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Synthesis, application and molecular modeling study of ionic liquid functionalized lactobionic acid, 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate, as a chiral selector in capillary electrophoresis.

Hui Xu, Zijie Feng, Yingxiang Du,

Recently, ionic liquids have been widely used for chiral separation. However, several papers have reported the use of ionic liquids as the sole chiral selector. In this work, a novel capillary electrophoresis method using the ionic liquid 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate (MSI-LA) as a chiral selector was developed for the enantioseparation of ... Read more >>

Analyst (The Analyst)
[2020, 145(3):1025-1032]

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Nanoscale engineering of porous Fe-doped Pd nanosheet assemblies for efficient methanol and ethanol electrocatalyses.

Hui Xu, Hongyuan Shang, Cheng Wang, Liujun Jin, Chunyan Chen, Yukou Du,

Although great successes have been accomplished on the controlled synthesis of 2D and 3D Pd-containing nanomaterials, tapping into the novel Pd-containing electrocatalysts that combined the advantages of both 2D and 3D structures remains a significant challenge. Here, an approach to systematically produce porous Fe-doped Pd nanosheet assemblies (NSAs) with a ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(3):2126-2132]

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Copper mediated C(sp2)-H amination and hydroxylation of phosphinamides.

Shang-Zheng Sun, Ming Shang, Hui Xu, Tai-Jin Cheng, Ming-Hong Li, Hui-Xiong Dai,

Copper mediated C(sp2)-H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, thus allowing for the rapid preparation of organophosphorus compounds in organic synthesis. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(9):1444-1447]

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Lithium promotes proliferation and suppresses migration of Schwann cells.

Xiao-Kun Gu, Xin-Rui Li, Mei-Ling Lu, Hui Xu,

Schwann cell proliferation, migration and remyelination of regenerating axons contribute to regeneration after peripheral nervous system injury. Lithium promotes remyelination by Schwann cells and improves peripheral nerve regeneration. However, whether lithium modulates other phenotypes of Schwann cells, especially their proliferation and migration remains elusive. In the current study, primary Schwann ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1955-1961]

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High-density surface protuberances endow ternary PtFeSn nanowires with high catalytic performance for efficient alcohol electro-oxidation.

Cheng Wang, Hui Xu, Fei Gao, Yangping Zhang, Tongxin Song, Caiqin Wang, Hongyuan Shang, Xing Zhu, Yukou Du,

Developing cost-effective catalysts with superb activity and stability to alcohol electro-oxidation is a decisive factor towards the progress of direct alcohol fuel cells (DAFCs). Rationally utilizing the architectural and surface microstructural sensitivity of nanocatalysts can significantly increase their electrocatalytic properties. Here, we report an appropriate route that allows the fabrication ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(39):18176-18182]

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Environmental exposure to lead and cadmium and hearing loss in Chinese adults: A case-control study.

Da-Hui Wang, Hui Xu, Yi-Hua Zheng, Dong-Sheng Gu, Ya-Jun Zhu, Ying Ren, Shi-Chang Wang, Lei Yang, Liang-Wen Xu,

Hearing loss is the second most common nonfatal problem affecting the Chinese population. Historical studies have suggested an association between exposure to heavy metals, such as cadmium and lead, and hearing loss. Few studies have investigated this relationship in the general population in China. We conducted a case-control study with ... Read more >>

PLoS ONE (PloS one)
[2020, 15(5):e0233165]

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Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity.

Chen Zhang, Xuedong Liu, Hui Xu, Gengyao Hu, Xiao Zhang, Zhen Xie, Dongyun Feng, Rui Wu, Gang Zhao, Ming Shi,

Neuroprotective strategies in the treatment of stroke have been attracting a great deal of attentions. Our previous clinical and basic studies have demonstrated that protopanaxadiol ginsenoside-Rd (Rd), a monomer compound extracted from Panax ginseng or Panax notoginseng, has neuroprotective effects against ischemic stroke, probably due to its ability to block ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8078]

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MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection.

