Full Text Journal Articles by
Author Ibrahim Sahin

Advertisement

Find full text journal articles






A novel BRCA1 duplication and new insights on the spectrum and frequency of germline large genomic rearrangements in BRCA1/BRCA2.

Ibrahim Sahin, Hanife Saat,

Heritable breast cancers account for 5% to 10% of all breast cancers, and monogenic, highly penetrant genes cause them. Around 90% of pathogenic variants in BRCA1 and BRCA2 are observed using gene sequencing, with another 10% identified through gene duplication/deletion analysis, which differs across various communities. In this study, we ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Clinical outcomes of non-diabetic COVID-19 patients with different blood glucose levels: a nationwide Turkish study (TurCoGlycemia).

Cem Haymana, Ibrahim Demirci, Ilker Tasci, Erman Cakal, Serpil Salman, Derun Ertugrul, Naim Ata, Ugur Unluturk, Selcuk Dagdelen, Aysegul Atmaca, Mustafa Sahin, Osman Celik, Tevfik Demir, Rifat Emral, Ibrahim Sahin, Murat Caglayan, Ilhan Satman, Alper Sonmez,

<h4>Purpose</h4>New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and prognosis of ... Read more >>

Endocrine (Endocrine)
[2021, 73(2):261-269]

Cited: 0 times

View full text PDF listing >>



Advertisement

BRAF Mutations as Actionable Targets: A Paradigm Shift in the Management of Colorectal Cancer and Novel Avenues.

Ibrahim Halil Sahin, Jim Klostergaard,

<i>BRAF</i> mutations in colorectal cancer have been studied over the past several decades. <i>BRAF</i> V600E mutation, a class I mutation, is the most common oncogenic <i>BRAF</i> alteration in colorectal cancer. Until recently, the <i>BRAF</i> V600E mutation was not among actionable genes for colorectal cancer. However, recent discoveries have revealed therapeutic ... Read more >>

JCO Oncol Pract (JCO oncology practice)
[2021, :OP2100160]

Cited: 0 times

View full text PDF listing >>



Mutation spectrum of hereditary myopathies in Turkish patients and novel variants.

Hanife Saat, Ibrahim Sahin,

Hereditary myopathies are a heterogeneous disorder known to be associated with more than 100 genes. Although hereditary myopathy subgroups can be partially described with traditional methods such as muscle biopsy, next-generation sequencing (NGS) is essential to reveal the disease's underlying genetic etiology and molecular mechanisms. In this study, we performed ... Read more >>

Ann Hum Genet (Annals of human genetics)
[2021, :]

Cited: 0 times

View full text PDF listing >>



A novel BRCA1 duplication and new insights on the spectrum and frequency of germline large genomic rearrangements in BRCA1/BRCA2

Ibrahim Sahin, Hanife Saat,

Heritable breast cancers account for 5 to 10% of all breast cancers, and monogenic, highly penetrant genes cause them. Around 90% of pathogenic variants in BRCA1 and BRCA2 are observed using gene sequencing, with another 10% identified through gene duplication/deletion analysis, which differs across various communities. In this study, we ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Correlation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathways.

Ceyhan Hacioglu, Ibrahim Ethem Sahin, Can Uyuk,

Vaginal delivery (VD) and elective cesarean (CS) delivery modes may cause significant differences in maternal and fetal metabolism. In this study, we aimed to investigate changes in lipid metabolism, oxidative and apoptotic signaling pathways during VD and CS in maternal and cord blood and placenta tissue. The study included two ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2021, 48(5):3991-3998]

Cited: 0 times

View full text PDF listing >>



Clinical Outcomes of Non-diabetic COVID-19 Patients with Different Blood Glucose Levels: A Nationwide Turkish Study (TurCoGlycemia)

Cem Haymana, Ibrahim Demirci, Ilker Tasci, Erman Cakal, Serpil Salman, Derun Ertugrul, Naim Ata, Ugur Unluturk, Selcuk Dagdelen, Aysegul Atmaca, Mustafa Sahin, Osman Celik, Tevfik Demir, Rifat Emral, Ibrahim Sahin, Murat Caglayan, Ilhan Satman, Alper Sonmez,

<h4>Purpose: </h4> New coronavirus disease 2019 (COVID-19) has a worse prognosis in patients with diabetes. However, there are insufficient data about the effect of hyperglycemia on COVID-19 prognosis in non-diabetic patients. This study aimed to investigate the relationship between random blood glucose levels measured at the time of diagnosis and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options.

