Full Text Journal Articles by
Author Hugo Segerer

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

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Ranibizumab in retinopathy of prematurity - one-year follow-up of ophthalmic outcomes and two-year follow-up of neurodevelopmental outcomes from the CARE-ROP study.

Andreas Stahl, Marie-Christine Bründer, Wolf A Lagrèze, Fanni E Molnár, Teresa Barth, Nicole Eter, Rainer Guthoff, Tim U Krohne, Johanna M Pfeil, ,

<h4>Purpose</h4>The primary endpoint results from the comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity (CARE-ROP) core study identified ranibizumab as an effective treatment to control acute retinopathy of prematurity (ROP). This study reports the 1- and 2-year follow-up data focusing on long-term functional outcomes and safety.<h4>Methods</h4>The ... Read more >>

Acta Ophthalmol (Acta ophthalmologica)
[2021, :]

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Active perinatal care of preterm infants in the German Neonatal Network.

Alexander Humberg, Christoph Härtel, Tanja K Rausch, Guido Stichtenoth, Philipp Jung, Christian Wieg, Angela Kribs, Axel von der Wense, Ursula Weller, Thomas Höhn, Dirk M Olbertz, Ursula Felderhoff-Müser, Rainer Rossi, Norbert Teig, Friedhelm Heitmann, Susanne Schmidtke, Bettina Bohnhorst, Matthias Vochem, Hugo Segerer, Jens Möller, Joachim G Eichhorn, Jürgen Wintgens, Ralf Böttger, Mechthild Hubert, Michael Dördelmann, Georg Hillebrand, Claudia Roll, Reinhard Jensen, Michael Zemlin, Michael Mögel, Claudius Werner, Stefan Schäfer, Thomas Schaible, Axel Franz, Michael Heldmann, Silke Ehlers, Olaf Kannt, Thorsten Orlikowsky, Hubert Gerleve, Katja Schneider, Roland Haase, Kai Böckenholt, Knud Linnemann, Egbert Herting, Wolfgang Göpel,

OBJECTIVE:To determine if survival rates of preterm infants receiving active perinatal care improve over time. DESIGN:The German Neonatal Network is a cohort study of preterm infants with birth weight <1500 g. All eligible infants receiving active perinatal care are registered. We analysed data of patients discharged between 2011 and 2016. ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(2):190-195]

Cited: 4 times

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KUNO-Kids birth cohort study: rationale, design, and cohort description.

Susanne Brandstetter, Antoaneta A Toncheva, Jakob Niggel, Christine Wolff, Silvia Gran, Birgit Seelbach-Göbel, Christian Apfelbacher, Michael Melter, Michael Kabesch, ,

<h4>Background</h4>Birth cohort studies can contribute substantially to the understanding of health and disease - in childhood and over the life course. The KUNO-Kids birth cohort study was established to investigate various aspects of child health, using novel omics technologies in a systems medicine approach.<h4>Results</h4>After 3 years of recruitment, 2515 infants and their ... Read more >>

Mol Cell Pediatr (Molecular and cellular pediatrics)
[2019, 6(1):1]

Cited: 2 times

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Betreuung von Neugeborenen diabetischer Mütter. Leitlinie der GNPI, DGPM, DDG, DGHWi, dem DHV, der DGKJ und DGGG. (2k-Level, AWMF-Leitlinien-Register Nr. 024/006, Juli 2017).

Hugo Segerer, Christoph Bührer, Thomas Kapellen, Elke Mattern, Babett Ramsauer, Thierry Somville, Andreas Trotter,

Z Geburtshilfe Neonatol (Zeitschrift fur Geburtshilfe und Neonatologie)
[2018, 222(3):107-114]

Cited: 1 time

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Influence of PCO2 Control on Clinical and Neurodevelopmental Outcomes of Extremely Low Birth Weight Infants.

