Full Text Journal Articles by
Author Igor Elman

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Migraine: interactions between brain's trait and state.

Edina Szabo, Stephen Green, Keerthana Deepti Karunakaran, Christine B Sieberg, Igor Elman, Rami Burstein, David Borsook,

It is well established that migraine is a multifactorial disorder. A deep understanding of migraine should be based upon both the underlying traits and the current states affected by different physiological, psychological, and environmental factors. At this point, there is no framework fully meeting these criteria. Here, we describe a ... Read more >>

CNS Spectr (CNS spectrums)
[2021, :1-9]

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A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration.

Kenneth Blum, Shan Kazmi, Edward J Modestino, Bill William Downs, Debasis Bagchi, David Baron, Thomas McLaughlin, Richard Green, Rehan Jalali, Panayotis K Thanos, Igor Elman, Rajendra D Badgaiyan, Abdalla Bowirrat, Mark S Gold,

This article describes a unique therapeutic precision intervention, a formulation of enkephalinase inhibitors, enkephalin, and dopamine-releasing neuronutrients, to induce dopamine homeostasis for detoxification and treatment of individuals genetically predisposed to developing reward deficiency syndrome (RDS). The formulations are based on the results of the addiction risk severity (GARS) test. Based ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(3):]

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Should We Embrace the Incorporation of Genetically Guided "Dopamine Homeostasis" in the Treatment of Reward Deficiency Syndrome (RSD) as a Frontline Therapeutic Modality?

Kenneth Blum, Ali Raza, Tiffany Schultz, Rehan Jalali, Richard Green, Raymond Brewer, Panyotis K Thanos, Thomas McLaughlin, David Baron, Abdalla Bowirrat, Igor Elman, B William Downs, Debasis Bagchi, Rajendra D Badgaiyan,

In 2019, the US Center for Disease Control and Prevention provided vital statistics related to drug overdoses in the United State1. They concluded that in the USA the number of deaths at almost 72,000 was due to 66.6% of opioid overdoses. In fact, the rate is alarming and increasing yearly. ... Read more >>

Acta Sci Neurol (Acta scientific neurology)
[2021, 4(2):17-24]

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Left to themselves: Time to target chronic pain in childhood rare diseases.

Christine B Sieberg, Alyssa Lebel, Erin Silliman, Scott Holmes, David Borsook, Igor Elman,

<h4>Background</h4>Chronic pain is prevalent among patients with rare diseases (RDs). However, little is understood about how biopsychosocial mechanisms may be integrated in the unique set of clinical features and therapeutic challenges inherent in their pain conditions.<h4>Methods</h4>This review presents examples of major categories of RDs with particular pain conditions. In addition, ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 126:276-288]

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High Genetic Addiction Risk Score (GARS) in Chronically Prescribed Severe Chronic Opioid Probands Attending Multi-pain Clinics: an Open Clinical Pilot Trial.

Mark Moran, Kenneth Blum, Jessica Valdez Ponce, Lisa Lott, Marjorie C Gondré-Lewis, Sampada Badgaiyan, Raymond Brewer, B William Downs, Philip Fynman, Alexander Weingarten, Jean Lud Cadet, David E Smith, David Baron, Panayotis K Thanos, Edward J Modestino, Rajendra D Badgaiyan, Igor Elman, Mark S Gold,

Millions of Americans experience pain daily. In 2017, opioid overdose claimed 64,000 lives increasing to 84,000 lives in 2020, resulting in a decrease in national life expectancy. Chronic opioid use results in dependency, drug tolerance, neuroadaptation, hyperalgesia, potential addictive behaviors, or Reward Deficiency Syndrome (RDS) caused by a hypodopaminergia. Evaluation ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2021, 58(7):3335-3346]

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Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains".

Igor Elman, Jaymin Upadhyay, Steven Lowen, Keerthana Karunakaran, Mark Albanese, David Borsook,

Although unconscious processing is a key element of mental operation, its neural correlates have not been established. Also, clinical observations suggest that unconscious processing may be involved in the pathophysiology of post-traumatic stress disorder (PTSD), but the neurobiological mechanisms underlying such impairments remain unknown. The purpose of the present study ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:604867]

Cited: 0 times

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Reduced cigarette smoking during injectable extended-release naltrexone treatment for opioid use disorder.

An-Li Wang, Zhenhao Shi, Igor Elman, Daniel D Langleben,

<h4>Background</h4>The prevalence of tobacco cigarette smoking in the US has declined to approximately 15%, yet, it remains over 90% among individuals with opioid use disorder regardless of whether they are currently using opioids illicitly or as opioid substitution therapy. This disparity raises the question of whether opioids facilitate smoking among ... Read more >>

Am J Drug Alcohol Abuse (The American journal of drug and alcohol abuse)
[2020, 46(4):472-477]

Cited: 0 times

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Author Correction: Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.

