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Role of gut microbiota in post-operative atrial fibrillation: a randomized trial of berberine

Huishan Wang, Jian Zhang, yang wang, hui Jiang, Dengshun Tao, Keyan Zhao, Zongtao Yin, Jinsong Han, Fang Ran, Yan Jin,

Post-operative atrial fibrillation (POAF) is one of the most common complications. However, the underlying factors governing POAF are not well understood. The aim of this study was to investigate the relationship between gut microbiota and POAF. Then, we conducted a randomized, double-blind, placebo-controlled trial with patients underwent isolated coronary artery ... Read more >>

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Growth direction dependent separate-channel charge transport in the organic weak charge-transfer co-crystal of anthracene-DTTCNQ.

Hui Jiang, Jun Ye, Peng Hu, Shengli Zhu, Yanqin Liang, Zhenduo Cui, Christian Kloc, Wenping Hu,

Co-crystallization is an efficient way of molecular crystal engineering to tune the electronic properties of organic semiconductors. In this work, we synthesized anthracene-4,8-bis(dicyanomethylene)4,8-dihydrobenzo[1,2-<i>b</i>:4,5-<i>b</i>']-dithiophene (DTTCNQ) single crystals as a template to study the crystal growth direction dependent charge transport properties and attempted to elucidate the mechanism by proposing a separate-channel charge ... Read more >>

Mater Horiz (Materials horizons)
[2022, :]

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Genome-wide annotation of protein-coding genes in pig.

Max Karlsson, Evelina Sjöstedt, Per Oksvold, Åsa Sivertsson, Jinrong Huang, María Bueno Álvez, Muhammad Arif, Xiangyu Li, Lin Lin, Jiaying Yu, Tao Ma, Fengping Xu, Peng Han, Hui Jiang, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Xun Xu, Jian Wang, Huanming Yang, Lars Bolund, Wen Zhong, Linn Fagerberg, Cecilia Lindskog, Fredrik Pontén, Jan Mulder, Yonglun Luo, Mathias Uhlen,

<h4>Background</h4>There is a need for functional genome-wide annotation of the protein-coding genes to get a deeper understanding of mammalian biology. Here, a new annotation strategy is introduced based on dimensionality reduction and density-based clustering of whole-body co-expression patterns. This strategy has been used to explore the gene expression landscape in ... Read more >>

BMC Biol (BMC biology)
[2022, 20(1):25]

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CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases.

Bin Zhang, Yuan Zhang, Lei Xiong, Yuzhe Li, Yunliang Zhang, Jiuliang Zhao, Hui Jiang, Can Li, Yunqi Liu, Xindong Liu, Haofei Liu, Yi-Fang Ping, Qiangfeng Cliff Zhang, Zheng Zhang, Xiu-Wu Bian, Yan Zhao, Xiaoyu Hu,

Inflammatory monocytes are key mediators of acute and chronic inflammation; yet, their functional diversity remains obscure. Single-cell transcriptome analyses of human inflammatory monocytes from COVID-19 and rheumatoid arthritis patients revealed a subset of cells positive for CD127, an IL-7 receptor subunit, and such positivity rendered otherwise inert monocytes responsive to ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2022, 219(2):]

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Effects of the Enhanced Public Health Intervention during the COVID-19 Epidemic on Respiratory and Gastrointestinal Infectious Diseases in China.

Lan Wang, Xiangyu Guo, Na Zhao, Yanyan Ouyang, Binghui Du, Wangli Xu, Ta-Chien Chan, Hui Jiang, Shelan Liu,

The public health interventions to mitigate COVID-19 could also potentially reduce the global activity of influenza. However, this strategy's impact on other common infectious diseases is unknown. We collected the data of ten respiratory infectious (RI) diseases, influenza-like illnesses (ILI), and seven gastrointestinal infectious (GI) diseases during 2015-2020 in China ... Read more >>

J Med Virol (Journal of medical virology)
[2022, :]

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Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint.

