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Author Ian A Blair

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Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation.

Wendy Yu, Kevin P Gillespie, Bonirath Chhay, Anne-Sophie Svensson, Per-Åke Nygren, Ian A Blair, Feifan Yu, Andrew Tsourkas,

Antibody-drug conjugates (ADCs) have demonstrated great therapeutic potential due to their ability to target the delivery of potent cytotoxins. However, the heterogeneous nature of conventional drug conjugation strategies can affect the safety, efficacy, and stability of ADCs. Site-specific conjugations can resolve these issues, but often require genetic modification of Immunoglobulin ... Read more >>

Bioconjug Chem (Bioconjugate chemistry)
[2021, :]

Cited: 0 times

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Reverse phase protein array reveals correlation of retinoic acid metabolism with cardiomyopathy in Friedreich's ataxia.

Jill S Napierala, Kimal Rajapakshe, Amanda Clark, Yu-Yun Chen, Shixia Huang, Clementina Mesaros, Peining Xu, Ian A Blair, Lauren A Hauser, Jennifer Farmer, David R Lynch, Dean P Edwards, Cristian Coarfa, Marek Napierala,

Identifying biomarkers is important for assessment of disease progression, prediction of symptom development, and determination of treatment effectiveness. While unbiased analyses of differential gene expression using next generation sequencing methods are now routinely conducted, proteomics studies are more challenging due to traditional methods predominantly being low-throughput and offering a limited ... Read more >>

Mol Cell Proteomics (Molecular & cellular proteomics : MCP)
[2021, :100094]

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Effects of systemic inflammation on relapse in early breast cancer.

Nicholas P McAndrew, Lisa Bottalico, Clementina Mesaros, Ian A Blair, Patricia Y Tsao, Jennifer M Rosado, Tapan Ganguly, Sarah J Song, Phyllis A Gimotty, Jun J Mao, Angela DeMichele,

Chronic inflammation has been a proposed mechanism of resistance to aromatase inhibitors in breast cancer. Stratifying by HER2 status, a matched case-control study from the Wellness After Breast Cancer-II cohort was performed to assess whether or not elevated serum inflammatory biomarkers (C-Reactive protein [CRP], interleukin-6 [IL-6], and serum amyloid A ... Read more >>

NPJ Breast Cancer (NPJ breast cancer)
[2021, 7(1):7]

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Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer.

Irfan Asangani, Ian A Blair, Gregory Van Duyne, Vincent J Hilser, Vera Moiseenkova-Bell, Stephen Plymate, Cynthia Sprenger, A Joshua Wand, Trevor M Penning,

Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven. Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and biochemical techniques. Structural characterization of AR and its complexes by cryo-electron microscopy would advance the development of N-terminal domain (NTD) and ligand-binding domain (LBD) antagonists. ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2021, 296:100240]

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Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth.

Samuel Parry, Rita Leite, M Sean Esplin, Radek Bukowski, Heping Zhang, Michael Varner, William W Andrews, George R Saade, John Ilekis, Uma M Reddy, Hao Huang, Yoel Sadovsky, Ian A Blair, Joseph Biggio, ,

<h4>Background</h4>Spontaneous preterm birth is a leading cause of neonatal morbidity and mortality. Early identification of at-risk women by reliable screening tests could reduce the spontaneous preterm birth rate, but conventional methods such as obstetrical history and maternal cervical length screening identify only a minority of spontaneous preterm birth cases. Cervicovaginal ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2020, 222(5):493.e1-493.e13]

Cited: 1 time

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation.

Yang Zhang, Yi Xu, Wenyun Lu, Jonathan M Ghergurovich, Lili Guo, Ian A Blair, Joshua D Rabinowitz, Xiaolu Yang,

The emergence of cancer from diverse normal tissues has long been rationalized to represent a common set of fundamental processes. However, these processes are not fully defined. Here, we show that forced expression of glucose-6-phosphate dehydrogenase (G6PD) affords immortalized mouse and human cells anchorage-independent growth in vitro and tumorigenicity in animals. ... Read more >>

Cell Metab (Cell metabolism)
[2021, 33(1):94-109.e8]

Cited: 3 times

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Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.

