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Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

Haoneng Tang, Yong Ke, Hang Ma, Lei Han, Lei Wang, Huifang Zong, Yunsheng Yuan, Zhenyu Wang, Yang He, Yunsong Chang, Shusheng Wang, Junjun Liu, Yali Yue, Wenbo Xu, Xiaoju Zhang, Ziqi Wang, Li Yang, Hua Chen, Yanlin Bian, Baohong Zhang, Yunji Liao, Haiyang Yin, Yi Chen, En Zhang, Xiaoxiao Zhang, Hua Jiang, Yueqing Xie, John Gilly, Mingyuan Wu, Tao Sun, Jianwei Zhu,

Emerging SARS-CoV-2 variants are threatening the efficacy of antibody therapies. Combination treatments including ACE2-Fc have been developed to overcome the evasion of neutralizing antibodies (NAbs) in individual cases. Here we conducted a comprehensive evaluation of this strategy by combining ACE2-Fc with NAbs of diverse epitopes on the RBD. NAb+ACE2-Fc combinations ... Read more >>

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KHDRBS3 promotes paclitaxel resistance and induces glycolysis through modulated MIR17HG/CLDN6 signaling in epithelial ovarian cancer.

Xin Wu, Ling Qiu, Hao Feng, Hao Zhang, Hailin Yu, Yan Du, Hao Wu, Shurong Zhu, Yuanyuan Ruan, Hua Jiang,

Paclitaxel (PTX) resistance contributes to mortality in epithelial ovarian cancer (EOC). Aerobic glycolysis is elevated in the tumor environment and may influence resistance to PTX in EOC. KH domain-containing, RNA-binding signal transduction-associated protein 3 (KHDRBS3) is an RNA binding protein that is up-regulated in EOC, but its underlying mechanism in ... Read more >>

Life Sci (Life sciences)
[2022, 293:120328]

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Exogenous growth hormone functionally alleviates glucocorticoid-induced longitudinal bone growth retardation in male rats by activating the Ihh/PTHrP signaling pathway.

Guoxuan Peng, Hong Sun, Hua Jiang, Qiang Wang, Lebin Gan, Ya Tian, Jianhui Sun, Dalin Wen, Jin Deng,

Glucocorticoid (GC)-induced longitudinal bone growth retardation is a common and severe adverse effect in pediatric patients receiving GC immunosuppressive therapy. Molecular mechanisms underlying GC-induced growth inhibition are unclear. GC withdrawal following short-term high-dose use is common, including in the immediate post-transplant period. However, whether skeleton growth recovery is sufficient or ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2022, :111571]

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A comparative study of condyle position in temporomandibular disorder patients with chewing side preference using cone-beam computed tomography.

Junli Ma, Jiazhu Wang, Dongzong Huang, Zhaowu Wang, Min Hu, Hongchen Liu, Hua Jiang,

<h4>Background</h4>Chewing side preference (CSP) could cause structural and morphological changes of temporomandibular joint (TMJ) and has been suggested as one aetiology of temporomandibular disorders (TMDs), but the condylar position in TMD patients with CSP is unknown.<h4>Objective</h4>To compare the condylar position in the TMD patients with and without CSP.<h4>Methods</h4>Ninety TMD patients ... Read more >>

J Oral Rehabil (Journal of oral rehabilitation)
[2022, 49(2):265-271]

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Dictamnine Inhibits the Adhesion to and Invasion of Uropathogenic Escherichia Coli (UPEC) to Urothelial Cells.

Wenbo Yang, Peng Liu, Ying Chen, Qingyu Lv, Zhongtian Wang, Wenhua Huang, Hua Jiang, Yuling Zheng, Yongqiang Jiang, Liping Sun,

Uropathogenic <i>Escherichia coli</i> (UPEC) is the most common pathogenic bacteria associated with urinary tract infection (UTI). UPEC can cause UTI by adhering to and invading uroepithelial cells. Fimbriae is the most important virulence factor of UPEC, and a potentially promising target in developing novel antibacterial treatments. In this study, the ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2022, 27(1):]

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Surgical resection of intradural extramedullary tumors in the atlantoaxial spine via a posterior approach.

Di-Hua Meng, Jia-Qi Wang, Kun-Xue Yang, Wei-You Chen, Cheng Pan, Hua Jiang,

<h4>Background</h4>The anatomical features of the atlantoaxial spine increase the difficulty of complete and safe removal of atlantoaxial intradural extramedullary (IDEM) tumors. Studies concerning surgical interventions <i>via</i> a posterior approach are limited.<h4>Aim</h4>To investigate the safety and efficacy of atlantoaxial IDEM tumor resection using a one-stage posterior approach.<h4>Methods</h4>We retrospectively analyzed clinical databases ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2022, 10(1):62-70]

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Is bivalirudin an alternative anticoagulant for extracorporeal membrane oxygenation (ECMO) patients? A systematic review and meta-analysis.

