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Author Huan Gao

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TCQA, A Natural Caffeoylquinic Acid Derivative Attenuates H2O2-Induced Neuronal Apoptosis by Suppressing Phosphorylation of MAPKs Signaling Pathway.

Yue Yang, Yufang Ding, Huan Gao, Xiaowen Jiang, Qingchun Zhao,

1,3,5-Tri-O-caffeoyl quinic acid is a caffeoylquinic acid derivative isolated from the roots of Arctium lappa L. Our previous studies have revealed that the ethyl acetate extract of the roots of A. lappa L. and the caffeoylquinic acids contained in it possess antioxidant properties, especially 1,3,5-tri-O-caffeoyl quinic acid. The present study aimed to ... Read more >>

Planta Med (Planta medica)
[2021, :]

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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

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Effect of petroleum hydrocarbon pollution levels on the soil microecosystem and ecological function.

Huan Gao, Manli Wu, Heng Liu, Yinrui Xu, Zeliang Liu,

Petroleum hydrocarbon pollution is a global problem. However, the effects of different petroleum pollution levels on soil microbial communities and ecological functions are still not clear. In this study, we analyzed the changes in microbial community structures and carbon and nitrogen transformation functions in oil-contaminated soils at different concentrations by ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2021, 293:118511]

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Effect of Orthodontic Treatment on Anterior Tooth Displacement in Patients with Periodontal Disease: A Meta-Analysis.

Jia Hou, Yunzhu Qian, Guowu Ma, Huan Gao, Jianxin Yang, Jianlin Fan,

<h4>Objective</h4>To systematically evaluate the effect of orthodontic treatment (ODT) on anterior tooth displacement (ATD) in patients with periodontal disease.<h4>Methods</h4>PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang databases were electronically searched for relevant literature studies on ODT and basic treatment for ATD in patients with periodontal disease, and ... Read more >>

J Healthc Eng (Journal of healthcare engineering)
[2021, 2021:8761215]

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Co-Quenching Effect between Lanthanum Metal-Organic Frameworks Luminophore and Crystal Violet for Enhanced Electrochemiluminescence Gene Detection.

Huan Gao, Xuan Wei, Meize Li, Lei Wang, Tianxiang Wei, Zhihui Dai,

Exploring new electrochemiluminescence (ECL) luminophores to construct high-efficiency sensing systems is always a hot direction for developing ECL sensors. Compared with other luminophores, metal-organic frameworks (MOFs) exhibit high mass transfer ability for accelerating the reactivity in its pore channels, which is conducive to improving the performance of ECL sensors. In ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, 17(45):e2103424]

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Polypharmacy and potentially inappropriate medications among elderly patients in the geriatric department at a single-center in China: A retrospective cross-sectional study.

Lina Tao, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Yueming Zhang, Yanqing Song,

<h4>Abstract</h4>The aging of the population has become a worldwide concern, especially in China. Polypharmacy and potentially inappropriate medications (PIMs) are prominent issues in elderly patients. Therefore, the aim of this study was to investigate the prevalence of polypharmacy and PIMs in older inpatients and further to explore the factors associated ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(42):e27494]

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Force Decoding of Caudal Forelimb Area and Rostral Forelimb Area in Chronic Stroke Rats.

Huan Gao, Minjian Sun, Ming Li, Chang Wang, Chaonan Yu, Yueming Wang, Kedi Xu,

Brain machine interfaces (BMIs) used for movement restoration primarily rely on studies of motor decoding. It has been proved that local field potentials (LFPs) from primary motor cortex and premotor cortex of normal rodents could be used for decoding motor signals. However, few studies have explored the decoding performance of ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2021, 68(10):3078-3086]

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Isotope fractionation (δ13C, δ15N) and microbial community response in degradation of petroleum hydrocarbons by biostimulation in contaminated soil.

Heng Liu, Manli Wu, Xiqian Guo, Huan Gao, Yinrui Xu,

This study investigated the isotope effects of δ<sup>13</sup>C and δ<sup>15</sup>N and microbial response during biodegradation of hydrocarbons by biostimulation with nitrate or compost in the petroleum-contaminated soil. Compost and KNO<sub>3</sub> amendments promoted the total petroleum hydrocarbon (TPH) removal accompanied by a significant increase of Actinobacteria and Firmicutes phyla. Soil alpha ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Managing the difficult airway: A survey of doctors with different seniority in China.

