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Author Hui Feng

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Suppressing Singlet Oxygen Formation during the Charge Process of Li-O2 Batteries with a Co3O4 Solid Catalyst Revealed by Operando Electron Paramagnetic Resonance.

Yang Lin, Qi Yang, Fushan Geng, Hui Feng, Mengdi Chen, Bingwen Hu,

Aprotic lithium-oxygen (Li-O2) batteries promise high energy, but the cycle life has been plagued by two major obstacles, the insulating products and highly reactive singlet oxygen (1O2), which cause higher overpotential and parasitic reactions, respectively. A solid-state catalyst is known to reduce overpotential; however, it is unclear whether it affects ... Read more >>

J Phys Chem Lett (The journal of physical chemistry letters)
[2021, :10346-10352]

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Retina Vascular Structures Near the Optic Disc and in the Macula in Primary Angle Closure Suspects.

Xiaohua Pan, Merry Zc Ruan, Wudi Fan, Kai Cao, Hui Feng, Zhongyin Hu, Yue Yang, Fancheng Yan, Mengya Zhao, Qian Liu, Min Fu, Fei Xiang, Richard K Lee, Shuning Li, Ying Han,

Ophthalmic Res (Ophthalmic research)
[2021, :]

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Specific interaction of an RNA-binding protein with the 3'-UTR of its target mRNA is critical to oomycete sexual reproduction.

Hui Feng, Chuanxu Wan, Zhichao Zhang, Han Chen, Zhipeng Li, Haibin Jiang, Maozhu Yin, Suomeng Dong, Daolong Dou, Yuanchao Wang, Xiaobo Zheng, Wenwu Ye,

Sexual reproduction is an essential stage of the oomycete life cycle. However, the functions of critical regulators in this biological process remain unclear due to a lack of genome editing technologies and functional genomic studies in oomycetes. The notorious oomycete pathogen Pythium ultimum is responsible for a variety of diseases ... Read more >>

PLoS Pathog (PLoS pathogens)
[2021, 17(10):e1010001]

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Setting the priorities straight - Species distribution models assist to prioritize conservation targets for the mangroves.

Achyut Kumar Banerjee, Hui Feng, Yuting Lin, Xinru Liang, Jiakai Wang, Yelin Huang,

Mangrove forests provide a wide range of ecosystem services, yet they are declining rapidly due to climate change and human activities. Identification of conservation priority targets across spatial and temporal scales may assist in planning and decision making, especially in areas having rich mangrove diversity but with limited response capacity. ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, :150937]

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Enablers and barriers to implementing care quality improvement program in nursing homes in China.

Yinan Zhao, Lulu Liao, Hui Feng, Huijing Chen, Hongting Ning,

<h4>Objective</h4>To explore the perspectives of key stakeholders on necessary factors to implement care quality improvement program.<h4>Methods</h4>We conducted qualitative descriptive research in eight nursing homes in four major prefecture-level cities of Changsha, Xiangtan, Zhuzhou, and Yueyang. Data of 50 clinical nurses and 64 nurse assistants were included and analyzed. Ethical approval ... Read more >>

BMC Geriatr (BMC geriatrics)
[2021, 21(1):532]

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Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy.

Bowen Li, Yu Cao, Mingjun Sun, Hui Feng,

Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type of regulatory non-coding RNA, are often incorporated into exosomes as signaling molecules. In this review, we discuss the expression of exosomal miRNAs from ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21916]

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Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC: a multicenter phase-II trial.

Tao Jiang, Pingyang Wang, Jie Zhang, Yanqiu Zhao, Jianying Zhou, Yun Fan, Yongqian Shu, Xiaoqing Liu, Helong Zhang, Jianxing He, Guanghui Gao, Xiaoqian Mu, Zhang Bao, Yanjun Xu, Renhua Guo, Hong Wang, Lin Deng, Ningqiang Ma, Yalei Zhang, Hui Feng, Sheng Yao, Jiarui Wu, Luonan Chen, Caicun Zhou, Shengxiang Ren,

This multicenter phase-II trial aimed to investigate the efficacy, safety, and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC. Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled. Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):355]

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Object Activity Scene Description, Construction, and Recognition.

