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Author Hui Zheng

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

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A female carrier of a novel DMD mutation with slightly skewed X-chromosome inactivation shows a suspected case of Becker muscular dystrophy in a Chinese family.

Jianfan Chen, Hui Zheng, Zhongju Wang, Jian Wang, Fei He, Cheng Zhang, Fu Xiong,

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are both caused by mutations in DMD gene effecting the expression of dystrophin. Generally female carriers are asymptomatic; however, it has been suggested that carriers may exhibit symptoms. We investigated a 6-year-old Chinese girl exhibiting a suspected BMD phenotype, including persistently ... Read more >>

Mol Genet Genomics (Molecular genetics and genomics : MGG)
[2021, :]

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Preoperative use of furosemide may increase the incidence of acute kidney injury after coronary artery bypass grafting: a propensity score-matched study.

Hui Zheng, Le Liu, Guoliang Fan, Zhigang Liu, Zhengqing Wang, Baocheng Chang,

<h4>Objectives</h4>Furosemide is usually administered before the Coronary artery bypass grafting (CABG) to improve water-sodium retention. However, no final conclusions are available on the postoperative renal outcome of furosemide. We evaluated the effect of preoperative furosemide on acute kidney injury (AKI) after CABG.<h4>Methods</h4>We recorded the use of furosemide 14 days before surgery ... Read more >>

Gen Thorac Cardiovasc Surg (General thoracic and cardiovascular surgery)
[2021, :]

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The echocardiographic ratio tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure predicts short-term adverse outcomes in acute pulmonary embolism.

Mads D Lyhne, Christopher Kabrhel, Nicholas Giordano, Asger Andersen, Jens Erik Nielsen-Kudsk, Hui Zheng, David M Dudzinski,

<h4>Aims</h4>Right ventricular (RV) failure causes death from acute pulmonary embolism (PE), due to a mismatch between RV systolic function and increased RV afterload. We hypothesized that an echocardiographic ratio of this mismatch [RV systolic function by tricuspid annular plane systolic excursion (TAPSE) divided by pulmonary arterial systolic pressure (PASP)] would ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2021, 22(3):285-294]

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Ligand fishing based on bioaffinity ultrafiltration for screening xanthine oxidase inhibitors from citrus plants.

Xin Dong, Bin Wang, Jun Cao, Hui Zheng, Li-Hong Ye,

Citrus plants are valuable medicinal plants with abundant flavonoids content in the parts of fruits and peels, which exhibit potential hypouricemic effect. In the present study, a ligand fishing assay was performed based on bio-affinity ultrafiltration for rapidly screening and identifying xanthine oxidase inhibitors from citrus plants. Under the optimal ... Read more >>

J Sep Sci (Journal of separation science)
[2021, :]

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Ubiquitin E3 ligase MID1 inhibits the innate immune response by ubiquitinating IRF3.

Xiangjie Chen, Ying Xu, Wenhui Tu, Fan Huang, Yibo Zuo, Hong-Guang Zhang, Lincong Jin, Qian Feng, Tengfei Ren, Jiuyi He, Ying Miao, Yukang Yuan, Qian Zhao, Jiapeng Liu, Renxia Zhang, Li Zhu, Feng Qian, Chuanwu Zhu, Hui Zheng, Jun Wang,

Interferon regulatory factor 3 (IRF3) is a critical transcription factor for inducing production of type I interferons (IFN-I) and regulating host antiviral response. Although IRF3 activation during viral infection has been extensively studied, the inhibitory regulation of IRF3 remains largely unexplored. Here, we revealed that Midline-1 (MID1) is a ubiquitin ... Read more >>

Immunology (Immunology)
[2021, :]

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Sex-related Differences in D-dimer Levels for Venous Thromboembolism Screening.