Ulrich H Thome, Jens Dreyhaupt, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Benjamin Ackermann, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Harald Bode, Maria Zernickel, Rainer Muche, Helmut D Hummler, ,

BACKGROUND:Levels or fluctuations in the partial pressure of CO2 (PCO2) may affect outcomes for extremely low birth weight infants. OBJECTIVES:In an exploratory analysis of a randomized trial, we hypothesized that the PCO2 values achieved could be related to significant outcomes. METHODS:On each treatment day, infants were divided into 4 groups: ... Read more >>

Neonatology (Neonatology)
[2018, 113(3):221-230]

Cited: 3 times

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Neurodevelopmental outcomes of extremely low birthweight infants randomised to different PCO2 targets: the PHELBI follow-up study.

Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Annett Bläser, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Harald Bode, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler, ,

<h4>Background</h4>Tolerating higher partial pressures of carbon dioxide (PCO<sub>2</sub>) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial.<h4>Methods</h4>Infants (n=359) between 400 and 1000 g birth weight and ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2017, 102(5):F376-F382]

Cited: 16 times

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Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?

Juliane Spiegler, Michael Preuß, Corinna Gebauer, Meike Bendiks, Egbert Herting, Wolfgang Göpel, , ,

<h4>Objective</h4>To assess whether breastmilk feeding is associated with a reduced risk of bronchopulmonary dysplasia (BPD). Secondary outcome measures analyzed were retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC).<h4>Study design</h4>In an ongoing multicenter cohort study, the data of 1433 very low birth weight infants born before 32 weeks of gestation and discharged ... Read more >>

J Pediatr (The Journal of pediatrics)
[2016, 169:76-80.e4]

Cited: 45 times

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Permissive hypercapnia in extremely low birthweight infants (PHELBI): a randomised controlled multicentre trial.

Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Corinna Gebauer, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Gerhard Alzen, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler, ,

<h4>Background</h4>Tolerating higher partial pressure of carbon dioxide (pCO2) in mechanically ventilated, extremely low birthweight infants might reduce ventilator-induced lung injury and bronchopulmonary dysplasia. We aimed to test the hypothesis that higher target ranges for pCO2 decrease the rate of bronchopulmonary dysplasia or death.<h4>Methods</h4>In this randomised multicentre trial, we recruited infants ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2015, 3(7):534-543]

Cited: 26 times

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Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network.

Kathrin Hanke, Annika Hartz, Maike Manz, Meike Bendiks, Friedhelm Heitmann, Thorsten Orlikowsky, Andreas Müller, Dirk Olbertz, Thomas Kühn, Jens Siegel, Axel von der Wense, Christian Wieg, Angela Kribs, Anja Stein, Julia Pagel, Egbert Herting, Wolfgang Göpel, Christoph Härtel, ,

<h4>Objective</h4>It was the aim of our study to evaluate the independent effect of preterm prelabor rupture of membranes (PPROM) as a cause of preterm delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks of gestation.<h4>Design</h4>Observational, epidemiological study design.<h4>Setting</h4>Population-based cohort, German Neonatal Network ... Read more >>

PLoS One (PloS one)
[2015, 10(4):e0122564]

Cited: 5 times

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Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants.

Christoph Härtel, Julia Pagel, Jan Rupp, Meike Bendiks, Florian Guthmann, Esther Rieger-Fackeldey, Matthias Heckmann, Axel Franz, Jan-Holger Schiffmann, Beate Zimmermann, Nico Hepping, Axel von der Wense, Christian Wieg, Egbert Herting, Wolfgang Göpel, ,

<h4>Objective</h4>To evaluate outcome data in an observational cohort of very low birth weight infants of the German Neonatal Network stratified to prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics.<h4>Study design</h4>Within the observational period (September 1, 2010, until December 31, 2012, n=5351 infants) study centers were categorized into 3 groups based on ... Read more >>

J Pediatr (The Journal of pediatrics)
[2014, 165(2):285-289.e1]

Cited: 33 times

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The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol.

