Full Text Journal Articles by
Author Hugues Bittard

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Molecular and nanoscale evaluation of N-cadherin expression in invasive bladder cancer cells under control conditions or GW501516 exposure.

Céline Elie-Caille, Isabelle Lascombe, Adeline Péchery, Hugues Bittard, Sylvie Fauconnet,

N-cadherin is a transmembrane glycoprotein expressed by mesenchymal origin cells and is located at the adherens junctions. It regulates also cell motility and contributes to cell signaling. In previous studies, we identified that its anomalous expression in bladder carcinoma was a tumor progression marker. A pharmacological approach to inhibit N-cadherin expression ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, 471(1-2):113-127]

Cited: 0 times

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Effects of Obesity on Postoperative Complications and Graft Survival After Kidney Transplantation.

Marie Fellmann, Loïc Balssa, Elise Clément, Pierre Frey, Alexandre Frontczak, Stéphane Bernardini, Éric Chabannes, Guillaume Guichard, Hugues Bittard, François Kleinclauss,

OBJECTIVE:The objective of this study was to analyze the effects of obesity on postoperative complications and patient and graft survival after kidney transplantation. METHODS:We retrospectively included 506 patients who received a kidney transplant in our center during eleven years. Obesity was defined by a body mass index ≥ 30 kg/m2 based ... Read more >>

Transplant. Proc. (Transplantation proceedings)
[2020, :]

Cited: 0 times

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Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up.

Christel Mathis, Isabelle Lascombe, Franck Monnien, Hugues Bittard, François Kleinclauss, Isabelle Bedgedjian, Sylvie Fauconnet, Séverine Valmary-Degano,

BACKGROUND:Non-muscle invasive bladder cancers (NMIBC: pTa, pT1) are characterised by a high risk of recurrence and/or progression. Identification of prognostic markers is needed to improve both diagnosis and management of the disease. The aim of this study was to analyse the expression of A-FABP (adipocyte-fatty acid binding protein) and to ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):1239]

Cited: 1 time

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Cell death and restoration of TRAIL-sensitivity by ciglitazone in resistant cervical cancer cells.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe,

Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(64):107744-107762]

Cited: 0 times

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Cross-cultural adaptation and validation of the French version of the Expanded Prostate cancer Index Composite questionnaire for health-related quality of life in prostate cancer patients.

Amélie Anota, Anne-Sophie Mariet, Philippe Maingon, Florence Joly, Jean-François Bosset, Anne-Valérie Guizard, Hugues Bittard, Michel Velten, Mariette Mercier,

Health-related quality of life (HRQoL) has been positioned as one of the major endpoints in oncology. Thus, there is a need to validate cancer-site specific survey instruments. This study aimed to perform a transcultural adaptation of the 50-item Expanded Prostate cancer Index Composite (EPIC) questionnaire for HRQoL in prostate cancer ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2016, 14(1):168]

Cited: 3 times

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Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells.

Adeline Péchery, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

GW501516 is a selective and high-affinity synthetic agonist of peroxisome proliferator-activated receptor β/δ (PPARβ/δ). This molecule promoted the inhibition of proliferation and apoptosis in few cancer cell lines, but its anticancer action has never been investigated in bladder tumor cells. Thus, this study was undertaken to determine whether GW501516 had ... Read more >>

Tumour Biol. (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2016, 37(11):14789-14802]

Cited: 3 times

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Flexible Ureterorenoscopy for Renal and Proximal Ureteral Stone in Patients with Previous Ureteral Stenting: Impact on Stone-Free Rate and Morbidity.

Jean-François Dessyn, Loïc Balssa, Eric Chabannes, Baptiste Jacquemet, Stéphane Bernardini, Hugues Bittard, Guillaume Guichard, François Kleinclauss,

To analyze results (stone-free rate [SFR]) and complications after flexible ureterorenoscopy (f-URS) for renal or lumbar ureteral lithiasis in patients with a previous ureteral stenting (US).We conducted a single-center retrospective study, including all f-URS procedures achieved in our department, between January 2004 and December 2010, for renal or lumbar ureteral ... Read more >>

J. Endourol. (Journal of endourology)
[2016, 30(10):1084-1088]

Cited: 3 times

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Comparison of the efficacy and morbidity of flexible ureterorenoscopy for lower pole stones compared with other renal locations.

