Full Text Journal Articles by
Author Ian Sinha

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Children are being sidelined by covid-19.

Ian Sinha, Davara Bennett, David C Taylor-Robinson,

BMJ (BMJ (Clinical research ed.))
[2020, 369:m2061]

Cited: 0 times

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Novel paediatric presentation of COVID-19 with ARDS and cytokine storm syndrome without respiratory symptoms.

Clare E Pain, Susanna Felsenstein, Gavin Cleary, Sarah Mayell, Karsten Conrad, Srikrishna Harave, Phuoc Duong, Ian Sinha, David Porter, Christian M Hedrich,

Lancet Rheumatol (The Lancet Rheumatology)
[2020, :]

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The ERS approach to e-cigarettes is entirely rational.

Andrew Bush, Jayesh Mahendra Bhatt, Will Carroll, Frances Child, Gary Connett, Iolo Doull, Francis Gilchrist, Jonathan Grigg, Simon Langton-Hewer, Julian Legg, Warren Lenney, James Paton, Michael Shields, Ian Sinha,

Eur. Respir. J. (The European respiratory journal)
[2020, 55(5):]

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Efficacy, safety and cost-effectiveness of hydroxychloroquine in children with COVID-19: A call for evidence.

Carlos E Rodríguez-Martínez, Ricardo M Fernandes, Daniel B Hawcutt, Ian P Sinha, Rafael Leite Pacheco,

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Improving outcomes for children with asthma: role of national audit.

Ian Sinha, Jennifer Quint, Michael Roberts, ,

Arch. Dis. Child. (Archives of disease in childhood)
[2020, :]

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COVID-19 infection in children.

Ian P Sinha, Rachel Harwood, Malcolm G Semple, Daniel B Hawcutt, Rebecca Thursfield, Omendra Narayan, Simon E Kenny, Russell Viner, Simon Langton Hewer, Kevin W Southern,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(5):446-447]

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Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation.

Charlotte King, Amanda McKenna, Niloufar Farzan, Susanne J Vijverberg, Marc P van der Schee, Anke H Maitland-van der Zee, Lambang Arianto, Hans Bisgaard, Klaus BØnnelykke, Vojko Berce, Uroš Potočnik, Katja Repnik, Bruce Carleton, Denise Daley, Fook Tim Chew, Wen Chin Chiang, Yang Yie Sio, Michelle M Cloutier, Herman T Den Dekker, Liesbeth Duijts, Johan C de Jongste, F Nicole Dijk, Gerard H Koppelman, Carlos Flores, Natalia Hernandez-Pacheco, Maria Pino-Yanes, Somnath Mukhopadhyay, Kaninika Basu, Lauren Bignell, Kelan G Tantisira, Steve Turner, Katia M Verhamme, Ben Francis, Munir Pirmohamed, Ian Sinha, Daniel B Hawcutt,

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary ... Read more >>

Pharmacogenomics J. (The pharmacogenomics journal)
[2020, :]

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Where next for inhaled corticosteroids in childhood asthma?

Ian P Sinha, Susanna R Dodd, Christopher Grime, Daniel B Hawcutt, Ricardo M Fernandes, Matthew R Roberts, Justus M Simba, Paula R Williamson,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(4):345]

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Developing a core outcome set for children with protracted bacterial bronchitis.

Francis J Gilchrist, Imran Ali, Malcolm Brodlie, Will D Carroll, Bridget Kemball, James Walker, Ian Sinha,

Background:Protracted bacterial bronchitis (PBB) is a chronic endobrochial infection and a leading cause of chronic wet cough in children. There is an urgent need for a randomised controlled trial to investigate the optimal treatment but there is no core outcome set (COS) to inform choice of outcomes. A COS is ... Read more >>

ERJ Open Res (ERJ open research)
[2020, 6(1):]

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Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma.

Paul J Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J Andrews, Elizabeth Miller, ,

BACKGROUND:Live attenuated influenza vaccine (LAIV) is recommended for annual influenza vaccination in children from age 2 years. However, some guidelines recommend against its use in children with asthma or recurrent wheeze due to concerns over its potential to induce wheezing. OBJECTIVE:We sought to assess the safety of LAIV in children ... Read more >>

J. Allergy Clin. Immunol. (The Journal of Allergy and Clinical Immunology)
[2020, 145(4):1157-1164.e6]

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A public health emergency among young people.

Andy Bush, Jayesh M Bhatt, Gary J Connett, Iolo Doull, Francis J Gilchrist, Jonathan Grigg, Simon C Langton Hewer, Julian Legg, Warren Lenney, Ian P Sinha,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(3):231-233]

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Patient-focused outcomes are infrequently reported in pediatric health information technology trials: a systematic review.

Matthew T Neame, Jerry Chacko, Jamie J Kirkham, Ian P Sinha, Daniel B Hawcutt,

OBJECTIVES:Billions of dollars have been invested in Health Information Technologies (HITs), and randomized controlled trials (RCTs) have been conducted to identify the effects of these interventions. Our objective was to identify the types of outcomes that were measured and reported in these RCTs. STUDY DESIGN AND SETTING:We completed a systematic ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2020, 119:117-125]

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National Asthma and COPD Audit Programme and the NHS Long Term Plan.

Ian P Sinha, James Calvert, Katherine C Hickman, John R Hurst, Viktoria McMillan, Jennifer K Quint, Sally J Singh, C Michael Roberts,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(10):841]

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Inhaled hypertonic saline for 3-6-year-olds with cystic fibrosis.

