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Author Ian Graham

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Development and field testing of a tool to elicit women's preferences among cervical cancer screening modalities.

Brianne Wood, Monica Taljaard, Ziad El-Khatib, Susan McFaul, Ian D Graham, Julian Little,

OBJECTIVE:The objective of the present study is to describe the development and field testing of a preference-elicitation tool for cervical cancer screening, meeting International Patient Decision Aids Standards (IPDAS) quality criteria. METHODS:We developed a tool designed to elicit women's preferences among cervical cancer screening modalities. The Ottawa Decision Support Framework ... Read more >>

J Eval Clin Pract (Journal of evaluation in clinical practice)
[2019, :]

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The accuracy of measures in screening adults for spiritual suffering in health care settings: a systematic review.

Sayna Bahraini, Wendy Gifford, Ian D Graham, Liquaa Wazni, Suzette Brémault-Phillips, Rebekah Hackbusch, Catrine Demers, Mary Egan,

OBJECTIVE:Guidelines for palliative and spiritual care emphasize the importance of screening patients for spiritual suffering. The aim of this review was to synthesize the research evidence of the accuracy of measures used to screen adults for spiritual suffering. METHODS:A systematic review of the literature. We searched five scientific databases to ... Read more >>

Palliat Support Care (Palliative & supportive care)
[2019, :1-14]

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Taking an integrated knowledge translation approach in research to develop the CONSORT-Equity 2017 reporting guideline: an observational study.

Janet Jull, Ian D Graham, Elizabeth Kristjansson, David Moher, Jennifer Petkovic, Manosila Yoganathan, Peter Tugwell, Vivian A Welch, ,

OBJECTIVE:We describe the use of an integrated knowledge translation (KT) approach in the development of the CONsolidated Standards Of Reporting Trials extension for equity ('CONSORT-Equity 2017'), and advisory board-research team members' ('the team') perceptions of the integrated KT process. DESIGN:This is an observational study to describe team processes and experience ... Read more >>

BMJ Open (BMJ open)
[2019, 9(7):e026866]

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Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts.

Tomasz Czechowski, Mauro A Rinaldi, Mufuliat Toyin Famodimu, Maria Van Veelen, Tony R Larson, Thilo Winzer, Deborah A Rathbone, David Harvey, Paul Horrocks, Ian A Graham,

Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by Plasmodium falciparum parasites. Other metabolites in A. annua or related species, particularly flavonoids, have been proposed to either act as antimalarials on their own or ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2019, 10:984]

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Evidence of commitment to research partnerships? Results of two web reviews.

Danielle de Moissac, Sarah Bowen, Ingrid Botting, Ian D Graham, Martha MacLeod, Karen Harlos, Charity Maritim Songok, Monique Bohémier,

BACKGROUND:Partnerships between academic researchers and health system leadership are often promoted by health research funding agencies as an important strategy in helping ensure that funded research is relevant and the results used. While potential benefits of such partnerships have been identified, there is limited guidance in the scientific literature for ... Read more >>

Health Res Policy Syst (Health research policy and systems)
[2019, 17(1):73]

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Understanding context: A concept analysis.

Janet E Squires, Ian Graham, Kainat Bashir, Letitia Nadalin-Penno, John Lavis, Jill Francis, Janet Curran, Jeremy M Grimshaw, Jamie Brehaut, Noah Ivers, Susan Michie, Michael Hillmer, Thomas Noseworthy, Jocelyn Vine, Melissa Demery Varin, Laura D Aloisio, Mary Coughlin, Alison M Hutchinson,

AIMS:To conduct a concept analysis of clinical practice contexts (work environments) in healthcare. BACKGROUND:Context is increasingly recognized as important to the development, delivery and understanding of implementation strategies; however, conceptual clarity about what comprises context is lacking. DESIGN:Modified Walker and Avant concept analysis comprised of 5 steps: 1) concept selection; ... Read more >>

J Adv Nurs (Journal of advanced nursing)
[2019, :]

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cis-12-oxo-phytodienoic acid represses Arabidopsis thaliana seed germination in shade light conditions.

Thiago Barros-Galvão, Anuja Dave, Adama Cole, David Harvey, Swen Langer, Tony R Larson, Fabián E Vaistij, Ian A Graham,

Light-dependent seed germination is induced by gibberellins (GA) and inhibited by abscisic acid (ABA). The widely accepted view of GA/ABA ratio controlling germination does not however explain the fact that seeds deficient in ABA still germinate poorly under shade light conditions that repress germination. In Arabidopsis, MOTHER-OF-FT-AND-TFL1 (MFT) acts as ... Read more >>

J. Exp. Bot. (Journal of experimental botany)
[2019, :]

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Attributes of context relevant to healthcare professionals' use of research evidence in clinical practice: a multi-study analysis.

