Full Text Journal Articles by
Author Ian M Sanne


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An incidental finding of chronic lymphocytic leukaemia in a patient with pulmonary tuberculosis.

Victoria R Parker, Jaclyn A Bennet, Ian M Sanne,

In this case report, we described a 48-year-old human immunodeficiency virus-negative man with pulmonary tuberculosis (TB) who had an incidental finding of concurrent chronic lymphocytic leukaemia. We highlighted the importance of considering other differential diagnoses when patients present with TB or haematological malignancies. We also discussed the difficulties in diagnosis ... Read more >>

S Afr J Infect Dis (Southern African journal of infectious diseases)
[2020, 35(1):218]

Cited: 0 times

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Predictors of switch to and early outcomes on third-line antiretroviral therapy at a large public-sector clinic in Johannesburg, South Africa.

Denise Evans, Kamban Hirasen, Rebecca Berhanu, Given Malete, Prudence Ive, David Spencer, Sharlaa Badal-Faesen, Ian M Sanne, Matthew P Fox,

<h4>Background</h4>While efficacy data exist, there are limited data on the outcomes of patients on third-line antiretroviral therapy (ART) in sub-Saharan Africa in actual practice. Being able to identify predictors of switch to third-line ART will be essential for planning for future need. We identify predictors of switch to third-line ART ... Read more >>

AIDS Res Ther (AIDS research and therapy)
[2018, 15(1):10]

Cited: 8 times

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The right combination - treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa.

Kamban Hirasen, Denise Evans, Mhairi Maskew, Ian M Sanne, Kate Shearer, Caroline Govathson, Given Malete, Sheryl A Kluberg, Matthew P Fox,

Background:Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) single-pill regimens, introduced in South Africa in April 2013, has simplified pill taking. We evaluated treatment outcomes among patients initiated on a FDC compared to a similar multi-pill ART regimen in Johannesburg, South Africa. ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2018, 10:17-29]

Cited: 5 times

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Does Disseminated Nontuberculous Mycobacterial Disease Cause False-Positive Determine TB-LAM Lateral Flow Assay Results? A Retrospective Review.

Jeremy S Nel, Christopher K Lippincott, Rebecca Berhanu, David C Spencer, Ian M Sanne, Prudence Ive,

We retrospectively reviewed the Determine TB-LAM lateral flow assay (LF-LAM) results among human immunodeficiency virus-infected patients with disseminated nontuberculous mycobacterial (NTM) disease. LF-LAM was positive in 19 of 21 patients without evidence of tuberculosis (TB) coinfection. Although TB-NTM coinfection may have been underdiagnosed, our results suggest that disseminated NTM disease ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(7):1226-1228]

Cited: 10 times

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Evaluation of Xpert MTB/RIF Versus AFB Smear and Culture to Identify Pulmonary Tuberculosis in Patients With Suspected Tuberculosis From Low and Higher Prevalence Settings.

Anne F Luetkemeyer, Cynthia Firnhaber, Michelle A Kendall, Xingye Wu, Gerald H Mazurek, Debra A Benator, Roberto Arduino, Michel Fernandez, Elizabeth Guy, Pamela Johnson, Beverly Metchock, Fred Sattler, Edward Telzak, Yun F Wang, Marc Weiner, Susan Swindells, Ian M Sanne, Diane V Havlir, Beatriz Grinsztejn, David Alland, ,

<h4>Background</h4>The Xpert MTB/RIF (Xpert) assay is a rapid nucleic acid amplification test widely used in settings of high tuberculosis prevalence to detect tuberculosis as well asrpoBmutations associated with rifampin resistance. Data are needed on the diagnostic performance of Xpert in lower-prevalence settings to inform appropriate use for both tuberculosis detection ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2016, 62(9):1081-1088]

Cited: 32 times

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Low-frequency nevirapine (NVP)-resistant HIV-1 variants are not associated with failure of antiretroviral therapy in women without prior exposure to single-dose NVP.

