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Author Humphrey Hung Chang Yao

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

Cited: 0 times

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Developmental and sexual dimorphic atlas of the prenatal mouse external genitalia at the single-cell level.

Ciro Maurizio Amato, Humphrey Hung-Chang Yao,

Birth defects of the external genitalia are among the most common in the world. Proper formation of the external genitalia requires a highly orchestrated process that involves special cell populations and sexually dimorphic hormone signaling. It is clear what the end result of the sexually dimorphic development is (a penis ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(25):]

Cited: 0 times

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Developmental Exposure to Tetrabromobisphenol A Has Minimal Impact on Male Rat Reproductive Health.

Paula R Brown, Sagi Enicole A Gillera, Suzanne E Fenton, Humphrey Hung-Chang Yao,

The flame retardant and plasticizer, tetrabromobisphenol-A (TBBPA) has rapidly become a common component in the manufacture of circuit boards and plastics worldwide. It is also an analog of bisphenol A (BPA), an endocrine disrupting chemical identified by the Endocrine Society. As such, TBBPA needs to be investigated for similar potential ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:59-65]

Cited: 0 times

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A tale of two tracts: history, current advances, and future directions of research on sexual differentiation of reproductive tracts†.

Fei Zhao, Humphrey Hung-Chang Yao,

Alfred Jost's work in the 1940s laid the foundation of the current paradigm of sexual differentiation of reproductive tracts, which contends that testicular hormones drive the male patterning of reproductive tract system whereas the female phenotype arises by default. Once established, the sex-specific reproductive tracts undergo morphogenesis, giving rise to ... Read more >>

Biol Reprod (Biology of reproduction)
[2019, 101(3):602-616]

Cited: 2 times

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At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad.

Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao,

The reproductive endocrine systems are vastly different between males and females. This sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. Most gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the ... Read more >>

Endocr Rev (Endocrine reviews)
[2018, 39(5):739-759]

Cited: 15 times

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Cell-based computational model of early ovarian development in mice.

Hannah M Wear, Annika Eriksson, Humphrey Hung-Chang Yao, Karen H Watanabe,

Despite its importance to reproduction, certain mechanisms of early ovarian development remain a mystery. To improve our understanding, we constructed the first cell-based computational model of ovarian development in mice that is divided into two phases: Phase I spans embryonic day 5.5 (E5.5) to E12.5; and Phase II spans E12.5 ... Read more >>

Biol Reprod (Biology of reproduction)
[2017, 97(3):365-377]

Cited: 1 time

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From the Cover: Teratogenic Effects of in Utero Exposure to Di-(2-Ethylhexyl)-Phthalate (DEHP) in B6:129S4 Mice.

Erica Ungewitter, Emmi Rotgers, Tanika Bantukul, Yasuhiko Kawakami, Grace E Kissling, Humphrey Hung-Chang Yao,

Intrauterine exposure to phthalates is known to cause disorders of male reproductive function including androgen insufficiency, decreased fertility, and germ cell defects in rodents. In this study, we set out to investigate the effects of intrauterine exposure to di-(2-ethylhexyl)-phthalate (DEHP) on fetal development of the B6:129S4 mouse strain. Time-mated pregnant ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2017, 157(1):8-19]

Cited: 4 times

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Response to "Comment on 'Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice'".

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):A46-7]

Cited: 7 times

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Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice.

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

<h4>Background</h4>Mice exposed to high levels of arsenic in utero have increased susceptibility to tumors such as hepatic and pulmonary carcinomas when they reach adulthood. However, the effects of in utero arsenic exposure on general physiological functions such as reproduction and metabolism remain unclear.<h4>Objectives</h4>We evaluated the effects of in utero exposure ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):336-343]

Cited: 17 times

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Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.

Chen-Che Jeff Huang, Humphrey Hung-Chang Yao,

Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2010, 77(6):489-496]

Cited: 14 times

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Loss of smad4 in Sertoli and Leydig cells leads to testicular dysgenesis and hemorrhagic tumor formation in mice.