Janet E Squires, Laura D Aloisio, Jeremy M Grimshaw, Kainat Bashir, Kristin Dorrance, Mary Coughlin, Alison M Hutchinson, Jill Francis, Susan Michie, Anne Sales, Jamie Brehaut, Janet Curran, Noah Ivers, John Lavis, Thomas Noseworthy, Jocelyn Vine, Michael Hillmer, Ian D Graham,

BACKGROUND:To increase the likelihood of successful implementation of evidence-based practices, researchers, knowledge users, and healthcare professionals must consider aspects of context that promote and hinder implementation in their setting. The purpose of the current study was to identify contextual attributes and their features relevant to implementation by healthcare professionals and ... Read more >>

Implement Sci (Implementation science : IS)
[2019, 14(1):52]

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Correction: Screening for osteoporosis: A systematic assessment of the quality and content of clinical practice guidelines, using the AGREE II instrument and the IOM Standards for Trustworthy Guidelines.

Lamia M Hayawi, Ian D Graham, Peter Tugwell, Said Yousef,

[This corrects the article DOI: 10.1371/journal.pone.0208251.]. ... Read more >>

PLoS ONE (PloS one)
[2019, 14(4):e0216196]

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Guidelines do not self-implement: time for a research paradigm shift from massive creation to effective implementation in evidence-based medicine research in China.

Junqiang Zhao, Melissa Demery Varin, Ian D Graham,

BMJ Evid Based Med (BMJ evidence-based medicine)
[2019, :]

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Interventions to improve emergency department use for mental health reasons: protocol for a mixed-methods systematic review.

Amanda Digel Vandyk, Mark Kaluzienski, Catherine Goldie, Yehudis Stokes, Amanda Ross-White, Jeremy Kronick, Matthew Gilmour, Colleen MacPhee, Ian D Graham,

BACKGROUND:Healthcare resources are limited and unnecessary, and inappropriate emergency department use is now a highly visible healthcare priority. Individuals visiting the emergency department for mental health-related reasons are often amongst the most frequent presenters. In response, researchers and clinicians have created interventions to streamline emergency department use and several primary ... Read more >>

Syst Rev (Systematic reviews)
[2019, 8(1):84]

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Determinants of coronary artery disease risk factor management across three world regions.

Min Zhao, Ian Graham, Marie Therese Cooney, Diederick E Grobbee, Ilonca Vaartjes, Kerstin Klipstein-Grobusch,

Background:The SUrvey of Risk Factors (SURF) indicated poor control of risk factors in subjects with established coronary heart disease (CHD). The present study aimed to investigate determinants of risk factor management in patients with CHD. Methods and results:SURF recruited 9987 consecutive patients with CHD from Europe, Asia and the Middle ... Read more >>

Heart Asia (Heart Asia)
[2019, 11(1):e011112]

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Providing culturally safe cancer survivorship care with Indigenous communities: study protocol for an integrated knowledge translation study.

Wendy Gifford, Roanne Thomas, Gwen Barton, Ian D Graham,

Background:Cancer among Indigenous people is increasing faster than overall Canadian rates. Lack of survivorship support, including screening and follow-up for recurrences, contributes to poor health outcomes and low 5-year survival rates. Historical trauma from colonization and lack of culturally safe and responsive healthcare has negatively affected Indigenous peoples' access to ... Read more >>

Pilot Feasibility Stud (Pilot and feasibility studies)
[2019, 5:33]

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Use of a maternal newborn audit and feedback system in Ontario: a collective case study.

Jessica Reszel, Sandra I Dunn, Ann E Sprague, Ian D Graham, Jeremy M Grimshaw, Wendy E Peterson, Holly Ockenden, Jodi Wilding, Ashley Quosdorf, Elizabeth K Darling, Deshayne B Fell, JoAnn Harrold, Andrea Lanes, Graeme N Smith, Monica Taljaard, Deborah Weiss, Mark C Walker,

BACKGROUND:As part of a larger study examining the effectiveness of the Maternal Newborn Dashboard, an electronic audit and feedback system to improve maternal-newborn care practices and outcomes, the purpose of this study was to increase our understanding of factors explaining variability in performance after implementation of the Dashboard in Ontario, ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2019, 28(8):635-644]

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Patient and Public Engagement in Integrated Knowledge Translation Research: Are we there yet?

