Full Text Journal Articles by
Author Ian F Musgrave

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Identifying the core concepts of pharmacology education.

Paul J White, Elizabeth A Davis, Marina Santiago, Tom Angelo, Alison Shield, Anna-Marie Babey, Barbara Kemp-Harper, Gregg Maynard, Hesham S Al-Sallami, Ian F Musgrave, Lynette B Fernandes, Suong N T Ngo, Tina Hinton,

Pharmacology education currently lacks an agreed knowledge curriculum. Evidence from physics and biology education indicates that core concepts are useful and effective structures around which such a curriculum can be designed to facilitate student learning. Building on previous work, we developed a novel, criterion-based method to identify the core concepts ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2021, 9(4):e00836]

Cited: 0 times

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Does herbal therapy for COVID-19 have implications for forensic practice?

Roger W Byard, Ian F Musgrave,

Forensic Sci Med Pathol (Forensic science, medicine, and pathology)
[2021, :]

Cited: 0 times

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Paracetamol (acetaminophen) hepatotoxicity increases in the presence of an added herbal compound.

Susan M Britza, Ian F Musgrave, Roger W Byard,

Hepatotoxicity from paracetamol/acetaminophen has occasionally been reported at lower than expected doses. As herbal preparations may interact with pharmaceutical drugs the following in vitro study was undertaken to determine whether the toxic effects of paracetamol on liver cell growth in culture would be exacerbated by the addition of psoralen, a ... Read more >>

Leg Med (Tokyo) (Legal medicine (Tokyo, Japan))
[2020, 47:101740]

Cited: 1 time

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Combined Liquid Chromatography-mass Spectrometry and Next-generation DNA Sequencing Detection of Adulterants and Contaminants in Analgesic and Anti-inflammatory Herbal Medicines.

Claire L Hoban, Ian F Musgrave, Roger W Byard, Christine Nash, Rachael Farrington, Garth Maker, Elly Crighton, Michael Bunce, Megan Coghlan,

INTRODUCTION:Methods for assessing the quality of herbal medicine preparations have advanced significantly in recent years in conjunction with increases in herbal medicine use and reports of adulteration and contamination. OBJECTIVE:This study examined the quality of analgesic and anti-inflammatory herbal medicine preparations available on the Australian market by detecting the presence ... Read more >>

Pharmaceut Med (Pharmaceutical medicine)
[2020, 34(1):49-61]

Cited: 1 time

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Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane ligand.

Biyun Sun, Madhu K Sundaraneedi, Hannah M Southam, Robert K Poole, Ian F Musgrave, F Richard Keene, J Grant Collins,

Linear and non-linear tetranuclear ruthenium(ii) complexes containing the bridging ligand bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane have been synthesised and their biological properties examined. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the ruthenium(ii) complexes were determined against six strains of bacteria: Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(38):14505-14515]

Cited: 2 times

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Exploring the Application of the DSA-TOF, a Direct, High-resolution Time-of-Flight Mass Spectrometry Technique for the Screening of Potential Adulterated and Contaminated Herbal Medicines.

Elly Crighton, Jason Weisenseel, Michael Bunce, Ian F Musgrave, Robert Trengove, Garth Maker,

Global consumption of complementary and alternative medicines, including herbal medicines, has increased substantially, and recent reports of adulteration demonstrate the need for high throughput and extensive pharmacovigilance to ensure product safety and quality. Three different standard reference materials and five previously analyzed herbal medicines have been used as a proof ... Read more >>

J Am Soc Mass Spectrom (Journal of the American Society for Mass Spectrometry)
[2019, 30(9):1713-1719]

Cited: 1 time

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Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health.

Elly Crighton, Megan L Coghlan, Rachael Farrington, Claire L Hoban, Matthew W P Power, Christine Nash, Ian Mullaney, Roger W Byard, Robert Trengove, Ian F Musgrave, Michael Bunce, Garth Maker,

Use of herbal medicines and supplements by consumers to prevent or treat disease, particularly chronic conditions continues to grow, leading to increased awareness of the minimal regulation standards in many countries. Fraudulent, adulterated and contaminated herbal and traditional medicines and dietary supplements are a risk to consumer health, with adverse ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2019, 176:112834]

Cited: 0 times

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Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015.

