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Author Idir Ouzaid

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Neoadjuvant Immunotherapy for Muscle-Invasive Bladder Cancer.

Arthur Peyrottes, Idir Ouzaid, Gianluigi Califano, Jean-Francois Hermieu, Evanguelos Xylinas,

<i>Background and Objectives</i>: Facing neoadjuvant chemotherapy followed by surgery, neoadjuvant immunotherapy is an innovative concept in localized muscle-invasive bladder cancer. Herein, we performed a review of the available and ongoing evidence supporting immune checkpoint inhibitor (ICI) administration in the early stages of bladder cancer treatment. <i>Materials and Methods</i>: A literature ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(8):]

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The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study.

Sinan Khadhouri, Kevin M Gallagher, Kenneth R MacKenzie, Taimur T Shah, Chuanyu Gao, Sacha Moore, Eleanor F Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Miles P Mannas, Taeweon Lee, Giancarlo Marra, Beatrice Lillaz, Juan Gómez Rivas, Jonathan Olivier, Mark A Assmus, Taha Uçar, Francesco Claps, Matteo Boltri, Tara Burnhope, Nkwam Nkwam, George Tanasescu, Nicholas E Boxall, Alison P Downey, Asim A Lal, Marta Antón-Juanilla, Holly Clarke, David H W Lau, Kathryn Gillams, Matthew Crockett, Matthew Nielsen, Yemisi Takwoingi, Naomi Chuchu, John O'Rourke, Graeme MacLennan, John S McGrath, Veeru Kasivisvanathan, ,

<h4>Objective</h4>To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation.<h4>Patients and methods</h4>This was an international multicentre prospective observational study. We included patients aged ≥16 years, ... Read more >>

BJU Int (BJU international)
[2021, :]

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Is it Worth Starting Sexual Rehabilitation Before Radical Prostatectomy? Results From a Systematic Review of the Literature.

Nadja Schoentgen, Gianluigi Califano, Celeste Manfredi, Javier Romero-Otero, Felix K H Chun, Idir Ouzaid, Jean-François Hermieu, Evanguelos Xylinas, Paolo Verze,

<b>Background and Purpose:</b> Sexual dysfunction (SD) is a frequent side effect associated with radical prostatectomy (RP) for prostate cancer (PCa). Some studies have showed the benefit associated with preoperative sexual rehabilitation (prehabilitation) and Enhanced Recovery After Surgery (ERAS) for RP, but no clear clinical recommendations are available yet. Our aim ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:648345]

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Percutaneous Ablation Versus Surgical Resection for Local Recurrence Following Partial Nephrectomy for Renal Cell Cancer: A Propensity Score Analysis (REPART Study-UroCCR 71).

Marie Brassier, Zine-Eddine Khene, Jean-Christophe Bernhard, Van Thi Dang, Idir Ouzaid, François Xavier Nouhaud, Jonathan Olivier, Cosmina Nedelcu, Nicolas Grenier, Luc Beuzit, Nicolas Doumerc, Karim Bensalah, Pierre Bigot, ,

<h4>Background</h4>Data comparing percutaneous ablation (PCA) and surgical resection (SR) for an isolated local recurrence (LR) following partial nephrectomy (PN) for renal cell carcinoma (RCC) are lacking.<h4>Objective</h4>To examine the outcomes between PCA and SR for an isolated LR following PN for RCC.<h4>Design, setting, and participants</h4>Patients who underwent PN for RCC and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Predictive factors of recurrence after surgery in patients with non-metastatic renal cell carcinoma with venous tumor thrombus (UroCCR-56 Study).

Michael Baboudjian, Bastien Gondran-Tellier, Zineddine Khene, Pierre Bigot, Arnaud Mejean, Hervé Lang, Cedric Lebacle, Nicolas Doumerc, Franck Bruyere, Francois-Xavier Nouhaud, Idir Ouzaid, Karim Bensalah, Jean Christophe Bernhard, Romain Boissier,

<h4>Purpose</h4>To assess the oncological outcomes of renal cell carcinoma (RCC) associated with tumor thrombus and identify predictive factors of recurrence.<h4>Methods</h4>Multi-institutional study that included patients with cT3-4N0-1M0 RCC with tumoral thrombus identified in the prospective UroCCR database (CNIL DR 2013-206; NCT03293563). pT3a without involvement of the renal vein were excluded. All ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Adherent perinephric fat affects perioperative outcomes after partial nephrectomy: a systematic review and meta-analysis.