Di-Huan Li, Ming-Wei Sun, Jian-Cheng Zhang, Chi Zhang, Lei Deng, Hua Jiang,

<h4>Background</h4>Anticoagulation is important for extracorporeal membrane oxygenation (ECMO). Heparin is widely used; however, in some cases, it is not suitable for patients. Bivalirudin has been recently proposed for ECMO patients, and there is no evidence regarding its effectiveness and safety.<h4>Objective</h4>We aimed to systematically review the effectiveness and safety of bivalirudin ... Read more >>

Thromb Res (Thrombosis research)
[2021, 210:53-62]

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Nanosized Carbon Macrocycles Based on a Planar Chiral Pseudo Meta- [2.2]Paracyclophane.

Jing He, Mohan Yu, Maofu Pang, Yanqing Fan, Zhe Lian, Ying Wang, Wenguang Wang, Yajun Liu, Hua Jiang,

Structural designs combining cycloparaphenylenes (CPPs) backbone with planar chiral [2.2]Paracyclophane ([2.2]PCP) lead to optical-active chiral macrocycles with intriguing properties. X-ray crystal analysis revealed aesthetic necklace-shaped structures and size-dependent packages with long-range channels. The macrocycles exhibit unique photophysical properties with high fluorescence quantum yield of up to 82%, and the fluorescent ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2021, :]

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Prognostic Value and Outcome for ETV6/RUNX1-Positive Pediatric Acute Lymphoblastic Leukemia: A Report From the South China Children's Leukemia Group.

Kun-Yin Qiu, Hong-Gui Xu, Xue-Qun Luo, Hui-Rong Mai, Ning Liao, Li-Hua Yang, Min-Cui Zheng, Wu-Qing Wan, Xue-Dong Wu, Ri-Yang Liu, Qi-Wen Chen, Hui-Qin Chen, Xiao-Fei Sun, Hua Jiang, Xing-Jiang Long, Guo-Hua Chen, Xin-Yu Li, Chang-Gang Li, Li-Bin Huang, Ya-Yun Ling, Dan-Na Lin, Chuan Wen, Wen-Yong Kuang, Xiao-Qin Feng, Zhong-Lv Ye, Bei-Yan Wu, Xiang-Lin He, Qiao-Ru Li, Li-Na Wang, Xian-Ling Kong, Lu-Hong Xu, Chi-Kong Li, Jian-Pei Fang,

<h4>Purpose</h4>To analyzed the outcome of ETV6/RUNX1-positive pediatric acute B lymphoblastic leukemia (B-ALL) with the aim of identifying prognostic value.<h4>Method</h4>A total of 2,530 pediatric patients who were diagnosed with B-ALL were classified into two groups based on the ETV6/RUNX1 status by using a retrospective cohort study method from February 28, 2008, ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:797194]

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Impaired bone marrow microenvironment and stem cells in transfusion-dependent beta-thalassemia.

Xiaoya Zhou, Li Huang, Jieying Wu, Yuhua Qu, Hua Jiang, Jinqiu Zhang, SiYuan Qiu, Can Liao, Xiang Xu, Jianchuan Xia, Qizhou Lian,

Beta-thalassemia (BT) is a hereditary disease caused by abnormal hemoglobin synthesis with consequent ineffective erythropoiesis. Patients with thalassemia major are dependent on long-term blood transfusions with associated long-term complications such as iron overload (IO). This excess iron can result in tissue damage, impaired organ function, and increased morbidity. Growing evidence ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2022, 146:112548]

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Models for Evaluation of Biological Age Based on Multi-omics

Ce Huang, Yingqian Zhu, Fengjiao Huo, Shengyu Feng, Xue Gong, Hua Jiang, Zhongmin Liu, Hailiang Liu,

Aging is a complex process of systemic degeneration at multiple cellular and tissue levels that has a complex mechanism. Individuals age at different rates, and there is a high degree of aging heterogeneity. Therefore, it is inaccurate to judge an individual’s degree of aging by their chronological age. We performed ... Read more >>

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Evaluating machine learning models for sepsis prediction: A systematic review of methodologies.