Hui Feng, Shanshan Wang, Haixiang Xu, Shuzhi Sam Ge,

Action recognition is a critical task for social robots to meaningfully engage with their environment. 3-D human skeleton-based action recognition has been an attractive research area in recent years. Although the existing approaches are good at action recognition, it is a great challenge to recognize a group of actions in ... Read more >>

IEEE Trans Cybern (IEEE transactions on cybernetics)
[2021, 51(10):5082-5092]

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High-throughput phenotyping-based QTL mapping reveals the genetic architecture of the salt stress tolerance of Brassica napus

Guofang Zhang, Jinzhi Zhou, Yan Peng, Zengdong Tan, Yuting Zhang, Hu Zhao, Dongxu Liu, Xiao Liu, Long Li, Liangqian Yu, Cheng Jin, Shuai Fang, Jiawei Shi, Zengdong Geng, Shanjing Yang, Guoxing Chen, Kede Liu, Qingyong Yang, Hui Feng, Liang Guo, Wanneng Yang,

Salt stress is a major limiting factor that severely affects the survival and growth of crops. It is important to understand the salt tolerance ability of Brassica napus and explore the underlying related genetic resources. We used a high-throughput phenotyping platform to quantify 2,111 image-based traits (i-traits) of a natural ... Read more >>

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Pathological Investigations And Correlation Research of Microfibrillar-Associated Protein 4 And Tropoelastin In Oral Submucous Fibrosis

Binjie Liu, Wenqun Gou, Hui Feng,

<h4>Background: </h4> Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a precancerous disorder with 7%-30% of malignant transformation and rising global prevalence. However, the precise pathogenesis and effective treatment still remains elusive and controversial despite superfluity of literature. Therefore, it is extremely necessary and significant to explore the ... Read more >>

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Longitudinal impact of metabolic syndrome and depressive symptoms on subsequent functional disability among middle-aged and older adults in China.

Hongting Ning, Yan Du, Yinan Zhao, Qingcai Liu, Xiaoyang Li, Hongyu Zhang, Dian Jiang, Hui Feng,

<h4>Background</h4>Few studies examining the impact of metabolic syndrome and depressive symptoms on subsequent functional disability are available.<h4>Objectives</h4>To determine the impact of baseline metabolic syndrome and depressive symptoms on subsequent functional disability.<h4>Methods</h4>This study used data from the 2011 baseline and 2013, 2015 and 2018 follow-up waves of the China Health and ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 296:216-223]

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Clinicopathological significance and prognostic value of P27 expression in gastric cancer patients: a meta-analysis.

Hui Feng, Hongmei Zhang, Zongting Yan,

Loss of P27 expression correlates with clinical progression in a variety of human cancers. However, the correlation between P27 expression and gastric cancer remains controversial. In this meta-analysis, we performed an electronic search based on six databases to select a sufficient number of studies. Pooled hazard ratio (HR) was used ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2021, :]

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Impact of Non-Alcoholic Simple Fatty Liver Disease on Antituberculosis Drug-Induced Liver Injury.

Yi-Hui Liu, Yan Guo, Hong Xu, Hui Feng, Dong-Ya Chen,

<h4>Objective</h4>To observe the effect of non-alcoholic simple fatty liver disease on drug-induced liver injury caused by tuberculosis.<h4>Methods</h4>We retrospectively analyzed the incidence, characteristics, and risk factors of antituberculosis drug-induced liver injury in 104 patients with initial treatment of tuberculosis complicated with non-alcoholic simple fatty liver disease. The patients were divided into ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2021, 14:3667-3671]

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LAMP assay for distinguishing Fusarium oxysporum and Fusarium commune in lotus (Nelumbo nucifera) rhizomes.

