Full Text Journal Articles by
Author Ian Kitai

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Access to paediatric formulations for the treatment of childhood tuberculosis.

Madlen Nash, Christophe Perrin, James A Seddon, Jennifer Furin, Janika Hauser, Ben Marais, Ian Kitai, Jeffrey Starke, Lindsay McKenna,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):855-857]

Cited: 0 times

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Choosing Wisely: Computed Tomography in the Diagnosis of Adolescents With Intrathoracic Tuberculosis.

Spenta Kakalia, Aparna Chakravarty, David Manson, Ray Lam, Valerie Waters, Ian Kitai,

In a retrospective study of adolescents with intrathoracic tuberculosis (TB), 26 out of the 81 (32%) patients had undergone chest computed tomography (CT). Chest CT was considered unnecessary in 7 (27%), necessary in 7 (27%), and possibly/probably helpful in 12 (46%). Promptly obtaining specimens for sputum smear microscopy, molecular testing, ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, :]

Cited: 0 times

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Dissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada.

Philipp Kohler, Nathalie Tijet, Hyunjin C Kim, Jennie Johnstone, Tom Edge, Samir N Patel, Christine Seah, Barbara Willey, Brenda Coleman, Karen Green, Irene Armstrong, Kevin Katz, Matthew P Muller, Jeff Powis, Susan M Poutanen, David Richardson, Alicia Sarabia, Andrew Simor, Allison McGeer, Roberto G Melano, ,

Surveillance data from Southern Ontario show that a majority of Verona Integron-encoded Metallo-β-lactamase (VIM)-producing Enterobacteriaceae are locally acquired. To better understand the local epidemiology, we analysed clinical and environmental blaVIM-positive Enterobacteriaceae from the area. Clinical samples were collected within the Toronto Invasive Bacterial Diseases Network (2010-2016); environmental water samples were ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18580]

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Inguinal mass in a 4-month-old boy.

Valerie J Waters, Reto M Baertschiger, Ian Kitai,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(29):E845]

Cited: 0 times

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2716. Persistence of 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Serotypes in Invasive Pneumococcal Disease in Adults in Southern Ontario Canada Despite Routine Pediatric Vaccination.

Allison McGeer, Agron Plevneshi, Karen Green, Brenda Coleman, Sarah Nayani, Wallis Rudnick, Andrew Simor, Wayne Gold, Kevin Katz, Ian Kitai, Jennie Johnstone, Irene Martin, Matthew P Muller, David Richardson, Alicia Sarabia,

AbstractBackgroundIn Ontario, Canada, PCV13 is covered for immunocompromised (IC) adults over 50y. PCV13 programs are thought not to be cost-effective in other adults because it is assumed that herd immunity from pediatric vaccination programs (PCV7 since 2005; PCV13 since 2010) will reduce PCV13 disease burden dramatically in adults. We analyzed ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S955-S956]

Cited: 0 times

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Analysis and Reporting of Tests for Tuberculosis Infection in Childhood Contacts of Infectious Source Cases.

Ian Kitai, Elizabeth Rea, Winsley Rose,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(8):e191]

Cited: 0 times

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Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada1.

Philipp P Kohler, Roberto G Melano, Samir N Patel, Shumona Shafinaz, Amna Faheem, Brenda L Coleman, Karen Green, Irene Armstrong, Huda Almohri, Sergio Borgia, Emily Borgundvaag, Jennie Johnstone, Kevin Katz, Freda Lam, Matthew P Muller, Jeff Powis, Susan M Poutanen, David Richardson, Anu Rebbapragada, Alicia Sarabia, Andrew Simor, Allison McGeer, ,

We analyzed population-based surveillance data from the Toronto Invasive Bacterial Diseases Network to describe carbapenemase-producing Enterobacteriaceae (CPE) infections during 2007-2015 in south-central Ontario, Canada. We reviewed patients' medical records and travel histories, analyzed microbiologic and clinical characteristics of CPE infections, and calculated incidence. Among 291 cases identified, New Delhi metallo-β-lactamase ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2018, 24(9):1674-1682]

Cited: 3 times

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Final Results of National Surveillance of Childhood Tuberculosis in Canada: 2013–2016.

Ryan Giroux, Aaryn Montgomery-Song, Raquel Consunji-Araneta, Ian Kitai, Shaun Morris,

AbstractBACKGROUNDThere is little detailed epidemiologic and clinical data about tuberculosis (TB) disease in children in Canada.OBJECTIVESThis study characterizes the epidemiologic, clinical, and treatment data for all cases of TB in children under age 15 in Canada surveyed through the Canadian Paediatric Surveillance Program’s (CPSP) Childhood Tuberculosis Study from October 2013 ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2018, 23(Suppl 1):e13-e13]

Cited: 0 times

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Prevalence of tuberculosis infection and disease in children referred for tuberculosis medical surveillance in Ontario: a single-cohort study.