Prasanna M Chandramouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A Whelan, Hisatsugu Maekawa, Uma M Sachdeva, Gordon Ruthel, Sarmistha Mukherjee, Noah Engel, Michael V Gonzalez, James Garifallou, Shinya Ohashi, Andres J Klein-Szanto, Clementina A Mesaros, Ian A Blair, Renata Pellegrino da Silva, Hakon Hakonarson, Eishi Noguchi, Joseph A Baur, Hiroshi Nakagawa,

During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While these cells were able to tolerate 2% EtOH for 8 h in both three-dimensional ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0239625]

Cited: 1 time

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Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells.

Yi Xu, Yang Zhang, Juan C García-Cañaveras, Lili Guo, Mengyuan Kan, Sixiang Yu, Ian A Blair, Joshua D Rabinowitz, Xiaolu Yang,

Embryonic stem cells can propagate indefinitely in a pluripotent state, able to differentiate into all types of specialized cells when restored to the embryo. What sustains their pluripotency during propagation remains unclear. Here, we show that core pluripotency factors OCT4 and SOX2 suppress chaperone-mediated autophagy (CMA), a selective form of ... Read more >>

Science (Science (New York, N.Y.))
[2020, 369(6502):397-403]

Cited: 4 times

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Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2.

Gretchen M Alicea, Vito W Rebecca, Aaron R Goldman, Mitchell E Fane, Stephen M Douglass, Reeti Behera, Marie R Webster, Curtis H Kugel, Brett L Ecker, M Cecilia Caino, Andrew V Kossenkov, Hsin-Yao Tang, Dennie T Frederick, Keith T Flaherty, Xiaowei Xu, Qin Liu, Dmitry I Gabrilovich, Meenhard Herlyn, Ian A Blair, Zachary T Schug, David W Speicher, Ashani T Weeraratna,

Older patients with melanoma (>50 years old) have poorer prognoses and response rates to targeted therapy compared with young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, especially ceramides. When melanoma ... Read more >>

Cancer Discov (Cancer discovery)
[2020, 10(9):1282-1295]

Cited: 4 times

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Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia.

Xiao Zhao, Kristin Lorent, Diana Escobar-Zarate, Ramakrishnan Rajagopalan, Kathleen M Loomes, Kevin Gillespie, Clementina Mesaros, Michelle A Estrada, Ian A Blair, Jeffrey D Winkler, Nancy B Spinner, Marcella Devoto, Michael Pack,

<h4>Background & aims</h4>Extrahepatic biliary atresia (BA) is a pediatric liver disease with no approved medical therapy. Recent studies using human samples and experimental modeling suggest that glutathione redox metabolism and heterogeneity play a role in disease pathogenesis. We sought to dissect the mechanistic basis of liver redox variation and explore ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 159(3):1068-1084.e2]

Cited: 1 time

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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.

Fuming Li, Peiwei Huangyang, Michelle Burrows, Kathy Guo, Romain Riscal, Jason Godfrey, Kyoung Eun Lee, Nan Lin, Pearl Lee, Ian A Blair, Brian Keith, Bo Li, M Celeste Simon,

The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not completely understood. We show here that hepatocyte-specific loss of the gluconeogenic enzyme fructose 1,6-bisphosphatase 1 (FBP1) disrupts liver metabolic homeostasis and promotes tumour progression. FBP1 is universally ... Read more >>

Nat Cell Biol (Nature cell biology)
[2020, 22(6):728-739]

Cited: 5 times

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Correction to "Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone".

Jessica R Murray, Clementina A Mesaros, Volker M Arlt, Albrecht Seidel, Ian A Blair, Trevor M Penning,

Chem Res Toxicol (Chemical research in toxicology)
[2019, 32(11):2365]

Cited: 0 times

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Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress.