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Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline ... Read more >>

Neonatology (Neonatology)
[2012, 101(4):301-305]

Cited: 20 times

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Epidemic microclusters of blood-culture proven sepsis in very-low-birth weight infants: experience of the German Neonatal Network.

Christoph Härtel, Kirstin Faust, Stefan Avenarius, Bettina Bohnhorst, Michael Emeis, Corinna Gebauer, Peter Groneck, Friedhelm Heitmann, Thomas Hoehn, Mechthild Hubert, Angela Kribs, Helmut Küster, Reinhard Laux, Michael Mögel, Dirk Müller, Dirk Olbertz, Claudia Roll, Jens Siegel, Anja Stein, Matthias Vochem, Ursula Weller, Axel von der Wense, Christian Wieg, Jürgen Wintgens, Claudia Hemmelmann, Arne Simon, Egbert Herting, Wolfgang Göpel, ,

<h4>Introduction</h4>We evaluated blood culture-proven sepsis episodes occurring in microclusters in very-low-birth-weight infants born in the German Neonatal Network (GNN) during 2009-2010.<h4>Methods</h4>Thirty-seven centers participated in GNN; 23 centers enrolled ≥50 VLBW infants in the study period. Data quality was approved by on-site monitoring. Microclusters of sepsis were defined as occurrence of ... Read more >>

PLoS One (PloS one)
[2012, 7(6):e38304]

Cited: 12 times

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ATP-binding cassette member A3 (E292V) gene mutation and pulmonary morbidity in very-low-birth-weight infants.

Christoph Härtel, Ursula Felderhoff-Müser, Corinna Gebauer, Thomas Hoehn, Angela Kribs, Reinhard Laux, Jens Möller, Hugo Segerer, Norbert Teig, Axel von der Wense, Christian Wieg, Guido Stichtenoth, Egbert Herting, Wolfgang Göpel, ,

ATP-binding cassette member A 3 (ABCA3) plays a critical role for the transport of surfactant phospholipids into the lamellar bodies of type II alveolar epithelial cells. Term infants carrying the E292V missense mutation of the gene encoding ABCA3 are likely to develop respiratory distress syndrome, and the mutation has also ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2012, 101(4):380-383]

Cited: 0 times

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Tumor necrosis factor-α promoter -308 G/A polymorphism and susceptibility to sepsis in very-low-birth-weight infants.

Christoph Härtel, Claudia Hemmelmann, Kirstin Faust, Corinna Gebauer, Thomas Hoehn, Angela Kribs, Reinhard Laux, Werner Nikischin, Hugo Segerer, Norbert Teig, Axel von der Wense, Christian Wieg, Egbert Herting, Wolfgang Göpel, ,

<h4>Objectives</h4>To determine whether the tumor necrosis factor-α -308 G/A polymorphism is associated with blood culture-proven sepsis in two large cohorts of very-low-birth-weight infants.<h4>Design</h4>Genetic association studies.<h4>Setting</h4>Prospective, population-based, multicentered cohort of 1944 very-low-birth-weight infants born in 14 German study centers between 2003 and 2008 and 976 mothers, and a second prospective cohort ... Read more >>

Crit Care Med (Critical care medicine)
[2011, 39(5):1190-1195]

Cited: 6 times

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Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes.

K Kempf, G Manzo, P Hanifi-Moghaddam, S Kappler, J Seissler, C Jaeger, B Boehm, M Roden, H Kolb, S Martin, N C Schloot, ,

Diabet Med (Diabetic medicine : a journal of the British Diabetic Association)
[2009, 26(12):1309-1310]

Cited: 1 time

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Does the enteral feeding advancement affect short-term outcomes in very low birth weight infants?

