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High-order functional interactions in ageing explained via alterations in the connectome in a whole-brain model

Marilyn Gatica, Fernando Rosas, Pedro A.M. Mediano, Ibai Diez, Stephan Swinnen, Patricio Orio, Rodrigo Cofré, Jesus Cortes,

The human brain generates a rich repertoire of spatio-temporal activity patterns, which support a wide variety of motor and cognitive functions. These patterns of activity change with age in a multi-factorial manner. One of these factors is the variations in the brain’s connectomics that occurs along the lifespan. However, the ... Read more >>

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A Controlled Thermoalgesic Stimulation Device for Exploring Novel Pain Perception Biomarkers.

Maider Nunez-Ibero, Borja Camino-Pontes, Ibai Diez, Asier Erramuzpe, Endika Martinez-Gutierrez, Sebastiano Stramaglia, Javier O Alvarez-Cienfuegos, Jesus M Cortes,

<h4>Objective</h4>To develop a new device for identifying physiological markers of pain perception by reading the brain's electrical activity and hemodynamic interactions while applying thermoalgesic stimulation.<h4>Methods</h4>We designed a compact prototype that generates well-controlled thermal stimuli using a computer-driven Peltier cell while simultaneously capturing electroencephalography (EEG) and photoplethysmography (PPG) signals. The study ... Read more >>

IEEE J Biomed Health Inform (IEEE journal of biomedical and health informatics)
[2021, 25(8):2948-2957]

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Unveiling the neuroimaging-genetic intersections in the human brain.

Ibai Diez, Jorge Sepulcre,

<h4>Purpose of review</h4>The prevalence of new public datasets of brain-wide and single-cell transcriptome data has created new opportunities to link neuroimaging findings with genetic data. The aim of this study is to present the different methodological approaches that have been used to combine this data.<h4>Recent findings</h4>Drawing from various sources of ... Read more >>

Curr Opin Neurol (Current opinion in neurology)
[2021, 34(4):480-487]

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Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain.

William Orwig, Ibai Diez, Elisenda Bueichekú, Patrizia Vannini, Roger Beaty, Jorge Sepulcre,

The ability to produce novel ideas is central to societal progress and innovation; however, little is known about the biological basis of creativity. Here, we investigate the organization of brain networks that support creativity by combining functional neuroimaging data with gene expression information. Given the multifaceted nature of creative thinking, ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2021, 15:694274]

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Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease

Edmarie Guzmán-Vélez, Ibai Diez, Dorothee Schoemaker, Enmanuelle Pardilla-Delgado, Clara Vila-Castelar, Joshua Fox-Fuller, Ana Baena, Reisa Sperling, Keith Johnson, Francisco Lopera, Jorge Sepulcre, Yakeel Quiroz,

<h4>ABSTRACT</h4> Amyloid-β and tau pathology in preclinical Alzheimer’s disease (AD) are hypothesized to propagate through brain networks that are critical for neural communication. We used high-resolution graph-based network analyses to test whether in vivo amyloid-β and tau burden related to segregation and integration of functional brain connections, and their association ... Read more >>

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Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration.

Antonio Jimenez-Marin, Ibai Diez, Garazi Labayru, Andone Sistiaga, Maria C Caballero, Pol Andres-Benito, Jorge Sepulcre, Isidro Ferrer, Adolfo Lopez de Munain, Jesus M Cortes,

<h4>Aim</h4>To delineate the neurogenetic profiles of brain degeneration patterns in myotonic dystrophy type I (DM1).<h4>Methods</h4>In two cohorts of DM1 patients, brain maps of volume loss (VL) and neuropsychological deficits (NDs) were intersected to large-scale transcriptome maps provided by the Allen Human Brain Atlas (AHBA). For validation, neuropathological and RNA analyses were performed in ... Read more >>

Neuropathol Appl Neurobiol (Neuropathology and applied neurobiology)
[2021, :]

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High-Order Interdependencies in the Aging Brain.

Marilyn Gatica, Rodrigo Cofré, Pedro A M Mediano, Fernando E Rosas, Patricio Orio, Ibai Diez, Stephan P Swinnen, Jesus M Cortes,

<b><i>Background:</i></b> Brain interdependencies can be studied from either a structural/anatomical perspective ("structural connectivity") or by considering statistical interdependencies ("functional connectivity" [FC]). Interestingly, while structural connectivity is by definition pairwise (white-matter fibers project from one region to another), FC is not. However, most FC analyses only focus on pairwise statistics and ... Read more >>

Brain Connect (Brain connectivity)
[2021, :]

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Connectivity adaptations in dopaminergic systems define the brain maturity of investors.

Elena Ortiz-Teran, Ibai Diez, Jorge Sepulcre, Joaquin Lopez-Pascual, Tomas Ortiz,

Investment decisions rely on perceptions from external stimuli along with the integration of inner brain-body signals, all of which are shaped by experience. As experience is capable of molding both the structure and function of the human brain, we have used a novel neuroimaging connectomic-genetic approach to investigate the influence ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11671]

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Network interdigitations of Tau and amyloid-beta deposits define cognitive levels in aging.

