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Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

<h4>Purpose</h4>RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.<h4>Materials and methods</h4>Men post prostatectomy were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001792]

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Reply by Authors.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

J Urol (The Journal of urology)
[2021, :101097JU000000000000179203]

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A Contemporary Analysis of Urethral Recurrence following Radical Cystectomy.

Abhinav Khanna, Andrew Zganjar, Timothy Lyon, Paras Shah, Matthew K Tollefson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, R Houston Thompson, Igor Frank, Stephen A Boorjian,

<h4>Introduction</h4>Oncologic outcomes following UR remain incompletely described, with reports limited by small cohort sizes. We evaluated risk factors for UR as well as cancer-specific survival (CSS) and overall survival (OS) among patients with UR.<h4>Methods</h4>We reviewed our institutional RC registry to identify patients with UR. Cox proportional hazards regression was used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001842]

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The Impact of Upper Tract Urothelial Carcinoma Diagnostic Modality on Intravesical Recurrence after Radical Nephroureterectomy: A Single Institution Series and Updated meta-Analysis.

Vidit Sharma, Tanner S Miest, Tristan S Juvet, Amir Toussi, Vignesh Packiam, Karim Chamie, Surena F Matin, Stephen A Boorjian, R Houston Thompson, Igor Frank, Matthew K Tollefson, Aaron M Potretzke,

<h4>Introduction</h4>Diagnostic ureteroscopic biopsy for upper tract urothelial carcinoma (UTUC) has been hypothesized to increase intravesical recurrence of urothelial carcinoma after radical nephroureterectomy (RNU). Moreover, the impact of ureteroscopy without biopsy or percutaneous biopsy on intravesical recurrence remains unknown. Herein, we compared post-RNU intravesical recurrences across UTUC diagnostic modalities.<h4>Methods</h4>Patients undergoing RNU ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001834]

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Incidence and predictors of occult preoperative deep vein thrombosis at radical cystectomy for urothelial carcinoma.

Tanner S Miest, Vidit Sharma, R Jeffrey Karnes, Stephen A Boorjian, R Houston Thompson, Igor Frank, Matthew K Tollefson,

<h4>Introduction</h4>Patients undergoing radical cystectomy are at high perioperative risk for deep vein thrombosis due to age, malignancy, recent transurethral resection, and neoadjuvant chemotherapy. We, therefore, evaluated the incidence and predictors of occult preoperative deep vein thrombosis prior to radical cystectomy for urothelial carcinoma.<h4>Methods</h4>We prospectively screened 52 asymptomatic patients with urothelial ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, :]

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Cancer Prevalence and Risk Stratification in Adults Presenting With Hematuria: A Population-Based Cohort Study.

Mitsuru Takeuchi, Jennifer S McDonald, Naoki Takahashi, Igor Frank, R Houston Thompson, Bernard F King, Akira Kawashima,

<h4>Objective</h4>To calculate the prevalence of renal cell carcinoma (RCC), upper urinary tract urothelial carcinoma (UT-UC), and lower urinary tract urothelial carcinoma (LT-UC) in patients with gross asymptomatic microhematuria (AMH) and symptomatic microhematuria (SMH).<h4>Patients and methods</h4>This study was a population-based retrospective descriptive study. The study was approved by both the Mayo ... Read more >>

Mayo Clin Proc Innov Qual Outcomes (Mayo Clinic proceedings. Innovations, quality & outcomes)
[2021, 5(2):308-319]

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The association of salvage intravesical therapy following BCG with pathologic outcomes and survival after radical cystectomy for patients with high-grade non-muscle invasive bladder cancer: A multi-institution analysis.

Vignesh T Packiam, Craig V Labbate, Stephen A Boorjian, Robert Tarrell, John C Cheville, Svetlana Avulova, Vidit Sharma, Matvey Tsivian, Brittany Adamic, Mohammad Mahmoud, Ryan P Werntz, Norm D Smith, R Jeffrey Karnes, Matthew K Tollefson, Gary D Steinberg, Igor Frank,

<h4>Introduction</h4>While numerous current clinical trials are testing novel salvage therapies (ST) for patients with recurrent nonmuscle invasive bladder cancer (NMIBC) after bacillus Calmette-Guérin (BCG), the natural history of this disease state has been poorly defined to date. Herein, we evaluated oncologic outcomes in patients previously treated with BCG and ST ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

Cited: 1 time

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Association of intraoperative hypothermia with oncologic outcomes following radical cystectomy.