Sheng Deng, Xin Ma, Yifan Chen, Hui Feng, Dongmei Zhou, Xiaoyu Wang, Yong Zhang, Min Zhao, Jinfeng Zhang, Paul Daly, Lihui Wei,

The yields of edible rhizome from the cultivation of the perennial hydrophyte lotus (<i>Nelumbo nucifera</i>) can be severely reduced by rhizome rot disease caused by <i>Fusarium</i> species. There is a lack of rapid field-applicable methods for detection of these pathogens on lotus plants displaying symptoms of rhizome-rot. <i>Fusarium commune</i> (91%) ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants.

Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan,

The successive emergences and accelerating spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages and evolved resistance to some ongoing clinical therapeutics increase the risks associated with the coronavirus disease 2019 (COVID-19) pandemic. An urgent intervention for broadly effective therapies to limit the morbidity and mortality of COVID-19 ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5000]

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Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial.

Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Ying-Rui Shi, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Wangjun Liao, Xiaohui He, Xiaozhong Chen, Zhigang Liu, Xianglin Yuan, Qi Li, Xiaoyan Lin, Shanghua Jing, Yanju Chen, Yin Lu, Ching-Yun Hsieh, Muh-Hwa Yang, Chia-Jui Yen, Jens Samol, Hui Feng, Sheng Yao, Patricia Keegan, Rui-Hua Xu,

Gemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double-blind, phase 3 trial (ClinicalTrials.gov identifier: NCT03581786), 289 patients with RM-NPC and no previous chemotherapy for recurrent or metastatic disease were randomized (1/1) to receive either toripalimab, a monoclonal antibody against human programmed ... Read more >>

Nat Med (Nature medicine)
[2021, 27(9):1536-1543]

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An improved technique for isolation and characterization of single-spore isolates of Plasmodiophora brassicae.

Mingcan Lv, Yifan Liu, Yue Wu, Jing Zhang, Xuyao Liu, Ruiqin Ji, Hui Feng,

Clubroot, caused by Plasmodiophora brassicae, is a soil-borne disease that occurs in cruciferous crops worldwide. P. brassicae usually exists as a mixture of several pathotypes, which has hampered the research on resistance mechanisms of cruciferous crops against P. brassicae. In this study, clubroot galls were collected from a field in ... Read more >>

Plant Dis (Plant disease)
[2021, :]

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Mapping of a Pale Green Mutant Gene and Its Functional Verification by Allelic Mutations in Chinese Cabbage (Brassica rapa L. ssp. pekinensis).

Yonghui Zhao, Shengnan Huang, Meidi Zhang, Yun Zhang, Hui Feng,

Leaves are the main organ for photosynthesis, and variations in leaf color affect photosynthesis and plant biomass formation. We created two similar whole-plant pale green mutants (<i>pem1</i> and <i>pem2</i>) from the double haploid (DH) Chinese cabbage line "FT" through ethyl methanesulfonate (EMS) mutagenesis of seeds. Photosynthetic pigment contents and net ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:699308]

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The mediating effect of skeletal muscle index on the relationship between menarcheal age and bone mineral density in premenopausal women by race/ethnicity.

Hongting Ning, Yan Du, Lan-Juan Zhao, Qing Tian, Hui Feng, Hong-Wen Deng,

<h4>Objective</h4>To examine the contribution of skeletal mass index (SMI) as a mediator in the relationship between menarcheal age and hip/spine bone mineral density (BMD) in premenopausal women by race/ethnicity.<h4>Methods</h4>The data of 4,329 participants (age ≥ 18; mean age=35.7 ± 9.5) of Whites (n = 2,543), African Americans (n = 1,236), and Asians (n = 550) enrolled from October ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2021, 28(10):1143-1149]

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Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome‑mediated inflammation.

