Full Text Journal Articles by
Author Ian Graham

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Optimising implementation of European guidelines on cardiovascular disease prevention in clinical practice: what is needed?

Izabella Uchmanowicz, Arno Hoes, Joep Perk, Gabrielle McKee, Margrét Hrönn Svavarsdóttir, Katarzyna Czerwińska-Jelonkiewicz, Arne Janssen, Anna Oleksiak, Paul Dendale, Ian M Graham,

Cardiovascular disease is a model example of a preventable condition for which practice guidelines are particularly important. In 2016, the joint task force created by the European Society of Cardiology (ESC) together with 10 other societies released the new version of the European guidelines on cardiovascular disease prevention. To facilitate ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487320926776]

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Applying an intersectionality lens to the Theoretical Domains Framework: a tool for thinking about how intersecting social identities and structures of power influence behaviour

Nicole Etherington, Isabel Braganca Rodrigues, Lora Giangregorio, Ian Graham, Alison Hoens, Danielle Kasperavicius, Christine Kelly, Julia Moore, Matteo Ponzano, Justin Presseau, Kathryn Sibley, Sharon Straus,

Abstract Background: A key component of the implementation process is identifying potential barriers and facilitators that need to be addressed. The Theoretical Domains Framework (TDF) is one of the most commonly used frameworks for this purpose. When applying the TDF, it is critical to understand the context in which behaviours ... Read more >>

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How do guideline developers identify, incorporate and report patient preferences? An international cross-sectional survey.

Jayden Blackwood, Melissa J Armstrong, Corinna Schaefer, Ian D Graham, Loes Knaapen, Sharon E Straus, Robin Urquhart, Anna R Gagliardi,

BACKGROUND:Guidelines based on patient preferences differ from those developed solely by clinicians and may promote patient adherence to guideline recommendations. There is scant evidence on how to develop patient-informed guidelines. This study aimed to describe how guideline developers identify, incorporate and report patient preferences. METHODS:We employed a descriptive cross-sectional survey ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):458]

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Development and Validation of a Tool to Assess the Quality of Clinical Practice Guideline Recommendations.

Melissa C Brouwers, Karen Spithoff, Kate Kerkvliet, Pablo Alonso-Coello, Jako Burgers, Francoise Cluzeau, Beatrice Férvers, Ian Graham, Jeremy Grimshaw, Steven Hanna, Monika Kastner, Michelle Kho, Amir Qaseem, Sharon Straus, Ivan D Florez,

Importance:Clinical practice guidelines (CPGs) may lack rigor and suitability to the setting in which they are to be applied. Methods to yield clinical practice guideline recommendations that are credible and implementable remain to be determined. Objective:To describe the development of AGREE-REX (Appraisal of Guidelines Research and Evaluation-Recommendations Excellence), a tool ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(5):e205535]

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Comparison of Transatlantic Approaches to Lipid Management: The AHA/ACC/Multisociety Guidelines vs the ESC/EAS Guidelines.

Maninder Singh, John W McEvoy, Safi U Khan, David A Wood, Ian M Graham, Roger S Blumenthal, Abhishek K Mishra, Erin D Michos,

The 2018 American Heart Association/American College of Cardiology/Multisociety (AHA/ACC) guidelines and the 2019 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on lipid management were published less than a year apart. Both guidelines focus on reducing cardiovascular risk, but they follow different approaches in terms of methods of risk estimation, ... Read more >>

Mayo Clin. Proc. (Mayo Clinic proceedings)
[2020, 95(5):998-1014]

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Stakeholders' engagement in co-producing policy-relevant knowledge to facilitate employment for persons with developmental disabilities.

Akram Khayatzadeh-Mahani, Krystle Wittevrongel, Lisa Petermann, Ian D Graham, Jennifer D Zwicker,

BACKGROUND:Persons with developmental disabilities (PWDD) face a number of individual, environmental and societal barriers when seeking employment. Integrated knowledge translation (IKT) involves ongoing and dynamic interactions between researchers and stakeholders for the purpose of engaging in mutually beneficial research to address these types of multi-faceted barriers. There is a knowledge ... Read more >>

Health Res Policy Syst (Health research policy and systems)
[2020, 18(1):39]

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When piloting health services interventions, what predicts real world behaviours? A systematic concept mapping review.