Zine-Eddine Khene, Gilles Dosin, Benoit Peyronnet, Anis Gasmi, Nicolas Doumerc, Idir Ouzaid, Benjamin Pradere, Marie Brassier, Mathieu Roumiguié, Romain Mathieu, Nathalie Rioux-Leclercq, Jay D Raman, Shahrokh Shariat, Karim Bensalah,

To investigate the association of adherent perinephric fat (APF) with perioperative outcomes, we conducted a systematic review and meta-analysis of the literature to clarify the impact of APF in patients undergoing partial nephrectomy. A systematic literature search using the Medline, Scopus, and Cochrane databases was performed in April 2019 and ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, 26(4):636-646]

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Clinical, surgical, pathological and follow-up features of kidney cancer patients with Von Hippel-Lindau syndrome: novel insights from a large consortium.

Umberto Capitanio, Giuseppe Rosiello, Selcuk Erdem, Isaline Rowe, Onder Kara, Eduard Roussel, Riccardo Campi, Tobias Klatte, Maximilian C Kriegmair, Mattia Sibona, Riccardo Bertolo, Idir Ouzaid, Maria Carmen Mir, Giancarlo Marra, Alessandro Larcher, Francesco Montorsi, Andrea Salonia, ,

<h4>Purpose</h4>To investigate the natural history and follow-up after kidney tumor treatment of Von Hippel-Lindau (VHL) patients.<h4>Materials and methods</h4>A multi-institutional European consortium of patients with VHL syndrome included 96 non-metastatic patients treated at 9 urological departments (1987-2018). Descriptive and survival analyses were performed.<h4>Results and limitations</h4>Median age at VHL diagnosis was 34 years ... Read more >>

World J Urol (World journal of urology)
[2021, 39(8):2969-2975]

Cited: 2 times

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Immune checkpoint inhibition in upper tract urothelial carcinoma.

Gianluigi Califano, Idir Ouzaid, Paolo Verze, Jean-Francois Hermieu, Vincenzo Mirone, Evanguelos Xylinas,

<h4>Introduction</h4>Immunotherapy is changing the way we think about and treat urothelial carcinoma (UC). The PD-1/PD-L1 pathway inhibition has shown robust efficacy, associated with an acceptable toxicity profile, in patients with locally advanced and metastatic unresectable disease, addressing a high decades-old unmet medical need.<h4>Material and methods</h4>Using the Pubmed database, we conducted ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1357-1367]

Cited: 4 times

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New immunotherapy treatments in non-muscle invasive bladder cancer.

Gianluigi Califano, Idir Ouzaid, Paolo Verze, Nadja Stivalet, Jean-François Hermieu, Evanguelos Xylinas,

Non-muscle invasive bladder cancer (NMIBC) is a highly heterogeneous disease that hides classes of patients who behave significantly differently under a favorable overall prognosis facade. Individual risk stratification and good decision making improve the patient outcomes. To date, radical cystectomy remains the treatment of choice in particularly aggressive subsets of ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2020, 73(10):945-953]

Cited: 2 times

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Postoperative Chemotherapy Bladder Instillation After Radical Nephroureterectomy: Results of a European Survey from the Young Academic Urologist Urothelial Cancer Group.

Tom-Régis Dobé, Gianluigi Califano, Friedrich-Carl von Rundstedt, Idir Ouzaid, Simone Albisinni, Atiqullah Aziz, Ettore Di Trapani, Kees Hendricksen, Wojciech Krajewski, Andrea Mari, Marco Moschini, Andrea Necchi, Aidan P Noon, Cedric Poyet, Benjamin Pradère, Michael Rink, Florian Roghmann, Paul Sargos, Roland Seiler, Francesco Soria, Malte W Vetterlein, Evanguelos Xylinas,

<h4>Background</h4>Level 1 evidence supports the administration of single postoperative intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC), in order to decrease intravesical recurrence risk.<h4>Objective</h4>The Young Academic Urologist Urothelial Cancer Group aimed to investigate the use of pIVC in daily practice among European colleagues.<h4>Design setting and ... Read more >>

Eur Urol Open Sci (European urology open science)
[2020, 22:45-50]

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Comparison of the prognosis of primary vs. progressive muscle invasive bladder cancer after radical cystectomy: Results from a large multicenter study.

François-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulié, Mathieu Roumiguié, Grégory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister,

<h4>Purpose</h4>To assess whether progressive and primary muscle invasive bladder cancer (MIBC) have different prognosis after radical cystectomy or not. To date only a few data are available on this topic with conflicting results. Further studies on large cohort are needed to clarify these outcomes that may influence bladder cancer management ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):195.e1-195.e6]

Cited: 1 time

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Surgical Management and Outcomes of Renal Tumors Arising from Horseshoe Kidneys: Results from an International Multicenter Collaboration.