Davina Banner, Marc Bains, Sandra Carroll, Damanpreet K Kandola, Danielle E Rolfe, Caroline Wong, Ian D Graham,

Plain English summary:There have been many attempts to improve how healthcare services are developed and delivered. Despite this, we know that there are many gaps and differences in practice and that these can lead to poor patient outcomes. In addition, there are also concerns that research is being undertaken that ... Read more >>

Res Involv Engagem (Research involvement and engagement)
[2019, 5:8]

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Inappropriateness of health care in Canada: a systematic review protocol.

Janet E Squires, Ian D Graham, Doris Grinspun, John Lavis, France Légaré, Robert Bell, Stephen Bornstein, Susan E Brien, Mark Dobrow, Megan Greenough, Carole A Estabrooks, Michael Hillmer, Tanya Horsley, Alan Katz, Christina Krause, Wendy Levinson, Adrian Levy, Michelina Mancuso, Alies Maybee, Steve Morgan, Letitia Nadalin Penno, Andrew Neuner, Tamara Rader, Janet Roberts, Gary Teare, Joshua Tepper, Amanda Vandyk, Denise Widmeyer, Michael Wilson, Jeremy M Grimshaw,

BACKGROUND:There is increasing recognition in Canada and globally that a substantial proportion of health care delivered is inappropriate as evidenced by (1) harmful and/or ineffective practices being overused, (2) effective clinical practices being underused, and (3) other clinical practices being misused. Inappropriate health care leads to negative patient experiences, poor ... Read more >>

Syst Rev (Systematic reviews)
[2019, 8(1):50]

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Effect of Patient-Centered Transitional Care Services on Clinical Outcomes in Patients Hospitalized for Heart Failure: The PACT-HF Randomized Clinical Trial.

Harriette G C Van Spall, Shun Fu Lee, Feng Xie, Urun Erbas Oz, Richard Perez, Peter R Mitoff, Manish Maingi, Michael C Tjandrawidjaja, Michael Heffernan, Mohammad I Zia, Liane Porepa, Mohamed Panju, Lehana Thabane, Ian D Graham, R Brian Haynes, Dilys Haughton, Kim D Simek, Dennis T Ko, Stuart J Connolly,

Importance:Health care services that support the hospital-to-home transition can improve outcomes in patients with heart failure (HF). Objective:To test the effectiveness of the Patient-Centered Care Transitions in HF transitional care model in patients hospitalized for HF. Design, Setting, and Participants:Stepped-wedge cluster randomized trial of 2494 adults hospitalized for HF across ... Read more >>

JAMA (JAMA)
[2019, 321(8):753-761]

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Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.

Lisa Pennells, Stephen Kaptoge, Angela Wood, Mike Sweeting, Xiaohui Zhao, Ian White, Stephen Burgess, Peter Willeit, Thomas Bolton, Karel G M Moons, Yvonne T van der Schouw, Randi Selmer, Kay-Tee Khaw, Vilmundur Gudnason, Gerd Assmann, Philippe Amouyel, Veikko Salomaa, Mika Kivimaki, Børge G Nordestgaard, Michael J Blaha, Lewis H Kuller, Hermann Brenner, Richard F Gillum, Christa Meisinger, Ian Ford, Matthew W Knuiman, Annika Rosengren, Debbie A Lawlor, Henry Völzke, Cyrus Cooper, Alejandro Marín Ibañez, Edoardo Casiglia, Jussi Kauhanen, Jackie A Cooper, Beatriz Rodriguez, Johan Sundström, Elizabeth Barrett-Connor, Rachel Dankner, Paul J Nietert, Karina W Davidson, Robert B Wallace, Dan G Blazer, Cecilia Björkelund, Chiara Donfrancesco, Harlan M Krumholz, Aulikki Nissinen, Barry R Davis, Sean Coady, Peter H Whincup, Torben Jørgensen, Pierre Ducimetiere, Maurizio Trevisan, Gunnar Engström, Carlos J Crespo, Tom W Meade, Marjolein Visser, Daan Kromhout, Stefan Kiechl, Makoto Daimon, Jackie F Price, Agustin Gómez de la Cámara, J Wouter Jukema, Benoît Lamarche, Altan Onat, Leon A Simons, Maryam Kavousi, Yoav Ben-Shlomo, John Gallacher, Jacqueline M Dekker, Hisatomi Arima, Nawar Shara, Robert W Tipping, Ronan Roussel, Eric J Brunner, Wolfgang Koenig, Masaru Sakurai, Jelena Pavlovic, Ron T Gansevoort, Dorothea Nagel, Uri Goldbourt, Elizabeth L M Barr, Luigi Palmieri, Inger Njølstad, Shinichi Sato, W M Monique Verschuren, Cherian V Varghese, Ian Graham, Oyere Onuma, Philip Greenland, Mark Woodward, Majid Ezzati, Bruce M Psaty, Naveed Sattar, Rod Jackson, Paul M Ridker, Nancy R Cook, Ralph B D'Agostino, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, ,

AIMS:There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied. METHODS ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(7):621-631]

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Barriers and facilitators of pediatric shared decision-making: a systematic review.