Orhan Agcaoglu, Atakan Sezer, Ozer Makay, Murat Faik Erdogan, Fahri Bayram, Sibel Guldiken, Marco Raffaelli, Yusuf Alper Sonmez, Yong-Sang Lee, Kyriakos Vamvakidis, Radu Mihai, Quan-Yang Duh, Baris Akinci, Faruk Alagol, Martin Almquist, Marcin Barczynski, Taner Bayraktaroglu, Eren Berber, Yusuf Bukey, Guldeniz Karadeniz Cakmak, Nuh Zafer Canturk, Zeynep Canturk, Mehmet Celik, Ozlem Celik, Banu Ozturk Ceyhan, Sergii Cherenko, Thomas Clerici, David Scott Coombes, Orhan Demircan, Oguzhan Deyneli, Gianlorenzo Dionigi, Ali Ugur Emre, Yesim Erbil, Ali Ilker Filiz, Hulya Ilıksu Gozu, Sibel Ozkan Gurdal, Gunay Gurleyik, Mehmet Haciyanli, Abut Kebudi, Seokmo Kim, Giannis Koutelidakis, Bekir Kuru, Meral Mert, Guzide Gonca Oruk, Serdar Ozbas, Fausto Palazzo, Rumen Pandev, Phillip Riss, Tevfik Sabuncu, Ibrahim Sahin, Gurhan Sakman, Fusun Saygili, Yasemin Giles Senyurek, Ilya Sleptsov, Sam Van Slycke, Serkan Teksoz, Tarik Terzioglu, Serdar Tezelman, Fatih Tunca, Mustafa Umit Ugurlu, Mehmet Uludag, Jesus Villar-Del-Moral, Menno Vriens, Dilek Yazici,

<h4>Purpose</h4>The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic.<h4>Methods</h4>We used ... Read more >>

Updates Surg (Updates in surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The clinical outcomes of COVID-19 infection in patients with a history of thyroid cancer: A nationwide study.

Mustafa Sahin, Cem Haymana, Ibrahim Demirci, Ilker Tasci, Emral Rıfat, Ugur Unluturk, Ilhan Satman, Tevfik Demir, Erman Cakal, Naim Ata, Derun Ertugrul, Serpil Salman, Ibrahim Sahin, Selcuk Dagdelen, Osman Celik, Murat Caglayan, Aysegul Atmaca, Alper Sonmez,

<h4>Background</h4>There are scarce published data in differentiated thyroid cancer patients about new coronavirus disease 2019 (COVID-19) disease outcomes and mortality. Here, we evaluated COVID-19 infection outcomes and mortality in thyroid cancer patients with COVID-19 infection.<h4>Design and methods</h4>We included a cohort of patients with thyroid cancer with PCR-confirmed COVID-19 disease from ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, :]

Cited: 1 time

View full text PDF listing >>



Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma.

Gokce Askan, Ibrahim Halil Sahin, Joanne F Chou, Aslihan Yavas, Marinela Capanu, Christine A Iacobuzio-Donahue, Olca Basturk, Eileen M O'Reilly,

<h4>Background</h4>Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ductal adenocarcinoma (PDAC) patients.<h4>Methods</h4>PDAC patients who underwent surgical resection between 01/2012-06/2014 were identified. CD44 and ESA expression was assessed by immunohistochemistry. Stroma was ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):385]

Cited: 0 times

View full text PDF listing >>



Unexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbul.