Eduard Roussel, Giovanni Tasso, Riccardo Campi, Maximilian C Kriegmair, Önder Kara, Tobias Klatte, Umberto Capitanio, Riccardo Bertolo, Alexandre Ingels, Selcuk Erdem, Loïc Baekelandt, Maria C Mir, Idir Ouzaid, Nicola Pavan, Benoit Beuselinck, Mauro Gacci, Andrea Minervini, Alessandro Volpe, Maarten Albersen, ,

<h4>Background</h4>Despite being the most frequent renal fusion anomaly, tumors arising from horseshoe kidneys (HSKs) are extremely rare and management guidance is lacking.<h4>Objective</h4>To evaluate the perioperative, oncological, and functional outcomes of surgically treated HSK tumors.<h4>Design, setting, and participants</h4>A retrospective, multicenter cohort study of 43 HSK tumors in 40 patients was conducted, ... Read more >>

Eur Urol (European urology)
[2021, 79(1):133-140]

Cited: 1 time

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Urology surgical activity and COVID-19: risk assessment at the epidemic peak: a Parisian multicentre experience.

Alexandre Ingels, Steeven Bibas, Maher Abdessater, Thomas Tabourin, Morgan Roupret, Emmanuel Chartier-Kastler, Gwendolyn Barker, Nouha Tobbal, Steeve Doizi, Olivier Cussenot, Doriane Prost, Francois Desgrandchamps, Idir Ouzaid, Paul Rollin, Jean-Francois Hermieu, Francois Audenet, Mickael Userovici, Arnaud Mejean, Julien Anract, Sabine Roux, Michael Peyromaure, Nicolas Couteau, Cédric Lebacle, Jacques Irani, Dimitri Vordos, René Yiou, Andras Hoznek, Cecile M Champy, Jose Batista Da Costa, Alexandre de la Taille,

BJU Int (BJU international)
[2020, 126(4):436-440]

Cited: 4 times

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Exploring Biological Predictive Factors of Progression After Surgery in High-Risk Renal Cell Carcinoma: Results From the French Cohort of the Randomized S-TRAC Trial Patients.

Idir Ouzaid, Solène Florence Kammerer-Jacquet, Zineddine Khene, Alain Ravaud, Jean-Jacques Patard, Karim Bensalah, Nathalie Rioux-Leclercq,

<b>Objective:</b> We aimed to explore biological predictive factors of progression after surgery in nonmetastatic renal cell carcinoma (RCC) using the collected tumors in the French cohort of the randomized S-TRAC trial patients. <b>Patients and Methods:</b> We analyzed the tumors of the French cohort of STRAC that included 44 cases of ... Read more >>

Front Surg (Frontiers in surgery)
[2020, 7:26]

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Trends in the practice of renal surgery for cancer in France after the introduction of robotic-assisted surgery: data from the National Health Care System Registry.

Idir Ouzaid, Jean-Christophe Bernhard, Pierre Bigot, François-Xavier Nouhaud, Jean-Alexandre Long, Romain Boissier, Pierre Gimel, Thomas Bodin, Jean-François Hetet, Arnaud Méjean, Laurence Albiges, Karim Bensalah, , ,

J Robot Surg (Journal of robotic surgery)
[2020, 14(5):799-801]

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Chronic Kidney Disease After Partial Nephrectomy in Patients With Preoperative Inconspicuous Renal Function - Curiosity or Relevant Issue?

Malin Nientiedt, Riccardo Bertolo, Riccardo Campi, Umberto Capitanio, Selcuk Erdem, Önder Kara, Tobias Klatte, Alessandro Larcher, Maria Carmen Mir, Idir Ouzaid, Eduard Roussel, Maciej Salagierski, Frank Waldbillig, Maximillian Christian Kriegmair,

<h4>Background</h4>Chronic kidney disease (CKD) is a severe long-term complication after partial nephrectomy (PN). Clinical and scientific focus lies on patients with impaired renal function at the time of surgery. Little data is available on patients with normal preoperative renal function (NPRF).<h4>Patients and methods</h4>Patients who underwent PN with a preoperative estimated ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(6):e754-e761]

Cited: 2 times

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Lymphadenectomy for Upper Tract Urothelial Carcinoma: A Systematic Review.