Lili Li, Jie Wang, Zijia Yang, Yiling Zhao, Hui Jiang, Luguang Jiang, Wenya Hou, Risheng Ye, Qun He, Martin Kupiec, Brian Luke, Qinhong Cao, Zhi Qi, Zhen Li, Huiqiang Lou,

Nucleotide metabolism fuels normal DNA replication and is also primarily targeted by the DNA replication checkpoint when replication stalls. To reveal a comprehensive interconnection between genome maintenance and metabolism, we analyzed the metabolomic changes upon replication stress in the budding yeast S. cerevisiae. We found that upon treatment of cells ... Read more >>

EMBO J (The EMBO journal)
[2022, :e108290]

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Decreased incidence of acute hemorrhagic conjunctivitis associated with enhanced public health intervention during the COVID-19 epidemic in China, 2020.

Li Zhang, Xiangyu Guo, Hui Jiang, Na Zhao, Wei Cheng, Wangli Xu, Shelan Liu,

Outbreaks of acute hemorrhagic conjunctivitis (AHC) are associated with a high disease burden. In this study, we investigated the association between enhanced public health intervention and the incidence of AHC during the COVID-19 pandemic in China. A total of 212,526 AHC cases were reported in China during 2015-2020. The overall ... Read more >>

Arch Virol (Archives of virology)
[2022, :]

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Efficacy of Wen-Dan Decoction in the treatment of patients with coronary heart disease: A protocol for systematic review and meta-analysis.

Xiaoyu Zhang, Yingwei Wang, Lufei Liu, Hui Jiang, Jing Wang, Yang Xiao, Jianwei Wang,

<h4>Background</h4>Coronary heart disease (CHD) is a heart disease caused by myocardial ischemia, hypoxia or necrosis due to stenosis or occlusion of lumen caused by coronary atherosclerosis. It belongs to ischemic cardiomyopathy and is more common in clinic. Previous studies have shown that Wen-Dan Decoction (WDD) is safe and effective, but ... Read more >>

Medicine (Baltimore) (Medicine)
[2022, 101(1):e28041]

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Radiomics nomogram for the preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma.

Yun Bian, Shiwei Guo, Hui Jiang, Suizhi Gao, Chengwei Shao, Kai Cao, Xu Fang, Jing Li, Li Wang, Chao Ma, Jianming Zheng, Gang Jin, Jianping Lu,

<h4>Purpose</h4>To develop and validate a radiomics nomogram for the preoperative prediction of lymph node (LN) metastasis in pancreatic ductal adenocarcinoma (PDAC).<h4>Materials and methods</h4>In this retrospective study, 225 patients with surgically resected, pathologically confirmed PDAC underwent multislice computed tomography (MSCT) between January 2014 and January 2017. Radiomics features were extracted from ... Read more >>

Cancer Imaging (Cancer imaging : the official publication of the International Cancer Imaging Society)
[2022, 22(1):4]

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Reduced endothelial activation upon human blood perfusion of pig kidney xenografts lacking MHC class I and three xenoantigens

Lin Lin, Franca Witjas, Konrad Fischer, Marten Engelse, Annemarie de Graaf, Beate Rieblinger, Andrea Fischer, Ying Wang, Monica Herrera, Anastasia Milusev, Fei Wang, Xue Liang, Xi Xiang, Lin Xie, Ping Liu, Fang Chen, Hui Jiang, Huanming Yang, Lars Bolund, Alain Despont, Robert Rieben, Katja Steiger, Cees van Kooten, Angelika Schnieke, Ton Rabelink, Yonglun Luo,

Genetically tailored pigs to eliminate human immune rejection of xenografts is one promising solution to the global donor organ shortage. The development of xenograft transplantation has however been hampered by incomplete understanding of its immune rejection and the inability to test this in a human transplantation setting. Here we use ... Read more >>

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Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto's thyroiditis-A meta-analysis of randomized controlled trials.

Hui Jiang, Xiaoluo Chen, Xiaoqin Qian, Shihe Shao,

<h4>Introduction</h4>Recent evidence suggested that vitamin D deficiency was associated with Hashimoto's thyroiditis (HT) pathogenesis and thyroid hypofunction. This study aimed to investigate whether vitamin D supplementation would be effective in the prevention and progression of hypothyroidism in patients with HT.<h4>Methods</h4>PubMed, Embase and the Cochrane library were searched for randomized controlled ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2022, :]

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Influence of sequencing depth on the fidelity and sensitivity of 1%-5% low-frequency mutation detection and recommendation for standardization of sequencing depth

Zhe Liu, Weijin Qiu, Shujin Fu, Xia Zhao, Jun Xia, Chunyu Geng, Youqian Yu, Ziling Li, Mingzhu Li, Hui Jiang, Fang Chen,

Sequencing depth has always played an important role in the accurate detection of low-frequency mutations. The increase of sequencing depth and the reasonable setting of threshold can maximize the probability of true positive mutation, or sensitivity. Here, we found that when the threshold was set as a fixed number of ... Read more >>

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Multifaceted roles of mitochondrial stress responses under ETC dysfunction - repair, destruction and pathogenesis.

