]

Cited: 4 times

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Dietary factors and pediatric multiple sclerosis: A case-control study.

Julia Pakpoor, Brandon Seminatore, Jennifer S Graves, Teri Schreiner, Amy T Waldman, Timothy E Lotze, Anita Belman, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jamie C McDonald, Janace Hart, Jayne M Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, Soe Mar, Ilana Kahn, John Rose, Suzan L Carmichael, Shelly Roalstad, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

BACKGROUND:The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. OBJECTIVE:To determine the association between dietary factors and MS in children. METHODS:Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(8):1067-1076]

Cited: 6 times

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Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS.

Milena A Gianfrancesco, Pernilla Stridh, Brooke Rhead, Xiaorong Shao, Edison Xu, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Maria Bäärnhielm, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Metayer, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels ... Read more >>

Neurology (Neurology)
[2017, 88(17):1623-1629]

Cited: 25 times

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Anti- N-Methyl-d-Aspartate (NMDA) Receptor Encephalitis.

Ilana Kahn, Guy Helman, Adeline Vanderver, Elizabeth Wells,

Anti- N-methyl-d-aspartate receptor (NMDAR) encephalitis has been shown to be a treatable form of autoimmune encephalitis, but there remains no standardized approach to immunotherapy. We designed an anonymous survey sent to members of the Child Neurology Society to identify the current practices among child neurologists. A total of 151 pediatric ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2017, 32(2):243-245]

Cited: 7 times

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Whole exome sequencing in patients with white matter abnormalities.

Adeline Vanderver, Cas Simons, Guy Helman, Joanna Crawford, Nicole I Wolf, Geneviève Bernard, Amy Pizzino, Johanna L Schmidt, Asako Takanohashi, David Miller, Amirah Khouzam, Vani Rajan, Erica Ramos, Shimul Chowdhury, Tina Hambuch, Kelin Ru, Gregory J Baillie, Sean M Grimmond, Ljubica Caldovic, Joseph Devaney, Miriam Bloom, Sarah H Evans, Jennifer L P Murphy, Nathan McNeill, Brent L Fogel, , Raphael Schiffmann, Marjo S van der Knaap, Ryan J Taft,

Here we report whole exome sequencing (WES) on a cohort of 71 patients with persistently unresolved white matter abnormalities with a suspected diagnosis of leukodystrophy or genetic leukoencephalopathy. WES analyses were performed on trio, or greater, family groups. Diagnostic pathogenic variants were identified in 35% (25 of 71) of patients. ... Read more >>

Ann. Neurol. (Annals of neurology)
[2016, 79(6):1031-1037]

Cited: 28 times

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Characteristic brain magnetic resonance imaging pattern in patients with macrocephaly and PTEN mutations.

Adeline Vanderver, Davide Tonduti, Ilana Kahn, Johanna Schmidt, Livija Medne, Jodie Vento, Kimberly A Chapman, Brendan Lanpher, Phillip Pearl, Andrea Gropman, Charles Lourenco, John-Steven Bamforth, Cynthia Sharpe, Mercédes Pineda, Jens Schallner, Olaf Bodamer, Simona Orcesi, Saskia A J Lesnik Oberstein, Erik A Sistermans, Helger G Yntema, Carsten Bonnemann, Amy T Waldman, Marjo S van der Knaap,

We describe an MRI phenotype seen in a series of patients with mutations in PTEN who have clinical features consistent with PTEN hamartoma tumor syndrome (PHTS). Retrospective review of clinical data and MRI was performed in 23 subjects evaluated in four different tertiary care centers with clinical programs in inherited ... Read more >>

Am. J. Med. Genet. A (American journal of medical genetics. Part A)
[2014, 164A(3):627-633]

Cited: 26 times

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Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

Valerie Cullen, S Pablo Sardi, Juliana Ng, You-Hai Xu, Ying Sun, Julianna J Tomlinson, Piotr Kolodziej, Ilana Kahn, Paul Saftig, John Woulfe, Jean-Christophe Rochet, Marcie A Glicksman, Seng H Cheng, Gregory A Grabowski, Lamya S Shihabuddin, Michael G Schlossmacher,

OBJECTIVE: Heterozygous mutations in the GBA1 gene elevate the risk of Parkinson disease and dementia with Lewy bodies; both disorders are characterized by misprocessing of α-synuclein (SNCA). A loss in lysosomal acid-β-glucosidase enzyme (GCase) activity due to biallelic GBA1 mutations underlies Gaucher disease. We explored mechanisms for the gene's association ... Read more >>

Ann. Neurol. (Annals of neurology)
[2011, 69(6):940-953]

Cited: 152 times

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Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration.

Brit Mollenhauer, Valerie Cullen, Ilana Kahn, Bryan Krastins, Tiago F Outeiro, Imelda Pepivani, Juliana Ng, Walter Schulz-Schaeffer, Hans A Kretzschmar, Pamela J McLean, Claudia Trenkwalder, David A Sarracino, Jean-Paul Vonsattel, Joseph J Locascio, Omar M A El-Agnaf, Michael G Schlossmacher,

Because accumulation of alpha-synuclein (alphaS) in the brain is a hallmark of Parkinson disease (PD) and related disorders, we examined its occurrence in human cerebrospinal fluid (CSF). Following affinity enrichment and trypsin digestion of CSF collected from a neurologically healthy donor, we identified several alphaS-derived peptides by mass spectrometry. The ... Read more >>

Exp. Neurol. (Experimental neurology)
[2008, 213(2):315-325]

Cited: 187 times

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