Tavis Hayes, Natasha Hudek, Ian D Graham, Doug Coyle, Jamie C Brehaut,

Modeling studies to inform the design of complex health services interventions often involves elements that differ from the intervention's ultimate real-world use. These "hypothetical" elements include pilot participants, materials, and settings. Understanding the conditions under which studies with "hypothetical" elements can yield valid results would greatly help advance health services ... Read more >>

BMC Med Res Methodol (BMC medical research methodology)
[2020, 20(1):76]

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How does integrated knowledge translation (IKT) compare to other collaborative research approaches to generating and translating knowledge? Learning from experts in the field.

Tram Nguyen, Ian D Graham, Kelly J Mrklas, Sarah Bowen, Margaret Cargo, Carole A Estabrooks, Anita Kothari, John Lavis, Ann C Macaulay, Martha MacLeod, David Phipps, Vivian R Ramsden, Mary J Renfrew, Jon Salsberg, Nina Wallerstein,

BACKGROUND:Research funders in Canada and abroad have made substantial investments in supporting collaborative research approaches to generating and translating knowledge as it is believed to increase knowledge use. Canadian health research funders have advocated for the use of integrated knowledge translation (IKT) in health research, however, there is limited research ... Read more >>

Health Res Policy Syst (Health research policy and systems)
[2020, 18(1):35]

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A qualitative study of persons with persistent postconcussion symptoms and clinicians with concussion expertise to inform the development of a concussion-specific questionnaire.

Jacquie van Ierssel, Jennifer O'Neil, Heidi Sveistrup, Shawn Marshall, Ian Graham,

Purpose: To explore the experiences of adults with persistent postconcussion symptoms and clinicians to inform the development of a concussion-specific questionnaire.Methods: Using a qualitative descriptive design, we conducted 10 focus groups with persons with persistent post-concussion symptoms (n = 35; female 66%; age range 19.0-65.1 years) and semi-structured interviews with clinicians with concussion ... Read more >>

Disabil Rehabil (Disability and rehabilitation)
[2020, :1-12]

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The concussion recovery questionnaire (CORE-Q): conceptual model development and item generation of a concussion-specific measure of functional status.

Jacquie Van Ierssel, Heidi Sveistrup, Shawn Marshall, Ian Graham,

Introduction: Defining and measuring limitations in functional status post-concussion has been challenging, as generic measures do not accurately reflect issues most relevant to adults with persistent post-concussion symptoms.Purpose: To develop a new concussion-specific measure of functional status for use in clinical practice and intervention trials.Method: We developed a conceptual model ... Read more >>

Brain Inj (Brain injury)
[2020, 34(5):619-629]

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Body mass index determines the response of plasma sulfur amino acids to methionine loading.

Amany K Elshorbagy, Ian Graham, Helga Refsum,

Evidence from human, animal and cellular studies suggests that high plasma total cysteine (tCys) is causally linked to human obesity, but determinants of population tCys variability are unknown. We hypothesized that tCys elevation in obesity may be mediated by an altered tCys response to intake of its precursor, methionine. We ... Read more >>

Biochimie (Biochimie)
[2020, 173:107-113]

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Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel.

Jan Borén, M John Chapman, Ronald M Krauss, Chris J Packard, Jacob F Bentzon, Christoph J Binder, Mat J Daemen, Linda L Demer, Robert A Hegele, Stephen J Nicholls, Børge G Nordestgaard, Gerald F Watts, Eric Bruckert, Sergio Fazio, Brian A Ference, Ian Graham, Jay D Horton, Ulf Landmesser, Ulrich Laufs, Luis Masana, Gerard Pasterkamp, Frederick J Raal, Kausik K Ray, Heribert Schunkert, Marja-Riitta Taskinen, Bart van de Sluis, Olov Wiklund, Lale Tokgozoglu, Alberico L Catapano, Henry N Ginsberg,

Eur. Heart J. (European heart journal)
[2020, :]

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Post-secondary students with symptoms of psychosis: A mixed-methods systematic review.

Victoria A Sanderson, Amanda Digel Vandyk, Ian D Graham, Sophie Lightfoot, Mackenzie Murawsky, Lindsey Sikora, Jean Daniel Jacob,

Post-secondary students are at a heightened risk of psychosis, yet little is known about this population. The aim of this study was to conduct a mixed-methods systematic review of psychosis among post-secondary students, including student characteristics, overall prevalence, risk factors, interventions, and their reported experiences. Procedures were modelled on the ... Read more >>

Int J Ment Health Nurs (International journal of mental health nursing)
[2020, :]

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Protocol for the development of guidance for stakeholder engagement in health and healthcare guideline development and implementation.