Shanshan Liu, Siqi Liu, Hui Jiang,

Electron transport chain (ETC) dysfunction is a common feature of mitochondrial diseases and induces severe cellular stresses, including mitochondrial membrane potential (Δψ<sub>m</sub> ) reduction, mitochondrial matrix acidification, metabolic derangements and proteostatic stresses. Extensive studies of ETC dysfunction in yeast, Caenorhabditis elegans, cultured cells and mouse models have revealed multiple mitochondrial stress ... Read more >>

FEBS J (The FEBS journal)
[2021, :]

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Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases.

Lin Jiang, Hui Jiang, Sheng Dai, Ying Chen, Youqiang Song, Clara Sze-Man Tang, Shirley Yin-Yu Pang, Shu-Leong Ho, Binbin Wang, Maria-Mercedes Garcia-Barcelo, Paul Kwong-Hang Tam, Stacey S Cherny, Mulin Jun Li, Pak Chung Sham, Miaoxin Li,

Identifying rare variants that contribute to complex diseases is challenging because of the low statistical power in current tests comparing cases with controls. Here, we propose a novel and powerful rare variants association test based on the deviation of the observed mutation burden of a gene in cases from a ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, :]

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A systematic review and meta-analysis of the relationship between erectile dysfunction and the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios.

Yuyang Zhang, Xingliang Feng, Xu Wu, Wei Zhang, Yutian Dai, Hui Jiang, Xiansheng Zhang,

Several studies were conducted to explore the association between haematological parameters and erectile dysfunction (ED), but the conclusions were contradictory with small sample size. The extensively search was conducted in PubMed, Cochrane Library and Web of science from inception to August 2021. Studies comparing the haematological parameter (at least NLR, ... Read more >>

Andrologia (Andrologia)
[2021, :e14337]

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Child behavior problems during COVID-19: Associations with parent distress and child social-emotional skills.

Jing Sun, Britt Singletary, Hui Jiang, Laura M Justice, Tzu-Jung Lin, Kelly M Purtell,

The COVID-19 pandemic and associated government-mandated shutdowns disrupted schooling, socialization, and family life for school-aged children during spring 2020. These disruptions may have contributed to increased child behavior problems. Thus, we examined behavior problems in 247 children aged 7 to 9 years during Ohio's shutdown period. We investigated whether differences in ... Read more >>

J Appl Dev Psychol (Journal of applied developmental psychology)
[2022, 78:101375]

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Bacteriological and molecular typing of Clostridium perfringens strains isolated in retail beef in Beijing, China.

Hui Jiang, Yu-Ming Qin, Xiao-Tong Yang, Qiao-Ling Li, Qing-Chun Shen, Jia-Bo Ding, Run-Yu Wei, Jian-Dong Zhang, Jia-Li Sun, Ming-Jun Sun, Xue-Zheng Fan,

Clostridium perfringens is an important zoonotic pathogen. This study was designed to explore the prevalence and toxin types of C. perfringens in retail beef collected from Beijing, China. Among 221 beef samples collected, 53 samples were positive for C. perfringens, resulting in the average prevalence as 23.98%. By toxin gene-based ... Read more >>

J Vet Med Sci (The Journal of veterinary medical science)
[2021, 83(10):1593-1596]

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Barriers to self-management of patients with adenomyosis: A qualitative study.

Rong Huang, Xiaohan Li, Hui Jiang, Quanlei Li,

<h4>Aim</h4>This study aims to explore the barriers to self-management of patients with adenomyosis.<h4>Design</h4>Phenomenological qualitative methodology.<h4>Methods</h4>Totally, 18 patients with diagnosis of adenomyosis participated in this study. We used purposive sampling for recruitment until data saturation. A qualitative research was conducted using in-depth interviews, which were tape recorded and transcribed verbatim. Colaizzi's ... Read more >>

Nurs Open (Nursing open)
[2021, :]

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Prediction of Tumor-Infiltrating CD20+ B-Cells in Patients with Pancreatic Ductal Adenocarcinoma Using a Multilayer Perceptron Network Classifier Based on Non-contrast MRI.