J J Reagh, Hui Zheng, Uwe Stolz, Blair A Parry, Anna M Chang, Stacey L House, Nicholas J Giordano, Jason Cohen, Adam J Singer, Samuel Francis, Jürgen H Prochaska, Eli Zeserson, Philipp S Wild, Alexander T Limkakeng, Elizabeth L Walters, Frank LoVecchio, Daniel Theodoro, Judd E Hollander, Christopher Kabrhel, Gregory J Fermann,

<h4>Background</h4>D-dimer is generally considered positive above 0.5 mg/L irrespective of sex. However, women have been shown to be more likely to have a positive D-dimer after controlling for other factors. Thus, differences may exist between males and females for using D-dimer as a marker of venous thromboembolic (VTE) disease. We ... Read more >>

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, :]

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Life-long body mass index trajectories and mortality in two generations.

Hui Zheng, Paola Echave, Neil Mehta, Mikko Myrskylä,

<h4>Purpose</h4>To identify life-long body mass index (BMI) trajectories across two related generations and estimate their associated mortality risks and population attributable deaths.<h4>Methods</h4>We use prospective cohort data from the Framingham Heart Study (1948-2011) original (4576 individuals, 3913 deaths) and offspring (3753 individuals, 967 deaths) cohorts and latent trajectory models to model ... Read more >>

Ann Epidemiol (Annals of epidemiology)
[2021, 56:18-25]

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Protocol for a cluster randomised controlled trial of the DAFNEplus (Dose Adjustment For Normal Eating) intervention compared with 5x1 DAFNE: a lifelong approach to promote effective self-management in adults with type 1 diabetes.

Elizabeth Coates, Stephanie Amiel, Wendy Baird, Mohammed Benaissa, Alan Brennan, Michael Joseph Campbell, Paul Chadwick, Tim Chater, Pratik Choudhary, Debbie Cooke, Cindy Cooper, Elizabeth Cross, Nicole De Zoysa, Mohammad Eissa, Jackie Elliott, Carla Gianfrancesco, Tim Good, David Hopkins, Zheng Hui, Julia Lawton, Fabiana Lorencatto, Susan Michie, Daniel John Pollard, David Rankin, Jose Schutter, Elaine Scott, Jane Speight, Stephanie Stanton-Fay, Carolin Taylor, Gillian Thompson, Nikki Totton, Lucy Yardley, Aleksandr Zaitcev, Simon Heller, ,

<h4>Introduction</h4>The successful treatment of type 1 diabetes (T1D) requires those affected to employ insulin therapy to maintain their blood glucose levels as close to normal to avoid complications in the long-term. The Dose Adjustment For Normal Eating (DAFNE) intervention is a group education course designed to help adults with T1D ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e040438]

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Topiramate, acupuncture, and BoNT-A for chronic migraine: a network meta-analysis.

Hui Zheng, Shi-Le Huang, Yao-Yao Chen, Tai-Chun Tang, Di Qin, Min Chen,

<h4>Background</h4>Botulinum neurotoxin A (BoNT-A) was the primary choice for preventive treatment of chronic migraine. Topiramate and acupuncture showed promising effect for chronic migraine, but their effectiveness relative to BoNT-A was rarely studied. We aimed to perform a network meta-analysis to compare the effectiveness and acceptability between topiramate, acupuncture, and BoNT-A.<h4>Methods</h4>We ... Read more >>

Acta Neurol Scand (Acta neurologica Scandinavica)
[2021, :]

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Altered modular segregation of brain networks during the cue-craving task contributes to the disrupted executive functions in internet gaming disorder.

Wei-Ran Zhou, Min Wang, Hui Zheng, Meng-Jing Wang, Guang-Heng Dong,

<h4>Background</h4>Previous studies have shown that gaming-related cues could induce gaming cravings and bring about changes in brain activities in subjects with Internet gaming disorder (IGD). However, little is known about the brain network organizations in IGD subjects during a cue-craving task and the relationship between this network organization and IGD ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2021, 107:110256]

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CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADS.

Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie, Dengbin Wang,

<h4>Background</h4>Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia compared with clinical model and COVID-19 reporting and data system (CO-RADS), and develop an open-source diagnostic tool with the ... Read more >>

J Transl Med (Journal of translational medicine)
[2021, 19(1):29]

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The effectiveness and safety of Tai Chi for patients with essential hypertension: study protocol for an open-label single-center randomized controlled trial.