Igor Elman, Margaret Howard, Jacob T Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7680]

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Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.

Igor Elman, Margaret Howard, Jacob T Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese,

Metabolic hormones stabilize brain reward and motivational circuits, whereas excessive opioid consumption counteracts this effect and may impair metabolic function. Here we addressed the role of metabolic processes in the course of the agonist medication-assisted treatment for opioid use disorder (OUD) with buprenorphine or methadone. Plasma lipids, hemoglobin A1C, body ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5617]

Cited: 1 time

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The failing cascade: Comorbid post traumatic stress- and opioid use disorders.

Igor Elman, David Borsook,

Opioid use disorder (OUD) is a mounting public health problem with substantial morbidity and mortality. Stress involvement in the course of OUD is generally accepted, but little is understood about the underlying neurobiological mechanisms in part due to a lack of laboratory-based models for chronic stress exposure. Post-traumatic stress disorder ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2019, 103:374-383]

Cited: 4 times

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When pain gets stuck: the evolution of pain chronification and treatment resistance.

David Borsook, Andrew M Youssef, Laura Simons, Igor Elman, Christopher Eccleston,

It is well-recognized that, despite similar pain characteristics, some people with chronic pain recover, whereas others do not. In this review, we discuss possible contributions and interactions of biological, social, and psychological perturbations that underlie the evolution of treatment-resistant chronic pain. Behavior and brain are intimately implicated in the production ... Read more >>

Pain (Pain)
[2018, 159(12):2421-2436]

Cited: 34 times

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Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli.

Igor Elman, Jaymin Upadhyay, Daniel D Langleben, Mark Albanese, Lino Becerra, David Borsook,

In patients with post-traumatic stress disorder (PTSD), a decrease in the brain reward function was reported in behavioral- and in neuroimaging studies. While pathophysiological mechanisms underlying this response are unclear, there are several lines of evidence suggesting over-recruitment of the brain reward regions by aversive stimuli rendering them unavailable to ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2018, 8(1):240]

Cited: 4 times

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Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors.

Kenneth Blum, Marjorie C Gondré-Lewis, David Baron, Panayotis K Thanos, Eric R Braverman, Jennifer Neary, Igor Elman, Rajendra D Badgaiyan,

Front Psychiatry (Frontiers in psychiatry)
[2018, 9:548]

Cited: 14 times

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Visuospatial and Sensory Integration Tasks in Patients With Schizophrenia or Schizoaffective Disorder: Relationship to Body Mass Index and Smoking.

Tyler S Vanderhoof, Tamara V Gurvits, Julie E Baker-Nolan, David Borsook, Igor Elman,

Neurological soft signs (NSSs) are highly prevalent among patients with schizophrenia, but their pathophysiological significance remains unclear. The present study employed perceptual-motor and visuospatial processing tests that have not yet been attempted in this patient population. Patients with schizophrenia or schizoaffective disorder (<i>n</i> = 42) and mentally healthy subjects (<i>n</i> ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2018, 9:473]

Cited: 0 times

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Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

Kenneth Blum, Edward J Modestino, Rajendra D Badgaiyan, David Baron, Panayotis K Thanos, Igor Elman, David Siwicki, Marcelo Febo, Mark S Gold,

Blum's laboratory first showed the benefits of naloxone or narcotic antagonists in the treatment of alcohol dependence. This seminal work published in Nature in the early 70's, in conjunction with many other studies, later served as the basis for the development of the narcotic antagonist (NTX) now used to treat ... Read more >>

EC Psychol Psychiatr (EC psychology and psychiatry)
[2018, 7(8):564-579]

Cited: 4 times

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Subliminal (latent) processing of pain and its evolution to conscious awareness.

David Borsook, Andrew M Youssef, Nadia Barakat, Christine B Sieberg, Igor Elman,

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2018, 88:1-15]

Cited: 3 times

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Threat Response System: Parallel Brain Processes in Pain vis-à-vis Fear and Anxiety.

Igor Elman, David Borsook,

Pain is essential for avoidance of tissue damage and for promotion of healing. Notwithstanding the survival value, pain brings about emotional suffering reflected in fear and anxiety, which in turn augment pain thus giving rise to a self-sustaining feedforward loop. Given such reciprocal relationships, the present article uses neuroscientific conceptualizations ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2018, 9:29]

Cited: 8 times

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Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems.