Qi Li, Jieyu Yu, Hao Zhang, Yinghao Meng, Yan Fang Liu, Hui Jiang, Mengmeng Zhu, Na Li, Jian Zhou, Fang Liu, Xu Fang, Jing Li, Xiaochen Feng, Jianping Lu, Chengwei Shao, Yun Bian,

Conventional chemotherapy has limited benefit in pancreatic ductal adenocarcinoma (PDAC), necessitating identification of novel therapeutic targets. Radiomics may enable non-invasive prediction of CD20 expression, a hypothesized therapeutic target in PDAC. To develop a machine learning classifier based on noncontrast magnetic resonance imaging for predicting CD20 expression in PDAC. Retrospective study ... Read more >>

Acad Radiol (Academic radiology)
[2021, :]

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Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability.

Hui Jiang, Shi-Jun Yin, Xu Wang, Min Lu, Hao Zhang, Feng-Qing Yang,

Two liposomes, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) + 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (PE) + cholesterol (Chol) (DSPC/PE/Chol liposomes) and soybean lecithin (SPC) + PE + Chol (SPC/PE/Chol liposomes), were prepared and fixed on the inner wall of capillary column by using the adhesion of polydopamine (PDA) membrane and the cross-linking property of glutaraldehyde (GA). The immobilized liposome capillary column (ILCC) has good repeatability ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 209:114513]

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First report of successful treatment for hemoglobin Bristol-Alesha by hemopoietic stem cell transplantation.

Shanshan Li, Kai Chen, Can Huang, Na Zhang, Hui Jiang, Shayi Jiang,

HBB gene mutations lead to many kinds of diseases, of which, except for the two most common diseases of thalassemia and sickle cell anemia, rare kinds of hemolytic anemia, such as hemoglobin Bristol-Alesha, are rarely reported, no ideal treatment in clinic. A child suffered from chronic recurrent hemolytic attacks and ... Read more >>

Ann Hematol (Annals of hematology)
[2021, :]

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Screening of Potential Thrombin and Factor Xa Inhibitors from the Danshen-Chuanxiong Herbal Pair through a Spectrum-Effect Relationship Analysis.

Xu Wang, Dai-Yan Zhang, Shi-Jun Yin, Hui Jiang, Min Lu, Feng-Qing Yang, Yuan-Jia Hu,

In this study; a spectrum-effect relationship analysis combined with a high-performance liquid chromatography-mass spectrometry (LC-MS) analysis was established to screen and identify active components that can inhibit thrombin and factor Xa (THR and FXa) in Salviae Miltiorrhizae Radix et Rhizoma-Chuanxiong Rhizoma (Danshen-Chuanxiong) herbal pair. Ten potential active compounds were predicted ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(23):]

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Ephedrine alleviates middle cerebral artery occlusion-induced neurological deficits and hippocampal neuronal damage in rats by activating PI3K/AKT signaling pathway.

Lixian Huang, Bo Zhao, Qunxian Li, Jing Wu, Hui Jiang, Qingbin Li,

Inflammation and oxidative stress are crucial in ischemic stroke. Ephedrine (EPH) has been proven to have anti-inflammatory and anti-oxidative stress effects. The present study analyzes whether EPH possessed neuroprotective effects and explored the underlying mechanisms of EPH based on an experimental model of middle cerebral artery occlusion (MCAO). We found ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4136-4149]

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Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections.

Hui Jiang, Yelin Yang, Yuping Qian, Chengwei Shao, Jianping Lu, Yun Bian, Jianming Zheng,

Objective:We aimed to develop the tumor budding (TB) score and to explore the association between the TB score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). Methods:In this retrospective study, 130 consecutive patients with PDAC underwent surgical resection between July 2016 and March 2019. The location and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:740212]

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The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor.

Tianle Zhu, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhang,

<h4>Background</h4>Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the ... Read more >>

Andrology (Andrology)
[2021, :]

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