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Author Hyemin Kim

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Lactic Acid Bacteria Exert a Hepatoprotective Effect against Ethanol-Induced Liver Injury in HepG2 Cells.

Ji Yeon Lee, Hyemin Kim, Yulah Jeong, Chang-Ho Kang,

Alcoholic liver fatty disease (ALFD) is caused by excessive and chronic alcohol consumption. Alcohol consumption causes an imbalance in the intestinal microflora, leading to liver disease induced by the excessive release of endotoxins into the hepatic portal vein. Therefore, research on the intestinal microflora to identify treatments for ALFD is ... Read more >>

Microorganisms (Microorganisms)
[2021, 9(9):]

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Generation of an ACTA2-EGFP reporter human induced pluripotent stem cell line, KITi001-C-41, using CRISPR/Cas9-mediated homologous recombination.

Seongyea Jo, Ji-Woo Kim, Haneul Noh, Hyemin Kim, Jong-Hoon Kim, Han-Jin Park,

Alpha-smooth muscle actin (α-SMA) is encoded by ACTA2 and is a key protein in the cellular contractile system of various mesodermal cell types, including hepatic stellate cells (HSCs), smooth muscle cells, and cardiomyocytes. α-SMA, which is a key protein in the development of hepatic fibrosis, is widely used as a ... Read more >>

Stem Cell Res (Stem cell research)
[2021, 56:102524]

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In Vivo Confirmation of the Antimicrobial Effect of Probiotic Candidates against Gardnerella vaginalis.

Hyemin Kim, YongGyeong Kim, Chang-Ho Kang,

Bacterial vaginosis (BV) is caused by a microbial imbalance of the vaginal ecosystem, causing genital discomfort and potentially even various complications in women. Moreover, research on the treatment or prevention of BV is increasing. In this study, we evaluated the antimicrobial and anti-inflammation effects of the lactic acid bacteria (LAB) ... Read more >>

Microorganisms (Microorganisms)
[2021, 9(8):]

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Accurate Prognosis Prediction of Pancreatic Ductal Adenocarcinoma Using Integrated Clinico-Genomic Data of Endoscopic Ultrasound-Guided Fine Needle Biopsy.

Joo Kyung Park, Hyemin Kim, Dae-Soon Son, Nayoung K D Kim, Young Kyung Sung, Minseob Cho, Chung Lee, Dong Hyo Noh, Se-Hoon Lee, Kyu Taek Lee, Jong Kyun Lee, Kee-Taek Jang, Woong-Yang Park, Kwang Hyuck Lee,

The aim of this study was to investigate the clinical utility of minimal specimens acquired from endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) and perform targeted deep sequencing as a prognosis prediction tool for pancreatic ductal adenocarcinoma (PDAC). A total of 116 specimens with pathologically confirmed PDAC via EUS-FNB were tested using ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(11):]

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Predictors for inpatient mortality during the first wave of the SARS-CoV-2 pandemic: A retrospective analysis.

Daniel Sammartino, Farrukh Jafri, Brennan Cook, Lisa La, Hyemin Kim, John Cardasis, Joshua Raff,

<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic overwhelmed healthcare systems, highlighting the need to better understand predictors of mortality and the impact of medical interventions.<h4>Methods</h4>This retrospective cohort study examined data from every patient who tested positive for COVID-19 and was admitted to White Plains Hospital between March 9, 2020, and June ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0251262]

Cited: 1 time

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Clinical Significance of Circulating Tumor Cells in Unresectable Pancreatic Ductal Adenocarcinomas

Hyemin Kim, Chan Mi Heo, Jinmyeong Oh, Eun Mi Lee, Juhee Park, Se-Hoon Lee, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Yoon-Kyoung Cho, Joo Kyung Park,

<h4>Background: </h4> Circulating tumour cells (CTCs) have emerged as liquid biopsy biomarker providing non-invasive assessment of cancer progression and biology. We investigated whether longitudinal analysis of CTCs could monitor disease progression, response to chemotherapy, and survival in patients with unresectable pancreatic ductal adenocarcinoma (PDAC). <h4>Methods:</h4> CTCs were isolated using a ... Read more >>

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Heat-Killed Lactic Acid Bacteria Inhibit Nitric Oxide Production via Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cells.