Valerie F Boltz, Yajing Bao, Shahin Lockman, Elias K Halvas, Mary F Kearney, James A McIntyre, Robert T Schooley, Michael D Hughes, John M Coffin, John W Mellors, ,

<h4>Background</h4>Low-frequency nevirapine (NVP)-resistant variants have been associated with virologic failure (VF) of initial NVP-based combination antiretroviral therapy (cART) in women with prior exposure to single-dose NVP (sdNVP). We investigated whether a similar association exists in women without prior sdNVP exposure.<h4>Methods</h4>Pre-cART plasma was analyzed by allele-specific polymerase chain reaction to quantify ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2014, 209(5):703-710]

Cited: 23 times

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Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: data from the ACTG A5175/PEARLS trial.

Steven A Safren, Katie B Biello, Laura Smeaton, Matthew J Mimiaga, Ann Walawander, Javier R Lama, Aadia Rana, Mulinda Nyirenda, Virginia M Kayoyo, Wadzanai Samaneka, Anjali Joglekar, David Celentano, Ana Martinez, Jocelyn E Remmert, Aspara Nair, Umesh G Lalloo, Nagalingeswaran Kumarasamy, James Hakim, Thomas B Campbell, ,

<h4>Background</h4>PEARLS, a large scale trial of antiretroviral therapy (ART) for HIV (n = 1,571, 9 countries, 4 continents), found that a once-daily protease inhibitor (PI) based regimen (ATV+DDI+FTC), but not a once-daily non-nucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) regimen (EFV+FTC/TDF), had inferior efficacy compared to a standard of care twice-daily ... Read more >>

PLoS One (PloS one)
[2014, 9(8):e104178]

Cited: 33 times

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Tuberculosis immune reconstitution inflammatory syndrome in A5221 STRIDE: timing, severity, and implications for HIV-TB programs.

Anne F Luetkemeyer, Michelle A Kendall, Mulinda Nyirenda, Xingye Wu, Prudence Ive, Constance A Benson, Janet W Andersen, Susan Swindells, Ian M Sanne, Diane V Havlir, Johnstone Kumwenda, ,

<h4>Rationale and objectives</h4>Earlier initiation of antiretroviral therapy (ART) in HIV-tuberculosis (TB) is associated with increased immune reconstitution inflammatory syndrome (IRIS). The severity, frequency, and complications of TB IRIS were evaluated in A5221, a randomized trial of earlier ART (within 2 weeks after TB treatment initiation) vs. later ART (8-12 weeks ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2014, 65(4):423-428]

Cited: 42 times

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Evaluation of two line probe assays for rapid detection of Mycobacterium tuberculosis, tuberculosis (TB) drug resistance, and non-TB Mycobacteria in HIV-infected individuals with suspected TB.

Anne F Luetkemeyer, Michelle A Kendall, Xingye Wu, Maria Cristina Lourenço, Ute Jentsch, Susan Swindells, Sarojini S Qasba, Jorge Sanchez, Diane V Havlir, Beatriz Grinsztejn, Ian M Sanne, Cynthia Firnhaber, ,

Limited performance data from line probe assays (LPAs), nucleic acid tests used for the rapid diagnosis of tuberculosis (TB), nontuberculosis mycobacteria (NTM), and Mycobacterium tuberculosis drug resistance are available for HIV-infected individuals, in whom paucibacillary TB is common. In this study, the strategy of testing sputum with GenoType MTBDRplus (MTBDR-Plus) ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2014, 52(4):1052-1059]

Cited: 21 times

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Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.