Hong-Fei Deng, Ming-Wei Sun, Yu Wang, Jun Zeng, Ting Yuan, Ting Li, Di-Huan Li, Wei Chen, Ping Zhou, Qi Wang, Hua Jiang,

Studies for sepsis prediction using machine learning are developing rapidly in medical science recently. In this review, we propose a set of new evaluation criteria and reporting standards to assess 21 qualified machine learning models for quality analysis based on PRISMA. Our assessment shows that (1.) the definition of sepsis ... Read more >>

iScience (iScience)
[2022, 25(1):103651]

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Novel method for high-density porous polyethylene ear reconstruction stent remodeling to achieve high satisfactory outcomes.

Rong Guo, Jianghui Ying, Xiao Yuan, Tingting Xi, Jiachao Xiong, Hua Jiang,

We aimed to explore a novel method for ear reconstruction stent remodeling to achieve high patient satisfactory outcomes. This study is a retrospective review of patients with congenital or acquired ear defects who were prepared for one-stage ear reconstruction with high-density porous polyethylene stent between May 2020 and May 2021. ... Read more >>

J Cosmet Dermatol (Journal of cosmetic dermatology)
[2021, :]

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Target-enriched sequencing enables accurate identification of bloodstream infections in whole blood.

Qian Li, Wenhua Huang, Shengwei Zhang, Yuling Zheng, Qingyu Lv, Decong Kong, Lei Zhang, Yan Zhang, Zhihu Zhao, Miaoyu Wang, Hua Jiang, Peng Liu, Yongqiang Jiang,

Bloodstream infections are within the top ten causes of death globally, with a mortality rate of up to 70%. Gold standard blood culture testing is time-consuming, resulting in delayed, but accurate, treatment. Molecular methods, such as RT-qPCR, have limited targets in one run. We present a new Ampliseq detection system ... Read more >>

J Microbiol Methods (Journal of microbiological methods)
[2022, 192:106391]

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Short chain fatty acids reduces OPCs loss by inhibiting activation of astrocytes via SGK1/IL-6 signaling pathway

Yanmin Gao, Di Xie, Yang Wang, Lei Niu, Hua Jiang,

Short chain fatty acids (SCFAs) are known to be actively involved in neurological disease, but their roles in hypoxic-ischemic brain injury (HIBI) is unclear. This study established a rat model of HIBI, then measured the changes in IL-6 and NLRP3, proliferation and apoptosis indicators of oligodendrocyte precursor cells (OPCs). The ... Read more >>

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The Cost-Effectiveness Analysis of Self-Efficacy-Focused Structured Education Program for Patients With Type 2 Diabetes Mellitus in Mainland China Setting.

Xinjun Jiang, Hua Jiang, Libo Tao, Mingzi Li,

<b>Objective:</b> To assess the long-term (50 years) cost-effectiveness of the self-efficacy-focused structured education program (SSEP) as opposed to routine education among patients with type 2 diabetes mellitus (T2DM) in mainland China from a healthcare service perspective. <b>Methods:</b> A cost-effectiveness analysis method was used. The IQVIA CORE Diabetes Model (version 9.0) ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:767123]

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Kinetics study of the natural split Npu DnaE intein in the generation of bispecific IgG antibodies.

Huifang Zong, Lei Han, Jie Chen, Zhidi Pan, Lei Wang, Rui Sun, Kai Ding, Yueqing Xie, Hua Jiang, Huili Lu, John Gilly, Baohong Zhang, Jianwei Zhu,

Rapid and efficient bispecific antibody (BsAb) production for industrial applications is still facing many challenges. We reported a technology platform for generating bispecific IgG antibodies, "Bispecific Antibody by Protein Trans-splicing (BAPTS)." While the "BAPTS" method has shown potential in high-throughput screening of BsAbs, further understanding and optimizing the methodology is ... Read more >>

Appl Microbiol Biotechnol (Applied microbiology and biotechnology)
[2022, 106(1):161-171]

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Coexistence of Quantum Hall and Quantum Anomalous Hall Phases in Disordered MnBi_{2}Te_{4}.

Hailong Li, Chui-Zhen Chen, Hua Jiang, X C Xie,

In most cases, to observe quantized Hall plateaus, an external magnetic field is applied in intrinsic magnetic topological insulators MnBi_{2}Te_{4}. Nevertheless, whether the nonzero Chern number (C≠0) phase is a quantum anomalous Hall (QAH) state, or a quantum Hall (QH) state, or a mixing state of both is still a ... Read more >>

Phys Rev Lett (Physical review letters)
[2021, 127(23):236402]

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Transcriptomic analyses and experimental verification reveal potential biomarkers and biological pathways of urinary tract infection.