Jennifer Petkovic, Alison Riddle, Elie A Akl, Joanne Khabsa, Lyubov Lytvyn, Pearl Atwere, Pauline Campbell, Kalipso Chalkidou, Stephanie M Chang, Sally Crowe, Leonila Dans, Fadi El Jardali, Davina Ghersi, Ian D Graham, Sean Grant, Regina Greer-Smith, Jeanne-Marie Guise, Glen Hazlewood, Janet Jull, S Vittal Katikireddi, Etienne V Langlois, Anne Lyddiatt, Lara Maxwell, Richard Morley, Reem A Mustafa, Francesco Nonino, Jordi Pardo Pardo, Alex Pollock, Kevin Pottie, John Riva, Holger Schünemann, Rosiane Simeon, Maureen Smith, Airton T Stein, Anneliese Synnot, Janice Tufte, Howard White, Vivian Welch, Thomas W Concannon, Peter Tugwell,

BACKGROUND:Stakeholder engagement has become widely accepted as a necessary component of guideline development and implementation. While frameworks for developing guidelines express the need for those potentially affected by guideline recommendations to be involved in their development, there is a lack of consensus on how this should be done in practice. ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):21]

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The accuracy of measures in screening adults for spiritual suffering in health care settings: A systematic review.

Sayna Bahraini, Wendy Gifford, Ian D Graham, Liquaa Wazni, Suzette Brémault-Phillips, Rebekah Hackbusch, Catrine Demers, Mary Egan,

OBJECTIVE:Guidelines for palliative and spiritual care emphasize the importance of screening patients for spiritual suffering. The aim of this review was to synthesize the research evidence of the accuracy of measures used to screen adults for spiritual suffering. METHODS:A systematic review of the literature. We searched five scientific databases to ... Read more >>

Palliat Support Care (Palliative & supportive care)
[2020, 18(1):89-102]

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Integrating Spinal Cord Injury - Quality of Life instruments into rehabilitation: Implementation science to guide adoption of patient-reported outcome measures.

Kristian P Nitsch, Kelsey Stipp, Kristen Gracz, Linda Ehrlich-Jones, Ian D Graham, Allen W Heinemann,

Context/objective: This study describes a development strategy for integrating the Spinal Cord Injury - Quality of Life (SCI-QOL) item banks into inpatient spinal cord injury (SCI) rehabilitation and recommendations for protocol implementation.Design: We adopted an implementation science approach to develop a strategy for adapting and contextualizing SCI-QOL use during SCI ... Read more >>

J Spinal Cord Med (The journal of spinal cord medicine)
[2020, :1-9]

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Applying an intersectionality lens to the Theoretical Domains Framework: a tool for thinking about how intersecting social identities and structures of power influence behaviour

Nicole Etherington, Isabel Braganca Rodrigues, Lora Giangregorio, Ian Graham, Alison Hoens, Danielle Kasperavicius, Christine Kelly, Julia Moore, Matteo Ponzano, Justin Presseau, Kathryn Sibley, Sharon Straus,

Abstract Background A key component of the implementation process is identifying potential barriers and facilitators that need to be addressed. The Theoretical Domains Framework (TDF) is one of the most commonly used frameworks for this purpose. When applying the TDF, it is critical to understand the context in which behaviours ... Read more >>

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Data accuracy in the Ontario birth Registry: a chart re-abstraction study.

Sandra Dunn, Andrea Lanes, Ann E Sprague, Deshayne B Fell, Deborah Weiss, Jessica Reszel, Monica Taljaard, Elizabeth K Darling, Ian D Graham, Jeremy M Grimshaw, JoAnn Harrold, Graeme N Smith, Wendy Peterson, Mark Walker,

BACKGROUND:Ontario's birth Registry (BORN) was established in 2009 to collect, interpret, and share critical data about pregnancy, birth and the early childhood period to facilitate and improve the provision of healthcare. Since the use of routinely-collected health data has been prioritized internationally by governments and funding agencies to improve patient ... Read more >>

BMC Health Serv Res (BMC health services research)
[2019, 19(1):1001]

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2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.