Baptiste Jacquemet, Lucille Martin, Julie Pastori, Vincent Bailly, Guillaume Guichard, Stéphane Bernardini, Eric Chabannes, Hugues Bittard, François Kleinclauss,

Flexible ureterorenoscopy (f-URS) for lower pole stones (LPS) compared with other renal locations can be challenging because of anatomic and technical considerations. We aimed to compare the stone-free rate (SFR) and surgical complication rate with f-URS for LPS vs other renal locations.We performed a retrospective, single-center study including 371 f-URS ... Read more >>

J. Endourol. (Journal of endourology)
[2014, 28(10):1183-1187]

Cited: 9 times

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The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism.

Emmanuelle Roche, Isabelle Lascombe, Hugues Bittard, Christiane Mougin, Sylvie Fauconnet,

Peroxisome Proliferator-Activated Receptor-β (PPARβ) is a ligand-inducible transcription factor activated by both natural (fatty acids and derivatives) and high affinity synthetic agonists. It is thought to play a role in angiogenesis development and Vascular Endothelial Growth Factor (VEGF) regulation but its contribution remains unclear. Until now, the PPARβ agonism effect ... Read more >>

Cell. Signal. (Cellular signalling)
[2014, 26(2):433-443]

Cited: 5 times

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Ureterorenoscopy with holmium-yttrium-aluminum-garnet fragmentation is a safe and efficient technique for stone treatment in patients with a body mass index superior to 30 kg/m2.

Gregory Delorme, Yann Nguyen Huu, Julien Lillaz, Stéphane Bernardini, Eric Chabannes, Guillaume Guichard, Hugues Bittard, François Kleinclauss,

The aim of the study was to analyze results and morbidity after flexible ureterorenoscopy in patients with a body mass index (BMI) >30 kg/m(2) and to compare with results obtained in a large cohort of nonobese patients.We conducted a retrospective study including all flexible ureterorenoscopy performed for stone retrieval in ... Read more >>

J. Endourol. (Journal of endourology)
[2012, 26(3):239-243]

Cited: 12 times

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The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL.

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Ciglitazone belongs to the thiazolidinediones class of antidiabetic drug family and is a high-affinity ligand for the Peroxisome Proliferator-Activated Receptor γ (PPARγ). Apart from its antidiabetic activity, this molecule shows antineoplastic effectiveness in numerous cancer cell lines.Using RT4 (derived from a well differentiated grade I papillary tumor) and T24 (derived ... Read more >>

PLoS ONE (PloS one)
[2011, 6(12):e28354]

Cited: 15 times

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Wegener's granulomatosis: a rare cause of hydronephrosis.

Julien Lillaz, Stéphane Bernardini, Marie-Paule Algros, Hugues Bittard, François Kleinclauss,

A seventy-one-year-old woman was hospitalized at our institution for a right-sided "renal colic" associated with an infectious background. Alithiasic ureterohydronephrosis was diagnosed by imaging. A urinary diversion was thus performed using a double J endoureteral stent. The etiologic assessment of the hydronephrosis showed the presence of a periureteral mass that ... Read more >>

Case Rep Med (Case reports in medicine)
[2011, 2011:814794]

Cited: 1 time

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Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells.

Marie Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe,

Thiazolidinediones, including rosiglitazone and troglitazone, are insulin-sensitizing drugs and high-affinity ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma). Apart from their antidiabetic activity, these molecules possess antitumor properties. We investigated their potential apoptotic effects on RT4 (derived from a well-differentiated Grade I papillary tumor) and T24 (derived from an undifferentiated ... Read more >>

Int. J. Cancer (International journal of cancer)
[2010, 127(8):1769-1784]

Cited: 12 times

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Effect of dutasteride on the risk of prostate cancer.