Claire L Hoban, Roger W Byard, Ian F Musgrave,

OBJECTIVE:Assessing adverse drug reactions (ADRs) is a proven method to estimate the safety of medicines. The ADRs to herbal medicines in Australia (and by inference, the safety of herbal medicines in Australia) remain unknown. This study examines spontaneous ADR cases to four of the most popular herbs in Australia from ... Read more >>

J Integr Med (Journal of integrative medicine)
[2019, 17(5):338-343]

Cited: 0 times

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Evidence for the efficacy and safety of herbal weight loss preparations.

Rachael Farrington, Ian F Musgrave, Roger W Byard,

Rising rates of obesity across the globe have been associated with an increase in the use of herbal preparations for weight control. However, the mechanisms of action for these substances are often not known, as is the potential for interaction with other herbal preparations or prescription pharmaceutical drugs. To investigate ... Read more >>

J Integr Med (Journal of integrative medicine)
[2019, 17(2):87-92]

Cited: 2 times

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Eukaryotic Cell Toxicity and HSA Binding of [Ru(Me4phen)(bb7)]2+ and the Effect of Encapsulation in Cucurbit[10]uril.

Biyun Sun, Ian F Musgrave, Anthony I Day, Kirsten Heimann, F Richard Keene, J Grant Collins,

The toxicity (IC50) of a series of mononuclear ruthenium complexes containing bis[4(4'-methyl-2,2'-bipyridyl)]-1,n-alkane (bbn) as a tetradentate ligand against three eukaryotic cell lines-BHK (baby hamster kidney), Caco-2 (heterogeneous human epithelial colorectal adenocarcinoma) and Hep-G2 (liver carcinoma)-have been determined. The results demonstrate that cis-α-[Ru(Me4phen)(bb7)]2+ (designated as α-Me4phen-bb7, where Me4phen = 3,4,7,8-tetramethyl-1,10-phenanthroline) showed ... Read more >>

Front Chem (Frontiers in chemistry)
[2018, 6:595]

Cited: 1 time

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Extended Low-Dose Exposure to Saxitoxin Inhibits Neurite Outgrowth in Model Neuronal Cells.

Katie O'Neill, Ian F Musgrave, Andrew Humpage,

The potent neurotoxin saxitoxin (STX) belongs to a group of structurally related analogues produced by both marine and freshwater phytoplankton. The toxins act by blocking voltage-gated sodium channels stopping the inflow of sodium ions and the generation of action potentials. Exposure from marine sources occurs as a result of consuming ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2017, 120(4):390-397]

Cited: 2 times

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Comparison of KP1019 and NAMI-A in tumour-mimetic environments.

Gemma K Gransbury, Peter Kappen, Chris J Glover, James N Hughes, Aviva Levina, Peter A Lay, Ian F Musgrave, Hugh H Harris,

NAMI-A and KP1019 are Ru(III)-based anti-metastatic and cytotoxic anti-cancer drugs, respectively, and have been proposed to be activated by reduction to Ru(II). The potential reduction of NAMI-A and KP1019 in the hypoxic environment of a tumour model of neuroblastoma was examined. Normoxic, hypoxic and necrotic tumour tissues were modelled by ... Read more >>

Metallomics (Metallomics : integrated biometal science)
[2016, 8(8):762-773]

Cited: 6 times

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Caffeine toxicity in forensic practice: possible effects and under-appreciated sources.

Ian F Musgrave, Rachael L Farrington, Claire Hoban, Roger W Byard,

Caffeine is considered a very safe stimulant and is widely consumed in a variety of forms, from pure caffeine to beverages and foods. Typically, death is only seen when gram quantities of caffeine are consumed, usually in suicide attempts. Even in this scenario, death is rare. However, there are special ... Read more >>

Forensic Sci Med Pathol (Forensic science, medicine, and pathology)
[2016, 12(3):299-303]

Cited: 8 times

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Low dose extended exposure to saxitoxin and its potential neurodevelopmental effects: A review.