Josephine M Bryant, Simon R Harris, Julian Parkhill, Rodney Dawson, Andreas H Diacon, Paul van Helden, Alex Pym, Aziah A Mahayiddin, Charoen Chuchottaworn, Ian M Sanne, Cheryl Louw, Martin J Boeree, Michael Hoelscher, Timothy D McHugh, Anna L C Bateson, Robert D Hunt, Solomon Mwaigwisya, Laura Wright, Stephen H Gillespie, Stephen D Bentley,

<h4>Background</h4>Recurrence of tuberculosis after treatment makes management difficult and is a key factor for determining treatment efficacy. Two processes can cause recurrence: relapse of the primary infection or re-infection with an exogenous strain. Although re-infection can and does occur, its importance to tuberculosis epidemiology and its biological basis is still ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2013, 1(10):786-792]

Cited: 98 times

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Relationship between weight, efavirenz exposure, and virologic suppression in HIV-infected patients on rifampin-based tuberculosis treatment in the AIDS Clinical Trials Group A5221 STRIDE Study.

Anne F Luetkemeyer, Susan L Rosenkranz, Darlene Lu, Florence Marzan, Prudence Ive, Evelyn Hogg, Susan Swindells, Constance A Benson, Beatriz Grinsztejn, Ian M Sanne, Diane V Havlir, Francesca Aweeka, ,

<h4>Background</h4>Rifampin (RIF) upregulates CYP 450 isoenzymes, potentially lowering efavirenz (EFV) exposure. The US EFV package insert recommends an EFV dose increase for patients on RIF weighing ≥50 kg. We conducted a pharmacokinetic study to evaluate EFV trough concentrations (Cmin) and human immunodeficiency virus (HIV) virologic suppression in patients on EFV ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2013, 57(4):586-593]

Cited: 36 times

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Effectiveness and safety of 30 mg versus 40 mg stavudine regimens: a cohort study among HIV-infected adults initiating HAART in South Africa.

Mhairi Maskew, Daniel Westreich, Matthew P Fox, Thapelo Maotoe, Ian M Sanne,

<h4>Background</h4>As stavudine remains an important and widely prescribed drug in resource-limited settings, the effect of a reduced dose of stavudine (from 40 mg to 30 mg) on outcomes of highly active antiretroviral therapy (HAART) remains an important public health question.<h4>Methods</h4>We analyzed prospectively collected data from the Themba Lethu Clinic in ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2012, 15(1):13]

Cited: 10 times

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Cohort profile: the Themba Lethu Clinical Cohort, Johannesburg, South Africa.

Matthew P Fox, Mhairi Maskew, A Patrick MacPhail, Lawrence Long, Alana T Brennan, Daniel Westreich, William B MacLeod, Pappie Majuba, Ian M Sanne,

The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment Guidelines, answer questions of national and international policy relevance and to combine an economic and epidemiologic focus on HIV research. The current objectives of the Themba ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2013, 42(2):430-439]

Cited: 56 times

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Poorer ART outcomes with increasing age at a large public sector HIV clinic in Johannesburg, South Africa.

Mhairi Maskew, Alana T Brennan, A Patrick MacPhail, Ian M Sanne, Matthew P Fox,

<h4>Background</h4>As the current HIV-positive population ages, the absolute number of patients >50 years on treatment is increasing.<h4>Methods</h4>We analyze the differences in treatment outcomes by age category (18-29, 30-39, 40-49, 50-59, and ≥ 60) among 9139 HIV-positive adults initiating ART in South Africa.<h4>Results</h4>The adjusted hazard ratios (HRs) for all-cause mortality increased ... Read more >>

J Int Assoc Physicians AIDS Care (Chic) (Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002))
[2012, 11(1):57-65]

Cited: 24 times

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Antiretroviral therapies in women after single-dose nevirapine exposure.