François Mach, Colin Baigent, Alberico L Catapano, Konstantinos C Koskinas, Manuela Casula, Lina Badimon, M John Chapman, Guy G De Backer, Victoria Delgado, Brian A Ference, Ian M Graham, Alison Halliday, Ulf Landmesser, Borislava Mihaylova, Terje R Pedersen, Gabriele Riccardi, Dimitrios J Richter, Marc S Sabatine, Marja-Riitta Taskinen, Lale Tokgozoglu, Olov Wiklund, ,

Eur. Heart J. (European heart journal)
[2020, 41(1):111-188]

Cited: 13 times

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ABA INSENSITIVE4 promotes rather than represses PHYA-dependent seed germination in Arabidopsis thaliana.

Thiago Barros-Galvão, Anuja Dave, Alison D Gilday, David Harvey, Fabián E Vaistij, Ian A Graham,

New Phytol. (The New phytologist)
[2020, 226(4):953-956]

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Pragmatic Strategy Empowering Paramedics to Assess Low-Risk Trauma Patients With the Canadian C-Spine Rule and Selectively Transport Them Without Immobilization: Protocol for a Stepped-Wedge Cluster Randomized Trial.

Christian Vaillancourt, Manya Charette, Monica Taljaard, Kednapa Thavorn, Elizabeth Hall, Brent McLeod, Dean Fergusson, Jamie Brehaut, Ian Graham, Lisa Calder, Tim Ramsay, Peter Tugwell, Peter Kelly, Sheldon Cheskes, Refik Saskin, Amy Plint, Martin Osmond, Colin Macarthur, Sharon Straus, Paula Rochon, Denis Prud'homme, Simone Dahrouge, Susan Marlin, Ian G Stiell,

BACKGROUND:Each year, half a million patients with a potential neck (c-spine) injury are transported to Ontario emergency departments (EDs). Less than 1.0% (1/100) of these patients have a neck bone fracture. Even less (1/200, 0.5%) have a spinal cord injury or nerve damage. Currently, paramedics transport all trauma victims (with ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(6):e16966]

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Connecting knowledge with action for health equity: a critical interpretive synthesis of promising practices.

Katrina M Plamondon, C Susana Caxaj, Ian D Graham, Joan L Bottorff,

Connecting knowledge with action (KWA) for health equity involves interventions that can redistribute power and resources at local, national, and global levels. Although there is ample and compelling evidence on the nature, distribution, and impact of health inequities, advancing health equity is inhibited by policy arenas shaped by colonial legacies ... Read more >>

Int J Equity Health (International Journal for Equity in Health)
[2019, 18(1):202]

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The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders.

Stuart G Nicholls, Kelly Carroll, Merrick Zwarenstein, Jamie C Brehaut, Charles Weijer, Spencer P Hey, Cory E Goldstein, Ian D Graham, Jeremy M Grimshaw, Joanne E McKenzie, Dean A Fergusson, Monica Taljaard, ,

BACKGROUND:There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled trials (RCTs) are designed with the intent of addressing this discrepancy. While pragmatic RCTs may increase the relevance of research ... Read more >>

Trials (Trials)
[2019, 20(1):765]

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Update on cardiovascular prevention in clinical practice: A position paper of the European Association of Preventive Cardiology of the European Society of Cardiology.

Massimo F Piepoli, Ana Abreu, Christian Albus, Marco Ambrosetti, Carlos Brotons, Alberico L Catapano, Ugo Corra, Bernard Cosyns, Christi Deaton, Ian Graham, Arno Hoes, Maja-Lisa Lochen, Benedetta Matrone, Josep Redon, Naveed Sattar, Yvo Smulders, Monica Tiberi,

European guidelines on cardiovascular prevention in clinical practice were first published in 1994 and have been regularly updated, most recently in 2016, by the Sixth European Joint Task Force. Given the amount of new information that has become available since then, components from the task force and experts from the ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(2):181-205]

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Identifying relevant concepts and factors for the sustainability of evidence-based practices within acute care contexts: a systematic review and theory analysis of selected sustainability frameworks.

Letitia Nadalin Penno, Barbara Davies, Ian D Graham, Chantal Backman, Ibo MacDonald, Julie Bain, Alekhya Mascarenhas Johnson, Julia Moore, Janet Squires,

BACKGROUND:There is growing recognition among healthcare professionals that the sustainability of evidence-based practices (EBPs) within different settings is variable and suboptimal. Understanding why a particular EBP might be sustained in one setting and not another remains unclear. Recent reviews illustrate the need to identify and analyze existing frameworks/models/theories (F/M/Ts) that ... Read more >>

Implement Sci (Implementation science : IS)
[2019, 14(1):108]

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