Timothy D Lyon, Igor Frank, Matthew K Tollefson, Robert F Tarrell, Paras H Shah, Robert H Thompson, Robert J Karnes, Stephen A Boorjian,

<h4>Introduction</h4>Intraoperative hypothermia (IOH) has been suggested to adversely impact outcomes following surgery. The objective of this study was to evaluate the association between IOH and survival following radical cystectomy (RC).<h4>Methods</h4>Patients who underwent RC for bladder cancer from 2003 to 2018 were identified in our cystectomy registry. Intraoperative temperatures were extracted ... Read more >>

Urol Oncol (Urologic oncology)
[2020, :]

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Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure

Sarah Minkler, Fabrice Lucien, Michael Kimber, Agnes Bourgois-Mochel, Margareth Musser, Chad Johannes, Igor Frank, John Cheville, Karin Allenspach, Jonathan Mochel,

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years1. Due to high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant ... Read more >>

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Development of a technique for evaluating the presence of malignant cells in prostatic fluid during robotic prostatectomy.

Timothy D Lyon, Michael R Henry, Paras H Shah, Stephen A Boorjian, Matthew K Tollefson, Igor Frank,

<h4>Introduction</h4>To develop a technique to collect fluid expressed during robot-assisted radical prostatectomy (RARP) to assess whether malignant cells may have been inadvertently introduced into the surgical field.<h4>Methods</h4>Men with clinically localized grade group 2 to 5 prostate adenocarcinoma undergoing RARP were identified. Following bladder neck division, fluid expressed via prostatic urethra ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):192.e1-192.e6]

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Does Ureteral Stent Drainage Prior to Cystectomy Increase the Risk of Subsequent Upper Tract Urothelial Carcinoma and Ureteral Complications?

Tanner S Miest, Vidit Sharma, Luca Boeri, Matthew K Tollefson, R Houston Thompson, Stephen A Boorjian, Igor Frank, R Jeffrey Karnes,

<h4>Objective</h4>To guide management of preoperative hydronephrosis prior to radical cystectomy (RC), we compared post-RC risks of upper tract urothelial carcinoma (UTUC) and ureteroenteric anastomotic complications between ureteral stent and percutaneous nephrostomy tube drainage.<h4>Methods</h4>Patients who underwent RC for urothelial carcinoma without a prior diagnosis of UTUC at our institution between 2000 ... Read more >>

Urology (Urology)
[2020, :]

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Squamous Cell Carcinoma of the Bladder Is Not Associated With High-risk HPV.

Jennifer Gordetsky, Andrew J Spieker, Maria Del Carmen Rodriguez Pena, Sonia Kamanda, Michele R Anderson, John Cheville, Steve Boorjian, Igor Frank, Carlos Prieto Granada, Eva Comperat, Michelle S Hirsch, Kenneth A Iczkowski, Brittney Imblum, Lauren Schwartz, Giovanna A Giannico, Soroush Rais-Bahrami,

<h4>Objective</h4>To evaluate the clinical features, pathologic features, and prevalence of human papilloma virus (HPV) in squamous cell carcinoma (SCC) of the bladder. SCC of the bladder is known to be associated with conditions that cause chronic inflammation/irritation. The literature is inconsistent regarding the association of HPV with pure SCC of ... Read more >>

Urology (Urology)
[2020, 144:158-163]

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Treatment Outcomes in Patients With Symptomatic Lymphoceles Following Radical Prostatectomy Depend Upon Size and Presence of Infection.

Jack R Andrews, Ilya Sobol, Igor Frank, Matthew T Gettman, R Houston Thompson, R Jeffrey Karnes, Stephen A Boorjian, Matthew K Tollefson,

<h4>Objective</h4>To guide treatment decisions for symptomatic lymphoceles after radical prostatectomy. We examined our experience to create a treatment algorithm.<h4>Materials and methods</h4>We evaluated all patients that underwent radical prostatectomy at our institution from 2003 to 2012. Presenting signs, management and treatment outcomes were evaluated.<h4>Results</h4>Of the 8081 patients who underwent radical prostatectomy ... Read more >>

Urology (Urology)
[2020, 143:181-185]

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Long-term outcomes of incidental prostate cancer at radical cystectomy.