Ilhan Satman, Ibrahim Demirci, Cem Haymana, Ilker Tasci, Serpil Salman, Naim Ata, Selcuk Dagdelen, Ibrahim Sahin, Rifat Emral, Erman Cakal, Aysegul Atmaca, Mustafa Sahin, Osman Celik, Tevfik Demir, Derun Ertugrul, Ugur Unluturk, Kazim Yalcin Arga, Murat Caglayan, Alper Sonmez,

<h4>Aims</h4>Type 2 diabetes mellitus (T2DM) is a risk factor for severe COVID-19. Our aim was to compare the clinical outcomes of patients with and without T2DM during the first hit of COVID-19 in Istanbul.<h4>Methods</h4>A retrospective population-based study was conducted including all consecutive adult symptomatic COVID-19 cases. Patients were confirmed with ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2021, 174:108753]

Cited: 1 time

View full text PDF listing >>



Clinical characteristics and outcomes of COVID-19 in patients with type 2 diabetes in Turkey: A nationwide study (TurCoviDia).

Alper Sonmez, Ibrahim Demirci, Cem Haymana, Ilker Tasci, Selcuk Dagdelen, Serpil Salman, Naim Ata, Ibrahim Sahin, Rifat Emral, Erman Cakal, Aysegul Atmaca, Mustafa Sahin, Osman Celik, Tevfik Demir, Derun Ertugrul, Ugur Unluturk, Murat Caglayan, Ilhan Satman,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has been reported to be associated with a more severe course in patients with type 2 diabetes mellitus (T2DM). However, severe adverse outcomes are not recorded in all patients. In this study, we assessed disease outcomes in patients with and without T2DM hospitalized for COVID-19.<h4>Methods</h4>A nationwide ... Read more >>

J Diabetes (Journal of diabetes)
[2021, 13(7):585-595]

Cited: 2 times

View full text PDF listing >>



Mismatch Repair (MMR) Gene Alteration and BRAF V600E Mutation Are Potential Predictive Biomarkers of Immune Checkpoint Inhibitors in MMR-Deficient Colorectal Cancer.

Ibrahim Halil Sahin, Subir Goyal, Yoanna Pumpalova, Mohamad B Sonbol, Satya Das, Sigurdis Haraldsdottir, Daniel Ahn, Kristen K Ciombor, Zhengjia Chen, Amber Draper, Jordan Berlin, Tanios Bekaii-Saab, Gregory B Lesinski, Bassel F El-Rayes, Christina Wu,

<h4>Background</h4>Immune checkpoint inhibitor (ICI) therapy is highly effective in metastatic mismatch repair-deficient (MMR-D) colorectal cancer (CRC). In this study, we evaluated molecular and clinical predictors of ICI response in MMR-D CRC.<h4>Materials and methods</h4>Patient databases at four cancer institutions were queried. The Fisher exact test was performed to test the association ... Read more >>

Oncologist (The oncologist)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Patient Risk Subgroups Predict Benefit of Adjuvant Chemotherapy in Stage II Rectal Cancer Patients Following Neoadjuvant Chemoradiation and Total Mesorectal Excision.

Samer Naffouje, Arvind Sabesan, Benjamin D Powers, Sophie Dessureault, Julian Sanchez, Michael Schell, Iman Imanirad, Ibrahim Sahin, Hao Xie, Seth Felder,

<h4>Background</h4>The benefit of adjuvant chemotherapy (AC) is unclear in stage II (cT3-T4 N0) rectal adenocarcinoma (RAC) after neoadjuvant chemoradiation (NCRT) and total mesorectal excision (TME). We aim to identify pathologic factors that influence overall survival (OS) and stratify patients into risk profiles to assess the AC benefit within each profile.<h4>Patients ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Defining the current role of immune checkpoint inhibitors in the treatment of mismatch repair-deficient/microsatellite stability-high colorectal cancer and shedding light on future approaches.