Wenbo Yang, Peng Liu, Yuling Zheng, Zhongtian Wang, Wenhua Huang, Hua Jiang, Qingyu Lv, Yuhao Ren, Yongqiang Jiang, Liping Sun,

Urinary tract infection (UTI) is a common infectious disease. Urinary tract pathogenic Escherichia coli (UPEC) is the main cause of UTIs. At present, antibiotics are mainly used for the treatment of UTIs. However, with the increase of drug resistance, the course of the disease is prolonged. Therefore, identifying the receptors ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):8529-8539]

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Fermitin family homolog 2 (Kindlin-2) affects vascularization during the wound healing process by regulating the Wnt/β-catenin signaling pathway in vascular endothelial cells.

Jianghui Ying, Qiang Wang, Lu Lu, Jiaqi Liu, Rong Guo, Hao Hu, Hua Jiang, Fazhi Qi,

Kindlin-2 is a member of the FERM-containing cytoskeletal protein family that regulates cell-matrix interactions. Previous studies have shown that Kindlin-2 recruits focal adhesion proteins and regulates integration by binding to the focal adhesion region of the integrin β-segment. Although Kindlin-2 has been reported to be involved in various skin diseases ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4654-4665]

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Knockdown of ETV4 promotes autophagy-dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1.

Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gong,

ETS variant transcription factor 4 (ETV4) is a common cancer-promoting transcription factor and its expression has been found to be significantly upregulated in glioblastoma multiforme (GBM), as determined via analysis of the Gene Expression Profiling Interactive Analysis (GEPIA) database. In addition, our previous study demonstrated that ETV4 expression was highly ... Read more >>

Oncol Lett (Oncology letters)
[2022, 23(2):41]

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Distinct Disease Severity Between Children and Older Adults With Coronavirus Disease 2019 (COVID-19): Impacts of ACE2 Expression, Distribution, and Lung Progenitor Cells.

Zhao Zhang, Liyan Guo, Li Huang, Che Zhang, Ruibang Luo, Liang Zeng, Huiying Liang, Qiuhui Li, Xiaoxia Lu, Xianfeng Wang, Chui Yan Ma, Jianbo Shao, Weiren Luo, Le Li, Li Liu, Ziyue Li, Xiaoya Zhou, Xiaoxian Zhang, Jie Liu, Jinjuan Yang, Ka Yi Kwan, Wei Liu, Yi Xu, Hua Jiang, Hongsheng Liu, Hui Du, Yanheng Wu, Guangyin Yu, Junhui Chen, Jieying Wu, Jinqiu Zhang, Can Liao, Huanhuan Joyce Chen, Zhiwei Chen, Hung-Fat Tse, Huimin Xia, Qizhou Lian,

<h4>Background</h4>Children and older adults with coronavirus disease 2019 (COVID-19) display a distinct spectrum of disease severity yet the risk factors aren't well understood. We sought to examine the expression pattern of angiotensin-converting enzyme 2 (ACE2), the cell-entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the role of ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(11):e4154-e4165]

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Optimizing RNAi-Target by Nicotiana benthamiana-Soybean Mosaic Virus System Drives Broad Resistance to Soybean Mosaic Virus in Soybean.

Hua Jiang, Kai Li, Junyi Gai,

Soybean mosaic virus (SMV) is a prevalent pathogen of soybean (<i>Glycine max</i>). Pyramiding multiple SMV-resistance genes into one individual is tedious and difficult, and even if successful, the obtained multiple resistance might be broken by pathogen mutation, while targeting viral genome <i>via</i> host-induced gene silencing (HIGS) has potential to explore ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:739971]

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Association between Subclavian Artery Plaques and Future Cardiovascular Events in a Hypertensive Cohort

Liying Mu, Lu Chen, Lijuan Du, Hua Jiang, Caixia Guo, Zening Jin,

<h4>Background: </h4> Atherosclerosis is one of the leading contributors to cardiovascular diseases. Subclinical atherosclerosis could occur long time before the presence of clinical symptoms and may have predictive value for future cardiovascular events. Existing carotid subclinical atherosclerotic markers have limited value. Subjects and Methods Patients admitted to the cardiac vascular ... Read more >>

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Preventive Effect of Gonggan (Citrus Reticulata Blanco Var. Gonggan) Peel Extract on Ethanol/HCl-Induced Gastric Injury in Mice via an Anti-oxidative Mechanism.

Ya Wu, Hua Jiang, Guangfang Chen, Xingxing Chen, Chengming Hu, Xiaofei Su, Fang Tan, Xin Zhao,

Gonggan (Citrus reticulata Blanco var. gonggan) is one of the most popular citruses. In this study, the effect of Gonggan peel extract (GPE) on gastric injury was investigated. The components in GPE were analysed by HPLC and the gastric injury model in mice was established by ethanol/hydrochloric acid. After treatment ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:715306]

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