Chang-Ho Kang, Jin-Seong Kim, Hyemin Kim, Hye Min Park, Nam-Soo Paek,

Heat-killed lactic acid bacteria perform immunomodulatory functions and are advantageous as probiotics, considering their long product shelf-life, easy storage, and convenient transportation. In this study, we aimed to develop appropriate heat treatments for industrial preparation of probiotics with antioxidant activity. Among 75 heat-killed strains, Lactococcus lactis MG5125 revealed the highest ... Read more >>

Probiotics Antimicrob Proteins (Probiotics and antimicrobial proteins)
[2021, 13(6):1530-1538]

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Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.

Tarik Seref Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hyemin Kim, Jennifer Wang, Megan Mair, Huilan Wang, Lifang Li, Alma Perez, Maria de Haro, Ying-Wooi Wan, Genevera Allen, Boxun Lu, Ismael Al-Ramahi, Zhandong Liu, Juan Botas,

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington's disease (HD), we profiled the gene expression alterations of <i>Drosophila</i> expressing human mutant <i>Huntingtin</i> (m<i>HTT</i>) in either ... Read more >>

Elife (eLife)
[2021, 10:]

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Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151

Bohm Lee, Jinyoung Lee, Yewon Jeon, Hyemin Kim, Minjae Kwon, Jung Eun Shin, Yongcheol Cho,

Gene expression profiling in response to nerve injury has been mainly focused on protein functions of coding genes to understand mechanisms of axon regeneration and to identify targets of potential therapeutics for nerve repair. However, the protein functions of several highly injury-induced genes including Gpr151 for regulating the regenerative ability ... Read more >>

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Brassinosteroid-BZR1/2-WAT1 module determines the high level of auxin signalling in vascular cambium during wood formation.

Jinsu Lee, Hyemin Kim, Sin-Gi Park, Hyeona Hwang, Seung-Il Yoo, Wonsil Bae, Eunhui Kim, Jaehoon Kim, Hwa-Yong Lee, Tae-Young Heo, Kwon Kyoo Kang, Yuree Lee, Chang Pyo Hong, Hyunwoo Cho, Hojin Ryu,

The tight regulation of local auxin homeostasis and signalling maxima in xylem precursor cells specifies the organising activity of the vascular cambium and consequently promotes xylem differentiation and wood formation. However, the molecular mechanisms underlying the local auxin signalling maxima in the vascular cambium are largely unknown. Here, we reveal ... Read more >>

New Phytol (The New phytologist)
[2021, 230(4):1503-1516]

Cited: 2 times

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Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151

Bohm Lee, Jinyoung Lee, Yewon Jeon, Eunsoo Jang, Yeonsoo Oh, Hyemin Kim, Minjae Kwon, Jung Eun Shin, Yongcheol Cho,

Gene expression profiling in response to nerve injury has been mainly focused on protein functions of coding genes to understand mechanisms of axon regeneration and to identify targets of potential therapeutics for nerve repair. However, the protein functions of several highly injury-induced genes including Gpr151 for regulating the regenerative ability ... Read more >>

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PDK1 is a negative regulator of axon regeneration.

Hyemin Kim, Jinyoung Lee, Yongcheol Cho,

Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions. To identify those molecules regulating axon regeneration, comparative analysis from dorsal root ganglion neurons at embryonic or adult ... Read more >>

Mol Brain (Molecular brain)
[2021, 14(1):31]

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The relationships of present vegetation, bacteria, and soil properties with soil organic matter characteristics in moist acidic tundra in Alaska.