Gerald L Andriole, David G Bostwick, Otis W Brawley, Leonard G Gomella, Michael Marberger, Francesco Montorsi, Curtis A Pettaway, Teuvo L Tammela, Claudio Teloken, Donald J Tindall, Matthew C Somerville, Timothy H Wilson, Ivy L Fowler, Roger S Rittmaster, ,

We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease.In this 4-year, multicenter, randomized, double-blind, placebo-controlled, parallel-group study, we compared dutasteride, at a dose of 0.5 mg daily, with placebo. Men ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2010, 362(13):1192-1202]

Cited: 475 times

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A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells.

Guillaume Boiteux, Isabelle Lascombe, Emmanuelle Roche, Marie-Laure Plissonnier, Anne Clairotte, Hugues Bittard, Sylvie Fauconnet,

Superficial pT1 bladder tumors are characterized by a high risk of recurrence and progression in grade and stage. Few studies provided evidence that loss of adipocyte-fatty acid binding protein (A-FABP) expression was associated with bladder cancer progression. A-FABP is a lipid binding protein playing a role in intracellular lipid transport ... Read more >>

Int. J. Cancer (International journal of cancer)
[2009, 124(8):1820-1828]

Cited: 36 times

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Expression analysis of VEGF-A and VEGF-B: relationship with clinicopathological parameters in bladder cancer.

Sylvie Fauconnet, Stephane Bernardini, Isabelle Lascombe, Guillaume Boiteux, Anne Clairotte, Franck Monnien, Eric Chabannes, Hugues Bittard,

The present investigation was conducted first to determine whether correlation exists between VEGF-A and -B mRNA levels and clinicopathological parameters and to assess their prognostic value in bladder cancer, then to clarify the expression level and biological significance of VEGF-A isoforms. Total RNA was isolated from 37 specimens of bladder ... Read more >>

Oncol. Rep. (Oncology reports)
[2009, 21(6):1495-1504]

Cited: 18 times

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Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.

Hervé Wallerand, Ying Cai, Zev A Wainberg, Isla Garraway, Isabelle Lascombe, Gaëlle Nicolle, Jean-Paul Thiery, Hugues Bittard, François Radvanyi, Robert R Reiter,

OBJECTIVES: A particular interest in epithelial-mesenchymal transition (EMT), which takes place during embryonic development, provided potential mechanisms involved in the progression of many epithelial tumors, including bladder cancer (BC). The phospho-Akt signaling pathway is supposed to be involved in invasion and progression of human tumors, including BC. Moreover, it has ... Read more >>

Urol. Oncol. (Urologic oncology)
[2010, 28(2):180-188]

Cited: 24 times

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Lymphocyte subsets in renal transplant recipients with de novo genitourinary malignancies.

Guillaume Guichard, Jean Michel Rebibou, Didier Ducloux, Dominique Simula-Faivre, Pierre Tiberghien, Jean Marc Chalopin, Hugues Bittard, Philippe Saas, François Kleinclauss,

INTRODUCTION: The incidence of genitourinary tumors (GUT) in renal transplant recipients (RTR) is higher than in the general population. We previously reported that CD4 lymphocytopenia is associated with a high incidence of skin cancer in RTR. Here, we investigate whether persistent CD4 T cell lymphopenia is associated with GUT occurrence. ... Read more >>

Urol. Int. (Urologia internationalis)
[2008, 80(3):257-263]

Cited: 2 times

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The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status.

Marie E Fondrevelle, Bernadette Kantelip, Robert E Reiter, Dominique K Chopin, Jean P Thiery, Franck Monnien, Hugues Bittard, Hervé Wallerand,

Twist is considered as transcription factor that regulates epithelial mesenchymal transition (EMT) by at least inhibition of E-cadherin expression. EMT is a key event in the tumor invasion process. The purpose of this study is to investigate the expression of Twist but also those of E- and N-cadherin in human ... Read more >>

Urol. Oncol. (Urologic oncology)
[2009, 27(3):268-276]

Cited: 37 times

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Accuracy of ultrasonography in diagnosis of testicular rupture after blunt scrotal trauma.

