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Author Hyun Soo Shin

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Comments on: Safety and efficacy of 3D-printed templates assisted CT-guided radioactive iodine-125 seed implantation for the treatment of recurrent cervical carcinoma after external beam radiotherapy.

Hyun Soo Shin,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e50]

Cited: 0 times

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Feasibility and early toxicity of focal or partial brachytherapy in prostate cancer patients.

Tae Heon Kim, Jong Nyeong Kim, Young Dong Yu, Seung Ryeol Lee, Young Kwon Hong, Hyun Soo Shin, Dong Soo Park,

<h4>Purpose</h4>The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients.<h4>Material and methods</h4>Medical records of eligible patients who underwent focal/partial LDR-BT and whole LDR-BT between 2015 and 2017 ... Read more >>

J Contemp Brachytherapy (Journal of contemporary brachytherapy)
[2020, 12(5):420-426]

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Self-crosslinking hyaluronic acid-carboxymethylcellulose hydrogel enhances multilayered 3D-printed construct shape integrity and mechanical stability for soft tissue engineering.

Gopinathan Janarthanan, Hyun Soo Shin, In-Gul Kim, Pyung Ji, Eun-Jae Chung, Chibum Lee, Insup Noh,

One of the primary challenges in extrusion-based 3D bioprinting is the ability to print self-supported multilayered constructs with biocompatible hydrogels. The bioinks should have sufficient post-printing mechanical stability for soft tissue and organ regeneration. Here, we report on the synthesis, characterization and 3D printability of hyaluronic acid (HA)-carboxymethylcellulose (CMC) hydrogels ... Read more >>

Biofabrication (Biofabrication)
[2020, 12(4):045026]

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Distinct effects of different adjuvants in the mouse model of allergic airway inflammation.

Hyun Soo Shin, Hye Rin Chun, Hye Young Na, Moah Sohn, Seul Hye Ryu, Wanho Choi, BaoqingHyunju In, Ji Soo Park, Sejung Park, Chae Gyu Park,

<h4>Background</h4>Allergic asthma was typically considered as an inflammatory disease mediated by type 2 immunity. However, recent studies revealed that asthma is a complex disease displaying a variety of phenotypes and endotypes.<h4>Objective</h4>We examined cellular phenotypes in the mouse model of allergic asthma sensitized with different adjuvants. The aim of our study ... Read more >>

Asian Pac J Allergy Immunol (Asian Pacific journal of allergy and immunology)
[2020, :]

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Cryopreserved Human Oocytes and Cord Blood Cells Can Produce Somatic Cell Nuclear Transfer-Derived Pluripotent Stem Cells with a Homozygous HLA Type.

Jeoung Eun Lee, Ji Yoon Lee, Chang-Hwan Park, Jin Hee Eum, Soo Kyung Jung, A-Reum Han, Dong-Won Seol, Jin Saem Lee, Hyun Soo Shin, Jung Ho Im, Taehoon Chun, Kyungsoo Ha, Deok Rim Heo, Tae Ki Yoon, Dong Ryul Lee,

Human pluripotent stem cells (PSCs) through somatic cell nuclear transfer (SCNT) may be an important source for regenerative medicine. The low derivation efficiency of stem cells and the accessibility of human oocytes are the main obstacles to their application. We previously reported that the efficiency of SCNT was increased by ... Read more >>

Stem Cell Reports (Stem cell reports)
[2020, 15(1):171-184]

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Re-Irradiation and Its Contribution to Good Prognosis in Recurrent Glioblastoma Patients.

Mi Sun Kim, Jaejoon Lim, Hyun Soo Shin, Kyung Gi Cho,

BACKGROUND:Radiation therapy, one of the strongest anti-cancer treatments, is already performed to treat primary glioblastoma; however, the effect of repeated radiation therapy for recurrent tumors has not been fully explored. The aim of this study was to determine the efficacy of re-irradiation in treating recurrent glioblastoma. METHODS:The study included 36 ... Read more >>

Brain Tumor Res Treat (Brain tumor research and treatment)
[2020, 8(1):29-35]

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New sparse implantation technique of I-125 low-dose-rate brachytherapy using concomitant short-term hormonal treatment for low and intermediate-risk prostate cancer: An initial study of therapeutic feasibility.