Elaine Tan, Ibrahim Halil Sahin,

<b>Introduction</b>: Mismatch repair deficient (MMR-D)/microsatellite instability-high (MSI-H) colorectal cancer (CRC) carries unique biologic features including high tumor mutation burden, increased amount of mutation-associated neoantigen generation, and the presence of marked tumor-infiltrating lymphocytes. Immune checkpoint inhibitor (ICI) therapy has rapidly changed the treatment algorithm of MMR-D/MSI-H CRC.<b>Areas covered</b>: In this review ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(7):735-742]

Cited: 2 times

View full text PDF listing >>



Locally advanced rectal adenocarcinoma: Treatment sequences, intensification, and rectal organ preservation.

Alec Bigness, Iman Imanirad, Ibrahim Halil Sahin, Hao Xie, Jessica Frakes, Sarah Hoffe, Danielle Laskowitz, Seth Felder,

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2021, 71(3):198-208]

Cited: 0 times

View full text PDF listing >>



Neoadjuvant and adjuvant treatment approaches for hepatocellular carcinoma: future outlook.

Ibrahim Halil Sahin, Lana Khalil, Ralph Millett, Ahmed Kaseb,

Hepatocellular carcinoma (HCC) is a highly aggressive and chemotherapy resistant cancer with unique biologic characteristics which makes this disease highly different than other gastrointestinal cancers. The mainstay of curative treatment in HCC is surgical resection, ablation, and transplantation. However, rates of recurrence are high and many patients are not initially ... Read more >>

Chin Clin Oncol (Chinese clinical oncology)
[2021, 10(1):7]

Cited: 0 times

View full text PDF listing >>



Regorafenib, an investigational agent for the treatment of cholangiocarcinoma.

Ibrahim Halil Sahin, Elaine Tan, Richard Kim,

<h4>Introduction</h4>Cholangiocarcinoma is a prevalent gastrointestinal cancer with a high mortality rate. A limited number of cholangiocarcinoma patients are diagnosed with early-stage disease but unfortunately, most patients present with an advanced-stage disease which is not amenable to curative surgical resection.<h4>Areas covered</h4>We discuss regorafenib, a multi-kinase inhibitor, which has been investigated as ... Read more >>

Expert Opin Investig Drugs (Expert opinion on investigational drugs)
[2021, 30(4):333-341]

Cited: 0 times

View full text PDF listing >>



Characteristics of patients with hypertension in a population with type 2 diabetes mellitus. Results from the Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Hypertension Study).

Tevfik Sabuncu, Alper Sonmez, Mehmet Ali Eren, Ibrahim Sahin, Demet Çorapçioğlu, Rıfkı Üçler, Şafak Akin, Cem Haymana, İbrahim Demirci, Ayşegül Atmaca, Halil Önder Ersöz, Ilhan Satman, Fahri Bayram, ,

<h4>Background</h4>The present survey aimed to find out the demographical and clinical characteristics of patients with hypertension in a population with type 2 diabetes mellitus (T2DM) in Turkey.<h4>Methods</h4>Patients with T2DM who were followed-up in tertiary endocrine units for at least last one year were recruited. Demographic, clinical and biochemical data of ... Read more >>

Prim Care Diabetes (Primary care diabetes)
[2021, 15(2):332-339]

Cited: 0 times

View full text PDF listing >>



Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease.