Vivian Lee, Michael D Gober, Hasan Bashir, Conor O'Day, Ian A Blair, Clementina Mesaros, Liwei Weng, Andrew Huang, Aaron Chen, Rachel Tang, Vince Anagnos, JiLon Li, Sophie Roling, Emilija Sagaityte, Andrew Wang, Chenyan Lin, Christopher Yeh, Cem Atillasoy, Christine Marshall, Tzvete Dentchev, Todd Ridky, John T Seykora,

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and is associated with cumulative UV exposure. Studies have shown that prolonged voriconazole use promotes cSCC formation; however, the biological mechanisms responsible for the increased incidence remain unclear. Here, we show that voriconazole directly increases oxidative ... Read more >>

Exp Dermatol (Experimental dermatology)
[2020, 29(1):29-38]

Cited: 1 time

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The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia.

Karin E Borgmann-Winter, Kai Wang, Sabyasachi Bandyopadhyay, Abolfazl Doostparast Torshizi, Ian A Blair, Chang-Gyu Hahn,

The complex and heterogeneous pathophysiology of schizophrenia can be deconstructed by integration of large-scale datasets encompassing genes through behavioral phenotypes. Genome-wide datasets are now available for genetic, epigenetic and transcriptomic variations in schizophrenia, which are then analyzed by newly devised systems biology algorithms. A missing piece, however, is the inclusion ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, 217:148-161]

Cited: 1 time

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Evaluation of antibodies for western blot analysis of frataxin protein isoforms.

Liwei Weng, Qingqing Wang, Sixiang Yu, Xiaolu Yang, David R Lynch, Clementina Mesaros, Ian A Blair,

Frataxin is the protein that is down-regulated in Friedreich ataxia (FRDA), an autosomal recessive genetic disease caused by an intronic GAA repeat expansion in intron-1 of the FXN gene. The GAA repeats result in epigenetic silencing of the FXN gene and reduced expression of the cytosolic full-length frataxin (1-210) protein. ... Read more >>

J Immunol Methods (Journal of immunological methods)
[2019, 474:112629]

Cited: 1 time

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The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting.

Ian A Blair, Jennifer Farmer, Steven Hersch, Jane Larkindale, David R Lynch, Jill Napierala, Marek Napierala, R Mark Payne, Sub H Subramony,

The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed. Biomarkers to monitor neurological disease progression include imaging, electrophysiological measures and measures of ... Read more >>

Future Sci OA (Future science OA)
[2019, 5(6):FSO398]

Cited: 5 times

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Metabolic Detection of Bruton's Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells.

Seung-Cheol Lee, Alexander A Shestov, Lili Guo, Qian Zhang, Jeffrey C Roman, Xiaobin Liu, Hong Y Wang, Stephen Pickup, Kavindra Nath, Pin Lu, Samuel Hofbauer, Clementina Mesaros, Y Lynn Wang, David S Nelson, Stephen J Schuster, Ian A Blair, Jerry D Glickson, Mariusz A Wasik,

Current methods to evaluate effects of kinase inhibitors in cancer are suboptimal. Analysis of changes in cancer metabolism in response to the inhibitors creates an opportunity for better understanding of the interplay between cell signaling and metabolism and, from the translational perspective, potential early evaluation of response to the inhibitors ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2019, 17(6):1365-1377]

Cited: 1 time

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Correction to Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia.

Lili Guo, Qingqing Wang, Liwei Weng, Lauren A Hauser, Cassandra J Strawser, Agostinho G Rocha, Andrew Dancis, Clementina Mesaros, David R Lynch, Ian A Blair,

Anal Chem (Analytical chemistry)
[2019, 91(3):2560]

Cited: 0 times

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Analytical Methods for Mass Spectrometry-Based Metabolomics Studies.

Siyu Wang, Ian A Blair, Clementina Mesaros,

The advancement of mass spectrometry-based analytical platform largely facilitates small-molecule metabolomics studies, which allows simultaneously analysis of a large number of metabolites from bio-samples and give a general picture of metabolic changes related to diseases or environmental alteration. Due to the large diversity of cellular metabolites, globally and precisely examining ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1140:635-647]

Cited: 0 times

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Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia.