Christoph Härtel, Berit Haase, Kathryn Browning-Carmo, Corinna Gebauer, Evelyn Kattner, Angela Kribs, Hugo Segerer, Norbert Teig, Axel von der Wense, Christian Wieg, Egbert Herting, Wolfgang Göpel,

<h4>Background and objectives</h4>Controversy exists regarding the optimal enteral feeding regimen of very low birth weight infants (VLBW). Rapid advancement of enteral feeding has been associated with an increased rate of necrotizing enterocolitis. In contrast, delaying enteral feeding may have unfavorable effects on nutrition, growth, and neurodevelopment. The aim is to ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2009, 48(4):464-470]

Cited: 24 times

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Very low birth weight infants as a model to study genetic influences on neonatal weight gain.

Juliane Spiegler, Evelyn Kattner, Matthias Vochem, Helmuth Küster, Jens Möller, Dirk Müller, Angela Kribs, Hugo Segerer, Christian Wieg, Werner Nikischin, Axel von der Wense, Corinna Gebauer, Egbert Herting, Wolfgang Göpel,

In a cohort of 829 preterm infants (birth weight below 1500 g) we identified 13 monozygotic, 10 same-sex dizygotic, and 12 same-sex matched singleton pairs. The difference in daily weight gain within pairs was significantly lower in monozygotic twins compared with dizygotic twins or matched singleton pairs. Our data support ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2008, 46(1):113-116]

Cited: 3 times

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Genetic polymorphisms of hemostasis genes and primary outcome of very low birth weight infants.

Christoph Härtel, Inke König, Stefan Köster, Evelyn Kattner, Eckhardt Kuhls, Helmut Küster, Jens Möller, Dirk Müller, Angela Kribs, Hugo Segerer, Christian Wieg, Egbert Herting, Wolfgang Göpel,

<h4>Background</h4>Recent investigations have reported an influence of thrombophilic mutations and antithrombotic risk factors with development of intraventricular hemorrhage. It was our objective for this study to investigate the impact of genetic polymorphisms of hemostasis genes on the primary outcome measures of sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage, and periventricular leukomalacia in ... Read more >>

Pediatrics (Pediatrics)
[2006, 118(2):683-689]

Cited: 26 times

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Polymorphisms of haemostasis genes as risk factors for preterm delivery.

Christoph Härtel, Sören von Otte, Julia Koch, Peter Ahrens, Evelyn Kattner, Hugo Segerer, Jens Möller, Klaus Diedrich, Wolfgang Göpel,

Clinical trials evaluating the potential benefit of anticoagulant treatment in pregnant women with inherited thrombophilia are based on the observation that a genetic predisposition to thrombosis is associated with frequent abortions and preterm birth. It was the aim of our study to delineate the impact of genetic polymorphisms with prothrombotic ... Read more >>

Thromb Haemost (Thrombosis and haemostasis)
[2005, 94(1):88-92]

Cited: 15 times

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Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants.

Peter Ahrens, Evelyn Kattner, Birgit Köhler, Christoph Härtel, Jürgen Seidenberg, Hugo Segerer, Jens Möller, Wolfgang Göpel, ,

Mutations of genes involved in the innate immune system have been reported to be associated with an increased sepsis rate in adults. We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 ... Read more >>

Pediatr Res (Pediatric research)
[2004, 55(4):652-656]

Cited: 73 times

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The effect of the Val34Leu polymorphism in the factor XIII gene in infants with a birth weight below 1500 g.

Wolfgang Göpel, Evelyn Kattner, Jürgen Seidenberg, Thomas Kohlmann, Hugo Segerer, Jens Möller, ,

OBJECTIVES: The 34Leu polymorphism of the factor XIII gene is associated with a low rate of brain infarction and a higher incidence of primary intracerebral hemorrhage in adults. We evaluated the effect of the polymorphism on the subsequent development of isolated intracranial hemorrhage and white matter disease in preterm infants ... Read more >>

J Pediatr (The Journal of pediatrics)
[2002, 140(6):688-692]

Cited: 5 times

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