Xinying Zhou, Lijie Zhang, Linmiao Lie, Zelin Zhang, Bo Zhu, Jiahui Yang, Yuchi Gao, Pengfei Li, Yingqi Huang, Hui Xu, Yanfen Li, Xialin Du, Chaoying Zhou, Shengfeng Hu, Qian Wen, Xiao-Ping Zhong, Li Ma,

OBJECTIVES:Interferons (IFNs) play multifunctional roles in host defense against infectious diseases by inducing IFN-stimulated genes (ISGs). However, little is known about how ISGs regulate host immune response to Mycobacterium tuberculosis (Mtb) infection, the major cause of tuberculosis (TB). METHODS:We thus profiled the potential effects and mechanisms of eight Mtb-induced ISGs ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury

Ruirui Zhang, Sailing Chen, Zhangchun Cheng, Yinying Shen, Sheng Yi, Hui Xu,

Abstract Background: Cytokines are essential cellular modulators of a variety of physiological and pathological activities, including peripheral nerve repair and regeneration. However, the molecular changes of these cellular mediators after peripheral nerve injury are not well clarified. The study is aimed to discover critical cytokines for the regenerative process of ... Read more >>

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Phase 2 Randomized, Double-blind Study of IL-17-Targeting with Secukinumab in Atopic Dermatitis.

Benjamin Ungar, Ana B Pavel, Randall Li, Grace Kimmel, John Nia, Peter Hashim, Hee Jin Kim, Margot Chima, Anjali S Vekaria, Yeriel Estrada, Hui Xu, Xiangyu Peng, Giselle K Singer, Danielle Baum, Yasaman Mansouri, Mark Taliercio, Emma Guttman-Yassky,

CAPSULE SUMMARY:In a clinical trial of moderate-to-severe atopic dermatitis/AD patients treated with anti IL-17mAb/secukinumab, no significant clinical or molecular improvements were seen, even among disease subtypes with high Th-17-skewing (intrinsic/Asian AD). ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Comparison of the effects of general and local anesthesia in lumbar interlaminar endoscopic surgery.

Xue-Fei Ye, Sheng Wang, Ai-Min Wu, Lin-Zheng Xie, Xiang-Yang Wang, Jiao-Xiang Chen, Hui Xu, Sun-Ren Sheng,

BACKGROUND:Percutaneous endoscopic lumbar discectomy (PELD) with an interlaminar approach is a technique used to treat lumbar disc hernia. It has not yet been established whether general or local anesthesia (LA) is preferable for lumbar interlaminar endoscopic surgery. METHODS:Between October, 2012 and June, 2016, 60 patients were recruited and randomly divided ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, :]

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Efficacy of ultrasound-guided technique for radial artery catheterization in pediatric populations: a systematic review and meta-analysis of randomized controlled trials.

Wen Zhang, Kunpeng Li, Hui Xu, Dawei Luo, Changbin Ji, Keshi Yang, Qinghua Zhao,

BACKGROUND:The use of an ultrasound-guided technique for radial arterial catheterization has not been well established in pediatric patients. We conducted a systematic review and meta-analysis to evaluate the efficacy of the ultrasound-guided technique for radial artery catheterization in pediatric populations. METHOD:A systematic review of PubMed, Medline, Embase, and the Cochrane ... Read more >>

Crit Care (Critical Care)
[2020, 24(1):197]

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A pH-responsive dissociable mesoporous silica-based nanoplatform enabling efficient dual-drug co-delivery and rapid clearance for cancer therapy.

Yongju He, Linjie Shao, Ibrahim Usman, Yao Hu, Anqiang Pan, Shuquan Liang, Hui Xu,

The balance between tumor accumulation and renal clearance has severely limited the efficacy of mesoporous silica-based drug nanocarriers in cancer therapy. Herein, a pH-responsive dissociable mesoporous silica-based nanoplatform with efficient dual-drug co-delivery, tumor accumulation and rapid clearance for cancer therapy is achieved by adjusting the wetting of the mesoporous silica ... Read more >>

Biomater Sci (Biomaterials science)
[2020, :]

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Copresentation of Tumor Antigens and Costimulatory Molecules via Biomimetic Nanoparticles for Effective Cancer Immunotherapy.

