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Consensus recommendations for the care of children receiving chronic dialysis in association with the COVID-19 epidemic.

Qian Shen, Mo Wang, Ruochen Che, Qiu Li, Jianhua Zhou, Fang Wang, Ying Shen, Jie Ding, Songming Huang, Hui-Kim Yap, Bradley A Warady, Hong Xu, Aihua Zhang, ,

Coronavirus disease 2019 (COVID-19) has rapidly spread not only in China but throughout the world. Children with kidney failure (chronic kidney disease (CKD) stage 5) are at significant risk for COVID-19. In turn, a set of recommendations for the prevention and control of the severe acute respiratory syndrome coronavirus 2 ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(7):1351-1357]

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Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.

Piming Zhao, Isaac D Liu, Jeffrey B Hodgin, Peter I Benke, Jeremy Selva, Federico Torta, Markus R Wenk, James A Endrizzi, Olivia West, Weixing Ou, Emily Tang, Denise Li-Meng Goh, Stacey Kiat-Hong Tay, Hui-Kim Yap, Alwin Loh, Nicole Weaver, Bonnie Sullivan, Austin Larson, Megan A Cooper, Khalid Alhasan, Abdullah A Alangari, Suha Salim, Evren Gumus, Karin Chen, Martin Zenker, Friedhelm Hildebrandt, Julie D Saba,

Sphingosine-1-phosphate (S1P) lyase is a vitamin B6-dependent enzyme that degrades sphingosine-1-phosphate in the final step of sphingolipid metabolism. In 2017, a new inherited disorder was described caused by mutations in SGPL1, which encodes sphingosine phosphate lyase (SPL). This condition is referred to as SPL insufficiency syndrome (SPLIS) or alternatively as ... Read more >>

J. Inherit. Metab. Dis. (Journal of inherited metabolic disease)
[2020, :]

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Prescribing peritoneal dialysis for high-quality care in children.

Bradley A Warady, Franz Schaefer, Arvind Bagga, Francisco Cano, Mignon McCulloch, Hui-Kim Yap, Rukshana Shroff,

BACKGROUND:Peritoneal dialysis (PD) remains the most widely used modality for chronic dialysis in children, particularly in younger children and in lower and middle income countries (LMICs). We present guidelines for dialysis initiation, modality selection, small solute clearance, and fluid removal in children on PD. A review of the literature and ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(3):333-340]

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Clofazimine in Mycobacterium abscessus peritonitis: A pediatric case report.

Archana Pinapala, Lee Jin Koh, Kar-Hui Ng, Paul A Tambyah, Hui-Kim Yap,

Peritonitis- and catheter-related infections due to nontuberculous mycobacteria (NTM) including Mycobacterium abscessus have been reported among adults on peritoneal dialysis (PD). There is no recommended antimicrobial regimen for the treatment of M. abscessus peritonitis. Clofazimine has emerged as an important adjuvant antimicrobial treatment of M. abscessus lung infection. We report, ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, :896860820909702]

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IL-13-driven alterations in hepatic cholesterol handling contributes to hypercholesterolemia in a rat model of minimal change disease.

Lauretta D Low, Liangjian Lu, Chang-Yien Chan, Jinmiao Chen, Henry H Yang, Hanry Yu, Caroline G L Lee, Kar-Hui Ng, Hui-Kim Yap,

Circulating factors have been implicated in the pathogenesis of minimal change disease (MCD), and may have direct effects on cholesterol metabolism. This study investigated the pathogenesis of hypercholesterolemia in an IL-13 overexpression rat model of MCD prior to the onset of proteinuria, so as to establish the direct contribution of ... Read more >>

Clin. Sci. (Clinical science (London, England : 1979))
[2020, 134(2):225-237]

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Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance.

Kar-Hui Ng, Summer Lixin Zhang, Hwee Cheng Tan, Swee Sen Kwek, October Michael Sessions, Chang-Yien Chan, Isaac Desheng Liu, Chun Kiat Lee, Paul Ananth Tambyah, Eng Eong Ooi, Hui-Kim Yap,

Detailed understanding of the roles of humoral and cellular immune responses in sterilizing dengue virus (DENV) infection in humans is required to inform effective vaccine development. We report an unusual case of persistent DENV infection in a lymphopenic renal transplant recipient who was therapeutically immunosuppressed to prevent organ rejection. Following ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2019, 26(5):601-605.e3]

Cited: 1 time

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Establishing a Core Outcome Set for Peritoneal Dialysis: Report of the SONG-PD (Standardized Outcomes in Nephrology-Peritoneal Dialysis) Consensus Workshop.