Shahin Lockman, Michael D Hughes, James McIntyre, Yu Zheng, Tsungai Chipato, Francesca Conradie, Fred Sawe, Aida Asmelash, Mina C Hosseinipour, Lerato Mohapi, Elizabeth Stringer, Rosie Mngqibisa, Abraham Siika, Diana Atwine, James Hakim, Douglas Shaffer, Cecilia Kanyama, Kara Wools-Kaloustian, Robert A Salata, Evelyn Hogg, Beverly Alston-Smith, Ann Walawander, Eva Purcelle-Smith, Susan Eshleman, James Rooney, Sibtain Rahim, John W Mellors, Robert T Schooley, Judith S Currier, ,

<h4>Background</h4>Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus.<h4>Methods</h4>In seven African countries, women infected with HIV-1 whose CD4+ T-cell counts were below 200 per cubic millimeter and who either had or had not taken single-dose nevirapine at least 6 ... Read more >>

N Engl J Med (The New England journal of medicine)
[2010, 363(16):1499-1509]

Cited: 83 times

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Initiating patients on antiretroviral therapy at CD4 cell counts above 200 cells/microl is associated with improved treatment outcomes in South Africa.

Matthew P Fox, Ian M Sanne, Francesca Conradie, Jennifer Zeinecker, Catherine Orrell, Prudence Ive, Mohammed Rassool, Marjorie Dehlinger, Charles van der Horst, James McIntyre, Robin Wood,

<h4>Objectives</h4>To compare treatment outcomes by starting CD4 cell counts using data from the Comprehensive International Program of Research on AIDS-South Africa trial.<h4>Design</h4>An observational cohort study.<h4>Methods</h4>Patients presenting to primary care clinics with CD4 cell counts below 350 cells/microl were randomized to either doctor or nurse-managed HIV care and followed for at ... Read more >>

AIDS (AIDS (London, England))
[2010, 24(13):2041-2050]

Cited: 48 times

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Association between cervical dysplasia and human papillomavirus in HIV seropositive women from Johannesburg South Africa.

Cynthia Firnhaber, Hoa Van Le, Audrey Pettifor, Doreen Schulze, Pam Michelow, Ian M Sanne, David A Lewis, Anna-Lise Williamson, Bruce Allan, Sophia Williams, Allen Rinas, Simon Levin, Jennifer S Smith,

<h4>Objective</h4>To examine the association between CD4 counts, HPV infection and the risk of cervical neoplasia among HIV-seropositive women.<h4>Methods</h4>A cross-sectional observational study was conducted among 1,010 HIV-seropositive women using cytology-based Pap smears. HPV DNA testing using Linear Array genotyping assay (Roche) was carried out in a subset of 191 patients. Multivariable-adjusted ... Read more >>

Cancer Causes Control (Cancer causes & control : CCC)
[2010, 21(3):433-443]

Cited: 59 times

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Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study.

Ian M Sanne, Daniel Westreich, Andrew P Macphail, Dennis Rubel, Pappie Majuba, Annelies Van Rie,

<h4>Background</h4>Clinical, immunologic and virologic outcomes at large HIV/AIDS care clinics in resource poor settings are poorly described beyond the first year of highly active antiretroviral treatment (HAART). We aimed to prospectively evaluate long-term treatment outcomes at a large scale HIV/AIDS care clinic in South Africa.<h4>Methods</h4>Cohort study of patients initiating HAART ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2009, 12:38]

Cited: 54 times

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Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world.

Arthi Vijayaraghavan, Molly Bates Efrusy, Peter D Mazonson, Osman Ebrahim, Ian M Sanne, Christopher C Santas,

<h4>Objective</h4>Determine the cost-effectiveness of initiating and monitoring highly active antiretroviral therapy (HAART) in developing countries according to developing world versus developed world guidelines.<h4>Design</h4>Lifetime Markov model incorporating costs, quality of life, survival, and transmission to sexual contacts.<h4>Methods</h4>We evaluated treating patients with HIV in South Africa according to World Health Organization (WHO) ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2007, 46(1):91-100]

Cited: 36 times

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Challenges in delivering antiretroviral treatment in resource poor countries.

Mina C Hosseinipour, Peter N Kazembe, Ian M Sanne, Charles M van der Horst,

AIDS (AIDS (London, England))
[2002, 16 Suppl 4:S177-87]

Cited: 8 times

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