Young Dong Yu, Jong Jin Oh, Hyun Soo Shin, Dong Soo Park,

This study aimed to evaluate the oncological outcomes and post-implantation complications of the concurrent androgen deprivation therapy (ADT) with I-125 low-dose-rate (LDR)-prostate brachytherapy (sparse implantation technique: SIT) in comparison with the conventional non-ADT using whole gland brachytherapy (CWT). 302 localized prostate cancer (PCa) patients were treated with CWT (implantation dose: ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18674]

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Tannic acid attenuates the formation of cancer stem cells by inhibiting NF-κB-mediated phenotype transition of breast cancer cells.

Dal-Ah Kim, Hack Sun Choi, Eun-Sun Ryu, Jiyeon Ko, Hyun-Soo Shin, Jong-Min Lee, Heesung Chung, Eunsung Jun, Eok-Soo Oh, Duk-Hee Kang,

Cancer stem cells (CSCs) are innately resistant to standard therapies, which positions CSCs in the focus of anti-cancer research. In this study, we investigated the potential inhibitory effect of tannic acid (TA) on CSCs. Our data demonstrated that TA (10 μM), at the concentration not inhibiting the proliferation of normal ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2019, 9(8):1664-1681]

Cited: 3 times

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A hepatocyte growth factor/MET-induced antiapoptotic pathway protects against radiation-induced salivary gland dysfunction.

Yeo Jun Yoon, Hyun-Soo Shin, Jae-Yol Lim,

OBJECTIVE:Hepatocyte growth factor (HGF) and its receptor MET are expressed in the salivary glands during developmental stages and tumor formation; however, the function of HGF in injured salivary gland tissues remains unclear. The present study investigated the role of HGF in protecting the salivary glands against radiation-induced injury using an ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 138:9-16]

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Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16).

Won Kyung Cho, Won Park, Doo Ho Choi, Yong Bae Kim, Chang-Ok Suh, Kyung Hwan Shin, Eui Kyu Chie, Jin Ho Kim, Seung Do Ahn, Su Ssan Kim, Kyubo Kim, Jin Hee Kim, Sung Ja Ahn, Sun Young Lee, Jeongshim Lee, Sang-Won Kim, Jeanny Kwon, Ki Jung Ahn, Hyun Soo Shin, Hyung Sik Lee, Nam Kwon Lee,

<h4>Purpose</h4>This multi-institutional study intended to investigate the effect of tumor bed boost in patients who achieved pathologic complete response (ypCR) following neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT).<h4>Materials and methods</h4>We identified 180 patients who initially had lymph node (LN) metastasis and achieved ypCR (ypT0/isN0) following NAC and BCT from the ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2019, 45:43-47]

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Upregulated microRNA-193a-3p is responsible for cisplatin resistance in CD44(+) gastric cancer cells.

So D Lee, Dayeon Yu, Do Y Lee, Hyun-Soo Shin, Jeong-Hyeon Jo, Yong C Lee,

Cisplatin is a well-known anticancer drug used to treat various cancers. However, development of cisplatin resistance has hindered the efficiency of this drug in cancer treatment. Development of chemoresistance is known to involve many signaling pathways. Recent attention has focused on microRNAs (miRNAs) as potentially important upstream regulators in the ... Read more >>

Cancer Sci (Cancer science)
[2019, 110(2):662-673]

Cited: 17 times

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Organotypic 3D Culture in Nanoscaffold Microwells Supports Salivary Gland Stem-Cell-Based Organization.

Hyun-Soo Shin, Hye Jin Hong, Won-Gun Koh, Jae-Yol Lim,

The self-organizing properties of stem cells have been exploited to generate organoids, organ-specific, cell-containing, three-dimensional (3D) structures. The present study aimed to introduce a novel bioengineering technique for driving the effective organization of adult tissue stem cells via niche-independent 3D microwell culture. Microwells were fabricated by photopatterning poly(ethylene glycol) hydrogel ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2018, 4(12):4311-4320]

Cited: 2 times

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Extended Culture of Bone Marrow with Granulocyte Macrophage-Colony Stimulating Factor Generates Immunosuppressive Cells.

Hye Young Na, Moah Sohn, Seul Hye Ryu, Wanho Choi, Hyunju In, Hyun Soo Shin, Chae Gyu Park,

Bone marrow-derived dendritic cells (BM-DCs) are generated from bone marrow (BM) cells cultured with granulocyte macrophage-colony stimulating factor (GM-CSF) for a week. In this study we investigated the effect of duration on the BM culture with GM-CSF. Within several months, the cells in the BM culture gradually expressed homogeneous levels ... Read more >>

Immune Netw (Immune network)
[2018, 18(2):e16]

Cited: 1 time

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Hypoxia-Activated Adipose Mesenchymal Stem Cells Prevents Irradiation-Induced Salivary Hypofunction by Enhanced Paracrine Effect Through Fibroblast Growth Factor 10.