Karine E Manera, David W Johnson, Jonathan C Craig, Jenny I Shen, Talia Gutman, Yeoungjee Cho, Angela Yee-Moon Wang, Edwina A Brown, Gillian Brunier, Jie Dong, Tony Dunning, Rajnish Mehrotra, Saraladevi Naicker, Roberto Pecoits-Filho, Jeffrey Perl, Martin Wilkie, Allison Tong, ,

Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of ... Read more >>

Am. J. Kidney Dis. (American Journal of Kidney Diseases)
[2020, 75(3):404-412]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study.

Camilla S Hanson, Talia Gutman, Jonathan C Craig, Sarah Bernays, Gayathri Raman, Yifan Zhang, Laura J James, Angelique F Ralph, Angela Ju, Karine E Manera, Armando Teixeira-Pinto, Andrea K Viecelli, Stephen I Alexander, Tom D Blydt-Hansen, Janis Dionne, Steven McTaggart, Mini Michael, Amanda Walker, Simon Carter, Scott E Wenderfer, Wolfgang C Winkelmayer, Detlef Bockenhauer, Allison Dart, Allison A Eddy, Susan L Furth, Debbie S Gipson, Stuart L Goldstein, Jaap Groothoff, Susan Samuel, Aditi Sinha, Nicholas J A Webb, Hui-Kim Yap, Michael Zappitelli, Helen Currier, Allison Tong,

RATIONALE & OBJECTIVE:Chronic kidney disease (CKD) has wide-ranging and long-term consequences for young people and their families. The omission of outcomes that are important to young people with CKD and their caregivers limits knowledge to guide shared decision making. We aimed to identify the outcomes that are important to young ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2019, 74(1):82-94]

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MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome.

Chang-Yien Chan, Lourdes Paula Resontoc, Md Abdul Qader, Yiong-Huak Chan, Isaac Desheng Liu, Perry Yew-Weng Lau, Mya Than, Wee-Song Yeo, Alwin Hwai-Liang Loh, Puay-Hoon Tan, Changli Wei, Jochen Reiser, Subhra K Biswas, Kar-Hui Ng, Hui-Kim Yap,

BACKGROUND:A lack of consensus exists as to the timing of kidney biopsy in children with steroid-dependent nephrotic syndrome (SDNS) where minimal change disease (MCD) predominates. This study aimed at examining the applicability of a biomarker-assisted risk score model to select SDNS patients at high risk of focal segmental glomerulosclerosis (FSGS) ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, 85(4):477-483]

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Long-term safety and tolerability of valsartan in children aged 6 to 17 years with hypertension.

Randall Lou-Meda, Brigitte Stiller, Zenaida L Antonio, Ewa Zielinska, Hui-Kim Yap, Hee Gyung Kang, Monique Tan, Robert D Glazer, Michele A Valentin, Linda Wang,

OBJECTIVE:The present study aimed to assess the long-term safety and tolerability of valsartan in hypertensive children aged 6-17 years, with or without chronic kidney disease (CKD). METHODS:This was an 18-month, open-label, multicentre, prospective study conducted in 150 patients with history of hypertension with or without CKD. The primary endpoint was long-term ... Read more >>

Pediatr. Nephrol. (Pediatric Nephrology (Berlin, Germany))
[2019, 34(3):495-506]

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Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop.

Allison Tong, Braden Manns, Angela Yee Moon Wang, Brenda Hemmelgarn, David C Wheeler, John Gill, Peter Tugwell, Robert Pecoits-Filho, Sally Crowe, Tess Harris, Wim Van Biesen, Wolfgang C Winkelmayer, Adeera Levin, Aliza Thompson, Vlado Perkovic, Angela Ju, Talia Gutman, Amelie Bernier-Jean, Andrea K Viecelli, Emma O'Lone, Jenny Shen, Michelle A Josephson, Yeoungjee Cho, David W Johnson, Bénédicte Sautenet, Marcello Tonelli, Jonathan C Craig, ,

There are an estimated 14,000 randomized trials published in chronic kidney disease. The most frequently reported outcomes are biochemical endpoints, rather than clinical and patient-reported outcomes including cardiovascular disease, mortality, and quality of life. While many trials have focused on optimizing kidney health, the heterogeneity and uncertain relevance of outcomes ... Read more >>

Kidney Int. (Kidney international)
[2018, 94(6):1053-1068]

Cited: 2 times

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Child and Parental Perspectives on Communication and Decision Making in Pediatric CKD: A Focus Group Study.