Mark S Gold, Kenneth Blum, Marcelo Febo, David Baron, Edward Justin Modestino, Igor Elman, Rajendra D Badgaiyan,

Anhedonia is a condition that leads to the loss of feelings pleasure in response to natural reinforcers like food, sex, exercise, and social activities. This disorder occurs in addiction, and an array of related neuropsychiatric syndromes, including schizophrenia, depression, and Post Traumatic Stress Disorder (PTSD). Anhedonia may by due to ... Read more >>

Front Biosci (Schol Ed) (Frontiers in bioscience (Scholar edition))
[2018, 10:309-325]

Cited: 16 times

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Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies.

Kenneth Blum, Marjorie Gondré-Lewis, Bruce Steinberg, Igor Elman, David Baron, Edward J Modestino, Rajendra D Badgaiyan, Mark S Gold,

The brain regions tied to pleasure can be triggered by engaging in sex, eating tasty food, watching a movie, accomplishments at school and athletics, consuming drugs, and noble efforts to help the community, the country, and the world. It is noteworthy that research suggests that the latter type of satisfaction, ... Read more >>

J Syst Integr Neurosci (Journal of systems and integrative neuroscience)
[2018, 4(1):]

Cited: 1 time

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Oral glucose tolerance test performance in olanzapine-treated schizophrenia-spectrum patients is predicted by BMI and triglycerides but not olanzapine dose or duration.

Jeffrey Guina, Sayon Roy, Ankur Gupta, Daniel D Langleben, Igor Elman,

<h4>Objective</h4>Olanzapine, an atypical antipsychotic, is associated with glucoregulatory abnormalities, but the nature of this link is not fully elucidated. This is the first olanzapine oral glucose tolerance test (oGTT) study to consider treatment dose and duration, and to compare complementary indices respectively assessing insulin sensitivity (Matsuda index) and resistance (homeostasis ... Read more >>

Hum Psychopharmacol (Human psychopharmacology)
[2017, 32(4):]

Cited: 0 times

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Post-traumatic stress symptoms in pathological gambling: Potential evidence of anti-reward processes.

Cheryl L Green, Ramzi W Nahhas, Arielle A Scoglio, Igor Elman,

Background Excessive gambling is considered to be a part of the addiction spectrum. Stress-like emotional states are a key feature both of pathological gambling (PG) and of substance addiction. In substance addiction, stress symptomatology has been attributed in part to "anti-reward" allostatic neuroadaptations, while a potential involvement of anti-reward processes ... Read more >>

J Behav Addict (Journal of behavioral addictions)
[2017, 6(1):98-101]

Cited: 5 times

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Clinical Correlates of Oral Glucose Tolerance Test Performance in Olanzapine-Treated Patients with Schizophrenia or Schizoaffective Disorder.

Jeffrey Guina, Ankur Gupta, Daniel D Langleben, Igor Elman,

J Clin Psychiatry (The Journal of clinical psychiatry)
[2016, 77(12):e1650-e1651]

Cited: 1 time

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Co-occurring Disordered Gambling Among Treatment-Seekers at a Community Outpatient Addiction Clinic.

Igor Elman, Jacob Borodovsky, Margaret Howard, Arielle Scoglio, Jackson Steinkamp, Amy Sobieszczyk, David Mysels, Mark Albanese,

<h4>Background</h4>Parallel to the ongoing expansion of legalized gambling activities is a growing concern about rising occurrence of uncontrollable gambling. People with preexisting gambling and/or chemical addictions may be particularly vulnerable, but the extent of such co-occurring conditions and their demographic and clinical characteristics have not been sufficiently elucidated. To that ... Read more >>

J Addict Med (Journal of addiction medicine)
[2016, 10(5):339-343]

Cited: 0 times

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Common Brain Mechanisms of Chronic Pain and Addiction.

Igor Elman, David Borsook,

While chronic pain is considered by some to be a CNS disease, little is understood about underlying neurobiological mechanisms. Addiction models have heuristic value in this regard, because both pain and addictive disorders are characterized by impaired hedonic capacity, compulsive drug seeking, and high stress. In drug addiction such symptomatology ... Read more >>

Neuron (Neuron)
[2016, 89(1):11-36]

Cited: 83 times

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The cerebellum and addiction: insights gained from neuroimaging research.

Eric A Moulton, Igor Elman, Lino R Becerra, Rita Z Goldstein, David Borsook,

Although cerebellar alterations have been consistently noted in the addiction literature, the pathophysiology of this link remains unclear. The cerebellum is commonly classified as a motor structure, but human functional neuroimaging along with clinical observations in cerebellar stroke patients and anatomical tract tracing in non-human primates suggests its involvement in ... Read more >>

Addict Biol (Addiction biology)
[2014, 19(3):317-331]

Cited: 56 times

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