Hui Feng, Xiaoyun Zhu, Yang Tang, Shouqiang Fu, Bingtan Kong, Ximing Liu,

Diabetic nephropathy (DN) is a primary cause of end‑stage renal disease. Despite the beneficial effects of astragaloside IV (AS)‑IV on renal disease, the underlying mechanism of its protective effects against DN has not been fully determined. The aims of the present study were to assess the effects of AS‑IV against DN ... Read more >>

Int J Mol Med (International journal of molecular medicine)
[2021, 48(2):]

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Comparative Transcriptome and Weighted Gene Co-expression Network Analysis Identify Key Transcription Factors of Rosa chinensis 'Old Blush' After Exposure to a Gradual Drought Stress Followed by Recovery.

Xin Jia, Hui Feng, Yanhua Bu, Naizhe Ji, Yingmin Lyu, Shiwei Zhao,

Rose is one of the most fundamental ornamental crops, but its yield and quality are highly limited by drought. The key transcription factors (TFs) and co-expression networks during rose's response to drought stress and recovery after drought stress are still limited. In this study, the transcriptomes of leaves of 2-year-old ... Read more >>

Front Genet (Frontiers in genetics)
[2021, 12:690264]

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Achieving highly efficient aggregation-induced emission, reversible and irreversible photochromism by heavy halogen-regulated photophysics and D-A molecular pattern-controlled photochemistry of through-space conjugated luminogens.

Zuping Xiong, Xiaoxiao Zhang, Longxiang Liu, Qiaozhi Zhu, Zhenni Wang, Hui Feng, Zhaosheng Qian,

It is extremely challenging but desirable to regulate the photophysical and photochemical processes of aggregation-induced emission luminogens (AIEgens) in distinct states in a controllable manner. Herein, we design two groups of AIEgens based on a triphenylacrylonitrile (TPAN) skeleton with through-space conjugation (TSC) property, demonstrate controlled regulation of photophysical emission efficiency/color ... Read more >>

Chem Sci (Chemical science)
[2021, 12(32):10710-10723]

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Failure to Guard: Mitochondrial Protein Quality Control in Cancer.

Joseph E Friedlander, Ning Shen, Aozhuo Zeng, Sovannarith Korm, Hui Feng,

Mitochondria are energetic and dynamic organelles with a crucial role in bioenergetics, metabolism, and signaling. Mitochondrial proteins, encoded by both nuclear and mitochondrial DNA, must be properly regulated to ensure proteostasis. Mitochondrial protein quality control (MPQC) serves as a critical surveillance system, employing different pathways and regulators as cellular guardians ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

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Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS-CoV-2 Neutralizing Antibody, Etesevimab, in Chinese Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.

Xiaojie Wu, Nanyang Li, Guoqin Wang, Wei Liu, Jicheng Yu, Guoying Cao, Jingjing Wang, Yuancheng Chen, Juan Ma, Jufang Wu, Haijing Yang, Xiaomeng Mao, Jinjie He, Yiqi Yu, Chao Qiu, Ning Li, Sheng Yao, Hui Feng, Jinghua Yan, Wenhong Zhang, Jing Zhang,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly worldwide. This study is the first to report the tolerability, safety, pharmacokinetics (PK), and immunogenicity of a recombinant human anti-SARS-CoV-2 monoclonal antibody, etesevimab (CB6, JS016, LY3832479, or LY-CoV016), in healthy adults. This paper describes a randomized, double-blind, placebo-controlled, phase ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, 65(8):e0035021]

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Ipomoea staphylina Attenuates Potassium Dichromate-Induced Nephrotoxicity in Wistar Rats via Antioxidant and Antiapoptotic Effects.

Hui Feng, Qiao Feng, Tingting Xiao, Ting Liu, Bi Guan, Sayed M Firdous, Jinping Huang,

Occupational and environmental exposure to chromium compounds leads to nephrotoxicity to humans and animals due to the overproduction of ROS. Our study was aimed to demonstrate the shielding effect of hydroethanolic extract of Ipomoea staphylina (HEIS) bark on male Wistar rats challenged with potassium dichromate (K<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub>). Division of animals was ... Read more >>

Dokl Biochem Biophys (Doklady. Biochemistry and biophysics)
[2021, 499(1):289-295]

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