Vignesh T Packiam, Matvey Tsivian, Svetlana Avulova, Vidit Sharma, Robert Tarrell, John C Cheville, Igor Frank, R Houston Thompson, Matthew K Tollefson, Matthew T Gettman, R Jeffrey Karnes, Prabin Thapa, Stephen A Boorjian,

<h4>Objective</h4>We evaluated the natural history and long-term outcomes of incidentally detected prostate cancer (PCa) at radical cystectomy (RC) for bladder cancer (BCa).<h4>Patients and methods</h4>We identified 1,640 male patients who underwent RC between 1992 and 2012. Patients were stratified as clinically insignificant and clinically significant PCa, based on Grade Group (GG) ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(11):848.e17-848.e22]

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AUTHOR REPLY.

Timothy D Lyon, Nilay D Shah, Matthew K Tollefson, Paras H Shah, Lindsey R Sangaralingham, Dennis Asante, R Houston Thompson, R Jeffrey Karnes, Igor Frank, Stephen A Boorjian,

Urology (Urology)
[2020, 136:111]

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Trends in Extended-Duration Venous Thromboembolism Prophylaxis Following Radical Cystectomy.

Timothy D Lyon, Nilay D Shah, Matthew K Tollefson, Paras H Shah, Lindsey R Sangaralingham, Dennis Asante, R Houston Thompson, R Jeffrey Karnes, Igor Frank, Stephen A Boorjian,

OBJECTIVE:To evaluate temporal trends in prescriptions for extended-duration pharmacologic prophylaxis (EDPP) intended to prevent venous thromboembolism following radical cystectomy (RC). MATERIALS AND METHODS:We used OptumLabs Data Warehouse, a national administrative claims database, to identify patients undergoing RC for bladder cancer from 2012 to 2017. Rates of outpatient prescriptions for EDPP ... Read more >>

Urology (Urology)
[2020, 136:105-111]

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Incidence and risk factors for peritoneal carcinomatosis following open radical cystectomy.

David Y Yang, Igor Frank, Ross A Avant, Adam R Miller, Prabin Thapa, Stephen A Boorjian, Matthew K Tollefson,

<h4>Objective</h4>To characterize the frequency and risk factors of peritoneal carcinomatosis (PC) in patients undergoing open radical cystectomy (RC).<h4>Methods</h4>We identified 3,285 patients with urothelial carcinoma treated with RC for curative intent between 1980 and 2016. At last follow-up, 72.1% (2,370/3,285) of patients had died, with a median follow-up of 8.6 years ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(12):886-892]

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Impact of time from biopsy to surgery on complications, functional and oncologic outcomes following radical prostatectomy.

Mary E Westerman, Vidit Sharma, George C Bailey, Stephen A Boorjian, Igor Frank, Matthew T Gettman, R Houston Thompson, Matthew K Tollefson, Robert Jeffrey Karnes,

<h4>Introduction</h4>To determine the impact of time from biopsy to surgery on outcomes following radical prostatectomy (RP) as the optimal interval between prostate biopsy and RP is unknown.<h4>Material and methods</h4>We identified 7, 350 men who underwent RP at our institution between 1994 and 2012 and had a prostate biopsy within one ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2019, 45(3):468-477]

Cited: 6 times

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Initial Experience with da Vinci Single-port Robot-assisted Radical Prostatectomies.

Deepak K Agarwal, Vidit Sharma, Amir Toussi, Boyd R Viers, Matthew K Tollefson, Matthew T Gettman, Igor Frank,

<h4>Background</h4>Single-port robotic surgery is being adopted for various surgical procedures. There have been interest in and clinical use of single-port robot-assisted radical prostatectomy (spRARP), but little reported data on feasibility and early outcomes.<h4>Objective</h4>To describe our institution's initial experience with spRARP utilizing the da Vinci single-port (SP) robotic system.<h4>Design, setting, and ... Read more >>

Eur Urol (European urology)
[2020, 77(3):373-379]

Cited: 8 times

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Sarcopenia and Response to Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer.

Timothy D Lyon, Igor Frank, Naoki Takahashi, Stephen A Boorjian, Michael R Moynagh, Paras H Shah, Robert F Tarrell, John C Cheville, Boyd R Viers, Matthew K Tollefson,

<h4>Introduction</h4>The objective of the study was to determine whether sarcopenia is associated with pathologic and survival outcomes for patients with muscle-invasive bladder cancer (MIBC) treated with neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC).<h4>Patients and methods</h4>We identified MIBC patients treated with cisplatin-based NAC in our cystectomy registry from 2000 to ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(3):216-222.e5]

Cited: 1 time

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A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.