Igor Duquesne, Idir Ouzaid, Yohann Loriot, Marco Moschini, Evanguelos Xylinas,

<h4>Background</h4>The role of lymphonodal dissection during surgery for a tumor of the urinary tract remains controversial.<h4>Objective</h4>To analyze anatomical bases of lymphonodal dissection in tumors of the upper urinary tract and analyze its impact on survival, recurrence, and staging. Acquisition of data: A web-based search for scientific articles using Medline/Pubmed was ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

Cited: 2 times

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Re: Impact of Adjuvant Chemotherapy in Patients with Adverse Features and Variant Histology at Radical Cystectomy for Muscle-invasive Carcinoma of the Bladder: Does Histologic Subtype Matter?

Marco Moschini, Idir Ouzaid, Evanguelos Xylinas, ,

Eur Urol (European urology)
[2019, 76(2):256-257]

Cited: 0 times

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Systematic Review and Pooled Analysis of the Impact of Renorrhaphy Techniques on Renal Functional Outcome After Partial Nephrectomy.

Riccardo Bertolo, Riccardo Campi, Maria Carmen Mir, Tobias Klatte, Maximilian C Kriegmair, Maciej Salagierski, Idir Ouzaid, Umberto Capitanio, ,

Despite the important relationship between renorrhaphy and functional outcomes of partial nephrectomy, the urological guidelines do not provide recommendations about the optimal renorrhaphy technique. We carried out the first pooled literature analysis of the impact of suture technique on ultimate renal function after partial nephrectomy. Three studies comparing interrupted versus ... Read more >>

Eur Urol Oncol (European urology oncology)
[2019, 2(5):572-575]

Cited: 5 times

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Active surveillance for non-muscle invasive bladder cancer.

Gautier Marcq, François Hénon, Idir Ouzaid, Jean Christophe Fantoni, Jean-François Hermieu, Evanguelos Xylinas,

Most of low grade (LG) bladder tumors will experience disease recurrence and very few of them (<2%) will experience disease progression. Therefore active surveillance (AS) for LG non-muscle invasive bladder cancer (NMIBC) has emerged. The goal of our study was to provide a literature review of AS for LG NMIBC ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2019, 8(1):54-60]

Cited: 1 time

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Contemporary surgical and technical aspects of transurethral resection of bladder tumor.

Idir Ouzaid, Fréderic Panthier, Jean-François Hermieu, Evanguelos Xylinas,

To date, transurethral resection of bladder tumor (TURBT) remains the gold standard of staging urothelial cancer of the bladder and treating non-muscle invasive bladder cancer (NMIBC). The primary goal of the procedure includes a proper diagnosis, correct staging, and removal all lesions. Herein, we discuss major contemporary surgical and technical ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2019, 8(1):21-24]

Cited: 2 times

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Contemporary best practice in the use of neoadjuvant chemotherapy in muscle-invasive bladder cancer.

Gautier Marcq, Edouard Jarry, Idir Ouzaid, Jean-François Hermieu, François Henon, Jean-Christophe Fantoni, Evanguelos Xylinas,

<h4>Background</h4>We aimed to provide a comprehensive literature review on the best practice management of patients with nonmetastatic muscle-invasive bladder cancer (MIBC) using neoadjuvant chemotherapy (NAC).<h4>Method</h4>Between July and September 2018, we conducted a systematic review using MEDLINE and EMBASE electronic bibliographic databases. The search strategy included the following terms: Neoadjuvant Therapy ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2019, 11:1756287218823678]

Cited: 2 times

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Urinary function and quality of life after radiotherapy for prostate cancer in patients with prior history of surgical treatment for benign prostatic hyperplasia.

Mélanie Guilhen, Christophe Hennequin, Idir Ouzaid, Ingrid Fumagalli, Valentine Martin, Sophie Guillerm, Pierre Mongiat-Artus, Vincent Ravery, François Desgrandchamps, Laurent Quéro,

<h4>Background</h4>To evaluate long-term IPSS score and urinary quality of life after radiotherapy for prostate cancer, in patients with prior history of surgical treatment for benign prostatic hyperplasia (BPH).<h4>Methods</h4>In this retrospective study, we reviewed medical records of patients treated in our department, between 2007 and 2013 with surgery for BPH followed ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2018, 13(1):209]

Cited: 1 time

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Managing female urethral diverticulum with a standardized technique using a pacifier-trick artifice to facilitate dissection.

Philippe Neveü, Idir Ouzaid, Evanguelos Xylinas, Christophe Egrot, Vincent Ravery, Jean-François Hermieu,

<h4>Introduction and hypothesis</h4>Managing urethral diverticula is challenging because of recurrence rate and postoperative complications. Herein, we report a standardized, single-institution experience of surgical treatment of urethral diverticula in women.<h4>Methods</h4>The medical record of 37 female patients treated for urethral diverticula between 2005 and 2017 in a single institution were reviewed. All ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2019, 30(5):789-794]

Cited: 1 time

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