Hui-Hui Liu, Yong Wang, Ming Zhong, Yu-Hui Li, Huan Gao, Jian-Feng Zhang, Wu-Hua Ma,

<h4>Abstract</h4>Although equipment and human resources are vital elements of difficult airway management (DAM). But the approach and practice of DAM are more important. So, we conducted the present survey to address anesthesiologists of different working years in this knowledge gap.This nationwide cross-sectional study was conducted from October 27, 2016 to ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(38):e27181]

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Weak arene/nickel interaction lights on monoarylation of alcohols

Zhiyan Huang, Kun Xie, Ge Meng, Jun He, Mingsong Shi, Junjie Ma, Huan Gao, Tingting Qiu, Yuxia Zhao, Shuang Yang, Xinyu Wei, Jiaxin Yan, Kang Wang, Jiadong Cai, Sheng Li, Dong Xue,

Despite a growing body of work in nickel catalysis, the potential of organo-photocatalyst serving both as an arene ligand and a sensitizer remains underexplored. Here, we describe such an organo-photocatalyst to promote arylation of alcohols. Mechanistic studies suggest that the formation of sandwich complex via weak arene/nickel interaction and the ... Read more >>

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

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Simultaneously Enhancing Efficiency and Stability of Perovskite Solar Cells Through Crystal Cross-Linking Using Fluorophenylboronic Acid.

Mingguang Li, Huan Gao, Longsheng Yu, Senlin Tang, Ying Peng, Chao Zheng, Ligang Xu, Ye Tao, Runfeng Chen, Wei Huang,

Organic-inorganic metal halide perovskites are regarded as one of the most promising candidates in the photovoltaic field, but simultaneous realization of high efficiency and long-term stability is still challenging. Here, a one-step solution-processing strategy is demonstrated for preparing efficient and stable inverted methylammonium lead iodide (MAPbI<sub>3</sub> ) perovskite solar cells ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, 17(38):e2102090]

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Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein.

Zhe Zhong, Weijie Chen, Huan Gao, Ningning Che, Min Xu, Lanqing Yang, Yingfang Zhang, Min Ye,

Gut microbiota is closely related to the Parkinson's disease (PD) pathogenesis. Additionally, aggregation of α-synuclein (α-syn) is central to PD pathogenesis. Here we identified the further mechanisms of gut microbiota in PD. A mouse model with PD was established via injection of MPTP. Normal or MPTP-induced PD like animals were ... Read more >>

Neurochem Res (Neurochemical research)
[2021, 46(11):3050-3058]

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Characteristics of the Jejunal Microbiota in 35-Day-Old Saba and Landrace Piglets.

Huan Gao, Yuting Yang, Zhenhui Cao, Jinming Ran, Chunyong Zhang, Ying Huang, Minghua Yang, Sumei Zhao, Qingcong An, Hongbin Pan,

The balanced microbiological system is a significant hallmark of piglet health. One of the crucial factors affecting intestinal microbiota is the host's genetics. This study explored the difference in the diversity of jejunal microbiota between Saba (SB) and Landrace (LA) piglets. Nine Saba and nine Landrace piglets were fed with ... Read more >>

Pol J Microbiol (Polish journal of microbiology)
[2020, 69(3):367-378]

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Development and validation of an immune gene set-based prognostic signature in cutaneous melanoma.

Qi Tian, Huan Gao, Wen Zhao, Yan Zhou, Jin Yang,

We aimed to fully understand the landscape of the skin cutaneous melanoma (SKCM) microenvironment and develop an immune prognostic signature that can predict the prognosis for SKCM patients. RNA sequencing data and clinical information were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases. The immune-prognostic signature was constructed by LASSO Cox regression ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, :]

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Network Pharmacology-Based Dissection of the Active Ingredients and Protective Mechanism of the Salvia Miltiorrhiza and Panax Notoginseng Herb Pair against Insulin Resistance.

Xin-Yu Yang, Wen-Xiao Wang, Yu-Xi Huang, Shi-Jun Yue, Bai-Yang Zhang, Huan Gao, Lei Zhang, Dan Yan, Yu-Ping Tang,

The <i>Salvia miltiorrhiza</i> and <i>Panax notoginseng</i> herb pair (DQ) has been widely utilized in traditional Chinese medicine for the longevity and for preventing and treating cardio-cerebrovascular diseases. Often associated with cardio-cerebrovascular diseases are comorbidities such as insulin resistance. However, the protective mechanisms of DQ against insulin resistance remain not well ... Read more >>

ACS Omega (ACS omega)
[2021, 6(27):17276-17288]

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Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.

Qi Tian, Yan Zhou, Lizhe Zhu, Huan Gao, Jin Yang,

<b>Background:</b> Ferroptosis is an iron-dependent programmed cell death process. Recent studies have found that ferroptosis inducers hold promising potential in the treatment of lung adenocarcinoma (LUAD). However, the comprehensive analysis about the prognostic value of ferroptosis-related genes in LUAD remains to be elucidated. <b>Methods:</b> The RNA sequencing data and corresponding ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:684259]

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Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children.

Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang,

Identification of exact causative genes is important for <i>in silico</i> drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of etiological genes. The network-based core gene identification method can effectively use the interactions between genes and ... Read more >>

Comput Struct Biotechnol J (Computational and structural biotechnology journal)
[2021, 19:3908-3921]

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A Novel Ferroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Breast Cancer.

Lizhe Zhu, Qi Tian, Siyuan Jiang, Huan Gao, Shibo Yu, Yudong Zhou, Yu Yan, Yu Ren, Jianjun He, Bin Wang,

<h4>Introduction</h4>Breast cancer is the most common malignant tumor in women worldwide. However, advanced multidisciplinary therapy cannot rescue the mortality of high-risk breast cancer metastasis. Ferroptosis is a newly discovered form of regulating cell death that related to cancer treatment, especially in eradicating aggressive malignancies that are resistant to traditional therapies. ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:670184]

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Visible light-induced alkylpyridylation of styrenes via a reductive radical three-component coupling.

Jing-Miao Yu, Li-Wen Zhu, Xiao-Yuan Hong, Huan Gao, Ting-Ting Chen,

A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported. Hantzsch ester was found to be key to initiate the overall reductive radical coupling reaction. This radical process realized difunctionalization of styrenes, selectively yielding alkylated pyridines in good to excellent yields with a wide tolerance ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2021, 19(25):5642-5648]

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Biological-based control strategies for MBR membrane biofouling: a review.

Yin Cui, Huan Gao, Ran Yu, Lei Gao, Manjun Zhan,

Membrane bioreactor (MBR) technology has been paid extensive attention for wastewater treatment because of its advantages of high effluent quality and minimized occupation space and sludge production. However, the membrane fouling is always an inevitable problem, which causes high operation and maintenance costs and prevents the wide use of MBR ... Read more >>

Water Sci Technol (Water science and technology : a journal of the International Association on Water Pollution Research)
[2021, 83(11):2597-2614]

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Modulating Polarization of Perovskite-Based Heterostructures via In Situ Semiconductor Generation and Enzyme Catalysis for Signal-Switchable Photoelectrochemical Biosensing.

Hao Yang, Min Zhang, Lei Wang, Renzhong Yu, Wenwen Tu, Zhaoyin Wang, Rui Wang, Huan Gao, Zhihui Dai,

Polarization of photoactive materials in current photoelectric (PE) systems is difficult to be adjusted, and thus electron-transfer routes of these systems are unchangeable, which limits their performance in photoelectrochemical (PEC) analysis. Herein, we attempted to modulate the polarization of perovskite-based heterostructures by both in situ semiconductor generation and enzyme catalysis. ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(23):8370-8378]

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Subgrouping by gene expression profiles to improve relapse risk prediction in paediatric B-precursor acute lymphoblastic leukaemia.

Qingsheng Huang, Jiayong Zhong, Huan Gao, Kuanrong Li, Huiying Liang,

Relapsed acute lymphoblastic leukaemia (ALL) remains a prevalent paediatric cancer and one of the most common causes of mortality from malignancy in children. Tailoring the intensity of therapy according to early stratification is a promising strategy but remains a major challenge due to heterogeneity and subtyping difficulty. In this study, ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(11):3782-3793]

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Hydrocarbon transformation pathways and soil organic carbon stability in the biostimulation of oil-contaminated soil: Implications of 13C natural abundance.

Heng Liu, Manli Wu, Huan Gao, Ning Yi, Xuhong Duan,

Mineralization, assimilation, and humification are key processes to detoxify oil-contaminated soil by biostimulation remediation strategies, and these processes are affected by stimulants. In this study, we investigated the effects of either inorganic salts or organic stimulants (organic compost and sawdust) on hydrocarbon transformation. Total petroleum hydrocarbons (TPH) and hydrocarbon components ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 788:147580]

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Isotope fractionation (δ 13C, δ15N) and microbial community response in degradation of petroleum hydrocarbons by biostimulation in contaminated soil

Heng Liu, Manli Wu, Xiqian Guo, Huan Gao, Yinrui Xu,

This study investigated the isotope effects of δ 13 C and δ 15 N and microbial response during biodegradation of hydrocarbons by biostimulation with nitrate or compost in the petroleum-contaminated soil. Compost and KNO 3 amendments promoted the total petroleum hydrocarbon (TPH) removal accompanied by a significant increase of Actinobacteria ... Read more >>

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