Yuxi Li, Dongling Zhong, Chao Dong, Lihong Shi, Yaling Zheng, Yongguo Liu, Qiaoqin Li, Hui Zheng, Juan Li, Tianyu Liu, Rongjiang Jin,

<h4>Background</h4>Evidence showed that Tai Chi may have beneficial effects among hypertensive individuals, although the results are not convincing. We aim to conduct a high-quality clinical trial with 24-h BP measurement to provide robust evidence of Tai Chi for essential hypertension.<h4>Methods</h4>This is an open-label single-center randomized controlled trial with 3 parallel ... Read more >>

BMC Complement Med Ther (BMC complementary medicine and therapies)
[2021, 21(1):23]

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Severe Vascular Complications Caused by Facial Autologous Fat Grafting: A Critical Review.

Kai Wang, Xiangke Rong, Juanli Dang, Jizhong Yang, Hui Zheng, Mengmeng Hou, Huichen Li, Conghang Jiang, Shaoheng Xiong, Lihong Qiu, Zhou Yu, Chenggang Yi,

<h4>Background</h4>Vascular embolism is the most severe complication after autologous fat grafting. With a worldwide increase in fat grafting, there has been a rise in severe vascular complications, such as ophthalmic artery embolism, cerebral artery embolism, and even death. This article aims to review the role of fat in causing severe ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2021, :]

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Cucurbituril and zwitterionic surfactant-based matrix solid-phase dispersion microextraction to simultaneously determine terpenoids from Radix Curcumae.

Yan Chen, Xiao-Ting Zhen, Ya-Ling Yu, Min-Zhen Shi, Jun Cao, Hui Zheng, Li-Hong Ye,

A rapid, efficient, and environmentally friendly matrix solid-phase dispersion microextraction was established to determine and quantify terpenoids in Radix Curcumae using ultra-high-performance liquid chromatography with a diode array detector. Various parameters affecting the extraction were investigated in detail, such as the grinding time, amount of adsorbent, type and concentration of ... Read more >>

J Sep Sci (Journal of separation science)
[2021, :]

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Endovascular Repair of Spontaneous Iliac Vein Rupture.

Hui Zheng, Wei-Zhu Yang, Kun Ke, Jing-Yao Huang,

Spontaneous iliac vein rupture is a relatively rare but fatal disease. Herein, 2 cases are reported. The two middle-aged and elderly females complaining of abdominal pain were admitted without any history of trauma. The computed tomography image both showed one huge hematoma in the lower abdominal cavity and the left ... Read more >>

Ann Vasc Surg (Annals of vascular surgery)
[2020, :]

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The imbalance between goal-directed and habitual systems in internet gaming disorder: Results from the disturbed thalamocortical communications.

Weiran Zhou, Hui Zheng, Min Wang, Yanbin Zheng, Shuaiyu Chen, Meng-Jing Wang, Guang-Heng Dong,

<h4>Background</h4>Converging evidence has identified the imbalance between goal-directed systems and habitual systems in the addiction process. The thalamocortical loop plays an important role in the habitual/goal-directed system. However, little is known about the role of the thalamus in goal-directed and habitual systems in Internet gaming disorder (IGD) patients. This study ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2021, 134:121-128]

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Correction to: Using a hepatitis B surveillance system evaluation in Fujian, Hainan, and Gansu provinces to improve data quality and assess program effectiveness, China, 2015.

Hui Zheng, Alexander J Millman, Jeanette J Rainey, Fuzhen Wang, Rui Zhang, Hong Chen, Zundong Yin, Huaqing Wang, Guomin Zhang,

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):962]

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Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging.