Katie O'Neill, Ian F Musgrave, Andrew Humpage,

Saxitoxin (STX) and its analogs, the paralytic shellfish toxins (PSTs), are a group of potent neurotoxins well known for their role in acute paralytic poisoning by preventing the generation of action potentials in neuronal cells. They are found in both marine and freshwater environments globally and although acute exposure from ... Read more >>

Environ Toxicol Pharmacol (Environmental toxicology and pharmacology)
[2016, 48:7-16]

Cited: 9 times

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Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity.

Sukanya Das, Lina Stark, Ian F Musgrave, Tara Pukala, Scott D Smid,

In this study we compared the effects of a diverse set of natural polyphenolics ligands on in silico interactive modelling, in vitro anti-aggregative properties and neuronal toxicity of β amyloid. The β amyloid-binding characteristics of optimised structural conformations of polyphenols with ascribed neuroprotective actions including punicalagin, myricetin, luteolin and honokiol ... Read more >>

Food Funct (Food & function)
[2016, 7(2):1138-1146]

Cited: 13 times

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The Amyloid Fibril-Forming Properties of the Amphibian Antimicrobial Peptide Uperin 3.5.

Antonio N Calabrese, Yanqin Liu, Tianfang Wang, Ian F Musgrave, Tara L Pukala, Rico F Tabor, Lisandra L Martin, John A Carver, John H Bowie,

The amphibian skin is a vast resource for bioactive peptides, which form the basis of the animals' innate immune system. Key components of the secretions of the cutaneous glands are antimicrobial peptides (AMPs), which exert their cytotoxic effects often as a result of membrane disruption. It is becoming increasingly evident ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2016, 17(3):239-246]

Cited: 8 times

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Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM).

Megan L Coghlan, Garth Maker, Elly Crighton, James Haile, Dáithí C Murray, Nicole E White, Roger W Byard, Matthew I Bellgard, Ian Mullaney, Robert Trengove, Richard J N Allcock, Christine Nash, Claire Hoban, Kevin Jarrett, Ross Edwards, Ian F Musgrave, Michael Bunce,

Globally, there has been an increase in the use of herbal remedies including traditional Chinese medicine (TCM). There is a perception that products are natural, safe and effectively regulated, however, regulatory agencies are hampered by a lack of a toolkit to audit ingredient lists, adulterants and constituent active compounds. Here, ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:17475]

Cited: 28 times

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A comparison of patterns of spontaneous adverse drug reaction reporting with St. John's Wort and fluoxetine during the period 2000-2013.

Claire L Hoban, Roger W Byard, Ian F Musgrave,

Herbal medicines are perceived to be safe by the general public and medical practitioners, despite abundant evidence from clinical trials and case reports that show herbal preparations can have significant adverse effects. The overall impact of adverse events to herbal medicines in Australia is currently unknown. Post marketing surveillance of ... Read more >>

Clin Exp Pharmacol Physiol (Clinical and experimental pharmacology & physiology)
[2015, 42(7):747-751]

Cited: 6 times

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Hemin as a generic and potent protein misfolding inhibitor.

Yanqin Liu, John A Carver, Lam H Ho, Abigail K Elias, Ian F Musgrave, Tara L Pukala,

Protein misfolding causes serious biological malfunction, resulting in diseases including Alzheimer's disease, Parkinson's disease and cataract. Molecules which inhibit protein misfolding are a promising avenue to explore as therapeutics for the treatment of these diseases. In the present study, thioflavin T fluorescence and transmission electron microscopy experiments demonstrated that hemin ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2014, 454(2):295-300]

Cited: 6 times

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SEVI, the semen enhancer of HIV infection along with fragments from its central region, form amyloid fibrils that are toxic to neuronal cells.