Guillaume Guichard, Jamal El Ammari, Carlos Del Coro, Damien Cellarier, Pierre Yves Loock, Eric Chabannes, Stéphane Bernardini, Hugues Bittard, François Kleinclauss,

OBJECTIVES: The aim of this study is to determine the accuracy of ultrasonography for the diagnosis of testis rupture after scrotal trauma and its sensitivity and specificity for testis rupture, tunica albuginea breach, testicular hematoma, testis avulsion, epididymis injuries, and hematocele. METHODS: Between 1996 and 2006, 33 patients underwent surgical ... Read more >>

Urology (Urology)
[2008, 71(1):52-56]

Cited: 35 times

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[Simultaneous embolization of a large arteriovenous fistula and a renal pseudoaneurysm].

Abdelhak Khallouk, Jalal Eddine El-Ammari, Hervé Wallerand, François Kleinclauss, Hugues Bittard, Stéphane Bernardini,

The authors report the cases of a 41-year-old woman with a large arteriovenous fistula between a branch of the renal artery and the main renal vein in the renal hilum and a peripheral pseudoaneurysm secondary to a knife wound to the kidney. These lesions were successfully treated by embolization. In ... Read more >>

Prog. Urol. (Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie)
[2006, 16(3):373-375]

Cited: 0 times

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[Prospective study of the results at 2 years of one or two cycles of BCG endovesical instillations in the urothelial tumors of the bladder pT1 G3 after completed transurethral resection].

Pascal Rischmann, Xavier Gamé, Catherine Mazerolles, Hugues Bittard, Olivier Bouchot, Jean-Luc Descottes, Dominique Chopin,

Prog. Urol. (Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie)
[2005, 15(6 Suppl 1):1266-1270]

Cited: 0 times

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Expression of E-cadherin and alpha-, beta-, gamma-catenins in patients with bladder cancer: identification of gamma-catenin as a new prognostic marker of neoplastic progression in T1 superficial urothelial tumors.

Anne Clairotte, Isabelle Lascombe, Sylvie Fauconnet, Frédéric Mauny, Sophie Félix, Marie-Paule Algros, Hugues Bittard, Bernadette Kantelip,

Loss of intercellular adhesion facilitates tumor invasion. To clarify the relation between altered expression of cell adhesion molecules and progression of T1 superficial bladder tumors, 101 cases (71 T1 tumors, 30 T2/T3 tumors) were examined immunohistochemically for E-cadherin and alpha-, beta-, and gamma-catenins. A highly significant correlation was observed between ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2006, 125(1):119-126]

Cited: 29 times

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[Vascular prostheses and renal transplantation].

Damien Cellarier, Guillaume Guichard, Pierre-Yves Loock, Stéphane Bernardini, Eric Chabannes, Hugues Bittard, François Kleinclauss,

OBJECTIVE: To evaluate the complications, the morbidity and mortality of renal transplantation in patients with a vascular prosthesis inserted either prior to or at the same time as renal transplantation. PATIENTS AND METHOD: Between January 2001 and January 2006, six renal transplantations were performed in patients with arterial vascular prostheses ... Read more >>

Prog. Urol. (Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie)
[2006, 16(5):554-558]

Cited: 1 time

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[Conservative management of Corynebacterium urealyticum encrusted cystitis].

Abdelhak Khallouk, Hervé Wallerand, François Kleinclauss, Hugues Bittard, Stéphane Bernardini,

The authors report the case of a 75-year-old patient who developed Corynebacterium urealyticum encrusted cystitis six months after open prostatectomy, complicated by vesicocutaneous fistula, which required bladder catheterization for several days. Encrustation of the bladder wall induced marked bilateral ureteropyelocaliceal dilatation without renal failure. Medical treatment by antibiotic therapy and ... Read more >>

Prog. Urol. (Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie)
[2006, 16(4):496-498]

Cited: 5 times

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