Sungjin Nam, Josu G Alday, Mincheol Kim, Hyemin Kim, Yongkang Kim, Taesung Park, Hyoun Soo Lim, Bang Yong Lee, Yoo Kyung Lee, Ji Young Jung,

Soil organic matter (SOM) is related to vegetation, soil bacteria, and soil properties; however, not many studies link all these parameters simultaneously, particularly in tundra ecosystems vulnerable to climate change. Our aim was to describe the relationships between vegetation, bacteria, soil properties, and SOM composition in moist acidic tundra by ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 772:145386]

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Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis.

Gyunggyu Lee, Hyemin Kim, Ji Young Park, Gyeongmin Kim, Jiyou Han, Seok Chung, Ji Hun Yang, Jang Su Jeon, Dong-Hun Woo, Choongseong Han, Sang Kyum Kim, Han-Jin Park, Jong-Hoon Kim,

Recent advances in pluripotent stem cell technology provide an alternative source of human hepatocytes to overcome the limitations of current toxicity tests. However, this approach requires optimization and standardization before it can be used as a fast and reliable toxicity screening system. Here, we designed and tested microwell culture platforms ... Read more >>

Biomaterials (Biomaterials)
[2021, 269:120529]

Cited: 2 times

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Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington’s Disease

Tarik Onur, Andrew Laitman, He Zhao, Ryan Keyho, Hyemin Kim, Jennifer Wang, Megan Mair, Alma Perez, Maria de Haro, Huilan Wang, Ying-Wooi Wan, Genevera Allen, Boxun Lu, Ismael Al-Ramahi, Zhandong Liu, Juan Botas,

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington’s disease (HD), we studied transcriptomic changes in HD human, HD mice, and Drosophila expressing human mutant Huntingtin ... Read more >>

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Correction: Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application.

Yoonsang Park, Yujin Kim, Heemin Chang, Sungyeon Won, Hyemin Kim, Woosung Kwon,

Correction for 'Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application' by Yoonsang Park et al., J. Mater. Chem. B, 2020, DOI: 10.1039/d0tb01334j. ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(42):9812]

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Biocompatible nitrogen-doped carbon dots: synthesis, characterization, and application.

Yoonsang Park, Yujin Kim, Heemin Chang, Sungyeon Won, Hyemin Kim, Woosung Kwon,

Carbon dots (CDs) are promising materials for biomedical applications owing to their unique properties, biocompatibility, and biodegradability. The current studies on CDs are focused on improving their functionality by modulating their electronic structure, which helps in controlling their chemical, optical, and electrical properties. Doping with heteroatoms is a typical approach ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, :]

Cited: 3 times

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Direct observation of quantum tunnelling charge transfers between molecules and semiconductors for SERS.

Nam-Jung Kim, Jayeong Kim, Jun-Beom Park, Hyemin Kim, Gyu-Chul Yi, Seokhyun Yoon,

We used high-quality ZnO nanostructures/graphene substrates for understanding the mechanisms of charge transfer (CT) that take place under nonplasmonic conditions. As the optimal conditions for CT processes are found, we studied the range of CT normal to the ZnO surface that is coated with nanoscale HfO2 layers with different thicknesses. ... Read more >>

Nanoscale (Nanoscale)
[2018, 11(1):45-49]

Cited: 3 times

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The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling.

Jinyoung Lee, Jung Eun Shin, Bohm Lee, Hyemin Kim, Yewon Jeon, Seung Hyun Ahn, Sung Wook Chi, Yongcheol Cho,

Axon regeneration is regulated by a neuron-intrinsic transcriptional program that is suppressed during development but that can be reactivated following peripheral nerve injury. Here we identify <i>Prom1</i>, which encodes the stem cell marker prominin-1, as a regulator of the axon regeneration program. <i>Prom1</i> expression is developmentally down-regulated, and the genetic ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(27):15955-15966]

Cited: 11 times

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Live-cell screening platform using human-induced pluripotent stem cells expressing fluorescence-tagged cytochrome P450 1A1.