David R Lynch, Jennifer Farmer, Lauren Hauser, Ian A Blair, Qing Qing Wang, Clementina Mesaros, Nathaniel Snyder, Sylvia Boesch, Melanie Chin, Martin B Delatycki, Paola Giunti, Angela Goldsberry, Chad Hoyle, Michael G McBride, Wolfgang Nachbauer, Megan O'Grady, Susan Perlman, S H Subramony, George R Wilmot, Theresa Zesiewicz, Colin Meyer,

<h4>Objective</h4>Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP production. Omaveloxolone, an Nrf2 activator and NF-kB suppressor, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(1):15-26]

Cited: 24 times

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Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.

Nelly Mauras, Lournaris Torres-Santiago, Richard Santen, Veronica Mericq, Judith Ross, Gerardo Colon-Otero, Ligeia Damaso, Jobayer Hossain, Qingqing Wang, Clementina Mesaros, Ian A Blair,

<h4>Objective</h4>The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including oestrogen catechols and quinones, which have been linked to breast carcinogenesis in post-menopausal women. We aimed to assess whether the route of administration of ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2019, 90(1):155-161]

Cited: 1 time

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Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin.

Kavindra Nath, Jeffrey Roman, David S Nelson, Lili Guo, Seung-Cheol Lee, Stepan Orlovskiy, Kevin Muriuki, Daniel F Heitjan, Stephen Pickup, Dennis B Leeper, Ian A Blair, Mary E Putt, Jerry D Glickson,

Lonidamine (LND), a metabolic modulator, sensitizes DB-1 human melanoma to doxorubicin (DOX) chemotherapy by acidifying and de-energizing the tumor. This report compares the effects of LND on two human melanoma lines, DB-1 and WM983B, which exhibit different metabolic properties. Using liquid chromatography mass spectrometry and Seahorse analysis, we show that ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):14654]

Cited: 1 time

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Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner.

Kathleen O'Neill, Jacqueline Alexander, Rikka Azuma, Rui Xiao, Nathaniel W Snyder, Clementina A Mesaros, Ian A Blair, Sara E Pinney,

Maternal diabetes and obesity induce marked abnormalities in glucose homeostasis and insulin secretion in the fetus, and are linked to obesity, diabetes, and metabolic disease in the offspring, with specific metabolic characterization based on offspring sex. Gestational diabetes (GDM) has profound effects on the intrauterine milieu, which may reflect and/or ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(9):]

Cited: 11 times

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Associations between improvement in genitourinary symptoms of menopause and changes in the vaginal ecosystem.

Caroline M Mitchell, Sujatha Srinivasan, Anna Plantinga, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks,

OBJECTIVE:The aim of the study was to identify associations between improvement in genitourinary symptoms of menopause (GSM) and vaginal microbiota, vaginal glycogen, and serum estrogen. METHODS:Thirty postmenopausal women enrolled in a hot flash treatment trial (oral estradiol vs venlafaxine vs placebo) who reported GSM and provided vaginal swabs at 0, ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2018, 25(5):500-507]

Cited: 5 times

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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Joshua D Ochocki, Sanika Khare, Markus Hess, Daniel Ackerman, Bo Qiu, Jennie I Daisak, Andrew J Worth, Nan Lin, Pearl Lee, Hong Xie, Bo Li, Bradley Wubbenhorst, Tobi G Maguire, Katherine L Nathanson, James C Alwine, Ian A Blair, Itzhak Nissim, Brian Keith, M Celeste Simon,

Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is "clear cell" renal cell carcinoma (ccRCC), which features consistent metabolic abnormalities, such as highly elevated glycogen and lipid deposition. By integrating metabolomics, genomic, and transcriptomic ... Read more >>

Cell Metab (Cell metabolism)
[2018, 27(6):1263-1280.e6]

Cited: 23 times

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