Junning Ma, Fuyao Liu, Wendy C Sheu, Zhouqi Meng, Ying Xie, Hui Xu, Miao Li, Ann T Chen, Jun Liu, Youmei Bao, Xue Zhang, Shenqi Zhang, Longbo Zhang, Zhiyong Zou, Haoan Wu, Haijun Wang, Yuwen Zhu, Jiangbing Zhou,

Nanoparticle (NP)-based cancer immunotherapy has been extensively explored. However, the efficacy of existing strategies is often limited by the lack of effective tumor-specific antigens or the inability to present costimulatory signal or both. Here, we report a novel approach to overcoming these limitations through surface coating with dendritic-tumor fusion cell ... Read more >>

Nano Lett. (Nano letters)
[2020, :]

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Primary pulmonary arterial sarcoma treated with endostar injection and radiotherapy.

Hui Xu, Wenyu Yang, Chenyun Wu,

We present a case of primary pulmonary arterial sarcoma (PPAS) treated with endostatin (endostar) injection and radiotherapy  discuss the diagnosis, clinical manifestations, and pathology of PPAS. The patient complained of cough with sputum, fever, and chest pain with hemoptysis. Numerous nodules were observed in the computed tomography (CT) scan. The ... Read more >>

Saudi Med J (Saudi medical journal)
[2020, 41(5):532-536]

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Prominent effect of platelet on improvement of liver cirrhosis.

Hui Xu, Xiao-Meng Jiang, Ying Wu, Yu-Mei Li, Yun-Wen Zheng, Nobuhiro Ohkohchi,

Thrombopoietin (TPO) can improve liver regeneration and fibrosis. We report on a patient with liver cirrhosis who received treatment with TPO to improve liver function. An 82-year-old male had liver cirrhosis with ascites due to hepatitis C virus infection. The Child-Pugh classification was Child B. The patient received human recombinant ... Read more >>

AME Case Rep (AME case reports)
[2020, 4:14]

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COVID-19 is a risk factor for severe liver damage for patients with intrahepatic cholestasis of pregnancy: a case report

Ling Ai, Jia Wei, Shaofang Wang, Xi Tan, Li Yan, Shangkun Liu, Liu Yang, Ailin Luo, Hui Xu,

Abstract Background: Patients with intrahepatic cholestasis of pregnancy (ICP) may present with slight liver damage. In the global outbreak, the number of pregnant women infected with coronavirus disease 2019 (COVID-19) is increasing. For the pregnant patients with ICP, COVID-19 may cause severe liver damage. Case presentation: A 31-year-old pregnant woman ... Read more >>

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Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia.

Hui Xu, Rongrong Yang, Christina Dintica, Xiuying Qi, Ruixue Song, David A Bennett, Weili Xu,

INTRODUCTION:The association of lifespan cognitive reserve (CR) with mild cognitive impairment (MCI) remains controversial. We aimed to examine the association of lifespan CR indicator with the risk of MCI and its progression to dementia, taking brain pathologies into account. METHODS:In a community-based cohort study (mean age, 79 years) with annual follow-up ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, :]

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Quantification of microbiota-related phenols and aromatic acids in mouse feces of a diabetic nephropathy model by simultaneous BDAPE derivatization using ultra-performance liquid chromatography-tandem mass spectrometry.

Xiaoli Zheng, Haonan Duan, Feifei Lin, Xiaomei Li, Jianhua Shen, Fanghui Han, Fubao Huang, Shilin Li, Lu Chang, Hui Xu, Kai Wang, Jia Liu,

In the intestine, several phenols and aromatic acids are generated by microbiota and are highly related to the formation of uremic toxins. Herein, we developed a new derivatization reagent, 2-bromo-1-[4-(dimethylamino)phenyl] ethyl ketone (BDAPE), that reacted simultaneously with phenols and aromatic acids. Following a reaction within 2 h at 60 °C in the ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2020, 412(13):3241-3252]

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Andrographolide: Synthetic Methods and Biological Activities.