Deepak L Bhatt, Michael Szarek, Bertram Pitt, Christopher P Cannon, Lawrence A Leiter, Darren K McGuire, Julia B Lewis, Matthew C Riddle, Silvio E Inzucchi, Mikhail N Kosiborod, David Z I Cherney, Jamie P Dwyer, Benjamin M Scirica, Clifford J Bailey, Rafael Díaz, Kausik K Ray, Jacob A Udell, Renato D Lopes, Pablo Lapuerta, P Gabriel Steg, ,

<h4>Background</h4>The efficacy and safety of sodium-glucose cotransporter 2 inhibitors such as sotagliflozin in preventing cardiovascular events in patients with diabetes with chronic kidney disease with or without albuminuria have not been well studied.<h4>Methods</h4>We conducted a multicenter, double-blind trial in which patients with type 2 diabetes mellitus (glycated hemoglobin level, ≥7%), ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(2):129-139]

Cited: 24 times

View full text PDF listing >>



ALTERED BLOOD AND AQUEOUS HUMOR LEVELS OF ASPROSIN, 4-HYDROXYNONENAL, AND 8-HYDROXY-DEOXYGUANOSINE IN PATIENTS WITH DIABETES MELLITUS AND CATARACT WITH AND WITHOUT DIABETIC RETINOPATHY.

Yavuz Oruc, Fatih Celik, Gokhan Ozgur, Emrullah Beyazyildiz, Kader Ugur, Meltem Yardim, Ibrahim Sahin, Ramazan Fazil Akkoc, Suleyman Aydin,

<h4>Purpose</h4>Diabetic retinopathy (DRP) is the formation of edema and small vessels in the retina due to high blood glucose levels. Asprosin is a hormone that stimulates the release of glucose from the liver into the circulation. Considering the relationship between oxidative stress and DRP, our study aimed to determine the ... Read more >>

Retina (Retina (Philadelphia, Pa.))
[2020, 40(12):2410-2416]

Cited: 3 times

View full text PDF listing >>



Pancreatic Cancer Stem Cells May Define Tumor Stroma Characteristics and Recurrence Patterns in Pancreatic Ductal Adenocarcinoma

Gokce Askan, Ibrahim Halil Sahin, Joanne Chou, Aslihan Yavas, Marinela Capanu, Christine Iacobuzio-Donahue, Olca Basturk, Eileen O'Reilly,

<h4>Background: </h4> Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. <h4>Methods: </h4>: PDAC patients who underwent surgical resection between 01/2012 -06/2014 were identified. CD44 and ESA expression ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Mini-laparoscopic adrenalectomy with transgastric specimen extraction.

Fatih Sumer, Yusuf Murat Bag, Mehmet Can Aydin, Bahri Evren, Emine Sener Aydin, Ibrahim Sahin, Cuneyt Kayaalp,

We aimed to describe the initial experience of mini-laparoscopic adrenalectomy combined with transgastric specimen extraction and to assess its safety and feasibility. We used only 5-mm trocars, three ports for left adrenalectomy and four for right. Intraoperative gastroscopy was performed for specimen extraction through the mouth via an endoscopic snare. ... Read more >>

Updates Surg (Updates in surgery)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes.

Murat Kabaklıoğlu, Murat Kaya, Ibrahim Ethem Şahin, Mehmet Gamsızkan, Atike Bahçıvan, Recep Eröz,

Rapamycin has antioxidant defense mechanisms and immune suppressive effects. To detect the short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes, mature male albino Wistar rats (n = 48) were included in the study as control, sham, early torsion-detorsion (T/D), early rapamycin treatment, early ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2021, 394(1):85-94]

Cited: 0 times

View full text PDF listing >>



Prediction of neuropathy, neuropathic pain and kinesiophobia in patients with type 2 diabetes and design of computerized clinical decision support systems by using artificial intelligence.

Filiz Ozdemir, Ali Ari, Melek Havva Kilcik, Davut Hanbay, Ibrahim Sahin,

Exercise is a key component for prevention and treatment of type 2 diabetes. However, diabetes complications affect exercise habits. Computerized clinical decision support systems (CCDSSs) may help specialists improve their decision-making abilities in the management of diseases. We hypothesized that patients' diabetic neuropathy, neuropathic pain, and kinesiophobia will quickly be ... Read more >>

Med Hypotheses (Medical hypotheses)
[2020, 143:110070]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.3294 s