Denise R Archambeault, Humphrey Hung-Chang Yao,

As the central component of canonical TGFbeta superfamily signaling, SMAD4 is a critical regulator of organ development, patterning, tumorigenesis, and many other biological processes. Because numerous TGFbeta superfamily ligands are expressed in developing testes, there may exist specific requirements for SMAD4 in individual testicular cell types. Previously, we reported that ... Read more >>

Biol Reprod (Biology of reproduction)
[2014, 90(3):62]

Cited: 11 times

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Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice.

Ivraym B Barsoum, Jaspreet Kaur, Renshan S Ge, Paul S Cooke, Humphrey Hung-Chang Yao,

Testes contain two distinct Leydig cell populations during development: fetal and adult Leydig cells (FLCs and ALCs, respectively). ALCs are not derived from FLCs, and it is unknown whether these two populations share common progenitors. We discovered that hedgehog (Hh) signaling is responsible for transforming steroidogenic factor 1-positive (SF1(+)) progenitors ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2013, 27(7):2657-2666]

Cited: 21 times

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Investigating the origins of somatic cell populations in the perinatal mouse ovaries using genetic lineage tracing and immunohistochemistry.

Chang Liu, Melissa Paczkowski, Manal Othman, Humphrey Hung-Chang Yao,

Genetic lineage tracing (or fate mapping) techniques are designed to permanently label progenitor cells of target tissues, thereby allowing delineation of the progenies of labeled cells during organogenesis. This technology has been widely used in the study of cell migration and lineage specification in various organs and organisms. Here, we ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2012, 825:211-221]

Cited: 4 times

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Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.

Chen-Che Jeff Huang, Chang Liu, Humphrey Hung-Chang Yao,

Functions of adrenal medulla, particularly synthesis of catecholamine, are under the control of glucocorticoids produced by the cortex. To further investigate whether development/differentiation of the adrenal medulla is associated with proper organization of the adrenal cortex, we examined development of the medulla in four different mouse models with various defects ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2012, 361(1-2):165-171]

Cited: 9 times

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Testicular somatic cells, not gonocytes, are the major source of functional activin A during testis morphogenesis.

Denise R Archambeault, Jessica Tomaszewski, Andrew J Childs, Richard A Anderson, Humphrey Hung-Chang Yao,

Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin A, the ... Read more >>

Endocrinology (Endocrinology)
[2011, 152(11):4358-4367]

Cited: 4 times

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Stem cell potential of the mammalian gonad.

Chia-Feng Liu, Ivraym Barsoum, Rupesh Gupta, Marie-Claude Hofmann, Humphrey Hung-Chang Yao,

Stem cells have enormous potential for therapeutic application because of their ability to self-renew and differentiate into different cell types. Gonads, which consist of somatic cells and germ cells, are the only organs capable of transmitting genetic materials to the offspring. Germ-line stem cells and somatic stem cells have been ... Read more >>

Front Biosci (Elite Ed) (Frontiers in bioscience (Elite edition))
[2009, 1:510-518]

Cited: 2 times

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Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.

Chen-Che Jeff Huang, Shinichi Miyagawa, Daisuke Matsumaru, Keith L Parker, Humphrey Hung-Chang Yao,

The adrenal capsule is postulated to harbor stem/progenitor cells, the progenies of which contribute to the growth of adrenocortex. We discovered that cells in the adrenal capsule are positive for Ptch1 and Gli1, genes indicative of responsiveness to the stimulation of Hedgehog (Hh) ligands. On the other hand, Sonic hedgehog ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(3):1119-1128]

Cited: 63 times

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Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion.

Denise R Archambeault, Humphrey Hung-Chang Yao,

Formation of tubular structures relies upon complex interactions between adjacent epithelium and mesenchyme. In the embryonic testes, dramatic compartmentalization leads to the formation of testis cords (epithelium) and the surrounding interstitium (mesenchyme). Sertoli cells, the epithelial cell type within testis cords, produce signaling molecules to orchestrate testis cord formation. The ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2010, 107(23):10526-10531]

Cited: 53 times

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Epithelial-mesenchymal crosstalk in Wolffian duct and fetal testis cord development.