Meng Hao, Hui Xu,

Andrographolide, a labdane diterpenoid, is extracted and isolated from the plants of Andrographis paniculata. Andrographolide and its derivatives exhibited a wide range of biological properties including anticancer activity, antibacterial activity, hepatoprotective activity, anti-inflammatory activity, antiviral activity, anti-malarial activity, antidiabetic activity, insecticidal activity, etc. As a continuation, this review aims at ... Read more >>

Mini Rev Med Chem (Mini reviews in medicinal chemistry)
[2020, :]

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Loss of tumor suppressor inositol polyphosphate 4-phosphatase type B impairs DNA double-strand break repair by destabilization of DNA tethering protein Rad50.

Yue Sun, Xuelian Ning, Jiankun Fan, Jiandong Hu, Yanting Jiang, Ziqi Hu, Joao A Paulo, Jichao Liu, Xiaohong Qiu, Hui Xu, Songbin Fu, Steven P Gygi, Jinwei Zhang, Chunshui Zhou,

Genome instability is the fundamental hallmark of malignant tumors. Tumor suppressors often play a role in maintaining genome stability. Our previous genetic screen identified inositol polyphosphate 4-phosphatase type B (INPP4B), primarily hydrolyzing phosphatidylinositol 3, 4-disphosphate, is a potential tumor suppressor in lung cancer cells. How INPP4B regulates the genome stability ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(4):292]

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A dual-functional buformin-mimicking poly(amido amine) for efficient and safe gene delivery.

Mei Lu, Haonan Xing, Lin Cheng, Hui Liu, Lang Lang, Tianzhi Yang, Xiaoyun Zhao, Hui Xu, Pingtian Ding,

Biguanides (i.e. metformin, phenformin and buformin) are antidiabetic drugs with potential antitumor effects. Herein, a polycationic polymer, N,N'-bis(cystamine)acrylamide-buformin (CBA-Bu), containing multiple biodegradable disulphide bonds and buformin-mimicking side chains was synthesised. CBA-Bu was equipped with high efficiency and safety profile for gene delivery, meanwhile exhibiting potential antitumor efficacy. As a gene ... Read more >>

J Drug Target (Journal of drug targeting)
[2020, :1-10]

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Right coronary artery-coronary sinus fistula diagnosed by three-dimensional echocardiography.

Xiao-Dong Li, Yan-Li Zhang, Qiao-Hui Su, Xiao-Cong Wang, Hui Xu,

Right coronary artery-coronary sinus fistula is a very rare congenital anomaly in which a right coronary artery fistula drains into the right atrium, right ventricle, or pulmonary artery. A right coronary artery-coronary sinus fistula was diagnosed in a 44-year-old man by three-dimensional echocardiography and confirmed by computed tomography angiography and ... Read more >>

J Clin Ultrasound (Journal of clinical ultrasound : JCU)
[2020, :]

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Virome of riverside phytocommunity ecosystem of an ancient canal

Shixing Yang, Tongling Shan, Yan Wang, Jie Yang, Xu Chen, Yuqing Xiao, Zhenqiang You, Yumin He, Min Zhao, Juan Lu, Zijun Yang, Ziyuan Dai, Qi Liu, Yuxin Yao, Xiang Lu, Hong Li, Rui Zhou, Wang Li, Chenglin Zhou, Xiaochun Wang, Quan Shen, Hui Xu, Xutao Deng, Eric Delwart, Wen Zhang,

Abstract Background The virus community in plants in a local plant ecosystem has remained largely unknown. In this study, we investigated the virus community in these wild and cultivated plants in Zhenjiang ancient canal ecosystem. Results using viral metagenomic approach, we investigated the viral community in leaf ... Read more >>

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Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline.

Ruixue Song, Hui Xu, Christina S Dintica, Kuan-Yu Pan, Xiuying Qi, Aron S Buchman, David A Bennett, Weili Xu,

BACKGROUND:The impact of cardiovascular risk burden on cognitive trajectories and brain structure changes remains unclear. OBJECTIVES:This study aimed to examine whether cardiovascular risk burden assessed by the Framingham General Cardiovascular Risk Score (FGCRS) is associated with cognitive decline and structural brain differences. METHODS:Within the Rush Memory and Aging Project, 1,588 ... Read more >>

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2020, 75(20):2525-2534]

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