Talia Gutman, Camilla S Hanson, Sarah Bernays, Jonathan C Craig, Aditi Sinha, Allison Dart, Allison A Eddy, Debbie S Gipson, Detlef Bockenhauer, Hui-Kim Yap, Jaap Groothoff, Michael Zappitelli, Nicholas J A Webb, Stephen I Alexander, Stuart L Goldstein, Susan Furth, Susan Samuel, Tom Blydt-Hansen, Janis Dionne, Mini Michael, Scott E Wenderfer, Wolfgang C Winkelmayer, Helen Currier, Steven McTaggart, Amanda Walker, Angelique F Ralph, Angela Ju, Laura J James, Simon Carter, Allison Tong,

BACKGROUND & OBJECTIVES:Effective communication and shared decision making improve quality of care and patient outcomes but can be particularly challenging in pediatric chronic disease because children depend on their parents and clinicians to manage complex health care and developmental needs. We aimed to describe the perspectives of children with chronic ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2018, 72(4):547-559]

Cited: 0 times

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Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Ségolène Aymé, Detlef Bockenhauer, Simon Day, Olivier Devuyst, Lisa M Guay-Woodford, Julie R Ingelfinger, Jon B Klein, Nine V A M Knoers, Ronald D Perrone, Julia Roberts, Franz Schaefer, Vicente E Torres, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer, ,

Rare kidney diseases encompass at least 150 different conditions, most of which are inherited. Although individual rare kidney diseases raise specific issues, as a group these rare diseases can have overlapping challenges in diagnosis and treatment. These challenges include small numbers of affected patients, unidentified causes of disease, lack of ... Read more >>

Kidney Int. (Kidney international)
[2017, 92(4):796-808]

Cited: 5 times

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Range and Heterogeneity of Outcomes in Randomized Trials of Pediatric Chronic Kidney Disease.

Lauren S H Chong, Benedicte Sautenet, Allison Tong, Camilla S Hanson, Susan Samuel, Michael Zappitelli, Allison Dart, Susan Furth, Allison A Eddy, Jaap Groothoff, Nicholas J A Webb, Hui-Kim Yap, Detlef Bockenhauer, Aditi Sinha, Stephen I Alexander, Stuart L Goldstein, Debbie S Gipson, Gayathri Raman, Jonathan C Craig,

OBJECTIVE:To determine the range and heterogeneity of outcomes reported in randomized controlled trials of interventions for children with chronic kidney disease (CKD). STUDY DESIGN:The Cochrane Kidney and Transplant Specialized Register was searched to March 2016. Randomized trials involving children across all stages of CKD were selected. All outcome domains and ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2017, 186:110-117.e11]

Cited: 2 times

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Peritoneal dialysis for the management of pediatric patients with acute kidney injury.

Anil Vasudevan, Kishore Phadke, Hui-Kim Yap,

Renal replacement therapy (RRT) is the most important supportive measure used in the management of acute kidney injury (AKI). Peritoneal dialysis (PD) is a safe, simple and inexpensive procedure and has been used in pediatric AKI patients, ranging from neonates to adolescents. It is the modality of choice for RRT ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2017, 32(7):1145-1156]

Cited: 3 times

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Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy.

Chang-Yien Chan, Kar-Hui Ng, Jinmiao Chen, Jinhua Lu, Caroline Guat-Lay Lee, Puay-Hoon Tan, Stanley C Jordan, Henry Yang He, Hui-Kim Yap,

Our established interleukin-13 (IL-13) overexpression rat model of minimal change-like nephropathy provided a platform to study the molecular signalling pathways in T-helper 2 (Th2) cytokine associated minimal change nephrotic syndrome (MCNS). We hypothesized that IL-13 may act directly on podocytes, causing podocyte foot process effacement and hence proteinuria in our ... Read more >>

Clin. Sci. (Clinical science (London, England : 1979))
[2016, 130(24):2317-2327]

Cited: 2 times

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Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): a protocol for establishing a core outcome set for children with chronic kidney disease.