Catherine Yang, Abdool S Yasseen, Jennifer Stimec, Elizabeth Rea, Valerie Waters, Ray Lam, Shaun K Morris, Ian Kitai,

BACKGROUND:There are few data about the utility of the Canadian tuberculosis medical surveillance system for detecting tuberculosis in children and adolescents. We sought to assess the prevalence of tuberculosis infection and disease in children and adolescents referred by the tuberculosis medical surveillance program who were evaluated at The Hospital for ... Read more >>

CMAJ Open (CMAJ open)
[2018, 6(3):E365-E371]

Cited: 0 times

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Factors Associated With 30-Day Mortality Rate in Respiratory Infections Caused by Streptococcus pneumoniae.

Matthew P Cheng, Isaac I Bogoch, Karen Green, Agron Plevneshi, Wallis Rudnick, Altynay Shigayeva, Allison McGeer, Todd C Lee, ,

In multivariable analysis of associations between initial antibiotic therapy and clinical outcomes in 5005 patients with microbiologically confirmed Streptococcus pneumoniae infections, "discordant" empiric antibiotic therapy was not associated with 30-day mortality rate (hazard ratio, 0.94; 95% confidence interval, .67-1.32). ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2018, 66(8):1282-1285]

Cited: 0 times

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Optimizing Blood Collection and Processing for Quantiferon-TB Gold in-Tube Testing Gives Low Rates of Indeterminate Results: Clinical Implications.

Faisal Kordy, Valerie Waters, Cathy Den-Hollander, Stanley Read, Ray Lam, Ian Kitai,

The rate of low-mitogen indeterminate interferon-gamma release assay results at a hospital with expert pediatric phlebotomy and rapid incubation of specimens was 0.96%. All low-mitogen indeterminate results were found to be associated with an immunocompromised or anergic state. We describe a child where an unexpected indeterminate interferon-gamma release assay test ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2018, 37(1):e22-e24]

Cited: 2 times

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Diagnosis and management of pediatric tuberculosis in Canada.

Ian Kitai, Shaun K Morris, Faisal Kordy, Ray Lam,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2017, 189(1):E11-E16]

Cited: 4 times

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Tuberculous lymphadenitis of the head and neck in Canadian children: Experience from a low-burden region.

Jason J Xu, Shazia Peer, Blake C Papsin, Ian Kitai, Evan J Propst,

Children are more likely than adults to develop extra-pulmonary tuberculosis (EPTB), which often presents as cervical lymphadenopathy. The role of surgery in management is uncertain. We reviewed all head and neck EPTB cases presenting to our tertiary care pediatric institution over a twelve-year period.All children 18 years of age and ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2016, 91:11-14]

Cited: 1 time

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Culture-positive Pediatric Tuberculosis in Toronto, Ontario: Sources of Infection and Relationship of Birthplace and Mycobacterial Lineage to Phenotype.

Jonathan H Rayment, Jennifer L Guthrie, Karen Lam, Michael Whelan, Brenda Lee, Frances B Jamieson, Ian Kitai,

Few data relate Mycobacterium tuberculosis (Mtb) lineage and disease phenotype in the pediatric population or examine the contribution of travel to the tuberculosis (TB)-endemic country in North America. We examined clinical, demographic and Mtb genotype data from patients with TB who were treated in Toronto between 2002 and 2012.Consecutive Mtb ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2016, 35(1):13-18]

Cited: 3 times

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Association of serotype with respiratory presentations of pneumococcal infection, Ontario, Canada, 2003-2011.

Altynay Shigayeva, Wallis Rudnick, Karen Green, Gregory Tyrrell, Walter H B Demczuk, Wayne L Gold, Jonathan Gubbay, Frances Jamieson, Agron Plevneshi, Sylvia Pong-Porter, Susan Richardson, Allison McGeer, ,

Pneumococcal disease burden is difficult to quantify due to limited data regarding non-bacteremic disease. We assessed serotype-specific differences in pneumococcal disease presentations in adults in Toronto, Canada.From 2003 to 2011, population-based surveillance for invasive pneumococcal disease was conducted and respiratory pneumococcal isolates collected in Metropolitan Toronto/Peel Region, Canada. Episodes of ... Read more >>

Vaccine (Vaccine)
[2016, 34(6):846-853]

Cited: 9 times

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Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs.