Chan-Mi Kim, Victor Montal, Ibai Diez, William Orwig, , Jorge Sepulcre,

Amyloid-beta (Aβ) plaques and tau neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD); their contribution to neurodegeneration and clinical manifestations are critical in understanding preclinical AD. At present, the mechanisms related to Aβ and tau pathogenesis leading to cognitive decline in older adults remain largely unknown. Here, we examined ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2021, 42(10):2990-3004]

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Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda.

David L Perez, Timothy R Nicholson, Ali A Asadi-Pooya, Indrit Bègue, Matthew Butler, Alan J Carson, Anthony S David, Quinton Deeley, Ibai Diez, Mark J Edwards, Alberto J Espay, Jeannette M Gelauff, Mark Hallett, Silvina G Horovitz, Johannes Jungilligens, Richard A A Kanaan, Marina A J Tijssen, Kasia Kozlowska, Kathrin LaFaver, W Curt LaFrance, Sarah C Lidstone, Ramesh S Marapin, Carine W Maurer, Mandana Modirrousta, Antje A T S Reinders, Petr Sojka, Jeffrey P Staab, Jon Stone, Jerzy P Szaflarski, Selma Aybek,

Functional neurological disorder (FND) was of great interest to early clinical neuroscience leaders. During the 20th century, neurology and psychiatry grew apart - leaving FND a borderland condition. Fortunately, a renaissance has occurred in the last two decades, fostered by increased recognition that FND is prevalent and diagnosed using "rule-in" ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2021, 30:102623]

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An ALE Meta-Analysis on Investment Decision-Making.

Elena Ortiz-Teran, Ibai Diez, Joaquin Lopez-Pascual,

It is claimed that investment decision-making should rely on rational analyses based on facts and not emotions. However, trying to make money out of market forecasts can trigger all types of emotional responses. As the question on how investors decide remains controversial, we carried out an activation likelihood estimation (ALE) ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(3):]

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Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study.

Petr Sojka, Ibai Diez, Martin Bareš, David L Perez,

In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2021, 42(5):1434-1445]

Cited: 2 times

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Creative Connections: Computational Semantic Distance Captures Individual Creativity and Resting-State Functional Connectivity.

William Orwig, Ibai Diez, Patrizia Vannini, Roger Beaty, Jorge Sepulcre,

Recent studies of creative cognition have revealed interactions between functional brain networks involved in the generation of novel ideas; however, the neural basis of creativity is highly complex and presents a great challenge in the field of cognitive neuroscience, partly because of ambiguity around how to assess creativity. We applied ... Read more >>

J Cogn Neurosci (Journal of cognitive neuroscience)
[2021, 33(3):499-509]

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Genes involved in cholesterol cascades are linked to brain connectivity in one third of autistic patients

Javier Rasero, Antonio Jimenez-Marin, Ibai Diez, Mazahir Hasan, Jesus Cortes,

The large heterogeneity in the symptomatology and severity of autism spectrum disorder (ASD) is a major drawback for the design of effective therapies. Beyond behavioral phenotypes, subtype stratification strategies that can be applied to large populations are needed, these combining different neurobiological characteristics and based on the large-scale organization of ... Read more >>

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Neurodegeneration trajectory in pediatric and adult/late DM1: A follow-up MRI study across a decade.

Garazi Labayru, Antonio Jimenez-Marin, Esther Fernández, Jorge Villanua, Miren Zulaica, Jesus M Cortes, Ibai Díez, Jorge Sepulcre, Adolfo López de Munain, Andone Sistiaga,

<h4>Objective</h4>To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential predictive markers of such progression.<h4>Methods</h4>21 DM1 patients (pediatric onset: N = 9; adult/late onset: N = 12) and 18 healthy controls (HC) were assessed longitudinally over 9.17 years through brain MRI. Additionally, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(10):1802-1815]

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Transcriptional Signatures of Synaptic Vesicle Genes Define Myotonic Dystrophy Type I Neurodegeneration

Antonio Jimenez-Marin, Ibai Diez, Garazi Labayru, Andone Sistiaga, Jorge Sepulcre, Adolfo Lopez de Munain, Jesus Cortes,

Despite significant research, the biological mechanisms underlying the brain degeneration in Myotonic Dystrophy Type I (DM1) remain largely unknown. Here we have assessed brain degeneration by measuring the volume loss (VL) and cognitive deficits (CD) in two cohorts of DM1 patients, and associating them to the large-scale brain transcriptome maps ... Read more >>

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A controlled thermoalgesic stimulation device to identify novel pain perception biomarkers

Maider Núñez Ibero, Borja Camino-Pontes, Ibai Diez, Asier Erramuzpe, Endika Martínez Gutiérrez, Sebastiano Stramaglia, Javier Ortiz Álvarez-Cienfuegos, Jesus Cortes,

<h4>Objective</h4> To develop a new device that will help identify physiological markers of pain perception by reading the brain’s electrical activity and the bodies hemodynamic interactions while applying thermoalgesic stimulation. <h4>Methods:</h4> We designed a compact prototype that generates well-controlled thermal stimuli using a computer driven Peltier cell while simultaneously capturing ... Read more >>

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Central neurogenetic signatures of the visuomotor integration system.