Denise R Archambeault, Jessica Tomaszewski, Avenel Joseph, Barry T Hinton, Humphrey Hung-Chang Yao,

Interactions between adjacent epithelial and mesenchymal tissues represent a highly conserved mechanism in embryonic organogenesis. In particular, the ability of the mesenchyme to instruct cellular differentiation of the epithelium is a fundamental requirement for the morphogenesis of tubular structures such as those found in the kidneys, lungs, and the developing ... Read more >>

Genesis (Genesis (New York, N.Y. : 2000))
[2009, 47(1):40-48]

Cited: 12 times

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Essential roles of inhibin beta A in mouse epididymal coiling.

Jessica Tomaszewski, Avenel Joseph, Denise Archambeault, Humphrey Hung-Chang Yao,

Testis-derived testosterone has been recognized as the key factor for morphogenesis of the Wolffian duct, the precursor of several male reproductive tract structures. Evidence supports that testosterone is required for the maintenance of the Wolffian duct via its action on the mesenchyme. However, it remains uncertain how testosterone alone is ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2007, 104(27):11322-11327]

Cited: 39 times

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Sexually dimorphic regulation of inhibin beta B in establishing gonadal vasculature in mice.

Humphrey Hung-Chang Yao, Jorie Aardema, Kirsten Holthusen,

Sexually dimorphic differentiation of gonads is accomplished through balanced interactions between positive and negative regulators. One of the earliest features of gonadal differentiation is the divergent patterning of the vasculature. A male-specific coelomic vessel develops on the anterior to posterior of the XY gonad, whereas this vessel is absent in ... Read more >>

Biol Reprod (Biology of reproduction)
[2006, 74(5):978-983]

Cited: 53 times

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Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

Erica Deutscher, Humphrey Hung-Chang Yao,

Members of the Wnt family of genes such as Wnt4, Wnt5a, and Wnt7a have been implicated in the formation and morphogenesis of the Müllerian duct into various parts of the female reproductive tract. These WNT ligands elicit their action via either the canonical WNT/beta-catenin or the non-canonical WNT/calcium pathway and ... Read more >>

Dev Biol (Developmental biology)
[2007, 307(2):227-236]

Cited: 49 times

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The road to maleness: from testis to Wolffian duct.

Ivraym Barsoum, Humphrey Hung-Chang Yao,

The establishment of the male internal reproductive system involves two crucial events: the formation of the testis and the maintenance and differentiation of the Wolffian duct. Testis formation, particularly the specification of Sertoli cell and Leydig cell lineages, is controlled strictly by genetic components initiated by the testis-determining gene SRY ... Read more >>

Trends Endocrinol Metab (Trends in endocrinology and metabolism: TEM)
[2006, 17(6):223-228]

Cited: 15 times

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Organogenesis of the ovary: a comparative review on vertebrate ovary formation.

Amy C Ditewig, Humphrey Hung-Chang Yao,

The general perspective of ovary organogenesis is that the ovary is the default organ which develops in the absence of testis-promoting factors. Testis formation, on the other hand, is a male-specific event promoted by active components that override the default ovarian process. However, when comparing the sex determination mechanism among ... Read more >>

Organogenesis (Organogenesis)
[2005, 2(2):36-41]

Cited: 7 times

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The pathway to femaleness: current knowledge on embryonic development of the ovary.

Humphrey Hung-Chang Yao,

Increasing evidence indicates that organogenesis of the ovary is not a passive process arising by default in the absence of the testis pathway. A coordinated interaction is actually in force between somatic cells and female germ cells in embryonic ovaries, thus creating a unique microenvironment that facilitates the formation of ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2005, 230(1-2):87-93]

Cited: 48 times

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