Altynay Shigayeva, Wallis Rudnick, Karen Green, Danny K Chen, Walter Demczuk, Wayne L Gold, Jennie Johnstone, Ian Kitai, Sigmund Krajden, Reena Lovinsky, Matthew Muller, Jeff Powis, Neil Rau, Sharon Walmsley, Gregory Tyrrell, Ari Bitnun, Allison McGeer, ,

In 2012/2013, a single dose of 13-valent pneumococcal conjugate vaccine (PCV13) was recommended for immunocompromised adults in the United States and Canada. To assess the potential benefits of this recommendation, we assessed the serotype-specific burden of invasive pneumococcal disease (IPD) among immunocompromised individuals.From 1995 to 2012, population-based surveillance for IPD ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2016, 62(2):139-147]

Cited: 31 times

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1704Optimal treatment of BCG Osteomyelitis: A Review.

Sarah Khan, Ian Kitai,

Open Forum Infect Dis (Open forum infectious diseases)
[2014, 1(Suppl 1):S455-S456]

Cited: 0 times

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Quantiferon Gold-in-tube assay for TB screening in HIV infected children: influence of quantitative values.

Winsley Rose, Ian Kitai, Fatima Kakkar, Stanley E Read, Marcel A Behr, Ari Bitnun,

BACKGROUND: HIV infected children are at increased risk of TB disease and require annual TB screening. Data on use of IGRA for TB screening in them are limited. We retrospectively evaluated the usefulness of Quantiferon Gold-in-tube test (QFT), an IGRA in screening for LTBI in relatively healthy, immunologically stable HIV ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2014, 14:516]

Cited: 3 times

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Nonresponding osteomyelitis in a two-year-old boy.

Sarah Khan, Jennifer Stimec, Ian Kitai,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2015, 187(12):901-904]

Cited: 0 times

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Epidemiology and clinical management of tuberculosis in children in Canada.

Shaun K Morris, Anne-Marie Demers, Ray Lam, Lisa G Pell, Ryan Jp Giroux, Ian Kitai,

Although often regarded as a foreign disease, latent tuberculosis or tuberculosis disease will be encountered in many clinical situations by the Canadian child health practitioner. There are key differences between tuberculosis in children and adults. In the present article, the changing epidemiology of tuberculosis in children in Canada and around ... Read more >>

Paediatr Child Health (Paediatrics & child health)
[2015, 20(2):83-88]

Cited: 4 times

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Utility of gastric aspirates for diagnosing tuberculosis in children in a low prevalence area: predictors of positive cultures and significance of non-tuberculous mycobacteria.

Faisal Kordy, Susan E Richardson, Derek Stephens, Ray Lam, Frances Jamieson, Ian Kitai,

In countries with low rates of tuberculosis (TB), yields of gastric aspirates (GAs) for Mycobacterium tuberculosis (MTB) culture are low. The significance of non-tuberculous mycobacteria (NTM) isolated from GA is uncertain.We reviewed clinical, microbiologic and radiologic data for children who underwent GA between 1999 and 2011 at Sick Kids, Toronto. ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2015, 34(1):91-93]

Cited: 8 times

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Relating Tuberculosis (TB) Contact Characteristics to QuantiFERON-TB-Gold and Tuberculin Skin Test Results in the Toronto Pediatric TB Clinic.

Winsley Rose, Stanley E Read, Ari Bitnun, Elizabeth Rea, Derek Stephens, Wanatpreeya Pongsamart, Ian Kitai,

Few data relate interferon-γ-release-assay results in children to source case sputum status, the best predictor of infectiousness of tuberculosis (TB) patients. We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and tuberculin skin test (TST) in children with different types of TB exposure.The TST and QFT were performed in referred TB-exposed children and ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2015, 4(2):96-103]

Cited: 7 times

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Encounters with an old foe: Childhood tuberculosis in Canada.

Ian Kitai, Shaun K Morris,

Paediatr Child Health (Paediatrics & child health)
[2014, 19(2):89-90]

Cited: 1 time

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Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization.

Kyla J Hildebrand, Adelle Atkinson, Ian Kitai,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2014, 33(7):787]

Cited: 1 time

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Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995-2011.

Wallis Rudnick, Zhong Liu, Altynay Shigayeva, Donald E Low, Karen Green, Agron Plevneshi, Roslyn Devlin, James Downey, Kevin Katz, Ian Kitai, Sigmund Krajden, Krystyna Ostrowska, David Richardson, Susan Richardson, Alicia Sarabia, Michael Silverman, Andrew E Simor, Gregory Tyrrell, Allison McGeer, ,

BACKGROUND: In 1995, a publicly funded pneumococcal vaccination program for 23-valent polysaccharide vaccine (PPV23) was introduced in Ontario. Conjugate vaccines were authorized in 2001 (PCV7), 2009 (PCV10) and 2010 (PCV13). METHODS: From 1995-2011, active, population-based surveillance for invasive pneumococcal disease (IPD) was conducted in Metropolitan Toronto and Peel Region, Canada. ... Read more >>

Vaccine (Vaccine)
[2013, 31(49):5863-5871]

Cited: 34 times

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