Haneen S Dwaib, Ghina Ajouz, Ibrahim AlZaim, Rim Rafeh, Ali Mroueh, Nahed Mougharbil, Marie-Elizabeth Ragi, Marwan Refaat, Omar Obeid, Ahmed F El-Yazbi,
Background The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels. Yet, structured interventions targeting the root pathologies are not forthcoming. Growing evidence implicates the inflammatory changes occurring in perivascular adipose tissue (PVAT) as early instigators ... Read more >>
J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(24):e023227]
Cited: 0 times
Haneen S Dwaib, Ibrahim AlZaim, Ghina Ajouz, Ali H Eid, Ahmed F El-Yazbi,
The Evolving view of gut microbiota has shifted towards describing the colonic flora as a dynamic organ in continuous interaction with systemic physiological processes. Alterations of the normal gut bacterial profile, known as dysbiosis, has been linked to a wide array of pathologies. Of particular interest is the cardiovascular-metabolic disease ... Read more >>
Mol Pharmacol (Molecular pharmacology)
[2021, :]
Cited: 0 times
Safaa H Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H Eid, Ahmed F El-Yazbi,
A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive store of excess calories, however this view evolved to include an endocrine role. Adipose tissue was shown to ... Read more >>
Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:707126]
Cited: 0 times
Ibrahim Chaaban, Haidy Hafez, Ibrahim AlZaim, Cynthia Tannous, Hanan Ragab, Aly Hazzaa, Salma Ketat, Asser Ghoneim, Mohamed Katary, Mohammad M Abd-Alhaseeb, Fouad A Zouein, Amgad Albohy, Ahmed Noby Amer, Ahmed F El-Yazbi, Ahmed S F Belal,
We managed to repurpose the old drug iodoquinol to a series of novel anticancer 7-iodo-quinoline-5,8-diones. Twelve compounds were identified as inhibitors of moderate to high potency on an inhouse MCF-7 cell line, of which 2 compounds (5 and 6) were capable of reducing NAD level in MCF-7 cells in concentrations ... Read more >>
Bioorg Chem (Bioorganic chemistry)
[2021, 113:105035]
Cited: 0 times
Safaa H Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H Eid, Assaad A Eid, Ahmed F El-Yazbi,
Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients' quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines fall short of halting the progression of diabetic nephropathy to end-stage renal disease. Moreover, prior literature reported manifestations of renal ... Read more >>
Biochem Pharmacol (Biochemical pharmacology)
[2021, 186:114491]
Cited: 2 times
Rana A Alaaeddine, Ibrahim AlZaim, Safaa H Hammoud, Aya Arakji, Ali H Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,
Antithrombotic drugs are widely used for primary and secondary prevention, as well as treatment of many cardiovascular disorders. Over the past few decades, major advances in the pharmacology of these agents have been made with the introduction of new drug classes as novel therapeutic options. Accumulating evidence indicates that the ... Read more >>
Clin Sci (Lond) (Clinical science (London, England : 1979))
[2021, 135(8):1015-1051]
Cited: 0 times
Ibrahim AlZaim, Safaa H Hammoud, Houssam Al-Koussa, Alaa Ghazi, Ali H Eid, Ahmed F El-Yazbi,
Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, subcutaneous and visceral adipose tissues undergo marked hypertrophy and hyperplasia in response to nutritional excess leading to hypoxia, adipokine ... Read more >>
Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:602088]
Cited: 7 times
Georges Hatem, Diana Ghanem, Eliane Kellen, Ibrahim AlZaim, Mathijs Goossens,
<h4>Background: </h4> Cancer burden in Lebanon is among the highest of countries in the Eastern Mediterranean Region, but around one third of cases could be avoided by reducing exposure to avoidable risk factors. We explored population awareness of cancer risk factors, predictors of higher awareness and to what extent awareness ... Read more >>
Cited: 0 times
Rana A Alaaeddine, Perihan A Elzahhar, Ibrahim AlZaim, Wassim Abou-Kheir, Ahmed S F Belal, Ahmed F El-Yazbi,
Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background for a number of disorders. Of importance are pathways involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities and their products are implicated in a range of pathophysiological ... Read more >>
Curr Med Chem (Current medicinal chemistry)
[2021, 28(11):2260-2300]
Cited: 2 times
Georges Hatem, Diana Ghanem, Eliane Kellen, Ibrahim AlZaim, Mathijs Goossens,
<h4>Background</h4>Lebanon has an increasing cancer burden. Sufficient knowledge of cancer risk factors and early cancer symptoms can help lower cancer burden by facilitating primary prevention and early diagnosis. This study (i) assessed Lebanese adults' knowledge and beliefs of cancer risk factors and early cancer symptoms, (ii) analyzed whether knowledge was ... Read more >>
Cancer Control (Cancer control : journal of the Moffitt Cancer Center)
[2021, 28:10732748211053149]
Cited: 0 times