Abigail K Elias, Denis Scanlon, Ian F Musgrave, John A Carver,

Semen-derived enhancer of viral infection (SEVI) is the term given to the amyloid fibrils formed by a 39-amino acid fragment (PAP248-286) of prostatic acidic phosphatase (PAP) found in human semen. SEVI enhances human immunodeficiency virus (HIV) infectivity by four to five orders of magnitude (Münch et al., 2007). Here, we ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2014, 1844(9):1591-1598]

Cited: 9 times

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Lethal hepatocellular necrosis associated with herbal polypharmacy in a patient with chronic hepatitis B infection.

John D Gilbert, Ian F Musgrave, Claire Hoban, Roger W Byard,

Following a short treatment for irritable bowel with the following herbs: Astragalus propinquus, Codonopsis pilosula, Paeonia sp., Atractylodes macrocephala, Pueraria sp., Poria cocos, Dioscorea opposita, Patriniae, Psoralea corylifolia, Alpinia katsumadai, Glycyrrhiza uralensis and Dolomiaea souliei sp. a 43-year-old woman developed acute severe liver failure requiring liver transplantation. Histopathological examination of ... Read more >>

Forensic Sci Int (Forensic science international)
[2014, 241:138-140]

Cited: 2 times

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Forensic problems with the composition and content of herbal medicines.

Lauren Blacksell, Roger W Byard, Ian F Musgrave,

A survey of herbal medicines available for internet and over-the-counter purchase in South Australia, Australia, was conducted looking specifically at those used for 'arthritis', 'cold and flu', 'gastrointestinal', 'stress' and 'premenstrual syndrome'. 121 products consisted of 29 in the 'arthritis' category, 33 in 'cold and flu', 19 in 'gastrointestinal' 30 ... Read more >>

J Forensic Leg Med (Journal of forensic and legal medicine)
[2014, 23:19-21]

Cited: 2 times

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Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation.

Yanqin Liu, Tara L Pukala, Ian F Musgrave, Danielle M Williams, Francis C Dehle, John A Carver,

Many protein misfolding diseases, for example, Alzheimer's, Parkinson's and Huntington's, are characterised by the accumulation of protein aggregates in an amyloid fibrillar form. Natural products which inhibit fibril formation are a promising avenue to explore as therapeutics for the treatment of these diseases. In this study we have shown, using ... Read more >>

Bioorg Med Chem Lett (Bioorganic & medicinal chemistry letters)
[2013, 23(23):6336-6340]

Cited: 34 times

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Dietary polyphenol-derived protection against neurotoxic β-amyloid protein: from molecular to clinical.

Scott D Smid, Jesper L Maag, Ian F Musgrave,

Polyphenolic compounds derived mainly from plant products have demonstrated neuroprotective properties in a number of experimental settings. Such protective effects have often been ascribed to antioxidant capacity, but specific augmentation of other cellular defences and direct interactions with neurotoxic proteins have also been demonstrated. With an emphasis on neurodegenerative conditions, ... Read more >>

Food Funct (Food & function)
[2012, 3(12):1242-1250]

Cited: 19 times

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Structural and activity changes in three bioactive anuran peptides when Asp is replaced by isoAsp.

Antonio N Calabrese, Katarina Markulic, Ian F Musgrave, Hui Guo, Lixin Zhang, John H Bowie,

The Asp and isoAsp isomers of three bioactive peptides, Crinia angiotensin 11 [APGDRIYHPF(OH)], uperin 1.1 [pEADPNAFYGLM(NH(2))] and citropin 1.1 [GLFDVIKKVASVIGGL(NH(2))] were tested for changes in (i) susceptibility towards proteolytic cleavage, (ii) activity (smooth muscle activity for Crinia angiotensin 11 and uperin 1.1 isomers, and antimicrobial activity for the two isomers ... Read more >>

Peptides (Peptides)
[2012, 38(2):427-436]

Cited: 1 time

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