Sounak Gupta, Carlos P Sosa, Farhad Kosari, Andrew Folpe, Kaustubh N Bhinge, Lin Yang, Alireza Agahi, Sarah H Johnson, Igor Frank, Stephen A Boorjian, Donna E Hansel, Hikmat A Al-Ahmadie, Victor E Reuter, George Vasmatzis, Rafael E Jimenez, Loren Herrera-Hernandez, John C Cheville,

Some rhabdomyosarcomas and sarcomatoid carcinomas with heterologous rhabdomyosarcomatous elements resemble high-grade neuroendocrine carcinoma, creating a diagnostic difficulty. The purpose of this study was to characterize the overlap of adult genitourinary rhabdomyosarcomas, excluding those occurring at paratesticular sites, with high-grade neuroendocrine carcinoma and identify features helpful in their separation. Seventeen cases ... Read more >>

Hum Pathol (Human pathology)
[2019, 88:48-59]

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Technical Considerations of Single Port Ureteroneocystostomy Utilizing da Vinci SP Platform.

Kevin J Hebert, Jason Joseph, Matthew Gettman, Matthew Tollefson, Igor Frank, Boyd R Viers,

OBJECTIVE:To demonstrate technical considerations of a true single port robotic assisted ureteroneocystostomy using the da Vinci SP platform (Intuitive Surgical, Sunnyvale, CA). METHODS:We present a 34 year-old female with an obliterative right distal ureteral stricture after undergoing a total abdominal hysterectomy for benign indications. After a period of ureteral rest, ... Read more >>

Urology (Urology)
[2019, 129:236]

Cited: 4 times

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Clinical predictors and survival outcome of patients receiving suboptimal neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer: a single-center experience.

Luca Boeri, Matteo Soligo, Igor Frank, Stephen A Boorjian, R Houston Thompson, Matthew Tollefson, Robert Tarrel, Fernando J Quevedo, John C Cheville, R Jeffrey Karnes,

<h4>Purpose</h4>To investigate the prevalence of and factors' association with receiving suboptimal neoadjuvant chemotherapy (NAC) and its impact on survival outcomes in patients with muscle-invasive bladder cancer (MIBC) treated with radical cystectomy (RC).<h4>Methods</h4>We reviewed 1119 patients treated with NAC and/or RC for cT2-cT4N0M0 BC. Patients were segregated into three groups: (i) ... Read more >>

World J Urol (World journal of urology)
[2019, 37(11):2409-2418]

Cited: 2 times

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Comprehensive characterization of perioperative reoperation following radical cystectomy.

Timothy D Lyon, Stephen A Boorjian, Paras H Shah, Robert Tarrell, John C Cheville, Igor Frank, R Jeffrey Karnes, R Houston Thompson, Matthew K Tollefson,

INTRODUCTION:To examine the nature, timing, and risk factors underlying return to the operating room (ROR) following radical cystectomy (RC). ROR has been proposed as a surgical quality metric based on data from the general surgery literature, but ROR has not been comprehensively characterized following RC. PATIENTS AND METHODS:We queried our ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):292.e11-292.e17]

Cited: 1 time

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Cigarette smoking is associated with adverse pathological response and increased disease recurrence amongst patients with muscle-invasive bladder cancer treated with cisplatin-based neoadjuvant chemotherapy and radical cystectomy: a single-centre experience.

Luca Boeri, Matteo Soligo, Igor Frank, Stephen A Boorjian, Robert H Thompson, Matthew Tollefson, Fernando J Quevedo, John C Cheville, Robert Jeffrey Karnes,

<h4>Objective</h4>To investigate the association between smoking status and pathological response to cisplatin-based neoadjuvant chemotherapy (NAC) and survival outcomes in patients with muscle-invasive bladder cancer (MIBC) treated with radical cystectomy (RC).<h4>Patients and methods</h4>We reviewed 201 patients treated with NAC and RC for cT2-cT4N0M0 BC between 01/1999 and 01/2015. Smoking status was ... Read more >>

BJU Int (BJU international)
[2019, 123(6):1011-1019]

Cited: 3 times

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