Ji-Woo Kim, Ilkyun Im, Hyemin Kim, Jang Su Jeon, Eun-Hye Kang, Seongyea Jo, Hang-Suk Chun, Seokjoo Yoon, Jong-Hoon Kim, Sang Kyum Kim, Han-Jin Park,

Human-induced pluripotent stem cells (hiPSCs) are invaluable sources for drug screening and toxicity tests because of their differentiation potential and proliferative capacity. Recently, the CRISPR-Cas9-mediated homologous recombination system has enabled reporter knock-ins at desired loci in hiPSCs, and here, we generated a hiPSC reporter line expressing mCherry-tagged cytochrome P450 1A1 ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(7):9141-9155]

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Biocompatible Organosilica Nanoparticles with Self-Encapsulated Phenyl Motifs for Effective UV Protection.

Jounghyun Yoo, Hyemin Kim, Heemin Chang, Wonchan Park, Sei Kwang Hahn, Woosung Kwon,

With increasing ozone depletion, ultraviolet (UV) exposure from sunlight has become a significant health risk. Although commercially available sun protectants provide reasonable protection, they have limitations in terms of safety and aesthetics. Here, we have developed biocompatible and biodegradable sunscreens by facile synthesis of organosilica nanoparticles (o-SNPs) with self-encapsulated phenyl ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(8):9062-9069]

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Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.

Hye-Yeong Jo, Hyo-Won Han, Inuk Jung, Ji Hyeon Ju, Soon-Jung Park, Sunghwan Moon, Dongho Geum, Hyemin Kim, Han-Jin Park, Sun Kim, Glyn N Stacey, Soo Kyung Koo, Mi-Hyun Park, Jung-Hyun Kim,

Although human induced pluripotent stem cell (hiPSC) lines are karyotypically normal, they retain the potential for mutation in the genome. Accordingly, intensive and relevant quality controls for clinical-grade hiPSCs remain imperative. As a conceptual approach, we performed RNA-seq-based broad-range genetic quality tests on GMP-compliant human leucocyte antigen (HLA)-homozygous hiPSCs and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3939]

Cited: 2 times

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Detection of Circulating Tumor Cells in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Evaluation as a Prognostic Marker.

Byeong Geun Song, Wooil Kwon, Hyemin Kim, Eun Mi Lee, Young Min Han, Hongbeom Kim, Yoonhyeong Byun, Kyung Bun Lee, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Jin-Young Jang, Joo Kyung Park,

Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but are infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage of pancreatic venous blood flow come to portal vein and pass through the liver, and they finally go out for peripheral blood. We thought that ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:616440]

Cited: 1 time

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Biodegradable Microneedle Patch Delivering Antigenic Peptide-Hyaluronate Conjugate for Cancer Immunotherapy.

Hyemin Kim, Keum-Yong Seong, Jung Ho Lee, Wonchan Park, Seung Yun Yang, Sei Kwang Hahn,

Antigenic peptide-delivery systems have been extensively investigated to harness the immune system for cancer therapy. Cytotoxic T-cell epitope peptide can induce an antigen-specific CD8<sup>+</sup> T-cell response, which subsequently inhibits the growth of antigen-bearing tumors. However, there are only a few facile tailored delivery systems of antigenic peptide for effective cancer ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2019, 5(10):5150-5158]

Cited: 3 times

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Hyaluronic Acid Derivatives for Translational Medicines.

Hyemin Kim, Myeonghwan Shin, Seulgi Han, Woosung Kwon, Sei Kwang Hahn,

The recent progress in various biomaterials with unique physiological and pharmacological properties has expedited the development of translational medicines for the diagnosis, prognosis, and therapy of intractable diseases. Hyaluronic acid (HA) is one of such biomaterials that has attracted great attention due to its unique characteristics for biomedical applications. In ... Read more >>

Biomacromolecules (Biomacromolecules)
[2019, 20(8):2889-2903]

Cited: 4 times

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