Kevin W Southern, Ian P Sinha,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(9):730-732]

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Assessing the impact of breathing retraining on asthma symptoms and dysfunctional breathing in children.

Claire Hepworth, Ian Sinha, Gemma L Saint, Daniel B Hawcutt,

OBJECTIVE:To assess the impact of breathing retraining on asthma symptoms and dysfunctional breathing (DB) in children. Breathing retraining can improve DB but there is a lack of evidence in pediatrics. METHODS:Participants attended outpatient physiotherapy appointments and received individually tailored interventions, particularly Buteyko breathing techniques. The primary outcome was the change ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(6):706-712]

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A systematic review of the effects of implementing clinical pathways supported by health information technologies.

Matthew T Neame, Jerry Chacko, Anna E Surace, Ian P Sinha, Daniel B Hawcutt,

OBJECTIVE:Health information technology (HIT) interventions include electronic patient records, prescribing, and ordering systems. Clinical pathways are multidisciplinary plans of care that enable the delivery of evidence-based healthcare. Our objective was to systematically review the effects of implementing HIT-supported clinical pathways. MATERIALS AND METHODS:A systematic review protocol was developed including Medline, ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2019, 26(4):356-363]

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Seizures and quinolone antibiotics in children: a systematic review of adverse events.

Matthew Neame, Charlotte King, Andrew Riordan, Anand Iyer, Rachel Kneen, Ian Sinha, Daniel B Hawcutt,

Background:Quinolone antibiotics have a broad spectrum of activity including against Gram-negative organisms (especially Pseudomonas), but their use has been associated with the development of seizures. Our objective was to evaluate the association between the administration of quinolones and seizures for three groups of children: those with epilepsy; those with other ... Read more >>

Eur J Hosp Pharm (European journal of hospital pharmacy : science and practice)
[2020, 27(2):60-64]

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Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis.

Mica Skilton, Ashma Krishan, Sanjay Patel, Ian P Sinha, Kevin W Southern,

BACKGROUND:Cystic fibrosis (CF) is the commonest inherited life-shortening illness in white populations, caused by a mutation in the gene that codes for the cystic fibrosis transmembrane regulator protein (CFTR), which functions as a salt transporter. This mutation mainly affects the airways where excess salt absorption dehydrates the airway lining leading ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 1:CD009841]

Cited: 1 time

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Biologics for paediatric severe asthma: trick or TREAT?

Sejal Saglani, Andrew Bush, Will Carroll, Steve Cunningham, Louise Fleming, Erol Gaillard, Atul Gupta, Clare Murray, Prasad Nagakumar, James Paton, Graham Roberts, Paul Seddon, Ian Sinha,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(4):294-296]

Cited: 2 times

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Trauma simulation training: a randomized controlled trial -evaluating the effectiveness of the Imperial Femoral Intramedullary Nailing Cognitive Task Analysis (IFINCTA) tool.

Rahul Bhattacharyya, Kapil Sugand, Bilal Al-Obaidi, Ian Sinha, Rajarshi Bhattacharya, Chinmay M Gupte,

Background and purpose - Cognitive task analysis (CTA) has been used extensively to train pilots and in other surgical specialties. However, the use of CTA within orthopedics is in its infancy. We evaluated the effectiveness of a novel CTA tool to improve understanding of the procedural steps in antegrade femoral ... Read more >>

Acta Orthop (Acta orthopaedica)
[2018, 89(6):689-695]

Cited: 1 time

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Correctors (specific therapies for class II CFTR mutations) for cystic fibrosis.

Kevin W Southern, Sanjay Patel, Ian P Sinha, Sarah J Nevitt,

BACKGROUND:Cystic fibrosis (CF) is a common life-shortening condition caused by mutation in the gene that codes for that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which functions as a salt transporter. F508del, the most common CFTR mutation that causes CF, is found in up to 80% to ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 8:CD010966]

Cited: 4 times

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A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol.

Emma Thomas-Jones, Amy Lloyd, Damian Roland, Gerri Sefton, Lyvonne Tume, Kerry Hood, Chao Huang, Dawn Edwards, Alison Oliver, Richard Skone, David Lacy, Ian Sinha, Jenny Preston, Brendan Mason, Nina Jacob, Robert Trubey, Heather Strange, Yvonne Moriarty, Aimee Grant, Davina Allen, Colin Powell,

BACKGROUND:In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-faceted socio-technical system to detect deterioration in children, which may or may not include a track and trigger ... Read more >>

BMC Pediatr (BMC pediatrics)
[2018, 18(1):244]

Cited: 1 time

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Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

Gemma L Saint, Malcolm G Semple, Ian Sinha, Daniel B Hawcutt,

Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a target therapeutic range between 10 ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(3):209-214]

Cited: 1 time

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Re: Response to the Analysis of Patient Outcomes in Two-Screw Versus Single-Screw Cephalomedullary Nail.

Matthew K J Jaggard, Ian Sinha, Angus Lewis, Rajarshi Bhattacharya,

J Orthop Trauma (Journal of orthopaedic trauma)
[2017, 31(8):e269]

Cited: 0 times

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Core Outcome Sets.

James Webbe, Ian Sinha, Chris Gale,

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2018, 103(3):163-166]

Cited: 2 times

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