Nicholas E Propson, Ethan R Roy, Alexandra Litvinchuk, Jörg Köhl, Hui Zheng,

Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer disease; however, their interrelatedness remains poorly understood. The complement pathway is a well-established regulator of innate immunity in the brain. Here, we report robust age-dependent increases in vascular inflammation, peripheral lymphocyte infiltration, and blood-brain barrier (BBB) permeability. ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(1):]

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Perineural dexmedetomidine added to ropivacaine for ultrasound-guided erector spinae plane block prolongs analgesia duration and reduces postoperative opioid consumption after thoracotomy: a prospective, randomized study

Qiang Wang, Ruoshan Liu, Shijing Wei, Guohua Zhang, Cheng Ni, Li Sun, Hui Zheng,

<h4>Background: </h4> Single-injection erector spinae plane block (ESPB) has been reported to be successfully used for analgesia after open thoracotomy. However, the duration of analgesia is not long enough. Adding dexmedetomidine to local anesthetics is frequently used to prolong the duration of single-injection regional nerve block. This randomized study was ... Read more >>

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Emergence of Japanese encephalitis among adults 40 years of age or older in northern China: Epidemiological and clinical characteristics.

Dan Wu, Xiaojing Chen, Wenjing Liu, Shihong Fu, Fan Li, Guodong Liang, Guang Yang, Hui Zheng, Junhong Li, Zundong Yin, Yixing Li, Huanyu Wang,

Japanese encephalitis (JE) is a vector-borne vaccine preventable infectious disease for which vaccine provides direct protection. China introduced nationwide JE vaccination of young children in 2007, rapidly achieving high coverage. In 2018, 1,800 JE cases were reported in China, with morbidity and mortality rates of 0.13/100,000 and 0.0097/100,000. Nationally, 64% ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2020, :]

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Dynamic Change of Pain Sensitisation at Acupoints in Patients with Knee Osteoarthritis and Disease Severity: A Multilevel Analysis of a Longitudinal Study

Guoyan Geng, Yong Yu, Mingsheng Sun, Zihan Yin, Jiao Chen, Hui Zheng, Dingju Cai, Liaojun Luo, Chunxia Yang, Ling Zhao, Fanrong Liang,

<h4>Background: </h4> and aim: Acupuncture alleviates pain and improves physical function in knee osteoarthritis (KOA). The therapeutic effect of acupuncture may depend on acupoint selection. This longitudinal study aimed to observe dynamic change of acupoint sensitization in knee osteoarthritis (KOA) patients, and to investigate the relationship between acupoint PPTs and ... Read more >>

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Analysis of Oral Microbial Dysbiosis Associated With Early Childhood Caries

Hui Zheng, Teng-Fei Xie, Shao-Kai Li, Xiao-Tong Qiao, Yan Feng, You-Guang Lu,

<h4>Background: </h4> "Core microbes" play a key role in the development of caries and lead to microflora disorders. Our goal was to detect the core microbes associated with the microbial flora imbalance in early childhood caries (ECC). <h4>Methods:</h4> Fifteen caries-free children and fifteen high-caries (DMFT≥10) children aged 4-6 years old ... Read more >>

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A novel TNFR2 agonist antibody expands highly potent regulatory T cells.

Heather Torrey, Willem M Kühtreiber, Yoshiaki Okubo, Lisa Tran, Katherine Case, Hui Zheng, Eva Vanamee, Denise L Faustman,

Regulatory T cells (T<sub>reg</sub> cells) restrict immune system activity, such as in response to self-antigens, and are switched on by tumor necrosis factor receptor 2 (TNFR2). Therapeutic activation of TNFR2, thereby expanding T<sub>reg</sub> cells and suppressing immune activity, may be beneficial to patients with various inflammatory diseases. Here, we characterized ... Read more >>

Sci Signal (Science signaling)
[2020, 13(661):]

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The effects of proprioceptive training on anterior cruciate ligament reconstruction rehabilitation: A systematic review and meta-analysis.

Jiang Ma, Di Zhang, Tianyu Zhao, Xiaoxiao Liu, Ju Wang, Hui Zheng, Song Jin,

<h4>Objective</h4>To determine the effectiveness of proprioceptive training on knee function and proprioception following anterior cruciate ligament reconstruction.<h4>Data sources</h4>PubMed, EMBASE, The Cochrane Library, Ovid, EBMSCO-<i>host</i>, ScienceDirect, CNKI, VIP, WanFang Data and CBM were searched until 2nd October 2020.<h4>Review methods</h4>Trials with proprioceptive training for patients with anterior cruciate ligament reconstruction were included. ... Read more >>

Clin Rehabil (Clinical rehabilitation)
[2020, :269215520970737]

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