Laura Boland, Ian D Graham, France Légaré, Krystina Lewis, Janet Jull, Allyson Shephard, Margaret L Lawson, Alexandra Davis, Audrey Yameogo, Dawn Stacey,

BACKGROUND:Shared decision-making (SDM) is rarely implemented in pediatric practice. Pediatric health decision-making differs from that of adult practice. Yet, little is known about the factors that influence the implementation of pediatric shared decision-making (SDM). We synthesized pediatric SDM barriers and facilitators from the perspectives of healthcare providers (HCP), parents, children, ... Read more >>

Implement Sci (Implementation science : IS)
[2019, 14(1):7]

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Developing guideline-based quality indicators: assessing gaps in pain management practice.

Valerie J Fiset, Barbara L Davies, Ian D Graham, Wendy Gifford, Kirsten Woodend,

AIM:In this article, the authors discuss a multiphase approach for developing quality indicators based on pain practice guidelines, and the challenges associated with the process. The presentation is based on previously published reporting standards for guideline-based quality indicators. METHODS:The following steps of the indicator development process were undertaken: topic selection; ... Read more >>

Int J Evid Based Healthc (International journal of evidence-based healthcare)
[2019, :]

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A Parent-Targeted and Mediated Video Intervention to Improve Uptake of Pain Treatment for Infants During Newborn Screening: A Pilot Randomized Controlled Trial.

Carolina Lavin Venegas, Monica Taljaard, Jessica Reszel, Sandra Dunn, Ian D Graham, JoAnn Harrold, Catherine Larocque, Becky Nicholls, Stuart Nicholls, Pat OʼFlaherty, Janet Squires, Bonnie Stevens, Marie-Josée Trépanier, Denise Harrison,

Most newborns undergo newborn screening blood tests. Breastfeeding, skin-to-skin care, and sweet solutions effectively reduce pain; however, these strategies are inconsistently used. We conducted a 2-armed pilot randomized controlled trial in a mother-baby unit to examine the feasibility and acceptability of a parent-targeted and -mediated video demonstrating use of these ... Read more >>

J Perinat Neonatal Nurs (The Journal of perinatal & neonatal nursing)
[2019, 33(1):74-81]

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Protocol for treatment of Achilles tendon ruptures; a systematic review with network meta-analysis.

Brad Meulenkamp, Dawn Stacey, Dean Fergusson, Brian Hutton, Risa Shorr Mlis, Ian D Graham,

BACKGROUND:Achilles tendon ruptures are a common injury and are increasing in incidence. Several management strategies exist for both non-operative and operative care, with each strategy offering unique risks and benefits. Traditional pairwise meta-analyses have been performed to compare management strategies; however, all treatment options have never been integrated in a ... Read more >>

Syst Rev (Systematic reviews)
[2018, 7(1):247]

Cited: 1 time

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Screening for osteoporosis: A systematic assessment of the quality and content of clinical practice guidelines, using the AGREE II instrument and the IOM Standards for Trustworthy Guidelines.

Lamia M Hayawi, Ian D Graham, Peter Tugwell, Said Yousef Abdelrazeq,

BACKGROUND:Numerous clinical practice guidelines (CPGs) are published to guide management of osteoporosis. Little is known about their quality or how recommendations have changed over time. OBJECTIVE:To systematically assess the quality and content of the guidelines on screening for osteoporosis, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) ... Read more >>

PLoS ONE (PloS one)
[2018, 13(12):e0208251]

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Reprint of: Impact of Lipids on Cardiovascular Health: JACC Health Promotion Series.

Brian A Ference, Ian Graham, Lale Tokgozoglu, Alberico L Catapano,

People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2018, 72(23 Pt B):2980-2995]

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A review protocol on research partnerships: a Coordinated Multicenter Team approach.

Femke Hoekstra, Kelly J Mrklas, Kathryn M Sibley, Tram Nguyen, Mathew Vis-Dunbar, Christine J Neilson, Leah K Crockett, Heather L Gainforth, Ian D Graham,

BACKGROUND:Research partnership approaches, in which researchers and stakeholders work together collaboratively on a research project, are an important component of research, knowledge translation, and implementation. Despite their growing use, a comprehensive understanding of the principles, strategies, outcomes, and impacts of different types of research partnerships is lacking. Generating high-quality evidence ... Read more >>

Syst Rev (Systematic reviews)
[2018, 7(1):217]

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