Hyun-Soo Shin, Songyi Lee, Young-Mo Kim, Jae-Yol Lim,

To explore the effects and mechanisms of paracrine factors secreted from human adipose mesenchymal stem cell (hAdMSCs) that are activated by hypoxia on radioprotection against irradiation-induced salivary hypofunction in subjects undergoing radiotherapy for head and neck cancers. An organotypic spheroid coculture model to mimic irradiation (IR)-induced salivary hypofunction was set ... Read more >>

Stem Cells (Stem cells (Dayton, Ohio))
[2018, 36(7):1020-1032]

Cited: 6 times

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Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy.

Ji Hyun Chang, Kyung Hwan Shin, Seung Do Ahn, Hae Jin Park, Eui Kyu Chie, Jin Ho Kim, Su Ssan Kim, Yong Bae Kim, Won Park, Yeon-Joo Kim, Hyun Soo Shin, Jin Hee Kim, Sun Young Lee, Kyubo Kim, Kyung Ran Park, Bae Kwon Jeong, Ja Young Kim, Suzy Kim,

PURPOSE:In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). METHODS:The data from the patients participating in two South Korean multi-institutional studies (KROG 14-22; N = 1842 and KROG 14-23; ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2018, 169(3):507-512]

Cited: 3 times

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Metformin ameliorates the Phenotype Transition of Peritoneal Mesothelial Cells and Peritoneal Fibrosis via a modulation of Oxidative Stress.

Hyun-Soo Shin, Jiyeon Ko, Dal-Ah Kim, Eun-Sun Ryu, Hye-Myung Ryu, Sun-Hee Park, Yong-Lim Kim, Eok-Soo Oh, Duk-Hee Kang,

Phenotype transition of peritoneum is an early mechanism of peritoneal fibrosis. Metformin, 5'-adenosine monophosphate-activated protein kinase (AMPK) activator, has recently received a new attention due to its preventive effect on organ fibrosis and cancer metastasis by inhibiting epithelial-to-mesenchymal transition (EMT). We investigated the effect of metformin on EMT of human ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):5690]

Cited: 14 times

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Competent antigen-presenting cells are generated from the long-term culture of splenocytes with granulocyte-macrophage colony-stimulating factor.

Seul Hye Ryu, Hye Young Na, Moah Sohn, Wanho Choi, Hyunju In, Hyun Soo Shin, Jae-Hoon Choi, Chae Gyu Park,

Dendritic cells (DCs) are routinely produced from the culture of mouse bone marrow (BM) with granulocyte-macrophage colony-stimulating factor (GM-CSF) within a period of 10days. Although splenic extramedullary myelopoiesis was suggested to occur under the influence of GM-CSF, the hematopoietic outcome of splenic culture with GM-CSF has not been scrutinized. We ... Read more >>

Immunol Lett (Immunology letters)
[2017, 188:96-107]

Cited: 2 times

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Effect of Polycalcium, a mixture of Polycan and calcium lactate-gluconate in a 1:9 weight ratio, on rats with surgery-induced osteoarthritis.

Jae-Suk Choi, Hyun-Soo Shin, Ki Young Kim, Sae Kwang Ku, In Soon Choi, Joo Wan Kim,

In the present study, the beneficial and synergistic effects of Polycalcium, a mixture of Polycan and calcium (Ca) lactate-gluconate in a 1:9 weight ratio, on a rat model of osteoarthritis (OA) were explored. Polycalcium (50, 100 and 200 mg/kg) was administered orally once per day for 28 days from 1 ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2015, 9(5):1780-1790]

Cited: 6 times

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Enhanced tissue remodelling efficacy of adipose-derived mesenchymal stem cells using injectable matrices in radiation-damaged salivary gland model.

Jeong-Seok Choi, Hye-Young An, Hyun-Soo Shin, Young-Mo Kim, Jae-Yol Lim,

The present study was conducted to introduce the use of a delivery carrier for local transplantation of human adipose tissue-derived mesenchymal stem cells (AdMSCs) into the salivary gland (SG) and analyse its ability to enhance radioprotection of AdMSCs against irradiation (IR)-induced damage. An injectable porcine small intestinal submucosa (SIS) matrix ... Read more >>

J Tissue Eng Regen Med (Journal of tissue engineering and regenerative medicine)
[2018, 12(2):e695-e706]

Cited: 3 times

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Possible benefits from post-mastectomy radiotherapy in node-negative breast cancer patients: a multicenter analysis in Korea (KROG 14-22).

Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Su Ssan Kim, Yong Bae Kim, Won Park, Yeon-Joo Kim, Hyun Soo Shin, Jin Hee Kim, Sun Young Lee, Kyubo Kim, Kyung Ran Park, Bae Kwon Jeong,

<h4>Purpose</h4>This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients.<h4>Materials and methods</h4>We retrospectively reviewed 1,828 patients with pT1-2N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(35):59800-59809]

Cited: 2 times

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Incorporating Risk Factors to Identify the Indication of Post-mastectomy Radiotherapy in N1 Breast Cancer Treated with Optimal Systemic Therapy: A Multicenter Analysis in Korea (KROG 14-23).

Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Ja Young Kim, Won Park, Yong Bae Kim, Yeon-Joo Kim, Jin Hee Kim, Kyubo Kim, Kyung Ran Park, Hyun Soo Shin, Bae Kwon Jeong, Sun Young Lee, Suzy Kim,

<h4>Purpose</h4>In a recent meta-analysis, post-mastectomy radiotherapy (PMRT) reduced any first recurrence (AFR) and improved survival in N1 and N2 patients. We investigated risk factors for AFR in N1 after optimal systemic therapy without PMRT, to define a subgroup of patients who may benefit from PMRT.<h4>Materials and methods</h4>One thousand three hundred ... Read more >>

Cancer Res Treat (Cancer research and treatment)
[2017, 49(3):739-747]

Cited: 8 times

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Functional spheroid organization of human salivary gland cells cultured on hydrogel-micropatterned nanofibrous microwells.

Hyun-Soo Shin, Yun-Min Kook, Hye Jin Hong, Young-Mo Kim, Won-Gun Koh, Jae-Yol Lim,

Development of a tissue-engineered, salivary bio-gland will benefit patients suffering from xerostomia due to loss of fluid-secreting acinar cells. This study was conducted to develop a bioengineering system to induce self-assembly of human parotid epithelial cells (hPECs) cultured on poly ethylene glycol (PEG) hydrogel-micropatterned polycaprolactone (PCL) nanofibrous microwells. Microwells were ... Read more >>

Acta Biomater (Acta biomaterialia)
[2016, 45:121-132]

Cited: 10 times

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Clinical efficacy of combination therapy with an alpha blocker and low-dose sildenafil on post-therapy lower urinary tract symptoms after low-dose-rate brachytherapy for prostate cancer.

Young Dong Yu, Moon Hyung Kang, Chang Il Choi, Hyun Soo Shin, Jong Jin Oh, Dong Soo Park,

<h4>Purpose</h4>To investigate the efficacy of tamsulosin monotherapy and tamsulosin with low-dose sildenafil combination therapy on lower urinary tract symptoms (LUTS) following low-dose-rate (LDR) brachytherapy in early prostate cancer patients.<h4>Methods</h4>From March 2008 to June 2014, of the 212 prostate cancer patients with a Gleason score ≤7 who received LDR brachytherapy, 80 ... Read more >>

World J Urol (World journal of urology)
[2016, 34(9):1269-1274]

Cited: 5 times

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Difference in the rate of rectal complications following prostate brachytherapy based on the prostate-rectum distance and the prostate longitudinal length among early prostate cancer patients.

Moon Hyung Kang, Young Dong Yu, Hyun Soo Shin, Jong Jin Oh, Dong Soo Park,

<h4>Purpose</h4>To investigate the difference in rectal complications rate following prostate low dose rate (LDR) brachytherapy based on prostate-rectum distance and prostate longitudinal length among early prostate cancer patients.<h4>Materials and methods</h4>From March 2008 to February 2013, 245 prostate cancer patients with a Gleason score ≤7 were treated with 125-I LDR brachytherapy. ... Read more >>

Korean J Urol (Korean journal of urology)
[2015, 56(9):637-643]

Cited: 6 times

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Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells.

Hyun-Soo Shin, Eun-Sun Ryu, Eok-Soo Oh, Duk-Hee Kang,

Epithelial-to-mesenchymal transition (EMT) and apoptosis of peritoneal mesothelial cells are known to be the earliest mechanisms of peritoneal fibrosis in peritoneal dialysis (PD). Endoplasmic reticulum (ER) stress with an unfolded protein response is regarded to have a role in the development of organ fibrosis. To investigate the potential role of ... Read more >>

Lab Invest (Laboratory investigation; a journal of technical methods and pathology)
[2015, 95(10):1157-1173]

Cited: 16 times

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