Allison Tong, Susan Samuel, Michael Zappitelli, Allison Dart, Susan Furth, Allison Eddy, Jaap Groothoff, Nicholas J A Webb, Hui-Kim Yap, Detlef Bockenhauer, Aditi Sinha, Stephen I Alexander, Stuart L Goldstein, Debbie S Gipson, Camilla S Hanson, Nicole Evangelidis, Sally Crowe, Tess Harris, Brenda R Hemmelgarn, Braden Manns, John Gill, Peter Tugwell, Wim Van Biesen, David C Wheeler, Wolfgang C Winkelmayer, Jonathan C Craig, ,

Children with chronic kidney disease (CKD), requiring dialysis or kidney transplantation, have a mortality rate of up to 30-fold higher than the general aged-matched population, and severely impaired quality of life. Symptoms such as fatigue and pain are prevalent and debilitating. Children with CKD are at risk of cognitive impairment, ... Read more >>

Trials (Trials)
[2016, 17:401]

Cited: 7 times

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T Lymphocyte Activation Markers as Predictors of Responsiveness to Rituximab among Patients with FSGS.

Chang-Yien Chan, Isaac Desheng Liu, Lourdes Paula Resontoc, Kar-Hui Ng, Yiong-Huak Chan, Perry Yew-Weng Lau, Mya Than, Stanley C Jordan, Kong-Peng Lam, Wee-Song Yeo, Hui-Kim Yap,

Rituximab is used with variable success in difficult FSGS. Because B cell depletion significantly affects T cell function, we characterized T cell subsets in patients with FSGS to determine if an immunologic signature predictive of favorable response to rituximab could be identified.Twenty-two consecutive patients with FSGS (median age =14.4 years ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2016, 11(8):1360-1368]

Cited: 6 times

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Metachronous B-cell and T-cell post-transplant lymphoproliferative disorders with features of chronic active Epstein-Barr virus infection.

Isaac Desheng Liu, Poh-Lin Tan, Christelle Xian-Ting Tan, Mas Suhaila Isa, Perry Yew-Weng Lau, Wee-Song Yeo, Swasti Chaturvedi, Mariflor Sarmiento Villegas, Kar-Hui Ng, Hui-Kim Yap, Siok-Bian Ng,

Am. J. Hematol. (American journal of hematology)
[2015, 90(10):E204-5]

Cited: 0 times

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Optimising utilisation of kidneys from very young deceased donors: the technique of en bloc kidney transplantation.

Ziting Wang, Hui Kim Yap, Krishnan Prabhakaran, Ho Yee Tiong,

Kidneys of paediatric deceased donors were previously considered suboptimal for older recipients. An 18-month-old deceased donor was made available via Singapore's Medical (Therapy, Education and Research) Act. To the best of our knowledge, she is the youngest local donor. We herein report a case of successful kidney transplantation, using the ... Read more >>

Singapore Med J (Singapore medical journal)
[2015, 56(8):e137-8]

Cited: 0 times

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Renal vascular thrombosis in the newborn.

Lourdes Paula R Resontoc, Hui-Kim Yap,

Neonatal renal vascular thrombosis is rare but has devastating sequelae. The renal vein is more commonly affected than the renal artery. Most neonates with renal vein thrombosis present with at least one of the three cardinal signs, namely, abdominal mass, macroscopic hematuria and thrombocytopenia, while unilateral renal artery thrombosis presents ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2016, 31(6):907-915]

Cited: 2 times

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Serum β2-microglobulin predicts mortality and transplant outcomes.

Keng-Thye Woo, Marjorie W Y Foo, H Lina Choong, Hui Kim Yap, Evan J C Lee, Choong-Meng Chan,

Kidney Int. (Kidney international)
[2014, 85(4):982]

Cited: 0 times

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Emergence of G186D mutation in the presence of R292K mutation in an immunocompromised child infected with influenza A/H3N2 virus, treated with oseltamivir.

Hong Kai Lee, Julian Wei-Tze Tang, Tze Ping Loh, Debra Han-Lin Kong, Yew-Weng Lau, Hui Kim Yap, Evelyn Siew-Chuan Koay,

An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2014, 52(5):1749-1750]

Cited: 3 times

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Genomics and disease progression in IgA nephritis.

Keng Thye Woo, Yeow Kok Lau, Hui Lin Choong, Han Khim Tan, Marjorie Wy Foo, Evan Jc Lee, Vathsala Anantharaman, Grace Sl Lee, Hui Kim Yap, Zhao Yi, Stephanie Fook-Chong, Kok Seng Wong, Choong Meng Chan,

Apart from clinical, histological and biochemical indices, genomics are now being employed to unravel the pathogenetic mechanisms in the disease progression of IgA nephritis (IgAN). The results of angiotensin converting enzyme (ACE) gene polymorphism have been controversial. Those patients with the DD genotype seem to have a poorer prognosis. However, ... Read more >>

Ann. Acad. Med. Singap. (Annals of the Academy of Medicine, Singapore)
[2013, 42(12):674-680]

Cited: 1 time

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