Elisenda Bueichekú, Maite Aznárez-Sanado, Ibai Diez, Federico d'Oleire Uquillas, Laura Ortiz-Terán, Abid Y Qureshi, Maria Suñol, Silvia Basaia, Elena Ortiz-Terán, Maria A Pastor, Jorge Sepulcre,

Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(12):6836-6843]

Cited: 4 times

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Brain Circuit Alterations and Cognitive Disability in Late-Onset Cobalamin D Disorder.

Javier De Las Heras, Ibai Diez, Antonio Jimenez-Marin, Alberto Cabrera, Daniela Ramos-Usuga, Marta Venecia Diaz-Fernandez, Leire Torices, Caroline E Nunes-Xavier, Rafael Pulido, Juan Carlos Arango-Lasprilla, Jesus M Cortes,

Neuroimaging studies describing brain circuits' alterations in cobalamin (vitamin B12)-deficient patients are limited and have not been carried out in patients with inborn errors of cobalamin metabolism. The objective of this study was to assess brain functionality and brain circuit alterations in a patient with an ultra-rare inborn error of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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High-order interdependencies in the aging brain

Marilyn Gatica, Rodrigo Cofré, Pedro A.M. Mediano, Fernando Rosas, Patricio Orio, Ibai Diez, S.P. Swinnen, Jesus Cortes,

Brain interdependencies can be studied either from a structural/anatomical perspective (“structural connectivity”, SC) or by considering statistical interdependencies (“functional connectivity”, FC). Interestingly, while SC is typically pairwise (white-matter fibers start in a certain region and arrive at another), FC is not; however, most FC analyses focus only on pairwise statistics ... Read more >>

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Low variability of dynamical functional connectivity in cerebellar networks

Izaro Fernandez-Iriondo, Antonio Jimenez-Marin, Ibai Diez, Paolo Bonifazi, Stephan Swinnen, Miguel Muñoz, Jesus Cortes,

Brain networks can be defined and explored using different types of connectivity. Here, we studied P=48 healthy participants with neuroimaging state-of-the-art techniques and analyzed the relationship between the actual structural connectivity (SC) networks (between 2514 regions of interest covering the entire brain and brainstem) and the dynamical functional connectivity (DFC) ... Read more >>

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Corrigendum to: -PTEN activity defines an axis for plasticity at cortico-amygdala synapses and influences social behavior.

Cristina Sánchez-Puelles, María Calleja-Felipe, Alberto Ouro, Ghassen Bougamra, Ana Arroyo, Ibai Diez, Asier Erramuzpe, Jesús Cortés, José Martínez-Hernández, Rafael Luján, Marta Navarrete, César Venero, Andrew Chan, Miguel Morales, José A Esteban, Shira Knafo,

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(2):849]

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PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior.

Cristina Sánchez-Puelles, María Calleja-Felipe, Alberto Ouro, Ghassen Bougamra, Ana Arroyo, Ibai Diez, Asier Erramuzpe, Jesús Cortés, José Martínez-Hernández, Rafael Luján, Marta Navarrete, César Venero, Andrew Chan, Miguel Morales, José A Esteban, Shira Knafo,

Phosphatase and tensin homolog on chromosome 10 (PTEN) is a tumor suppressor and autism-associated gene that exerts an important influence over neuronal structure and function during development. In addition, it participates in synaptic plasticity processes in adulthood. As an attempt to assess synaptic and developmental mechanisms by which PTEN can ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(2):505-524]

Cited: 5 times

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Early-life trauma endophenotypes and brain circuit-gene expression relationships in functional neurological (conversion) disorder.

Ibai Diez, Anna G Larson, Vihang Nakhate, Erin C Dunn, Gregory L Fricchione, Timothy R Nicholson, Jorge Sepulcre, David L Perez,

Functional neurological (conversion) disorder (FND) is a neuropsychiatric condition whereby individuals present with sensorimotor symptoms incompatible with other neurological disorders. Early-life maltreatment (ELM) is a risk factor for developing FND, yet few studies have investigated brain network-trauma relationships in this population. In this neuroimaging-gene expression study, we used two graph ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

Cited: 10 times

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Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1.

Garazi Labayru, Ibai Diez, Jorge Sepulcre, Esther Fernández, Miren Zulaica, Jesús M Cortés, Adolfo López de Munain, Andone Sistiaga,

<h4>Background</h4>Myotonic Dystrophy type 1 (DM1) is a slowly progressive myopathy characterized by varying multisystemic involvement. Several cerebral features such as brain atrophy, ventricular enlargement, and white matter lesions (WMLs) have frequently been described. The aim of this study is to investigate the structural organization of the brain that defines the ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:102078]

Cited: 8 times

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